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Hans Heidner

TitleProfessor
InstitutionUniversity of Texas at San Antonio
DepartmentBiology
Address1 UTSA Cir
San Antonio TX 78249
Phone(210) 458-5767
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    Dr. Heidner’s research focuses on the replication of alphaviruses in vertebrate and mosquito cells, as well as the use of alphavirus-based vectors for cell targeting and vaccine applications and development. Alphaviruses are mosquito-borne, zoonotic pathogens that cause outbreaks in humans and animals. Alphaviruses remain a global issue, and each continent has humans at risk from one or more of these arthropod-borne viruses (arboviruses). Humans infected with the alphavirus experience severe encephalitis to polyarthritis. Most infections also cause fever, headaches and muscle pains to severe headache, seizures, and possibly even death.
    Dr. Heidner’s research also focuses on the design and evaluation of recombinant alphaviruses for the purpose of targeting virus particles to specific cell types such as tumor cells, and to enhance innate and adaptive immune responses to virus-expressed vaccine antigens. He is working on research that could be used to deliver vaccine antigens derived from a broad range of pathogens.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Krishnavajhala HR, Williams J, Heidner H. An influenza A virus vaccine based on an M2e-modified alphavirus. Arch Virol. 2018 Feb; 163(2):483-488. PMID: 29079954.
      Citations:    Fields:    Translation:HumansAnimalsCellsPHPublic Health
    2. Cunningham AL, Dang KM, Yu JJ, Guentzel MN, Heidner HW, Klose KE, Arulanandam BP. Enhancement of vaccine efficacy by expression of a TLR5 ligand in the defined live attenuated Francisella tularensis subsp. novicida strain U112?iglB::fljB. Vaccine. 2014 Sep 08; 32(40):5234-40. PMID: 25050972.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    3. Yahirun JJ, Hamplová D. CHILDREN'S UNION STATUS AND CONTACT WITH MOTHERS: A CROSS-NATIONAL STUDY. Demogr Res. 2014 Jan-Jun; 30:1413-1444. PMID: 10405372.
      Citations: 13     Fields:    Translation:AnimalsCells
    4. Yahirun JJ, Hamplová D. CHILDREN'S UNION STATUS AND CONTACT WITH MOTHERS: A CROSS-NATIONAL STUDY. Demogr Res. 2014 Jan-Jun; 30:1413-1444. PMID: 15051384.
      Citations: 6     Fields:    Translation:Cells
    5. Cano-Monreal GL, Williams JC, Heidner HW. An arthropod enzyme, Dfurin1, and a vertebrate furin homolog display distinct cleavage site sequence preferences for a shared viral proprotein substrate. J Insect Sci. 2010; 10:29. PMID: 20578951.
      Citations: 1     Fields:    Translation:AnimalsCells
    6. Thomas JM, Moen ST, Gnade BT, Vargas-Inchaustegui DA, Foltz SM, Suarez G, Heidner HW, König R, Chopra AK, Peterson JW. Recombinant Sindbis virus vectors designed to express protective antigen of Bacillus anthracis protect animals from anthrax and display synergy with ciprofloxacin. Clin Vaccine Immunol. 2009 Nov; 16(11):1696-9. PMID: 19759250.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    7. Balasuriya UBR, Snijder EJ, Heidner HW, Zhang J, Zevenhoven-Dobbe JC, Boone JD, McCollum WH, Timoney PJ, MacLachlan NJ. Development and characterization of an infectious cDNA clone of the virulent Bucyrus strain of Equine arteritis virus. J Gen Virol. 2007 Mar; 88(Pt 3):918-924. PMID: 17325365.
      Citations: 14     Fields:    Translation:AnimalsCells
    8. Klimstra WB, Williams JC, Ryman KD, Heidner HW. Targeting Sindbis virus-based vectors to Fc receptor-positive cell types. Virology. 2005 Jul 20; 338(1):9-21. PMID: 15922395.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    9. Chew DS, Choi KP, Heidner H, Leung MY. Palindromes in SARS and Other Coronaviruses. INFORMS J Comput. 2004; 16(4):331-340. PMID: 24966663.
      Citations:    
    10. Thomas JM, Klimstra WB, Ryman KD, Heidner HW. Sindbis virus vectors designed to express a foreign protein as a cleavable component of the viral structural polyprotein. J Virol. 2003 May; 77(10):5598-606. PMID: 12719552.
      Citations: 22     Fields:    Translation:AnimalsCells
    11. Balasuriya UB, Heidner HW, Davis NL, Wagner HM, Hullinger PJ, Hedges JF, Williams JC, Johnston RE, David Wilson W, Liu IK, James MacLachlan N. Alphavirus replicon particles expressing the two major envelope proteins of equine arteritis virus induce high level protection against challenge with virulent virus in vaccinated horses. Vaccine. 2002 Feb 22; 20(11-12):1609-17. PMID: 11858869.
      Citations: 27     Fields:    Translation:AnimalsCellsPHPublic Health
    12. Boehme KW, Popov VL, Heidner HW. The host range phenotype displayed by a Sindbis virus glycoprotein variant results from virion aggregation and retention on the surface of mosquito cells. J Virol. 2000 Dec; 74(23):11398-406. PMID: 11070041.
      Citations: 2     Fields:    Translation:AnimalsCells
    13. Balasuriya UB, Heidner HW, Hedges JF, Williams JC, Davis NL, Johnston RE, MacLachlan NJ. Expression of the two major envelope proteins of equine arteritis virus as a heterodimer is necessary for induction of neutralizing antibodies in mice immunized with recombinant Venezuelan equine encephalitis virus replicon particles. J Virol. 2000 Nov; 74(22):10623-30. PMID: 11044106.
      Citations: 18     Fields:    Translation:AnimalsCellsPHPublic Health
    14. Boehme KW, Williams JC, Johnston RE, Heidner HW. Linkage of an alphavirus host-range restriction to the carbohydrate-processing phenotypes of the host cell. J Gen Virol. 2000 Jan; 81(Pt 1):161-70. PMID: 10640554.
      Citations: 5     Fields:    Translation:AnimalsCells
    15. Klimstra WB, Heidner HW, Johnston RE. The furin protease cleavage recognition sequence of Sindbis virus PE2 can mediate virion attachment to cell surface heparan sulfate. J Virol. 1999 Aug; 73(8):6299-306. PMID: 10400721.
      Citations: 35     Fields:    Translation:AnimalsCells
    16. Paredes AM, Heidner H, Thuman-Commike P, Prasad BV, Johnston RE, Chiu W. Structural localization of the E3 glycoprotein in attenuated Sindbis virus mutants. J Virol. 1998 Feb; 72(2):1534-41. PMID: 9445057.
      Citations: 27     Fields:    Translation:AnimalsCells
    17. McKnight KL, Simpson DA, Lin SC, Knott TA, Polo JM, Pence DF, Johannsen DB, Heidner HW, Davis NL, Johnston RE. Deduced consensus sequence of Sindbis virus strain AR339: mutations contained in laboratory strains which affect cell culture and in vivo phenotypes. J Virol. 1996 Mar; 70(3):1981-9. PMID: 8627724.
      Citations: 45     Fields:    Translation:AnimalsCells
    18. Heidner HW, Knott TA, Johnston RE. Differential processing of sindbis virus glycoprotein PE2 in cultured vertebrate and arthropod cells. J Virol. 1996 Mar; 70(3):2069-73. PMID: 8627739.
      Citations: 16     Fields:    Translation:AnimalsCells
    19. Heidner HW, Johnston RE. The amino-terminal residue of Sindbis virus glycoprotein E2 influences virus maturation, specific infectivity for BHK cells, and virulence in mice. J Virol. 1994 Dec; 68(12):8064-70. PMID: 7966596.
      Citations: 12     Fields:    Translation:AnimalsCells
    20. Heidner HW, McKnight KL, Davis NL, Johnston RE. Lethality of PE2 incorporation into Sindbis virus can be suppressed by second-site mutations in E3 and E2. J Virol. 1994 Apr; 68(4):2683-92. PMID: 7908062.
      Citations: 19     Fields:    Translation:AnimalsCells
    21. DeMaula CD, Heidner HW, Rossitto PV, Pierce CM, MacLachlan NJ. Neutralization determinants of United States bluetongue virus serotype ten. Virology. 1993 Jul; 195(1):292-6. PMID: 7686312.
      Citations: 7     Fields:    Translation:Cells
    22. MacLachlan NJ, Rossitto PV, Heidner HW, Iezzi LG, Yilma TD, DeMaula CD, Osburn BI. Variation amongst the neutralizing epitopes of bluetongue viruses isolated in the United States in 1979-1981. Vet Microbiol. 1992 Jun 15; 31(4):303-16. PMID: 1379766.
      Citations: 2     Fields:    Translation:AnimalsCells
    23. Heidner HW, Iezzi LG, Osburn BI, MacLachlan NJ. Genetic variation and evolutionary relationships amongst bluetongue viruses endemic in the United States. Virus Res. 1991 Oct; 21(2):91-109. PMID: 1661983.
      Citations: 5     Fields:    Translation:AnimalsCells
    24. MacLachlan NJ, Jagels G, Rossitto PV, Moore PF, Heidner HW. The pathogenesis of experimental bluetongue virus infection of calves. Vet Pathol. 1990 Jul; 27(4):223-9. PMID: 2169663.
      Citations: 18     Fields:    Translation:AnimalsCells
    25. Heidner HW, Rossitto PV, MacLachlan NJ. Identification of four distinct neutralizing epitopes on bluetongue virus serotype 10 using neutralizing monoclonal antibodies and neutralization-escape variants. Virology. 1990 Jun; 176(2):658-61. PMID: 1693250.
      Citations: 2     Fields:    Translation:AnimalsCells
    26. Heidner HW, Iezzi LG, MacLachlan NJ. A simplified procedure for oligonucleotide fingerprint analysis of multiple bluetongue virus genome segments utilizing small gels. J Virol Methods. 1989 Nov; 26(2):223-8. PMID: 2559104.
      Citations:    Fields:    Translation:AnimalsCells
    27. Whetter LE, Maclachlan NJ, Gebhard DH, Heidner HW, Moore PF. Bluetongue virus infection of bovine monocytes. J Gen Virol. 1989 Jul; 70 ( Pt 7):1663-76. PMID: 2544659.
      Citations: 17     Fields:    Translation:AnimalsCells
    28. Richards RG, MacLachlan NJ, Heidner HW, Fuller FJ. Comparison of virologic and serologic responses of lambs and calves infected with bluetongue virus serotype 10. Vet Microbiol. 1988 Dec; 18(3-4):233-42. PMID: 2852871.
      Citations: 7     Fields:    Translation:AnimalsCells
    29. Heidner HW, MacLachlan NJ, Fuller FJ, Richards RG, Whetter LE. Bluetongue virus genome remains stable throughout prolonged infection of cattle. J Gen Virol. 1988 Oct; 69 ( Pt 10):2629-36. PMID: 2459303.
      Citations: 3     Fields:    Translation:AnimalsCells
    30. Greene RT, Walker RL, Nicholson WL, Heidner HW, Levine JF, Burgess EC, Wyand M, Breitschwerdt EB, Berkhoff HA. Immunoblot analysis of immunoglobulin G response to the Lyme disease agent (Borrelia burgdorferi) in experimentally and naturally exposed dogs. J Clin Microbiol. 1988 Apr; 26(4):648-53. PMID: 3366860.
      Citations: 24     Fields:    Translation:AnimalsCells
    31. MacLachlan NJ, Heidner HW, Fuller FJ. Humoral immune response of calves to bluetongue virus infection. Am J Vet Res. 1987 Jul; 48(7):1031-5. PMID: 2820272.
      Citations: 6     Fields:    Translation:Animals
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