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Christina Sobin

TitleDr.
Faculty RankProfessor
InstitutionUniversity of Texas at El Paso
DepartmentPublic Health Sciences, College of Health Sciences
Address500 West University
University of Texas El Paso
El Paso TX 79912
Phone9157477274
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    Other Positions
    TitleAdjunct Researcher
    InstitutionThe Rockefeller University
    DepartmentNeuroendocrinology

    TitleAdjunct Faculty
    InstitutionThe Rockefeller University
    DepartmentNeuroendocrinology


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    My laboratory studies brain and behavior during development. In child studies, we examine cognitive concomitants and sequelae of genetic variants and medical conditions; these provide a natural manipulation of brain mechanisms that may be unrecognized as critical for key mental functions, particularly visual attention, working memory, inhibitory control, and motor dexterity. Our work is translational and we use results from child studies to guide the development of new animal models. Currently, we are studying the effects on brain and behavior of early chronic low-level lead exposure. In child studies, we have provided new evidence of a genetic variant (hPEPT2) that increases low blood lead burden and predicts unique working memory and motor deficits in young males exposed to low-level lead. In mouse low-level lead exposure studies, we have begun to characterize memory deficits using a novel odor recognition task and quantified loss of microglia in dentate gyrus following early chronic low-level lead exposure. As we attempt to replicate these first results, future studies, will test effects in an hPEPT2 transgenic mouse model.

    Collapse Research 
    Collapse research activities and funding
    K08HD040321     (SOBIN, CHRISTINA)Jun 1, 2001 - May 31, 2006
    NIH
    Attention in Children with the 22q11 Deletion Syndrome
    Role: Principal Investigator

    R21HD060120     (SOBIN, CHRISTINA)Apr 9, 2009 - May 31, 2013
    NIH
    Lead, Genes, and Cognition in Underserved Children
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Carlson LM, Champagne FA, Cory-Slechta DA, Dishaw L, Faustman E, Mundy W, Segal D, Sobin C, Starkey C, Taylor M, Makris SL, Kraft A. Potential frameworks to support evaluation of mechanistic data for developmental neurotoxicity outcomes: A symposium report. Neurotoxicol Teratol. 2020 Mar - Apr; 78:106865. PMID: 32068112.
      Citations: 1     Fields:    Translation:HumansAnimals
    2. Golub MS, Sobin CA. Statistical modeling with litter as a random effect in mixed models to manage "intralitter likeness". Neurotoxicol Teratol. 2020 Jan - Feb; 77:106841. PMID: 31863841.
      Citations: 4     Fields:    Translation:Animals
    3. Flores-Montoya MG, Bill CA, Vines CM, Sobin C. Early chronic low-level lead exposure reduced C-C chemokine receptor 7 in hippocampal microglia. Toxicol Lett. 2019 Oct 10; 314:106-116. PMID: 31306743.
      Citations:    Fields:    Translation:AnimalsCells
    4. Dominguez S, Flores-Montoya MG, Sobin C. Early chronic exposure to low-level lead alters total hippocampal microglia in pre-adolescent mice. Toxicol Lett. 2019 Mar 01; 302:75-82. PMID: 30352268.
      Citations: 1     Fields:    Translation:AnimalsCells
    5. Alvarez J, Del Rio M, Mayorga T, Dominguez S, Flores-Montoya MG, Sobin C. A Comparison of Child Blood Lead Levels in Urban and Rural Children Ages 5-12 Years Living in the Border Region of El Paso, Texas. Arch Environ Contam Toxicol. 2018 Nov; 75(4):503-511. PMID: 30056617.
      Citations: 1     Fields:    Translation:HumansPHPublic Health
    6. Del Rio M, Alvarez J, Mayorga T, Dominguez S, Sobin C. A comparison of arsenic exposure in young children and home water arsenic in two rural West Texas communities. BMC Public Health. 2017 10 27; 17(1):850. PMID: 29078766.
      Citations: 2     Fields:    Translation:HumansPHPublic Health
    7. Sobin C, Flores-Montoya MG, Alvarez JM. Early chronic low-level Pb exposure alters global exploratory behaviors but does not impair spatial and object memory retrieval in an object-in-place task in pre-adolescent C57BL/6J mice. Neurotoxicol Teratol. 2017 05; 61:104-114. PMID: 28089843.
      Citations: 2     Fields:    Translation:Animals
    8. Sobin C. Correspondence: Assessment of learning, memory and attention in developmental neurotoxicology. Neurotoxicol Teratol. 2017 Jan - Feb; 59:76-77. PMID: 27979759.
      Citations:    Fields:    Translation:HumansAnimals
    9. Garcia LB, Sobin C, Tomaka J, Santiago I, Palacios R, Walker WS. A Comparison of Water-Related Perceptions and Practices Among West Texas and South New Mexico Colonia Residents Using Hauled-Stored and Private Well Water. J Environ Health. 2016 Sep; 79(2):14-20. PMID: 29115810.
      Citations: 1     Fields:    Translation:HumansPHPublic Health
    10. Mouton PR, Sobin C. Developing a census of brain cells for the corticoendogram of human consciousness. J Chem Neuroanat. 2016 Oct; 76(Pt B):61-63. PMID: 26518538.
      Citations:    Fields:    
    11. Flores-Montoya MG, Alvarez JM, Sobin C. Olfactory recognition memory is disrupted in young mice with chronic low-level lead exposure. Toxicol Lett. 2015 Jul 02; 236(1):69-74. PMID: 25936521.
      Citations: 4     Fields:    Translation:HumansAnimalsPHPublic Health
    12. Sobin C, Flores-Montoya MG, Gutierrez M, Parisi N, Schaub T. d-Aminolevulinic acid dehydratase single nucleotide polymorphism 2 (ALAD2) and peptide transporter 2*2 haplotype (hPEPT2*2) differently influence neurobehavior in low-level lead exposed children. Neurotoxicol Teratol. 2015 Jan-Feb; 47:137-45. PMID: 25514583.
      Citations: 10     Fields:    Translation:Humans
    13. Flores-Montoya MG, Sobin C. Early chronic lead exposure reduces exploratory activity in young C57BL/6J mice. J Appl Toxicol. 2015 Jul; 35(7):759-65. PMID: 25219894.
      Citations: 8     Fields:    Translation:Animals
    14. Basgen JM, Sobin C. Early chronic low-level lead exposure produces glomerular hypertrophy in young C57BL/6J mice. Toxicol Lett. 2014 Feb 10; 225(1):48-56. PMID: 24300173.
      Citations: 9     Fields:    Translation:AnimalsCells
    15. Sobin C, Montoya MG, Parisi N, Schaub T, Cervantes M, Armijos RX. Microglial disruption in young mice with early chronic lead exposure. Toxicol Lett. 2013 Jun 20; 220(1):44-52. PMID: 23598043.
      Citations: 10     Fields:    Translation:AnimalsCells
    16. Sobin C, Parisi N, Schaub T, de la Riva E. A Bland-Altman comparison of the Lead Care® System and inductively coupled plasma mass spectrometry for detecting low-level lead in child whole blood samples. J Med Toxicol. 2011 Mar; 7(1):24-32. PMID: 20886381.
      Citations: 10     Fields:    Translation:HumansPHPublic Health
    17. Sobin C, Parisi N, Schaub T, Gutierrez M, Ortega AX. d-Aminolevulinic acid dehydratase single nucleotide polymorphism 2 and peptide transporter 2*2 haplotype may differentially mediate lead exposure in male children. Arch Environ Contam Toxicol. 2011 Oct; 61(3):521-9. PMID: 21327641.
      Citations: 10     Fields:    Translation:HumansPHPublic Health
    18. Sobin C, Gutierrez M, Alterio H. Polymorphisms of delta-aminolevulinic acid dehydratase (ALAD) and peptide transporter 2 (PEPT2) genes in children with low-level lead exposure. Neurotoxicology. 2009 Nov; 30(6):881-7. PMID: 19723536.
      Citations: 14     Fields:    Translation:Humans
    19. Sobin C, Kiley-Brabeck K, Monk SH, Khuri J, Karayiorgou M. Sex differences in the behavior of children with the 22q11 deletion syndrome. Psychiatry Res. 2009 Mar 31; 166(1):24-34. PMID: 19217670.
      Citations: 8     Fields:    Translation:HumansCells
    20. Sobin C, Monk SH, Kiley-Brabeck K, Khuri J, Karayiorgou M. Neuromotor deficits in children with the 22q11 deletion syndrome. Mov Disord. 2006 Dec; 21(12):2082-9. PMID: 16991148.
      Citations: 13     Fields:    Translation:HumansCells
    21. Sobin C, Kiley-Brabeck K, Dale K, Monk SH, Khuri J, Karayiorgou M. Olfactory disorder in children with 22q11 deletion syndrome. Pediatrics. 2006 Sep; 118(3):e697-703. PMID: 16908619.
      Citations: 7     Fields:    Translation:HumansCells
    22. Kiley-Brabeck K, Sobin C. Social skills and executive function deficits in children with the 22q11 Deletion Syndrome. Appl Neuropsychol. 2006; 13(4):258-68. PMID: 17362146.
      Citations: 30     Fields:    Translation:HumansCells
    23. Sobin C, Kiley-Brabeck K, Karayiorgou M. Lower prepulse inhibition in children with the 22q11 deletion syndrome. Am J Psychiatry. 2005 Jun; 162(6):1090-9. PMID: 15930057.
      Citations: 49     Fields:    Translation:HumansCells
    24. Sobin C, Kiley-Brabeck K, Karayiorgou M. Associations between prepulse inhibition and executive visual attention in children with the 22q11 deletion syndrome. Mol Psychiatry. 2005 Jun; 10(6):553-62. PMID: 15520831.
      Citations: 20     Fields:    Translation:HumansCellsCTClinical Trials
    25. Sobin C, Kiley-Brabeck K, Daniels S, Khuri J, Taylor L, Blundell M, Anyane-Yeboa K, Karayiorgou M. Neuropsychological characteristics of children with the 22q11 Deletion Syndrome: a descriptive analysis. Child Neuropsychol. 2005 Feb; 11(1):39-53. PMID: 15823982.
      Citations: 38     Fields:    Translation:HumansCells
    26. Karayiorgou M, Torrington M, Abecasis GR, Pretorius H, Robertson B, Kaliski S, Lay S, Sobin C, Möller N, Lundy SL, Blundell ML, Gogos JA, Roos JL. Phenotypic characterization and genealogical tracing in an Afrikaner schizophrenia database. . 2004 Jan 01; 124B(1):20-8. PMID: 14681908.
      Citations:    
    27. Sobin C, Kiley-Brabeck K, Daniels S, Blundell M, Anyane-Yeboa K, Karayiorgou M. Networks of attention in children with the 22q11 deletion syndrome. Dev Neuropsychol. 2004; 26(2):611-26. PMID: 15456687.
      Citations: 35     Fields:    Translation:HumansCells
    28. Wijsman EM, Rosenthal EA, Hall D, Blundell ML, Sobin C, Heath SC, Williams R, Brownstein MJ, Gogos JA, Karayiorgou M. Genome-wide scan in a large complex pedigree with predominantly male schizophrenics from the island of Kosrae: evidence for linkage to chromosome 2q. Mol Psychiatry. 2003 Jul; 8(7):695-705, 643. PMID: 12874606.
      Citations: 18     Fields:    Translation:HumansCells
    29. Sobin C, Roos JL, Pretorius H, Lundy LS, Karayiorgou M. A comparison study of early non-psychotic deviant behavior in Afrikaner and US patients with schizophrenia or schizoaffective disorder. Psychiatry Res. 2003 Feb 15; 117(2):113-25. PMID: 12606014.
      Citations: 4     Fields:    Translation:Humans
    30. Liu H, Heath SC, Sobin C, Roos JL, Galke BL, Blundell ML, Lenane M, Robertson B, Wijsman EM, Rapoport JL, Gogos JA, Karayiorgou M. Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophrenia. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3717-22. PMID: 11891283.
      Citations: 91     Fields:    Translation:HumansCells
    31. Sobin C, Blundell ML, Conry A, Weiller F, Gavigan C, Haiman C, Karayiorgou M. Early, non-psychotic deviant behavior in schizophrenia: a possible endophenotypic marker for genetic studies. Psychiatry Res. 2001 Mar 25; 101(2):101-13. PMID: 11286814.
      Citations: 6     Fields:    Translation:Humans
    32. Sobin C, Blundell ML, Karayiorgou M. Phenotypic differences in early- and late-onset obsessive-compulsive disorder. Compr Psychiatry. 2000 Sep-Oct; 41(5):373-9. PMID: 11011834.
      Citations: 16     Fields:    Translation:Humans
    33. Sobin C, Blundell ML, Weiller F, Gavigan C, Haiman C, Karayiorgou M. Evidence of a schizotypy subtype in OCD. J Psychiatr Res. 2000 Jan-Feb; 34(1):15-24. PMID: 10696829.
      Citations: 13     Fields:    Translation:Humans
    34. Sobin C, Alpert M. Emotion in speech: the acoustic attributes of fear, anger, sadness, and joy. J Psycholinguist Res. 1999 Jul; 28(4):347-65. PMID: 10380660.
      Citations: 22     Fields:    Translation:Humans
    35. Sobin C, Blundell M, Weiller F, Gavigan C, Haiman C, Karayiorgou M. Phenotypic characteristics of Obsessive-Compulsive Disorder ascertained in adulthood. J Psychiatr Res. 1999 May-Jun; 33(3):265-73. PMID: 10367993.
      Citations: 2     Fields:    Translation:Humans
    36. Karayiorgou M, Sobin C, Blundell ML, Galke BL, Malinova L, Goldberg P, Ott J, Gogos JA. Family-based association studies support a sexually dimorphic effect of COMT and MAOA on genetic susceptibility to obsessive-compulsive disorder. Biol Psychiatry. 1999 May 01; 45(9):1178-89. PMID: 10331110.
      Citations: 50     Fields:    Translation:HumansCells
    37. Bennett RL, Karayiorgou M, Sobin CA, Norwood TH, Kay MA. Identification of an interstitial deletion in an adult female with schizophrenia, mental retardation, and dysmorphic features: further support for a putative schizophrenia-susceptibility locus at 5q21-23.1. Am J Hum Genet. 1997 Dec; 61(6):1450-4. PMID: 9399892.
      Citations: 6     Fields:    Translation:HumansCells
    38. Sobin C, Sackeim HA. Psychomotor symptoms of depression. Am J Psychiatry. 1997 Jan; 154(1):4-17. PMID: 8988952.
      Citations: 97     Fields:    Translation:Humans
    39. Sobin C, Sackeim HA, Prudic J, Devanand DP, Moody BJ, McElhiney MC. Predictors of retrograde amnesia following ECT. Am J Psychiatry. 1995 Jul; 152(7):995-1001. PMID: 7793470.
      Citations: 29     Fields:    Translation:HumansCTClinical Trials
    40. Horwath E, Wolk SI, Goldstein RB, Wickramaratne P, Sobin C, Adams P, Lish JD, Weissman MM. Is the comorbidity between social phobia and panic disorder due to familial cotransmission or other factors? Arch Gen Psychiatry. 1995 Jul; 52(7):574-82. PMID: 7598634.
      Citations: 6     Fields:    Translation:Humans
    41. Goldstein RB, Weissman MM, Adams PB, Horwath E, Lish JD, Charney D, Woods SW, Sobin C, Wickramaratne PJ. Psychiatric disorders in relatives of probands with panic disorder and/or major depression. Arch Gen Psychiatry. 1994 May; 51(5):383-94. PMID: 8179462.
      Citations: 12     Fields:    Translation:Humans
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