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Marc B. Cox

Faculty RankProfessor
InstitutionUniversity of Texas at El Paso
AddressEl Paso TX
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    My laboratory studies chaperone proteins that bind to and regulate the steroid hormone receptors. At least twelve chaperone and cochaperone proteins are required for normal receptor function, including Hsp70 and Hsp90. All of these factors offer the potential opportunity for therapeutic intervention. We are interested in understanding the manner in which these factors influence receptor folding, hormone binding, nuclear translocation, dimerization, and DNA binding. One group of cochaperones termed immunophilins are of particular interest as they are the only receptor-associated cochaperones that display specificity towards small subsets of Hsp90 substrate proteins. Two immunophilins, FKBP51 and FKBP52, specifically regulate glucocorticoid, androgen and progesterone receptor function in cells and whole animal models. Using various biochemical and cellular approaches in yeast and mammalian cells, my lab is actively working to understand the molecular mechanism by which the FKBP proteins influence receptor function. In addition, we are developing and employing strategies to identify selective FKBP inhibitors that could be used to treat hormone-related diseases such as prostate cancer. Over the last fourteen years I have worked in the areas of steroid hormone receptor function, environmental endocrine disruption, and chaperone biology. During that time I acquired a vast amount of experience in both the molecular chaperone field and the steroid hormone receptor field. I have published extensively on the cochaperone regulation of receptor function, most recently focused on the FKBP immunophilin proteins.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Soto OB, Ramirez CS, Koyani R, Rodriguez-Palomares IA, Dirmeyer JR, Grajeda B, Roy S, Cox MB. Structure and function of the TPR-domain immunophilins FKBP51 and FKBP52 in normal physiology and disease. J Cell Biochem. 2023 Apr 23. PMID: 37087733.
      Citations:    Fields:    
    2. van Oosten-Hawle P, Backe SJ, Ben-Zvi A, Bourboulia D, Brancaccio M, Brodsky J, Clark M, Colombo G, Cox MB, De Los Rios P, Echtenkamp F, Edkins A, Freeman B, Goloubinoff P, Houry W, Johnson J, LaPointe P, Li W, Mezger V, Neckers L, Nillegoda NB, Prahlad V, Reitzel A, Scherz-Shouval R, Sistonen L, Tsai FTF, Woodford MR, Mollapour M, Truman AW. Second Virtual International Symposium on Cellular and Organismal Stress Responses, September 8-9, 2022. Cell Stress Chaperones. 2023 01; 28(1):1-9. PMID: 36602710.
      Citations:    Fields:    Translation:Humans
    3. Ortiz NR, Guy N, Garcia YA, Sivils JC, Galigniana MD, Cox MB. Functions of the Hsp90-Binding FKBP Immunophilins. Subcell Biochem. 2023; 101:41-80. PMID: 36520303.
      Citations:    Fields:    
    4. Hiatt RA, Carrasco YP, Paciorek AL, Kaplan L, Cox MB, Crespo CJ, Feig A, Hueffer K, McFerrin H, Norris K, Roberts-Kirchhoff E, Saetermoe CL, Silver GB, Snyder K, Zavala AR, Parangan-Smith AG. Enhancing grant-writing expertise in BUILD institutions: Building infrastructure leading to diversity. PLoS One. 2022; 17(9):e0274100. PMID: 36137156.
      Citations:    Fields:    Translation:Humans
    5. Ekpenyong O, Cooper C, Ma J, Guy NC, Payan AN, Ban F, Cherkasov A, Cox MB, Liang D, Xie H. Bioanalytical Assay Development and Validation for the Pharmacokinetic Study of GMC1, a Novel FKBP52 Co-chaperone Inhibitor for Castration Resistant Prostate Cancer. Pharmaceuticals (Basel). 2020 Nov 13; 13(11). PMID: 33202977.
    6. Singh JK, Hutt DM, Tait B, Guy NC, Sivils JC, Ortiz NR, Payan AN, Komaragiri SK, Owens JJ, Culbertson D, Blair LJ, Dickey C, Kuo SY, Finley D, Dyson HJ, Cox MB, Chaudhary J, Gestwicki JE, Balch WE. Management of Hsp90-Dependent Protein Folding by Small Molecules Targeting the Aha1 Co-Chaperone. Cell Chem Biol. 2020 03 19; 27(3):292-305.e6. PMID: 32017918.
      Citations: 8     Fields:    Translation:HumansCells
    7. Harris DC, Garcia YA, Samaniego CS, Rowlett VW, Ortiz NR, Payan AN, Maehigashi T, Cox MB. Functional Comparison of Human and Zebra Fish FKBP52 Confirms the Importance of the Proline-Rich Loop for Regulation of Steroid Hormone Receptor Activity. Int J Mol Sci. 2019 Oct 28; 20(21). PMID: 31661769.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    8. Mazaira GI, Zgajnar NR, Lotufo CM, Daneri-Becerra C, Sivils JC, Soto OB, Cox MB, Galigniana MD. Nuclear Receptors: A Historical Perspective. Methods Mol Biol. 2019; 1966:1-5. PMID: 31041734.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    9. Mazaira GI, Zgajnar NR, Lotufo CM, Daneri-Becerra C, Sivils JC, Soto OB, Cox MB, Galigniana MD. The Nuclear Receptor Field: A Historical Overview and Future Challenges. Nucl Receptor Res. 2018; 5. PMID: 30148160.
    10. Cox MB, Johnson JL. Evidence for Hsp90 Co-chaperones in Regulating Hsp90 Function and Promoting Client Protein Folding. Methods Mol Biol. 2018; 1709:397-422. PMID: 29177674.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    11. Collins TW, Aley SB, Boland T, Corral G, Cox MB, Echegoyen LE, Grineski SE, Morera OF, Nazeran H. BUILDing SCHOLARS: enhancing diversity among U.S. biomedical researchers in the Southwest. BMC Proc. 2017; 11(Suppl 12):12. PMID: 29375655.
    12. Joshi JB, Patel D, Morton DJ, Sharma P, Zou J, Hewa Bostanthirige D, Gorantla Y, Nagappan P, Komaragiri SK, Sivils JC, Xie H, Palaniappan R, Wang G, Cox MB, Chaudhary J. Inactivation of ID4 promotes a CRPC phenotype with constitutive AR activation through FKBP52. Mol Oncol. 2017 04; 11(4):337-357. PMID: 28252832.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    13. Maiar? M, Tochiki KK, Cox MB, Annan LV, Bell CG, Feng X, Hausch F, G?ranton SM. The stress regulator FKBP51 drives chronic pain by modulating spinal glucocorticoid signaling. Sci Transl Med. 2016 Feb 10; 8(325):325ra19. PMID: 26865567.
      Citations: 38     Fields:    Translation:AnimalsCells
    14. Suh JH, Chattopadhyay A, Sieglaff DH, Storer Samaniego C, Cox MB, Webb P. Similarities and Distinctions in Actions of Surface-Directed and Classic Androgen Receptor Antagonists. PLoS One. 2015; 10(9):e0137103. PMID: 26332122.
      Citations: 2     Fields:    Translation:HumansCells
    15. Storer Samaniego C, Suh JH, Chattopadhyay A, Olivares K, Guy N, Sivils JC, Dey P, Yumoto F, Fletterick RJ, Strom AM, Gustafsson J?, Webb P, Cox MB. The FKBP52 Cochaperone Acts in Synergy with ?-Catenin to Potentiate Androgen Receptor Signaling. PLoS One. 2015; 10(7):e0134015. PMID: 26207810.
      Citations: 6     Fields:    Translation:HumansCells
    16. Shrestha S, Sun Y, Lufkin T, Kraus P, Or Y, Garcia YA, Guy N, Ramos P, Cox MB, Tay F, Lin VC. Tetratricopeptide repeat domain 9A negatively regulates estrogen receptor alpha activity. Int J Biol Sci. 2015; 11(4):434-47. PMID: 25798063.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    17. Guy NC, Garcia YA, Cox MB. Therapeutic Targeting of the FKBP52 Co-Chaperone in Steroid Hormone Receptor-Regulated Physiology and Disease. Curr Mol Pharmacol. 2015; 9(2):109-25. PMID: 25986565.
      Citations: 20     Fields:    Translation:HumansAnimals
    18. Guy NC, Garcia YA, Sivils JC, Galigniana MD, Cox MB. Functions of the Hsp90-binding FKBP immunophilins. Subcell Biochem. 2015; 78:35-68. PMID: 25487015.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    19. Schmidt U, Buell DR, Ionescu IA, Gassen NC, Holsboer F, Cox MB, Novak B, Huber C, Hartmann J, Schmidt MV, Touma C, Rein T, Herrmann L. A role for synapsin in FKBP51 modulation of stress responsiveness: Convergent evidence from animal and human studies. Psychoneuroendocrinology. 2015 Feb; 52:43-58. PMID: 25459892.
      Citations: 13     Fields:    Translation:HumansAnimals
    20. Liang S, Bian X, Liang D, Sivils JC, Neckers LM, Cox MB, Xie H. Solution formulation development and efficacy of MJC13 in a preclinical model of castration-resistant prostate cancer. Pharm Dev Technol. 2016; 21(1):121-6. PMID: 25380396.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    21. Sangster JL, Zhang Y, Hernandez R, Garcia YA, Sivils JC, Cox MB, Snow DD, Kolok AS, Bartelt-Hunt SL. Bioavailability and fate of sediment-associated trenbolone and estradiol in aquatic systems. Sci Total Environ. 2014 Oct 15; 496:576-584. PMID: 25108798.
      Citations: 2     Fields:    Translation:Animals
    22. Erlejman AG, De Leo SA, Mazaira GI, Molinari AM, Camisay MF, Fontana V, Cox MB, Piwien-Pilipuk G, Galigniana MD. NF-?B transcriptional activity is modulated by FK506-binding proteins FKBP51 and FKBP52: a role for peptidyl-prolyl isomerase activity. J Biol Chem. 2014 Sep 19; 289(38):26263-26276. PMID: 25104352.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    23. Rodina A, Taldone T, Kang Y, Patel PD, Koren J, Yan P, DaGama Gomes EM, Yang C, Patel MR, Shrestha L, Ochiana SO, Santarossa C, Maharaj R, Gozman A, Cox MB, Erdjument-Bromage H, Hendrickson RC, Cerchietti L, Melnick A, Guzman ML, Chiosis G. Affinity purification probes of potential use to investigate the endogenous Hsp70 interactome in cancer. ACS Chem Biol. 2014 Aug 15; 9(8):1698-705. PMID: 24934503.
      Citations: 15     Fields:    Translation:HumansCells
    24. Erlejman AG, Lagadari M, Harris DC, Cox MB, Galigniana MD. Molecular chaperone activity and biological regulatory actions of the TPR-domain immunophilins FKBP51 and FKBP52. Curr Protein Pept Sci. 2014 May; 15(3):205-15. PMID: 24694367.
      Citations: 8     Fields:    Translation:HumansCells
    25. Paul A, Garcia YA, Zierer B, Patwardhan C, Gutierrez O, Hildenbrand Z, Harris DC, Balsiger HA, Sivils JC, Johnson JL, Buchner J, Chadli A, Cox MB. The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors. J Biol Chem. 2014 May 30; 289(22):15297-308. PMID: 24753260.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    26. Jehle K, Cato L, Neeb A, Muhle-Goll C, Jung N, Smith EW, Buzon V, Carb? LR, Est?banez-Perpi?? E, Schmitz K, Fruk L, Luy B, Chen Y, Cox MB, Br?se S, Brown M, Cato AC. Coregulator control of androgen receptor action by a novel nuclear receptor-binding motif. J Biol Chem. 2014 Mar 28; 289(13):8839-51. PMID: 24523409.
      Citations: 19     Fields:    Translation:HumansCells
    27. Shafi AA, Cox MB, Weigel NL. Androgen receptor splice variants are resistant to inhibitors of Hsp90 and FKBP52, which alter androgen receptor activity and expression. Steroids. 2013 Jun; 78(6):548-54. PMID: 23380368.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    28. Schmid AB, Lagleder S, Gr?wert MA, R?hl A, Hagn F, Wandinger SK, Cox MB, Demmer O, Richter K, Groll M, Kessler H, Buchner J. The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop. EMBO J. 2012 Mar 21; 31(6):1506-17. PMID: 22227520.
      Citations: 104     Fields:    Translation:AnimalsCells
    29. O'Leary JC, Dharia S, Blair LJ, Brady S, Johnson AG, Peters M, Cheung-Flynn J, Cox MB, de Erausquin G, Weeber EJ, Jinwal UK, Dickey CA. A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51. PLoS One. 2011; 6(9):e24840. PMID: 21935478.
      Citations: 56     Fields:    Translation:HumansAnimals
    30. Touma C, Gassen NC, Herrmann L, Cheung-Flynn J, B?ll DR, Ionescu IA, Heinzmann JM, Knapman A, Siebertz A, Depping AM, Hartmann J, Hausch F, Schmidt MV, Holsboer F, Ising M, Cox MB, Schmidt U, Rein T. FK506 binding protein 5 shapes stress responsiveness: modulation of neuroendocrine reactivity and coping behavior. Biol Psychiatry. 2011 Nov 15; 70(10):928-36. PMID: 21907973.
      Citations: 100     Fields:    Translation:HumansAnimalsCells
    31. Storer CL, Dickey CA, Galigniana MD, Rein T, Cox MB. FKBP51 and FKBP52 in signaling and disease. Trends Endocrinol Metab. 2011 Dec; 22(12):481-90. PMID: 21889356.
      Citations: 108     Fields:    Translation:HumansAnimalsCells
    32. Hartmann J, Wagner KV, Liebl C, Scharf SH, Wang XD, Wolf M, Hausch F, Rein T, Schmidt U, Touma C, Cheung-Flynn J, Cox MB, Smith DF, Holsboer F, M?ller MB, Schmidt MV. The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress. Neuropharmacology. 2012 Jan; 62(1):332-9. PMID: 21839098.
      Citations: 95     Fields:    Translation:Animals
    33. De Leon JT, Iwai A, Feau C, Garcia Y, Balsiger HA, Storer CL, Suro RM, Garza KM, Lee S, Kim YS, Chen Y, Ning YM, Riggs DL, Fletterick RJ, Guy RK, Trepel JB, Neckers LM, Cox MB. Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):11878-83. PMID: 21730179.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    34. Sellin Jeffries MK, Conoan NH, Cox MB, Sangster JL, Balsiger HA, Bridges AA, Cowman T, Knight LA, Bartelt-Hunt SL, Kolok AS. The anti-estrogenic activity of sediments from agriculturally intense watersheds: assessment using in vivo and in vitro assays. Aquat Toxicol. 2011 Sep; 105(1-2):189-98. PMID: 21723217.
      Citations: 8     Fields:    Translation:AnimalsPHPublic Health
    35. Sivils JC, Storer CL, Galigniana MD, Cox MB. Regulation of steroid hormone receptor function by the 52-kDa FK506-binding protein (FKBP52). Curr Opin Pharmacol. 2011 Aug; 11(4):314-9. PMID: 21511531.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    36. Cox MB, Johnson JL. The role of p23, Hop, immunophilins, and other co-chaperones in regulating Hsp90 function. Methods Mol Biol. 2011; 787:45-66. PMID: 21898226.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    37. Hildenbrand ZL, Molugu SK, Paul A, Avila GA, Herrera N, Xiao C, Cox MB, Bernal RA. High-yield expression and purification of the Hsp90-associated p23, FKBP52, HOP and SGTa proteins. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Oct 15; 878(28):2760-4. PMID: 20829124.
      Citations: 2     Fields:    Translation:HumansCells
    38. Sunnotel O, Hiripi L, Lagan K, McDaid JR, De Le?n JM, Miyagawa Y, Crowe H, Kaluskar S, Ward M, Scullion C, Campbell A, Downes CS, Hirst D, Barton D, Mocanu E, Tsujimura A, Cox MB, Robson T, Walsh CP. Alterations in the steroid hormone receptor co-chaperone FKBPL are associated with male infertility: a case-control study. Reprod Biol Endocrinol. 2010 Mar 08; 8:22. PMID: 20210997.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    39. Jinwal UK, Koren J, Borysov SI, Schmid AB, Abisambra JF, Blair LJ, Johnson AG, Jones JR, Shults CL, O'Leary JC, Jin Y, Buchner J, Cox MB, Dickey CA. The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules. J Neurosci. 2010 Jan 13; 30(2):591-9. PMID: 20071522.
      Citations: 103     Fields:    Translation:HumansAnimalsCells
    40. Balsiger HA, de la Torre R, Lee WY, Cox MB. A four-hour yeast bioassay for the direct measure of estrogenic activity in wastewater without sample extraction, concentration, or sterilization. Sci Total Environ. 2010 Feb 15; 408(6):1422-9. PMID: 20074779.
      Citations: 7     Fields:    Translation:AnimalsPHPublic Health
    41. Balsiger HA, Cox MB. Yeast-based reporter assays for the functional characterization of cochaperone interactions with steroid hormone receptors. Methods Mol Biol. 2009; 505:141-56. PMID: 19117143.
      Citations: 3     Fields:    Translation:Animals
    42. Riggs DL, Cox MB, Tardif HL, Hessling M, Buchner J, Smith DF. Noncatalytic role of the FKBP52 peptidyl-prolyl isomerase domain in the regulation of steroid hormone signaling. Mol Cell Biol. 2007 Dec; 27(24):8658-69. PMID: 17938211.
      Citations: 78     Fields:    Translation:AnimalsCells
    43. Cox MB, Riggs DL, Hessling M, Schumacher F, Buchner J, Smith DF. FK506-binding protein 52 phosphorylation: a potential mechanism for regulating steroid hormone receptor activity. Mol Endocrinol. 2007 Dec; 21(12):2956-67. PMID: 17717070.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    44. Tranguch S, Cheung-Flynn J, Daikoku T, Prapapanich V, Cox MB, Xie H, Wang H, Das SK, Smith DF, Dey SK. Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation. Proc Natl Acad Sci U S A. 2005 Oct 04; 102(40):14326-31. PMID: 16176985.
      Citations: 110     Fields:    Translation:AnimalsCells
    45. Cheung-Flynn J, Prapapanich V, Cox MB, Riggs DL, Suarez-Quian C, Smith DF. Physiological role for the cochaperone FKBP52 in androgen receptor signaling. Mol Endocrinol. 2005 Jun; 19(6):1654-66. PMID: 15831525.
      Citations: 90     Fields:    Translation:HumansAnimalsCells
    46. Riggs DL, Cox MB, Cheung-Flynn J, Prapapanich V, Carrigan PE, Smith DF. Functional specificity of co-chaperone interactions with Hsp90 client proteins. Crit Rev Biochem Mol Biol. 2004 Sep-Dec; 39(5-6):279-95. PMID: 15763706.
      Citations: 54     Fields:    Translation:HumansAnimals
    47. Cox MB, Miller CA. Cooperation of heat shock protein 90 and p23 in aryl hydrocarbon receptor signaling. Cell Stress Chaperones. 2004 Mar; 9(1):4-20. PMID: 15270073.
      Citations: 27     Fields:    Translation:AnimalsCells
    48. Cox MB, Miller CA. Pharmacological and genetic analysis of 90-kDa heat shock isoprotein-aryl hydrocarbon receptor complexes. Mol Pharmacol. 2003 Dec; 64(6):1549-56. PMID: 14645686.
      Citations: 8     Fields:    Translation:AnimalsCells
    49. Cox MB, Miller CA. The p23 co-chaperone facilitates dioxin receptor signaling in a yeast model system. Toxicol Lett. 2002 Mar 24; 129(1-2):13-21. PMID: 11879970.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
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