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Legier V. Rojas

TitleInvestigator
Faculty RankProfessor
InstitutionUniversidad Central Del Caribe
DepartmentPhysiology
AddressUniversidad Central del Caribe
Call Box 60-237
Bayamon PR 00960
Phone787-798-3001 X2302
Fax787-785-3425
vCardDownload vCard

    Collapse Biography 
    Collapse awards and honors
    1985 - 1987Scholarship award from the Sci. Hum. Development, Council of the CUV
    1990 - 1992Award Research PS. Level I Prize “National Council of Research” , CONICIT, Venezuela
    1992 - 1994Award Research PS. Level I Prize “National Council of Research” , CONICIT, Venezuela
    1995 - 1997Award Research PS. Level II Prize “National Council of Research” , CONICIT, Venezuela
    1995 - 1996Award Scientific Human. Development,, Council of the CUV
    1999Selected Member of the Society of General Physiologist
    2000CMBN Scientific Liaison
    2010Liaison between Title V and the Educational Resources Facilities of UCC

    Collapse Overview 
    Collapse overview
    I have a broad background in research and more recently in Informatics as Director of the Learning and Informatics Resources Center (LIRC) at UCC and as Liaison for the Educational Resources Center of the Title V proposal at UCC, Initially as researcher in a postdoctoral fellowship at the Neurobiology Institute of the UPR-Medical Sciences, I carried out collaborative single channel acquisition and analysis of molecules related to drug addiction, hearing research, and glia, all of them involving a large group of interactions at several levels and with national and international researchers. At the Physiology Department at UCC, I expanded my research to include neurophysiological studies associated with animal behavior during thyroid dysfunction in which I trained more than 30 undergraduate, medical, and graduate students in collaborative projects. All this experience was as PI or Co-Investigator on several university NIH-funded grants. The most successful collaborative interaction of my laboratory concerned the involvement at the molecular level relating to physiological alterations of single channels working with the UPR molecular group in which (at that time) the key factor was proximity allowing for easy communication.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Inyushin M, Zayas-Santiago A, Rojas L, Kucheryavykh L. On the Role of Platelet-Generated Amyloid Beta Peptides in Certain Amyloidosis Health Complications. Front Immunol. 2020; 11:571083. PMID: 33123145.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    2. Inyushin M, Zayas-Santiago A, Rojas L, Kucheryavykh Y, Kucheryavykh L. Platelet-generated amyloid beta peptides in Alzheimer's disease and glaucoma. Histol Histopathol. 2019 Aug; 34(8):843-856. PMID: 30945258.
      Citations: 10     Fields:    Translation:HumansCells
    3. Inyushin MY, Sanabria P, Rojas L, Kucheryavykh Y, Kucheryavykh L. Aß Peptide Originated from Platelets Promises New Strategy in Anti-Alzheimer's Drug Development. Biomed Res Int. 2017; 2017:3948360. PMID: 29018812.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    4. Aß Peptide Originated from Platelets Promises New Strategy in Anti-Alzheimer’s Drug Development. 2017; 10. View Publication.
    5. Inyushin M, Kucheryavih Y, Kucheryavih L, Rojas L, Khmelinskii I, Makarov V. Superparamagnetic Properties of Hemozoin. Sci Rep. 2016 05 18; 6:26212. PMID: 27188748.
      Citations: 5     Fields:    
    6. Huertas A, Wessinger WD, Kucheryavykh YV, Sanabria P, Eaton MJ, Skatchkov SN, Rojas LV, Maldonado-Martínez G, Inyushin MY. Quinine enhances the behavioral stimulant effect of cocaine in mice. Pharmacol Biochem Behav. 2015 Feb; 129:26-33. PMID: 25482328.
      Citations: 1     Fields:    Translation:Animals
    7. Velásquez-Martínez MC, Vázquez-Torres R, Rojas LV, Sanabria P, Jiménez-Rivera CA. Alpha-1 adrenoreceptors modulate GABA release onto ventral tegmental area dopamine neurons. Neuropharmacology. 2015 Jan; 88:110-21. PMID: 25261018.
      Citations: 9     Fields:    Translation:AnimalsCells
    8. López, C., Segarra, J., Miranda, L., Rojas, L. . Anxiety-Related Behaviors in Mice During Methimazole Treatment. 2014; 33(1)(PRHSJ):78.
    9. Inyushin MY, Huertas A, Kucheryavykh YV, Kucheryavykh LY, Tsydzik V, Sanabria P, Eaton MJ, Skatchkov SN, Rojas LV, Wessinger WD. L-DOPA Uptake in Astrocytic Endfeet Enwrapping Blood Vessels in Rat Brain. Parkinsons Dis. 2012; 2012:321406. PMID: 22888467.
      Citations:    
    10. Fernández-Mongil M, Venza CJ, Rivera A, Lasalde-Dominicci JA, Burggren W, Rojas LV. Triiodothyronine (T3) action on aquatic locomotor behavior during metamorphosis of the bullfrog Rana catesbeiana. Int J Dev Biol. 2009; 53(1):101-8. PMID: 19123131.
      Citations:    Fields:    Translation:Animals
    11. Rojas LV, Nieves K, Suarez E, Ortiz AP, Rivera A, Romaguera J. Thyroid-stimulating hormone and follicle-stimulating hormone status in Hispanic women during the menopause transition. Ethn Dis. 2008; 18(2 Suppl 2):S2-230-4. PMID: 18646355.
      Citations: 3     Fields:    Translation:Humans
    12. Guzmán GR, Ortiz-Acevedo A, Ricardo A, Rojas LV, Lasalde-Dominicci JA. The polarity of lipid-exposed residues contributes to the functional differences between Torpedo and muscle-type nicotinic receptors. J Membr Biol. 2006; 214(3):131-8. PMID: 17530159.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    13. Navedo MF, Lasalde-Dominicci JA, Báez-Pagán CA, Díaz-Pérez L, Rojas LV, Maselli RA, Staub J, Schott K, Zayas R, Gomez CM. Novel beta subunit mutation causes a slow-channel syndrome by enhancing activation and decreasing the rate of agonist dissociation. Mol Cell Neurosci. 2006 May-Jun; 32(1-2):82-90. PMID: 16624571.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    14. Santiago J, Guzmán GR, Torruellas K, Rojas LV, Lasalde-Dominicci JA. Tryptophan scanning mutagenesis in the TM3 domain of the Torpedo californica acetylcholine receptor beta subunit reveals an alpha-helical structure. Biochemistry. 2004 Aug 10; 43(31):10064-70. PMID: 15287734.
      Citations: 9     Fields:    Translation:AnimalsCells
    15. López-Hernández GY, Sánchez-Padilla J, Ortiz-Acevedo A, Lizardi-Ortiz J, Salas-Vincenty J, Rojas LV, Lasalde-Dominicci JA. Nicotine-induced up-regulation and desensitization of alpha4beta2 neuronal nicotinic receptors depend on subunit ratio. J Biol Chem. 2004 Sep 03; 279(36):38007-15. PMID: 15247303.
      Citations: 21     Fields:    Translation:AnimalsCells
    16. Ortiz-Acevedo A, Melendez M, Asseo AM, Biaggi N, Rojas LV, Lasalde-Dominicci JA. Tryptophan scanning mutagenesis of the gammaM4 transmembrane domain of the acetylcholine receptor from Torpedo californica. J Biol Chem. 2004 Oct 01; 279(40):42250-7. PMID: 15247226.
      Citations: 8     Fields:    Translation:AnimalsCells
    17. Navedo M, Nieves M, Rojas L, Lasalde-Dominicci JA. Tryptophan substitutions reveal the role of nicotinic acetylcholine receptor alpha-TM3 domain in channel gating: differences between Torpedo and muscle-type AChR. Biochemistry. 2004 Jan 13; 43(1):78-84. PMID: 14705933.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    18. Guzmán GR, Santiago J, Ricardo A, Martí-Arbona R, Rojas LV, Lasalde-Dominicci JA. Tryptophan scanning mutagenesis in the alphaM3 transmembrane domain of the Torpedo californica acetylcholine receptor: functional and structural implications. Biochemistry. 2003 Oct 28; 42(42):12243-50. PMID: 14567686.
      Citations: 18     Fields:    Translation:AnimalsCells
    19. Rojas LV, Bonilla L, Baez S, Lasalde-Dominicci JA. Thyroid hormones regulate the frequency of miniature end-plate currents in pre- and prometamorphic stages of the tadpole tail. J Neurosci Res. 2003 Mar 01; 71(5):670-8. PMID: 12584725.
      Citations: 3     Fields:    Translation:AnimalsCells
    20. Skatchkov SN, Rojas L, Eaton MJ, Orkand RK, Biedermann B, Bringmann A, Pannicke T, Veh RW, Reichenbach A. Functional expression of Kir 6.1/SUR1-K(ATP) channels in frog retinal Müller glial cells. Glia. 2002 May; 38(3):256-67. PMID: 11968063.
      Citations: 9     Fields:    Translation:AnimalsCells
    21. Gomez CM, Maselli RA, Vohra BP, Navedo M, Stiles JR, Charnet P, Schott K, Rojas L, Keesey J, Verity A, Wollmann RW, Lasalde-Dominicci J. Novel delta subunit mutation in slow-channel syndrome causes severe weakness by novel mechanisms. Ann Neurol. 2002 Jan; 51(1):102-12. PMID: 11782989.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    22. Santiago J, Guzmàn GR, Rojas LV, Marti R, Asmar-Rovira GA, Santana LF, McNamee M, Lasalde-Dominicci JA. Probing the effects of membrane cholesterol in the Torpedo californica acetylcholine receptor and the novel lipid-exposed mutation alpha C418W in Xenopus oocytes. J Biol Chem. 2001 Dec 07; 276(49):46523-32. PMID: 11567020.
      Citations: 26     Fields:    Translation:AnimalsCells
    23. Cruz-Martín A, Mercado JL, Rojas LV, McNamee MG, Lasalde-Dominicci JA. Tryptophan substitutions at lipid-exposed positions of the gamma M3 transmembrane domain increase the macroscopic ionic current response of the Torpedo californica nicotinic acetylcholine receptor. J Membr Biol. 2001 Sep 01; 183(1):61-70. PMID: 11547353.
      Citations: 7     Fields:    Translation:AnimalsCells
    24. Tamamizu S, Guzmán GR, Santiago J, Rojas LV, McNamee MG, Lasalde-Dominicci JA. Functional effects of periodic tryptophan substitutions in the alpha M4 transmembrane domain of the Torpedo californica nicotinic acetylcholine receptor. Biochemistry. 2000 Apr 25; 39(16):4666-73. PMID: 10769122.
      Citations: 25     Fields:    Translation:AnimalsCells
    25. Rojas L, Orkand RK. K+ Channel density increases selectively in the endfoot of retinal glial cells during development of Rana catesbiana. Glia. 1999 Jan 15; 25(2):199-203. PMID: 9890634.
      Citations: 2     Fields:    Translation:AnimalsCells
    26. Loureiro CL, Rojas LV. Macropatch technique on neuromuscular junction from toad tadpole tail. Acta Cient Venez. 1991; 42(3):160-2. PMID: 1668845.
      Citations:    Fields:    Translation:AnimalsCells
    27. Argibay JA, Arispe NJ, Rojas LV. Potassium currents in cut skeletal muscle fibers from toad Bufo marinus: activation and decline under maintained depolarizations. Acta Cient Venez. 1988; 39(4):328-35. PMID: 3152041.
      Citations:    Fields:    Translation:Animals
    28. Arispe NJ, Argibay JA, Rojas LV. Sodium currents in skeletal muscle fibres from the toad Bufo marinus. Q J Exp Physiol. 1984 Jul; 69(3):507-19. PMID: 6089256.
      Citations: 2     Fields:    Translation:Animals
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