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Luisa Alvarado

TitlePrincipal Investigator & Project Director
Faculty RankProfessor
InstitutionPonce Health Sciences University
AddressP.O. Box 7043
Ponce PR 00755
Phone7878442080 Ext. 1435
ORCID ORCID Icon0000-0002-1905-1524 Additional info
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    Collapse Biography 
    Collapse awards and honors
    2007Founding Member Award, Puerto Rico Taskforce on Prematurity, March of Dimes, Puerto Rico
    2007Special Achievement Award, American Academy of Pediatrics
    2010Certificate of Appreciation Puerto Rico Physician Master Trainer for Dengue Management, CDC - Dengue Branch
    2010Distinguished Service Rendered as a Member of the Committee on Pediatric Workforce, 2007-2010, American Academy of Pediatrics
    2011Exemplary Service as a Physician Master Trainer for the Dengue Clinical Case Management Course, CDC - Dengue Branch
    2018Nakano Citation Award for the “Persistence of ZIKV in Body Fluids – NEJM 2017 , Centers for Disease Control and Prevention

    Collapse Overview 
    Collapse overview
    After completing my pediatric residency training in Boston, Massachusetts in 1982, I returned to Puerto Rico and practiced as a general pediatrician having the privilege of caring for 2 generations of pediatric patients. At the same time I started my academic career at the Ponce School of Medicine (PSM) through teaching and clinical supervision of students and residents in my clinical practice and the medical school campus. I am now Professor of Pediatrics of the Ponce Health Sciences University (PHSU) and have enjoyed an exciting career of over 30 years as clinician, educator, academic administrator and most recently researcher at the School of Medicine and its principal clinical affiliate, Centro Médico Episcopal San Lucas (CMESL) in Ponce. My interest in arboviral diseases emanated from clinical practice and thrived as I became an expert trainer for the Dengue Clinical Management Course offered by the CDC and the Puerto Rico Department of Health to practicing physicians from 2011 to 2013. My work as a dengue physician trainer lead to a Centers for Disease Control and Prevention (CDC) Cooperative Agreement to study dengue epidemiology, prevention and outcomes from an institution-based surveillance system in Ponce in 2012 that continues to the present. This grant was instrumental in the implementation of the first Sentinel Enhanced Dengue and Acute Febrile Illness (AFI) Surveillance System (SEDSS) in Puerto Rico. Under my leadership from 2012-2020, over 30,000 febrile cases were enrolled from a population of 500,000 in southern Puerto Rico, reaching a diagnosis in about 40% of cases. SEDSS facilitated the study of AFI caused by dengue virus (DENV), Influenza A and B and other common respiratory viruses and emergent pathogens: chikungunya (CHIKV) and Zika virus (ZIKV). As Principal Investigator and Program Director for SEDSS, I was able to strengthen the collaboration between the PHSU School of Medicine and Public Health Programs and the CMESL clinical site in the conduction of research. Most importantly, I had the privilege of mentoring public health and medical students, and clinical residents promoting their interest and skills in research, which is research capacity building for Puerto Rico. In 2017, during the Zika epidemic, the SEDSS collaboration with the Puerto Rico Department of Health for the notification to mothers with ZIKV infection during pregnancy, lead to the implementation of studies: Pediatric Outcomes of Prenatal ZIKV Exposure (POPZE cohort study) under my leadership, and Outcomes of Postnatal Zika Infection (OPAZi case-control study) under my mentoring. I was able to contribute to the medical literature on the epidemiology and clinical presentation of Zika in children, and our team presented on the pediatric outcomes of prenatal and postnatal Zika infections at local and national meetings. With funding from the National Institutes of Health (NIH) and along with Dr. Mary Rodriguez-Rabassa Co-Principal Investigator, we continue the study of prenatal ZIKV exposure's outcomes and explore environmental and health system factors that affect child health and development. Through this study, my research path has returned to the field of Pediatrics, my professional passion. And it is this pathway that lead to the NIH funded COVID 19 research: Study of Life Experiences, Adversity and Resilience (SOLEAR study) on how the pandemic impacted vulnerable Hispanic children and families. The experiences and accomplishments described above have prepared me to assume an important role in research of early life adversities and future health disparities, aiming to identify protective factors and the best preventive measures.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Powers JM, Lyski ZL, Weber WC, Denton M, Streblow MM, Mayo AT, Haese NN, Nix CD, Rodr?guez-Santiago R, Alvarado LI, Rivera-Amill V, Messer WB, Streblow DN. Infection with chikungunya virus confers heterotypic cross-neutralizing antibodies and memory B-cells against other arthritogenic alphaviruses predominantly through the B domain of the E2 glycoprotein. PLoS Negl Trop Dis. 2023 03; 17(3):e0011154. PMID: 36913428.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Ream S, Ma J, Rodriguez T, Sarabia-Gonzalez A, Alvarado LA, Dwivedi AK, Mukherjee D. Ethnic/racial differences in risk factors and clinical outcomes among patients with amyloidosis. Am J Med Sci. 2023 03; 365(3):232-241. PMID: 36543303.
      Citations:    Fields:    Translation:Humans
    3. Paz-Bailey G, S?nchez-Gonz?lez L, Torres-Velasquez B, Jones ES, Perez-Padilla J, Sharp TM, Lorenzi O, Delorey M, Munoz-Jordan JL, Tomashek KM, Waterman SH, Alvarado LI, Rivera-Amill V. Predominance of Severe Plasma Leakage in Pediatric Patients With Severe Dengue in Puerto Rico. J Infect Dis. 2022 11 28; 226(11):1949-1958. PMID: 35510941.
      Citations: 1     Fields:    Translation:HumansCells
    4. Alvarado-Domenech LI, Rivera-Amill V, Appleton AA, Rosario-Villafa?e V, Repollet-Carrer I, Borges-Rodr?guez M, P?rez-Rodr?guez NM, Olivieri-Ramos O, Gonz?lez M, Gonz?lez-Montalvo C, Mu?iz-Forestier W, Vargas-Lasalle L, P?rez-Padilla J, Paz-Bailey G, Rodr?guez-Rabassa M. Early Childhood Neurodevelopmental Outcomes in Children with Prenatal Zika Virus Exposure: A Cohort Study in Puerto Rico. J Pediatr. 2022 08; 247:38-45.e5. PMID: 35577118.
      Citations: 2     Fields:    Translation:HumansCells
    5. Quandelacy TM, Adams LE, Munoz J, Santiago GA, Kada S, Johansson MA, Alvarado LI, Rivera-Amill V, Paz-Bailey G. Reduced spread of influenza and other respiratory viral infections during the COVID-19 pandemic in southern Puerto Rico. PLoS One. 2022; 17(4):e0266095. PMID: 35476785.
      Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
    6. Philipovskiy A, Ghafouri R, Dwivedi AK, Alvarado L, McCallum R, Maegawa F, Konstantinidis IT, Hakim N, Shurmur S, Awasthi S, Gaur S, Corral J. Association Between Tumor Mutation Profile and Clinical Outcomes Among Hispanic-Latino Patients With Metastatic Colorectal Cancer. Front Oncol. 2021; 11:772225. PMID: 35141142.
    7. Salcido A, Robles EH, Chaudhary K, Alvarado L, I?iguez SD, Vargas-Medrano J, Diaz-Pacheco V, Villanos MT, Gadad BS, Martin SL. Association of ADHD and Obesity in Hispanic Children on the US-Mexico Border: A Retrospective Analysis. Front Integr Neurosci. 2021; 15:749907. PMID: 35069136.
    8. Medina FA, Vila F, Premkumar L, Lorenzi O, Paz-Bailey G, Alvarado LI, Rivera-Amill V, de Silva A, Waterman S, Mu?oz-Jord?n J. Capacity of a Multiplex IgM Antibody Capture ELISA to Differentiate Zika and Dengue Virus Infections in Areas of Concurrent Endemic Transmission. Am J Trop Med Hyg. 2021 12 20; 106(2):585-592. PMID: 34929668.
      Citations:    Fields:    Translation:HumansCellsPHPublic Health
    9. Volkman HR, P?rez-Padilla J, Wong JM, S?nchez-Gonz?lez L, Acevedo-Molina L, Lugo-Men?ndez M, Oliveras Garc?a CA, Adams LE, Frasqueri-Quintana VM, Rodriguez-Gonzalez R, Gonz?lez-Cosme JA, Calvo D?az AE, Alvarado LI, Rivera-Amill V, Brown J, Wong KK, Bertr?n-Pasarell J, Paz-Bailey G. Characteristics and clinical outcomes of patients hospitalized with laboratory-confirmed COVID-19-Puerto Rico, March-August 2020. PLoS One. 2021; 16(12):e0260599. PMID: 34855817.
      Citations:    Fields:    Translation:Humans
    10. S?nchez-Gonz?lez L, Quandelacy TM, Johansson M, Torres-Vel?squez B, Lorenzi O, Tavarez M, Torres S, Alvarado LI, Paz-Bailey G. Viral etiology and seasonal trends of pediatric acute febrile illness in southern Puerto Rico; a seven-year review. PLoS One. 2021; 16(2):e0247481. PMID: 33606839.
      Citations: 4     Fields:    Translation:Humans
    11. Sharp TM, Quandelacy TM, Adams LE, Aponte JT, Lozier MJ, Ryff K, Flores M, Rivera A, Santiago GA, Mu?oz-Jord?n JL, Alvarado LI, Rivera-Amill V, Garcia-Negr?n M, Waterman SH, Paz-Bailey G, Johansson MA, Rivera-Garcia B. Epidemiologic and spatiotemporal trends of Zika Virus disease during the 2016 epidemic in Puerto Rico. PLoS Negl Trop Dis. 2020 09; 14(9):e0008532. PMID: 32956416.
      Citations: 9     Fields:    Translation:HumansCellsPHPublic Health
    12. Thakur B, Alvarado L, Dodoo C, Salazar R, Espay AJ, Dwivedi AK. Ethnic Differences Between Hispanics and Non-Hispanic Whites in Neuropsychiatric Symptoms Predict Conversion to Mild Cognitive Impairment. J Geriatr Psychiatry Neurol. 2021 11; 34(6):622-631. PMID: 32909879.
      Citations: 3     Fields:    Translation:Humans
    13. Paz-Bailey G, Quandelacy TM, Adams LE, Olsen SJ, Blanton L, Munoz-Jordan JL, Lozier M, Alvarado LI, Johansson MA. Recent influenza activity in tropical Puerto Rico has become synchronized with mainland US. Influenza Other Respir Viruses. 2020 09; 14(5):515-523. PMID: 32614504.
      Citations: 4     Fields:    Translation:HumansCellsPHPublic Health
    14. Arya S, Dwivedi AK, Alvarado L, Kupesic-Plavsic S. Exposure of U.S. population to endocrine disruptive chemicals (Parabens, Benzophenone-3, Bisphenol-A and Triclosan) and their associations with female infertility. Environ Pollut. 2020 Oct; 265(Pt A):114763. PMID: 32806428.
      Citations: 9     Fields:    Translation:Humans
    15. Frasqueri-Quintana VM, Oliveras Garc?a CA, Adams LE, Torres-Figueroa X, Iriarte RI, Ryff K, S?nchez-Gonz?lez L, P?rez G?mez V, P?rez-Rodr?guez NM, Alvarado LI, Paz-Bailey G. Injury-Related Emergency Department Visits After Hurricane Maria in a Southern Puerto Rico Hospital. Disaster Med Public Health Prep. 2020 02; 14(1):63-70. PMID: 31455463.
      Citations: 7     Fields:    Translation:HumansPHPublic Health
    16. Caraballo E, Poole-Smith BK, Tomashek KM, Torres-Velasquez B, Alvarado LI, Lorenzi OD, Ramos C, Carri?n J, Hunsperger E. The detection of anti-dengue virus IgM in urine in participants enrolled in an acute febrile illness study in Puerto Rico. PLoS Negl Trop Dis. 2020 01; 14(1):e0007971. PMID: 31995560.
      Citations:    Fields:    Translation:HumansCells
    17. Adams LE, Vargas L, Frasqueri-Quintana VM, Torres-Figueroa X, Ryff K, Sanchez-Gonzalez L, Little E, Ciampaglio K, Reyes Claudio JM, Ponton-Cruz E, Santiago W, Paz-Bailey G, Alvarado LI. Evaluation of Emergency Department-Based Surveillance Systems at 2 Healthcare Facilities After Hurricane Maria: Puerto Rico, 2017-2018. Disaster Med Public Health Prep. 2019 Sep 02; 17:e1. PMID: 31475668.
      Citations: 2     Fields:    
    18. Alvarado LI, Lorenzi OD, Torres-Vel?squez BC, Sharp TM, Vargas L, Mu?oz-Jord?n JL, Hunsperger EA, P?rez-Padilla J, Rivera A, Gonz?lez-Zeno GE, Galloway RL, Glass Elrod M, Mathis DL, Oberste MS, Nix WA, Henderson E, McQuiston J, Singleton J, Kato C, Garc?a-Gubern C, Santiago-Rivera W, Muns-Sosa R, Ortiz-Rivera JD, Jim?nez G, Rivera-Amill V, And?jar-P?rez DA, Horiuchi K, Tomashek KM. Distinguishing patients with laboratory-confirmed chikungunya from dengue and other acute febrile illnesses, Puerto Rico, 2012-2015. PLoS Negl Trop Dis. 2019 07; 13(7):e0007562. PMID: 31329598.
      Citations: 6     Fields:    Translation:Humans
    19. Santiago GA, Sharp TM, Rosenberg E, Sosa Cardona II, Alvarado L, Paz-Bailey G, Mu?oz-Jord?n JL. Prior Dengue Virus Infection Is Associated With Increased Viral Load in Patients Infected With Dengue but Not Zika Virus. Open Forum Infect Dis. 2019 Jul 01; 6(7). PMID: 31363765.
    20. P?rez-Padilla J, Paz-Bailey G, Meaney-Delman D, Doyle K, Gary J, Rodriguez DM, Bhatnagar J, P?rez-Rodriguez NM, Montalvo S, Alvarado L, Sharp TM. Persistent Zika Virus Infection Associated with Early Fetal Demise: A Case Report. Open J Obstet Gynecol. 2019 May; 9(5):698-706. PMID: 31799062.
    21. Hsu CH, Cruz-Lopez F, Vargas Torres D, Perez-Padilla J, Lorenzi OD, Rivera A, Staples JE, Lugo E, Munoz-Jordan J, Fischer M, Garcia Gubern C, Rivera Garcia B, Alvarado L, Sharp TM. Risk factors for hospitalization of patients with chikungunya virus infection at sentinel hospitals in Puerto Rico. PLoS Negl Trop Dis. 2019 01; 13(1):e0007084. PMID: 30640900.
      Citations: 10     Fields:    Translation:HumansCells
    22. Medina FA, Torres G, Acevedo J, Fonseca S, Casiano L, De Le?n-Rodr?guez CM, Santiago GA, Doyle K, Sharp TM, Alvarado LI, Paz-Bailey G, Mu?oz-Jord?n JL. Duration of the Presence of Infectious Zika Virus in Semen and Serum. J Infect Dis. 2019 01 01; 219(1):31-40. PMID: 30059980.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    23. Lozier MJ, Rosenberg ES, Doyle K, Adams L, Klein L, Mu?oz-Jordan J, Alvarado LI, Sharp TM, Paz-Bailey G. Prolonged Detection of Zika Virus Nucleic Acid Among Symptomatic Pregnant Women: A Cohort Study. Clin Infect Dis. 2018 08 01; 67(4):624-627. PMID: 29534160.
      Citations: 15     Fields:    Translation:HumansCells
    24. Read JS, Torres-Velasquez B, Lorenzi O, Rivera Sanchez A, Torres-Torres S, Rivera LV, Capre-Franceschi SM, Garcia-Gubern C, Munoz-Jordan J, Santiago GA, Alvarado LI. Symptomatic Zika Virus Infection in Infants, Children, and Adolescents Living in Puerto Rico. JAMA Pediatr. 2018 07 01; 172(7):686-693. PMID: 29813148.
      Citations: 12     Fields:    Translation:HumansCellsPHPublic Health
    25. Tomashek KM, Lorenzi OD, And?jar-P?rez DA, Torres-Vel?squez BC, Hunsperger EA, Munoz-Jordan JL, Perez-Padilla J, Rivera A, Gonzalez-Zeno GE, Sharp TM, Galloway RL, Glass Elrod M, Mathis DL, Oberste MS, Nix WA, Henderson E, McQuiston J, Singleton J, Kato C, Garc?a Gubern C, Santiago-Rivera W, Cruz-Correa J, Muns-Sosa R, Ortiz-Rivera JD, Jim?nez G, Galarza IE, Horiuchi K, Margolis HS, Alvarado LI. Clinical and epidemiologic characteristics of dengue and other etiologic agents among patients with acute febrile illness, Puerto Rico, 2012-2015. PLoS Negl Trop Dis. 2017 Sep; 11(9):e0005859. PMID: 28902845.
      Citations: 33     Fields:    Translation:Humans
    26. Paz-Bailey G, Rosenberg ES, Doyle K, Munoz-Jordan J, Santiago GA, Klein L, Perez-Padilla J, Medina FA, Waterman SH, Gubern CG, Alvarado LI, Sharp TM. Persistence of Zika Virus in Body Fluids - Final Report. N Engl J Med. 2018 Sep 27; 379(13):1234-1243. PMID: 28195756.
      Citations: 206     Fields:    
    27. Sharp TM, Ryff KR, Alvarado L, Shieh WJ, Zaki SR, Margolis HS, Rivera-Garcia B. Surveillance for Chikungunya and Dengue During the First Year of Chikungunya Virus Circulation in Puerto Rico. J Infect Dis. 2016 Dec 15; 214(suppl 5):S475-S481. PMID: 27920177.
      Citations: 24     Fields:    Translation:HumansCells
    28. Erratum: Vol. 65, No. 44. MMWR Morb Mortal Wkly Rep. 2016 Dec 09; 65(48):1382. PMID: 27932779.
      Citations:    Fields:    
    29. Lozier M, Adams L, Febo MF, Torres-Aponte J, Bello-Pagan M, Ryff KR, Munoz-Jordan J, Garcia M, Rivera A, Read JS, Waterman SH, Sharp TM, Rivera-Garcia B. Incidence of Zika Virus Disease by Age and Sex - Puerto Rico, November 1, 2015-October 20, 2016. MMWR Morb Mortal Wkly Rep. 2016 Nov 11; 65(44):1219-1223. PMID: 27832051.
      Citations: 38     Fields:    Translation:Humans
    30. Adams L, Bello-Pagan M, Lozier M, Ryff KR, Espinet C, Torres J, Perez-Padilla J, Febo MF, Dirlikov E, Martinez A, Munoz-Jordan J, Garcia M, Segarra MO, Malave G, Rivera A, Shapiro-Mendoza C, Rosinger A, Kuehnert MJ, Chung KW, Pate LL, Harris A, Hemme RR, Lenhart A, Aquino G, Zaki S, Read JS, Waterman SH, Alvarado LI, Alvarado-Ramy F, Valencia-Prado M, Thomas D, Sharp TM, Rivera-Garcia B. Update: Ongoing Zika Virus Transmission - Puerto Rico, November 1, 2015-July 7, 2016. MMWR Morb Mortal Wkly Rep. 2016 Aug 05; 65(30):774-9. PMID: 27490087.
      Citations: 34     Fields:    Translation:HumansCellsPHPublic Health
    31. Dirlikov E, Ryff KR, Torres-Aponte J, Thomas DL, Perez-Padilla J, Munoz-Jordan J, Caraballo EV, Garcia M, Segarra MO, Malave G, Simeone RM, Shapiro-Mendoza CK, Reyes LR, Alvarado-Ramy F, Harris AF, Rivera A, Major CG, Mayshack M, Alvarado LI, Lenhart A, Valencia-Prado M, Waterman S, Sharp TM, Rivera-Garcia B. Update: Ongoing Zika Virus Transmission - Puerto Rico, November 1, 2015-April 14, 2016. MMWR Morb Mortal Wkly Rep. 2016 May 06; 65(17):451-5. PMID: 27149205.
      Citations: 24     Fields:    Translation:HumansCellsPHPublic Health
    32. Gregory CJ, Lorenzi OD, Col?n L, Garc?a AS, Santiago LM, Rivera RC, Berm?dez LJ, B?ez FO, Aponte DV, Tomashek KM, Gutierrez J, Alvarado L. Utility of the tourniquet test and the white blood cell count to differentiate dengue among acute febrile illnesses in the emergency room. PLoS Negl Trop Dis. 2011 Dec; 5(12):e1400. PMID: 22163057.
      Citations: 22     Fields:    Translation:HumansCellsPHPublic Health
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