Gene Regulatory Networks

"Gene Regulatory Networks" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Interacting DNA-encoded regulatory subsystems in the GENOME that coordinate input from activator and repressor TRANSCRIPTION FACTORS during development, cell differentiation, or in response to environmental cues. The networks function to ultimately specify expression of particular sets of GENES for specific conditions, times, or locations.

Descriptor ID	D053263
MeSH Number(s)	G05.360.080.689.360
Concept/Terms	Gene Regulatory Networks Gene Regulatory Networks Gene Regulatory Network Network, Gene Regulatory Networks, Gene Regulatory Regulatory Network, Gene Regulatory Networks, Gene Gene Networks Gene Network Network, Gene Networks, Gene Transcriptional Networks Network, Transcriptional Networks, Transcriptional Transcriptional Network Gene Circuits Gene Circuits Circuit, Gene Circuits, Gene Gene Circuit Gene Modules Gene Modules Module, Gene Modules, Gene Gene Module

Below are MeSH descriptors whose meaning is more general than "Gene Regulatory Networks".

Biological Sciences [G]
Genetic Phenomena [G05]
Genetic Structures [G05.360]
Base Sequence [G05.360.080]
Regulatory Sequences, Nucleic Acid [G05.360.080.689]
Gene Regulatory Networks [G05.360.080.689.360]

Below are MeSH descriptors whose meaning is related to "Gene Regulatory Networks".

Below are MeSH descriptors whose meaning is more specific than "Gene Regulatory Networks".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Gene Regulatory Networks" by people in this website by year, and whether "Gene Regulatory Networks" was a major or minor topic of these publications.

Bar chart showing 115 publications over 20 distinct years, with a maximum of 11 publications in 2016 and 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2007	1	2	3
2008	2	0	2
2009	4	1	5
2010	3	3	6
2011	1	6	7
2012	2	3	5
2013	2	4	6
2014	2	3	5
2015	3	3	6
2016	4	7	11
2017	1	0	1
2018	2	8	10
2019	2	5	7
2020	3	8	11
2021	2	7	9
2022	0	2	2
2023	1	2	3
2024	3	5	8
2025	1	5	6
2026	0	2	2

Below are the most recent publications written about "Gene Regulatory Networks" by people in Profiles.

Zhao P, El Fadel O, Le A, Mangleburg CG, Dhindsa J, Wu T, Zhao J, Huang M, Amoh B, Marella AS, Li Y, Seyfried NT, Levey AI, Liu Z, Al-Ramahi I, Botas J, Shulman JM. Systems genetic dissection of brain gene expression reveals excitotoxic mechanisms of Alzheimer's disease. Mol Psychiatry. 2026 Jun; 31(6):3462-3481.

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Heredia-Negr?n F, Nagamatsu ST, Carrasquillo-Carrion K, Hurd Y, Rompala G, Mel?n K, Garcia-Vassallo G, Roche-Lima A, Montalvo-Ortiz JL. Building epigenetic risk scores of opioid use disorder: Insights from human postmortem brain data. Transl Psychiatry. 2026 Jan 09; 16(1):62.

View in: PubMed
Young CD, Carey KM, Dill CD, Nunez SK, Griffen TL, Dammer EB, Lillard JW. Integrated systems biology reveals an 8-gene signature predicting early-stage lung adenocarcinoma progression and patient survival. Sci Rep. 2025 Oct 06; 15(1):34762.

View in: PubMed
Awai A, Johnson EL, Leng T, Patrickson J, Zody MC, Lillard JW. Stratifying ALS Patients by Mode of Inheritance Reveals Transcriptomic Signatures Specific to sALS and fALS. Int J Mol Sci. 2025 Sep 22; 26(18).

View in: PubMed
Cheng J, Cheng M, Sinha S, Cely I, Gladkikh S, Han MT, Zhang G, Zhou Z, Chugh R, Ahn IS, Diamante G, Wang YC, Wang Z, Bennett BJ, Cai H, Allayee H, Hazen SL, Lusis AJ, Shih DM, Yang X. Trimethylamine-N-Oxide Affects Cell Type-Specific Pathways and Networks in Mouse Aorta to Promote Atherosclerotic Plaque Vulnerability. Arterioscler Thromb Vasc Biol. 2025 Oct; 45(10):1784-1798.

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Taniai T, Shimada S, Akiyama Y, Hatano M, Yasukawa K, Igarashi Y, Tsukihara S, Tanji Y, Kodera K, Okazaki K, Haruki K, Nara A, Yagi K, Akahoshi K, Ban D, Asahina Y, Ikegami T, Tanabe M, Tanaka S. Integrative transcriptome profiling elucidates molecular and immunovascular characteristics of macrotrabecular HCC. Hepatology. 2026 Feb 01; 83(2):231-248.

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Gao Z, Su Y, Jiao G, Lou Z, Chang L, Yu R, Xu C, Han X, Wang Z, Li J, Deng XW, He H. Cell-Type Specific miRNA Regulatory Network Responses to ABA Stress Revealed by Time Series Transcriptional Atlases in Arabidopsis. Adv Sci (Weinh). 2025 Mar; 12(9):e2415083.

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Sharafshah A, Lewandrowski KU, Elman I, Baron D, Thanos PK, Hanna C, Gold MS, Badgaiyan RD, Cadet JL, Modestino EJ, Braverman ER, Dennen CA, Makale M, Sunder K, Murphy KT, Bowirrat A, Pinhasov A, Gondre-Lewis M, Gardner E, Sipple D, Jafari N, Zeine F, Khalsa J, Fiorelli RKA, Blum K. A Comprehensive 4-layered In Silico Pharmacogenomics Analysis of the Genetic Addiction Risk Severity (GARS) Test: Strong Genetic Evidence Supporting GARS as a Novel Personalized Pre-addiction Assessment Tool in the Opioid Crisis Era. Curr Pharm Biotechnol. 2025; 26(13):2153-2180.

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Carey KM, Young CD, Clark AJ, Dammer EB, Singh R, Lillard JW. Subtype-specific analysis of gene co-expression networks and immune cell profiling reveals high grade serous ovarian cancer subtype linkage to variable immune microenvironment. J Ovarian Res. 2024 Dec 03; 17(1):240.

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Clark AJ, Singh R, Leonis RL, Stahlberg EA, Clark ZS, Lillard JW. Gene Co-Expression Network Analysis Associated with Endometrial Cancer Tumorigenesis and Survival Outcomes. Int J Mol Sci. 2024 Nov 18; 25(22).

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