alpha-Defensins

"alpha-Defensins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

DEFENSINS found in azurophilic granules of neutrophils and in the secretory granules of intestinal PANETH CELLS.

Descriptor ID	D023084
MeSH Number(s)	D12.644.050.200.050 D12.776.543.695.054.200.050
Concept/Terms	alpha-Defensins alpha-Defensins alpha Defensins Antimicrobial Peptides, Neutrophil Antimicrobial Peptides, Neutrophil Neutrophil Antimicrobial Peptides Peptides, Neutrophil Antimicrobial

Below are MeSH descriptors whose meaning is more general than "alpha-Defensins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Antimicrobial Cationic Peptides [D12.644.050]
Defensins [D12.644.050.200]
alpha-Defensins [D12.644.050.200.050]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Pore Forming Cytotoxic Proteins [D12.776.543.695]
Antimicrobial Cationic Peptides [D12.776.543.695.054]
Defensins [D12.776.543.695.054.200]
alpha-Defensins [D12.776.543.695.054.200.050]

Below are MeSH descriptors whose meaning is related to "alpha-Defensins".

Below are MeSH descriptors whose meaning is more specific than "alpha-Defensins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "alpha-Defensins" by people in this website by year, and whether "alpha-Defensins" was a major or minor topic of these publications.

Bar chart showing 7 publications over 6 distinct years, with a maximum of 2 publications in 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	1	0	1
2007	1	0	1
2013	1	0	1
2017	1	1	2
2021	1	0	1
2025	1	0	1

Below are the most recent publications written about "alpha-Defensins" by people in Profiles.

Thangaiyan R, Sakwe AM, Hawkins AT, Washington MK, Ballard BR, Izban MG, Chirwa SS, Hildreth JEK, Shanker A, Blum DL, M'Koma AE. Functional characterization of novel anti-DEFA5 monoclonal antibody clones 1A8 and 4F5 in inflammatory bowel disease colitis tissues. Inflamm Res. 2025 Jan 30; 74(1):30.

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Rana T, Korolkova OY, Rachakonda G, Williams AD, Hawkins AT, James SD, Sakwe AM, Hui N, Wang L, Yu C, Goodwin JS, Izban MG, Offodile RS, Washington MK, Ballard BR, Smoot DT, Shi XZ, Forbes DS, Shanker A, M'Koma AE. Linking bacterial enterotoxins and alpha defensin 5 expansion in the Crohn's colitis: A new insight into the etiopathogenetic and differentiation triggers driving colonic inflammatory bowel disease. PLoS One. 2021; 16(3):e0246393.

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Prado MKB, Locachevic GA, Zoccal KF, Paula-Silva FWG, Fontanari C, Ferreira JC, Pereira PAT, Gardinassi LG, Ramos SG, Sorgi CA, Darini ALC, Faccioli LH. Leukotriene B4 is essential for lung host defence and alpha-defensin-1 production during Achromobacter xylosoxidans infection. Sci Rep. 2017 12 15; 7(1):17658.

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Williams AD, Korolkova OY, Sakwe AM, Geiger TM, James SD, Muldoon RL, Herline AJ, Goodwin JS, Izban MG, Washington MK, Smoot DT, Ballard BR, Gazouli M, M'Koma AE. Human alpha defensin 5 is a candidate biomarker to delineate inflammatory bowel disease. PLoS One. 2017; 12(8):e0179710.

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Johnson CA, Rachakonda G, Kleshchenko YY, Nde PN, Madison MN, Pratap S, Cardenas TC, Taylor C, Lima MF, Villalta F. Cellular response to Trypanosoma cruzi infection induces secretion of defensin a-1, which damages the flagellum, neutralizes trypanosome motility, and inhibits infection. Infect Immun. 2013 Nov; 81(11):4139-48.

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Madison MN, Kleshchenko YY, Nde PN, Simmons KJ, Lima MF, Villalta F. Human defensin alpha-1 causes Trypanosoma cruzi membrane pore formation and induces DNA fragmentation, which leads to trypanosome destruction. Infect Immun. 2007 Oct; 75(10):4780-91.

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Boyaka PN, Lillard JW, McGhee J. Interleukin 12 and innate molecules for enhanced mucosal immunity. Immunol Res. 1999; 20(3):207-17.

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Aley SB, Zimmerman M, Hetsko M, Selsted ME, Gillin FD. Killing of Giardia lamblia by cryptdins and cationic neutrophil peptides. Infect Immun. 1994 Dec; 62(12):5397-403.

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