"Conotoxins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Peptide neurotoxins from the marine fish-hunting snails of the genus CONUS. They contain 13 to 29 amino acids which are strongly basic and are highly cross-linked by disulfide bonds. There are three types of conotoxins, omega-, alpha-, and mu-. OMEGA-CONOTOXINS inhibit voltage-activated entry of calcium into the presynaptic membrane and therefore the release of ACETYLCHOLINE. Alpha-conotoxins inhibit the postsynaptic acetylcholine receptor. Mu-conotoxins prevent the generation of muscle action potentials. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)
| Descriptor ID |
D020916
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| MeSH Number(s) |
D20.888.590.162 D23.946.580.590.162 D23.946.833.590.162
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Conotoxins".
Below are MeSH descriptors whose meaning is more specific than "Conotoxins".
This graph shows the total number of publications written about "Conotoxins" by people in this website by year, and whether "Conotoxins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1997 | 1 | 0 | 1 |
| 2001 | 1 | 0 | 1 |
| 2004 | 2 | 0 | 2 |
| 2005 | 1 | 1 | 2 |
| 2008 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2013 | 2 | 0 | 2 |
| 2014 | 1 | 1 | 2 |
| 2017 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
| 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Conotoxins" by people in Profiles.
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Espiritu MJ, Taylor JK, Sugai CK, Thapa P, Loening NM, Gusman E, Baoanan ZG, Baumann MH, Bingham JP. Characterization of the Native Disulfide Isomers of the Novel ?-Conotoxin PnID: Implications for Further Increasing Conotoxin Diversity. Mar Drugs. 2023 Jan 19; 21(2).
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Wiere S, Sugai C, Espiritu MJ, Aurelio VP, Reyes CD, Yuzon N, Whittal RM, Tytgat J, Peigneur S, Bingham JP. Research into the Bioengineering of a Novel a-Conotoxin from the Milked Venom of Conus obscurus. Int J Mol Sci. 2022 Oct 11; 23(20).
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Leffler AE, Kuryatov A, Zebroski HA, Powell SR, Filipenko P, Hussein AK, Gorson J, Heizmann A, Lyskov S, Tsien RW, Poget SF, Nicke A, Lindstrom J, Rudy B, Bonneau R, Holford M. Discovery of peptide ligands through docking and virtual screening at nicotinic acetylcholine receptor homology models. Proc Natl Acad Sci U S A. 2017 09 19; 114(38):E8100-E8109.
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Thapa P, Zhang RY, Menon V, Bingham JP. Native chemical ligation: a boon to peptide chemistry. Molecules. 2014 Sep 12; 19(9):14461-83.
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Thapa P, Espiritu MJ, Cabalteja CC, Bingham JP. Conotoxins and their regulatory considerations. Regul Toxicol Pharmacol. 2014 Oct; 70(1):197-202.
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Espiritu MJ, Cabalteja CC, Sugai CK, Bingham JP. Incorporation of post-translational modified amino acids as an approach to increase both chemical and biological diversity of conotoxins and conopeptides. Amino Acids. 2014 Jan; 46(1):125-51.
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Kapono CA, Thapa P, Cabalteja CC, Guendisch D, Collier AC, Bingham JP. Conotoxin truncation as a post-translational modification to increase the pharmacological diversity within the milked venom of Conus magus. Toxicon. 2013 Aug; 70:170-8.
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Yang K, Buhlman L, Khan GM, Nichols RA, Jin G, McIntosh JM, Whiteaker P, Lukas RJ, Wu J. Functional nicotinic acetylcholine receptors containing a6 subunits are on GABAergic neuronal boutons adherent to ventral tegmental area dopamine neurons. J Neurosci. 2011 Feb 16; 31(7):2537-48.
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Holford M, Zhang MM, Gowd KH, Azam L, Green BR, Watkins M, Ownby JP, Yoshikami D, Bulaj G, Olivera BM. Pruning nature: Biodiversity-derived discovery of novel sodium channel blocking conotoxins from Conus bullatus. Toxicon. 2009 Jan; 53(1):90-8.
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Copeland RL, Leggett YA, Kanaan YM, Taylor RE, Tizabi Y. Neuroprotective effects of nicotine against salsolinol-induced cytotoxicity: implications for Parkinson's disease. Neurotox Res. 2005 Nov; 8(3-4):289-93.