src Homology Domains

"src Homology Domains" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Regions of AMINO ACID SEQUENCE similarity in the SRC-FAMILY TYROSINE KINASES that fold into specific functional tertiary structures. The SH1 domain is a CATALYTIC DOMAIN. SH2 and SH3 domains are protein interaction domains. SH2 usually binds PHOSPHOTYROSINE-containing proteins and SH3 interacts with CYTOSKELETAL PROTEINS.

Descriptor ID	D018909
MeSH Number(s)	G02.111.570.820.709.275.750.500.750
Concept/Terms	src Homology Domains src Homology Domains Homology Domain, src Homology Domains, src src Homology Domain SH Domains SH Domain SH2 Domain SH2 Domain SH2 Domains src Homology Region 2 Domain SH3 Domain SH3 Domain SH3 Domains SH1 Domain SH1 Domain SH1 Domains

Below are MeSH descriptors whose meaning is more general than "src Homology Domains".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Molecular Structure [G02.111.570]
Molecular Conformation [G02.111.570.820]
Protein Conformation [G02.111.570.820.709]
Protein Structural Elements [G02.111.570.820.709.275]
Protein Domains [G02.111.570.820.709.275.750]
Protein Interaction Domains and Motifs [G02.111.570.820.709.275.750.500]
src Homology Domains [G02.111.570.820.709.275.750.500.750]

Below are MeSH descriptors whose meaning is related to "src Homology Domains".

Below are MeSH descriptors whose meaning is more specific than "src Homology Domains".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "src Homology Domains" by people in this website by year, and whether "src Homology Domains" was a major or minor topic of these publications.

Bar chart showing 11 publications over 11 distinct years, with a maximum of 1 publications in 1996 and 1997 and 2000 and 2001 and 2004 and 2005 and 2009 and 2011 and 2014 and 2016 and 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1997	1	0	1
2000	0	1	1
2001	0	1	1
2004	0	1	1
2005	0	1	1
2009	1	0	1
2011	0	1	1
2014	0	1	1
2016	0	1	1
2018	0	1	1

Below are the most recent publications written about "src Homology Domains" by people in Profiles.

Wei C, Banu K, Garzon F, Basgen JM, Philippe N, Yi Z, Liu R, Choudhuri J, Fribourg M, Liu T, Cumpelik A, Wong J, Khan M, Das B, Keung K, Salem F, Campbell KN, Kaufman L, Cravedi P, Zhang W, O'Connell PJ, He JC, Murphy B, Menon MC. SHROOM3-FYN Interaction Regulates Nephrin Phosphorylation and Affects Albuminuria in Allografts. J Am Soc Nephrol. 2018 11; 29(11):2641-2657.

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Adams G, Zhou J, Wang W, Wu H, Quan J, Liu Y, Xia P, Wang Z, Zhou S, Jiang J, Mo F, Zhuang X, Thomas K, Hill DL, Aikhionbare FO, He P, Liu X, Ding X, Yao X. The Microtubule Plus End Tracking Protein TIP150 Interacts with Cortactin to Steer Directional Cell Migration. J Biol Chem. 2016 09 23; 291(39):20692-706.

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Fredericks GJ, Hoffmann FW, Rose AH, Osterheld HJ, Hess FM, Mercier F, Hoffmann PR. Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex. Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):16478-83.

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Page BD, Khoury H, Laister RC, Fletcher S, Vellozo M, Manzoli A, Yue P, Turkson J, Minden MD, Gunning PT. Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity. J Med Chem. 2012 Feb 09; 55(3):1047-55.

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Page BD, Fletcher S, Yue P, Li Z, Zhang X, Sharmeen S, Datti A, Wrana JL, Trudel S, Schimmer AD, Turkson J, Gunning PT. Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain. Bioorg Med Chem Lett. 2011 Sep 15; 21(18):5605-9.

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Fletcher S, Page BD, Zhang X, Yue P, Li ZH, Sharmeen S, Singh J, Zhao W, Schimmer AD, Trudel S, Turkson J, Gunning PT. Antagonism of the Stat3-Stat3 protein dimer with salicylic acid based small molecules. ChemMedChem. 2011 Aug 01; 6(8):1459-70.

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Ross JA, Chen Y, M?ller J, Barylko B, Wang L, Banks HB, Albanesi JP, Jameson DM. Dimeric endophilin A2 stimulates assembly and GTPase activity of dynamin 2. Biophys J. 2011 Feb 02; 100(3):729-737.

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Zhao W, Jaganathan S, Turkson J. A cell-permeable Stat3 SH2 domain mimetic inhibits Stat3 activation and induces antitumor cell effects in vitro. J Biol Chem. 2010 Nov 12; 285(46):35855-65.

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Zhang X, Yue P, Fletcher S, Zhao W, Gunning PT, Turkson J. A novel small-molecule disrupts Stat3 SH2 domain-phosphotyrosine interactions and Stat3-dependent tumor processes. Biochem Pharmacol. 2010 May 15; 79(10):1398-409.

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Drewry JA, Fletcher S, Yue P, Marushchak D, Zhao W, Sharmeen S, Zhang X, Schimmer AD, Gradinaru C, Turkson J, Gunning PT. Coordination complex SH2 domain proteomimetics: an alternative approach to disrupting oncogenic protein-protein interactions. Chem Commun (Camb). 2010 Feb 14; 46(6):892-4.

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