A state arrived at through prolonged and strong contraction of a muscle. Studies in athletes during prolonged submaximal exercise have shown that muscle fatigue increases in almost direct proportion to the rate of muscle glycogen depletion. Muscle fatigue in short-term maximal exercise is associated with oxygen lack and an increased level of blood and muscle lactic acid, and an accompanying increase in hydrogen-ion concentration in the exercised muscle.

Descriptor ID	D018763
MeSH Number(s)	G11.427.550
Concept/Terms	Muscle Fatigue Muscle Fatigue Muscular Fatigue Fatigue, Muscular Fatigue, Muscle

Below are MeSH descriptors whose meaning is more general than "Muscle Fatigue".

Below are MeSH descriptors whose meaning is related to "Muscle Fatigue".

Below are MeSH descriptors whose meaning is more specific than "Muscle Fatigue".