Muscarinic Antagonists

"Muscarinic Antagonists" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system.

Descriptor ID	D018727
MeSH Number(s)	D27.505.519.625.120.200.500 D27.505.696.577.120.200.500
Concept/Terms	Muscarinic Antagonists Muscarinic Antagonists Antagonists, Muscarinic Antimuscarinics Antimuscarinic Agents Agents, Antimuscarinic Cholinergic Muscarinic Antagonists Antagonists, Cholinergic Muscarinic Muscarinic Antagonists, Cholinergic

Below are MeSH descriptors whose meaning is more general than "Muscarinic Antagonists".

Chemicals and Drugs [D]
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Molecular Mechanisms of Pharmacological Action [D27.505.519]
Neurotransmitter Agents [D27.505.519.625]
Cholinergic Agents [D27.505.519.625.120]
Cholinergic Antagonists [D27.505.519.625.120.200]
Muscarinic Antagonists [D27.505.519.625.120.200.500]
Physiological Effects of Drugs [D27.505.696]
Neurotransmitter Agents [D27.505.696.577]
Cholinergic Agents [D27.505.696.577.120]
Cholinergic Antagonists [D27.505.696.577.120.200]
Muscarinic Antagonists [D27.505.696.577.120.200.500]

Below are MeSH descriptors whose meaning is related to "Muscarinic Antagonists".

Below are MeSH descriptors whose meaning is more specific than "Muscarinic Antagonists".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Muscarinic Antagonists" by people in this website by year, and whether "Muscarinic Antagonists" was a major or minor topic of these publications.

Bar chart showing 11 publications over 9 distinct years, with a maximum of 2 publications in 2008 and 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	1	0	1
2001	0	1	1
2003	0	1	1
2004	1	0	1
2008	1	1	2
2009	1	0	1
2013	0	1	1
2016	0	1	1
2018	2	0	2

Below are the most recent publications written about "Muscarinic Antagonists" by people in Profiles.

Jo T, Michihata N, Yamana H, Sasabuchi Y, Matsui H, Urushiyama H, Mitani A, Yamauchi Y, Fushimi K, Nagase T, Yasunaga H. Reduction in exacerbation of COPD in patients of advanced age using the Japanese Kampo medicine Dai-kenchu-to: a retrospective cohort study. Int J Chron Obstruct Pulmon Dis. 2019; 14:129-139.

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Sobieraj DM, Baker WL, Nguyen E, Weeda ER, Coleman CI, White CM, Lazarus SC, Blake KV, Lang JE. Association of Inhaled Corticosteroids and Long-Acting Muscarinic Antagonists With Asthma Control in Patients With Uncontrolled, Persistent Asthma: A Systematic Review and Meta-analysis. JAMA. 2018 04 10; 319(14):1473-1484.

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Matera MG, Sanduzzi A, Alfano R, Cazzola M. Aclidinium bromide inhalation powder for the long-term, maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease including chronic bronchitis and emphysema. Expert Rev Clin Pharmacol. 2016 Jun; 9(6):771-7.

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Zhan X, Yin P, Heinbockel T. The basal forebrain modulates spontaneous activity of principal cells in the main olfactory bulb of anesthetized mice. Front Neural Circuits. 2013; 7:148.

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Felicilda-Reynaldo RF. A review of anticholinergic medications for overactive bladder symptoms. Medsurg Nurs. 2013 Mar-Apr; 22(2):119-23.

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Prat M, Fern?ndez D, Buil MA, Crespo MI, Casals G, Ferrer M, Tort L, Castro J, Monle?n JM, Gavald? A, Miralpeix M, Ramos I, Dom?nech T, Vilella D, Ant?n F, Huerta JM, Espinosa S, L?pez M, Sentellas S, Gonz?lez M, Albert? J, Segarra V, C?rdenas A, Beleta J, Ryder H. Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinol esters as potent and long-acting muscarinic antagonists with potential for minimal systemic exposure after inhaled administration: identification of (3R)-3-{[hydroxy(di-2-thienyl)acetyl]oxy}-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide (aclidinium bromide). J Med Chem. 2009 Aug 27; 52(16):5076-92.

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Monjok EM, Kulkarni KH, Kouamou G, McKoy M, Opere CA, Bongmba ON, Njie YF, Ohia SE. Inhibitory action of hydrogen sulfide on muscarinic receptor-induced contraction of isolated porcine irides. Exp Eye Res. 2008 Dec; 87(6):612-6.

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Rasmussen BA, Perry DC, O'Neil J, Manaye KF, Tizabi Y. Effects of nicotine on sensorimotor gating impairment induced by long-term treatment with neurotoxic NMDA antagonism. Neurotox Res. 2008 May-Jun; 13(3-4):151-61.

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Devan BD, Sierra-Mercado D, Jimenez M, Bowker JL, Duffy KB, Spangler EL, Ingram DK. Phosphodiesterase inhibition by sildenafil citrate attenuates the learning impairment induced by blockade of cholinergic muscarinic receptors in rats. Pharmacol Biochem Behav. 2004 Dec; 79(4):691-9.

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Oyachi N, Lakshmanan J, Ahanya SN, Bassiri D, Atkinson JB, Ross MG. Development of ovine fetal ileal motility: role of muscarinic receptor subtypes. Am J Obstet Gynecol. 2003 Oct; 189(4):953-7.

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