Connexins

"Connexins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A group of homologous proteins which form the intermembrane channels of GAP JUNCTIONS. The connexins are the products of an identified gene family which has both highly conserved and highly divergent regions. The variety contributes to the wide range of functional properties of gap junctions.

Descriptor ID	D017630
MeSH Number(s)	D12.776.543.585.250
Concept/Terms	Connexins Connexins Gap Junction Protein Junction Protein, Gap Gap Junction Proteins Junction Proteins, Gap Gap Junction Channel Proteins

Below are MeSH descriptors whose meaning is more general than "Connexins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Membrane Transport Proteins [D12.776.543.585]
Connexins [D12.776.543.585.250]

Below are MeSH descriptors whose meaning is related to "Connexins".

Below are MeSH descriptors whose meaning is more specific than "Connexins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Connexins" by people in this website by year, and whether "Connexins" was a major or minor topic of these publications.

Bar chart showing 27 publications over 15 distinct years, with a maximum of 3 publications in 2004 and 2012 and 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	1	0	1
2003	1	0	1
2004	3	0	3
2006	1	1	2
2007	1	1	2
2009	0	1	1
2012	3	0	3
2014	2	0	2
2015	1	1	2
2016	3	0	3
2017	2	0	2
2018	2	0	2
2019	1	0	1
2020	0	1	1
2021	0	1	1

Below are the most recent publications written about "Connexins" by people in Profiles.

Lewis KJ, Cabahug-Zuckerman P, Boorman-Padgett JF, Basta-Pljakic J, Louie J, Stephen S, Spray DC, Thi MM, Seref-Ferlengez Z, Majeska RJ, Weinbaum S, Schaffler MB. Estrogen depletion on In vivo osteocyte calcium signaling responses to mechanical loading. Bone. 2021 11; 152:116072.

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McCutcheon S, Majeska RJ, Spray DC, Schaffler MB, Vazquez M. Apoptotic Osteocytes Induce RANKL Production in Bystanders via Purinergic Signaling and Activation of Pannexin Channels. J Bone Miner Res. 2020 05; 35(5):966-977.

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Gu S, Biswas S, Rodriguez L, Li Z, Li Y, Riquelme MA, Shi W, Wang K, White TW, Reilly M, Lo WK, Jiang JX. Connexin 50 and AQP0 are Essential in Maintaining Organization and Integrity of Lens Fibers. Invest Ophthalmol Vis Sci. 2019 09 03; 60(12):4021-4032.

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Jezzini SH, Merced A, Blagburn JM. Shaking-B misexpression increases the formation of gap junctions but not chemical synapses between auditory sensory neurons and the giant fiber of Drosophila melanogaster. PLoS One. 2018; 13(8):e0198710.

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Seref-Ferlengez Z, Urban-Maldonado M, Sun HB, Schaffler MB, Suadicani SO, Thi MM. Role of pannexin 1 channels in load-induced skeletal response. Ann N Y Acad Sci. 2019 04; 1442(1):79-90.

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Cabahug-Zuckerman P, Stout RF, Majeska RJ, Thi MM, Spray DC, Weinbaum S, Schaffler MB. Potential role for a specialized ?3 integrin-based structure on osteocyte processes in bone mechanosensation. J Orthop Res. 2018 02; 36(2):642-652.

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Hu Z, Shi W, Riquelme MA, Shi Q, Biswas S, Lo WK, White TW, Gu S, Jiang JX. Connexin 50 Functions as an Adhesive Molecule and Promotes Lens Cell Differentiation. Sci Rep. 2017 07 13; 7(1):5298.

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Seref-Ferlengez Z, Maung S, Schaffler MB, Spray DC, Suadicani SO, Thi MM. P2X7R-Panx1 Complex Impairs Bone Mechanosignaling under High Glucose Levels Associated with Type-1 Diabetes. PLoS One. 2016; 11(5):e0155107.

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P?zier AP, Jezzini SH, Bacon JP, Blagburn JM. Shaking B Mediates Synaptic Coupling between Auditory Sensory Neurons and the Giant Fiber of Drosophila melanogaster. PLoS One. 2016; 11(4):e0152211.

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Cheung WY, Fritton JC, Morgan SA, Seref-Ferlengez Z, Basta-Pljakic J, Thi MM, Suadicani SO, Spray DC, Majeska RJ, Schaffler MB. Pannexin-1 and P2X7-Receptor Are Required for Apoptotic Osteocytes in Fatigued Bone to Trigger RANKL Production in Neighboring Bystander Osteocytes. J Bone Miner Res. 2016 Apr; 31(4):890-9.

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