HLA-DR4 Antigen

"HLA-DR4 Antigen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An HLA-DR antigen which is associated with HLA-DRB1 CHAINS encoded by DRB1*04 alleles.

Descriptor ID	D015804
MeSH Number(s)	D12.776.395.550.509.400.440.400.040 D12.776.543.550.440.400.440.400.040 D23.050.301.500.400.400.440.400.040 D23.050.301.500.450.400.440.389.937 D23.050.705.552.410.400.440.389.040 D23.050.705.552.450.400.440.389.937
Concept/Terms	HLA-DR4 Antigen HLA-DR4 Antigen Antigen, HLA-DR4 HLA DR4 Antigen HLA-DR4

Below are MeSH descriptors whose meaning is more general than "HLA-DR4 Antigen".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Glycoproteins [D12.776.395]
Membrane Glycoproteins [D12.776.395.550]
Histocompatibility Antigens Class II [D12.776.395.550.509]
HLA-D Antigens [D12.776.395.550.509.400]
HLA-DR Antigens [D12.776.395.550.509.400.440]
HLA-DR Serological Subtypes [D12.776.395.550.509.400.440.400]
HLA-DR4 Antigen [D12.776.395.550.509.400.440.400.040]
Membrane Proteins [D12.776.543]
Membrane Glycoproteins [D12.776.543.550]
Histocompatibility Antigens Class II [D12.776.543.550.440]
HLA-D Antigens [D12.776.543.550.440.400]
HLA-DR Antigens [D12.776.543.550.440.400.440]
HLA-DR Serological Subtypes [D12.776.543.550.440.400.440.400]
HLA-DR4 Antigen [D12.776.543.550.440.400.440.400.040]
Biological Factors [D23]
Antigens [D23.050]
Antigens, Surface [D23.050.301]
Histocompatibility Antigens [D23.050.301.500]
Histocompatibility Antigens Class II [D23.050.301.500.400]
HLA-D Antigens [D23.050.301.500.400.400]
HLA-DR Antigens [D23.050.301.500.400.400.440]
HLA-DR Serological Subtypes [D23.050.301.500.400.400.440.400]
HLA-DR4 Antigen [D23.050.301.500.400.400.440.400.040]
HLA Antigens [D23.050.301.500.450]
HLA-D Antigens [D23.050.301.500.450.400]
HLA-DR Antigens [D23.050.301.500.450.400.440]
HLA-DR Serological Subtypes [D23.050.301.500.450.400.440.389]
HLA-DR4 Antigen [D23.050.301.500.450.400.440.389.937]
Isoantigens [D23.050.705]
Histocompatibility Antigens [D23.050.705.552]
Histocompatibility Antigens Class II [D23.050.705.552.410]
HLA-D Antigens [D23.050.705.552.410.400]
HLA-DR Antigens [D23.050.705.552.410.400.440]
HLA-DR Serological Subtypes [D23.050.705.552.410.400.440.389]
HLA-DR4 Antigen [D23.050.705.552.410.400.440.389.040]
HLA Antigens [D23.050.705.552.450]
HLA-D Antigens [D23.050.705.552.450.400]
HLA-DR Antigens [D23.050.705.552.450.400.440]
HLA-DR Serological Subtypes [D23.050.705.552.450.400.440.389]
HLA-DR4 Antigen [D23.050.705.552.450.400.440.389.937]

Below are MeSH descriptors whose meaning is related to "HLA-DR4 Antigen".

Below are MeSH descriptors whose meaning is more specific than "HLA-DR4 Antigen".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "HLA-DR4 Antigen" by people in this website by year, and whether "HLA-DR4 Antigen" was a major or minor topic of these publications.

Bar chart showing 9 publications over 7 distinct years, with a maximum of 2 publications in 2006 and 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	1	0	1
2006	0	2	2
2009	1	0	1
2013	1	0	1
2016	1	0	1
2017	0	1	1
2018	1	1	2

Below are the most recent publications written about "HLA-DR4 Antigen" by people in Profiles.

Okaa UJ, Ledesma Taira C, Dos Santos Dias L, Dobson H, Kujoth GC, Campuzano A, Homan EJ, Thompson GR, Hung CY, Deepe GS, W?thrich M, Klein BS. Endoglucanase 2 (Eng2), a shared immunodominant antigen in dimorphic fungi that elicits immunity during infection. J Clin Invest. 2025 Nov 17; 135(22).

View in: PubMed
Hung CY, Zhang H, Castro-Lopez N, Ostroff GR, Khoshlenar P, Abraham A, Cole GT, Negron A, Forsthuber T, Peng T, Galgiani JN, Ampel NM, Yu JJ. Glucan-Chitin Particles Enhance Th17 Response and Improve Protective Efficacy of a Multivalent Antigen (rCpa1) against Pulmonary Coccidioides posadasii Infection. Infect Immun. 2018 11; 86(11).

View in: PubMed
Nalawade SA, Ji N, Raphael I, Pratt A, Kraig E, Forsthuber TG. Aire is not essential for regulating neuroinflammatory disease in mice transgenic for human autoimmune-diseases associated MHC class II genes HLA-DR2b and HLA-DR4. Cell Immunol. 2018 09; 331:38-48.

View in: PubMed
Hurtgen BJ, Hung CY. Rational Design of T Lymphocyte Epitope-Based Vaccines Against Coccidioides Infection. Methods Mol Biol. 2017; 1625:45-64.

View in: PubMed
Hurtgen BJ, Castro-Lopez N, Jim?nez-Alzate MDP, Cole GT, Hung CY. Preclinical identification of vaccine induced protective correlates in human leukocyte antigen expressing transgenic mice infected with Coccidioides posadasii. Vaccine. 2016 10 17; 34(44):5336-5343.

View in: PubMed
Li W, Murthy AK, Lanka GK, Chetty SL, Yu JJ, Chambers JP, Zhong G, Forsthuber TG, Guentzel MN, Arulanandam BP. A T cell epitope-based vaccine protects against chlamydial infection in HLA-DR4 transgenic mice. Vaccine. 2013 Nov 19; 31(48):5722-8.

View in: PubMed
Yu JJ, Goluguri T, Guentzel MN, Chambers JP, Murthy AK, Klose KE, Forsthuber TG, Arulanandam BP. Francisella tularensis T-cell antigen identification using humanized HLA-DR4 transgenic mice. Clin Vaccine Immunol. 2010 Feb; 17(2):215-22.

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Murthy AK, Cong Y, Murphey C, Guentzel MN, Forsthuber TG, Zhong G, Arulanandam BP. Chlamydial protease-like activity factor induces protective immunity against genital chlamydial infection in transgenic mice that express the human HLA-DR4 allele. Infect Immun. 2006 Dec; 74(12):6722-9.

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Kort JJ, Kawamura K, Fugger L, Weissert R, Forsthuber TG. Efficient presentation of myelin oligodendrocyte glycoprotein peptides but not protein by astrocytes from HLA-DR2 and HLA-DR4 transgenic mice. J Neuroimmunol. 2006 Apr; 173(1-2):23-34.

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Klehmet J, Shive C, Guardia-Wolff R, Petersen I, Spack EG, Boehm BO, Weissert R, Forsthuber TG. T cell epitope spreading to myelin oligodendrocyte glycoprotein in HLA-DR4 transgenic mice during experimental autoimmune encephalomyelitis. Clin Immunol. 2004 Apr; 111(1):53-60.

View in: PubMed

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