"Somatostatin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal.
| Descriptor ID |
D013004
|
| MeSH Number(s) |
D06.472.699.327.700.875 D06.472.699.587.780 D12.644.400.400.700.875 D12.644.548.365.700.875 D12.644.548.586.780 D12.776.631.650.405.700.875
|
| Concept/Terms |
Somatostatin- Somatostatin
- SRIH-14
- Somatotropin Release-Inhibiting Factor
- Somatotropin Release Inhibiting Factor
- Cyclic Somatostatin
- Somatostatin-14
- Somatostatin 14
- Somatotropin Release-Inhibiting Hormone
- Somatotropin Release Inhibiting Hormone
- Somatostatin, Cyclic
|
Below are MeSH descriptors whose meaning is more general than "Somatostatin".
Below are MeSH descriptors whose meaning is more specific than "Somatostatin".
This graph shows the total number of publications written about "Somatostatin" by people in this website by year, and whether "Somatostatin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 2 | 2 |
| 1998 | 1 | 0 | 1 |
| 1999 | 1 | 1 | 2 |
| 2000 | 1 | 0 | 1 |
| 2002 | 1 | 1 | 2 |
| 2003 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 2 | 0 | 2 |
| 2010 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
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click here.
Below are the most recent publications written about "Somatostatin" by people in Profiles.
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Oviedo HV. Connectivity motifs of inhibitory neurons in the mouse Auditory Cortex. Sci Rep. 2017 12 05; 7(1):16987.
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Kuruva M, Shah HR, Dunn AL, McDonald JE. 111In-Pentetreotide Imaging in Diffuse Idiopathic Neuroendocrine Hyperplasia of the Lung. Clin Nucl Med. 2016 Mar; 41(3):239-40.
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Afanador L, Mexhitaj I, Diaz C, Ordonez D, Baker L, Angulo JA. The role of the neuropeptide somatostatin on methamphetamine and glutamate-induced neurotoxicity in the striatum of mice. Brain Res. 2013 May 13; 1510:38-47.
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Felicilda-Reynaldo RF. Block the bleed: pharmacologic therapies for gastroesophageal variceal bleeding. Medsurg Nurs. 2012 Mar-Apr; 21(2):107-10; quiz 111.
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Martinez CO, Do VH, Derrick BE. Endogenous opioid peptides contribute to associative LTP in the hippocampal CA3 region. Neurobiol Learn Mem. 2011 Sep; 96(2):207-17.
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Wang J, Angulo JA. Methamphetamine induces striatal neurokinin-1 receptor endocytosis primarily in somatostatin/NPY/NOS interneurons and the role of dopamine receptors in mice. Synapse. 2011 Apr; 65(4):300-8.
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Tan W, Janczewski WA, Yang P, Shao XM, Callaway EM, Feldman JL. Silencing preB?tzinger complex somatostatin-expressing neurons induces persistent apnea in awake rat. Nat Neurosci. 2008 May; 11(5):538-40.
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Fournier JR, Baez-Trinidad L, Acosta A, Marrero M, Correa-Rivas M, Rodr?guez-Becerra J, Nieves F. Bladder pheochromocytoma: case presentation and the use of OctreoScan for localization of extra-adrenal tumor sites in a pediatric patient. P R Health Sci J. 2008 Mar; 27(1):107-11.
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Cyr JE, Pearson DA, Nelson CA, Lyons BA, Zheng Y, Bartis J, He J, Cantorias MV, Howell RC, Francesconi LC. Isolation, characterization, and biological evaluation of syn and anti diastereomers of [(99m)Tc]technetium depreotide: a somatostatin receptor binding tumor imaging agent. J Med Chem. 2007 Sep 06; 50(18):4295-303.
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Huang XG, Yee BK, Nag S, Chan ST, Tang F. Behavioral and neurochemical characterization of transgenic mice carrying the human presenilin-1 gene with or without the leucine-to-proline mutation at codon 235. Exp Neurol. 2003 Oct; 183(2):673-81.