"Selegiline" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability. (From AMA Drug Evaluations Annual, 1994, p385) The compound without isomeric designation is Deprenyl.
| Descriptor ID |
D012642
|
| MeSH Number(s) |
D02.092.471.683.915
|
| Concept/Terms |
Selegiline- Selegiline
- Selegiline, (R)-Isomer
- Selegyline
- L-Deprenyl
|
Below are MeSH descriptors whose meaning is more general than "Selegiline".
Below are MeSH descriptors whose meaning is more specific than "Selegiline".
This graph shows the total number of publications written about "Selegiline" by people in this website by year, and whether "Selegiline" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Selegiline" by people in Profiles.
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Lu BY, Agapoff JR, Olson DJ, Williams SR, Roller A, Goebert D. Rapid and sustained improvement in treatment-refractory depression through use of acute intravenous ketamine and concurrent transdermal selegiline: A case series. J Affect Disord. 2020 02 01; 262:40-42.
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Kowalko JE, Rohner N, Rompani SB, Peterson BK, Linden TA, Yoshizawa M, Kay EH, Weber J, Hoekstra HE, Jeffery WR, Borowsky R, Tabin CJ. Loss of schooling behavior in cavefish through sight-dependent and sight-independent mechanisms. Curr Biol. 2013 Oct 07; 23(19):1874-83.
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Schifitto G, Yiannoutsos CT, Ernst T, Navia BA, Nath A, Sacktor N, Anderson C, Marra CM, Clifford DB. Selegiline and oxidative stress in HIV-associated cognitive impairment. Neurology. 2009 Dec 08; 73(23):1975-81.
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Csoka AB, Shipko S. Persistent sexual side effects after SSRI discontinuation. Psychother Psychosom. 2006; 75(3):187-8.
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Mazzio EA, Harris N, Soliman KF. Food constituents attenuate monoamine oxidase activity and peroxide levels in C6 astrocyte cells. Planta Med. 1998 Oct; 64(7):603-6.
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Youdim MB, Banerjee DK, Kelner K, Offutt L, Pollard HB. Steroid regulation of monoamine oxidase activity in the adrenal medulla. FASEB J. 1989 Apr; 3(6):1753-9.
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Youdim MB, Banerjee DK, Pollard HB. Isolated chromaffin cells from adrenal medulla contain primarily monoamine oxidase B. Science. 1984 May 11; 224(4649):619-21.