Hydrochlorothiazide

"Hydrochlorothiazide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.

Descriptor ID	D006852
MeSH Number(s)	D02.886.590.700.135.261.476 D02.886.655.500.261.476 D03.633.100.174.261.476
Concept/Terms	Hydrochlorothiazide Hydrochlorothiazide HCTZ Dichlothiazide Dihydrochlorothiazide HydroDIURIL HydroDIURIL Oretic Oretic Sectrazide Sectrazide Esidrix Esidrix Esidrex Hypothiazide Hypothiazide

Below are MeSH descriptors whose meaning is more general than "Hydrochlorothiazide".

Chemicals and Drugs [D]
Organic Chemicals [D02]
Sulfur Compounds [D02.886]
Sulfones [D02.886.590]
Sulfonamides [D02.886.590.700]
Benzothiadiazines [D02.886.590.700.135]
Chlorothiazide [D02.886.590.700.135.261]
Hydrochlorothiazide [D02.886.590.700.135.261.476]
Thiazides [D02.886.655]
Benzothiadiazines [D02.886.655.500]
Chlorothiazide [D02.886.655.500.261]
Hydrochlorothiazide [D02.886.655.500.261.476]
Heterocyclic Compounds [D03]
Heterocyclic Compounds, Fused-Ring [D03.633]
Heterocyclic Compounds, 2-Ring [D03.633.100]
Benzothiadiazines [D03.633.100.174]
Chlorothiazide [D03.633.100.174.261]
Hydrochlorothiazide [D03.633.100.174.261.476]

Below are MeSH descriptors whose meaning is related to "Hydrochlorothiazide".

Below are MeSH descriptors whose meaning is more specific than "Hydrochlorothiazide".

Hydrochlorothiazide
Trichlormethiazide

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Hydrochlorothiazide" by people in this website by year, and whether "Hydrochlorothiazide" was a major or minor topic of these publications.

Bar chart showing 16 publications over 9 distinct years, with a maximum of 4 publications in 2008

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2005	1	0	1
2006	2	0	2
2007	1	1	2
2008	4	0	4
2009	2	0	2
2010	1	0	1
2011	1	0	1
2013	1	1	2
2019	0	1	1

Below are the most recent publications written about "Hydrochlorothiazide" by people in Profiles.

Roshandel G, Khoshnia M, Poustchi H, Hemming K, Kamangar F, Gharavi A, Ostovaneh MR, Nateghi A, Majed M, Navabakhsh B, Merat S, Pourshams A, Nalini M, Malekzadeh F, Sadeghi M, Mohammadifard N, Sarrafzadegan N, Naemi-Tabiei M, Fazel A, Brennan P, Etemadi A, Boffetta P, Thomas N, Marshall T, Cheng KK, Malekzadeh R. Effectiveness of polypill for primary and secondary prevention of cardiovascular diseases (PolyIran): a pragmatic, cluster-randomised trial. Lancet. 2019 08 24; 394(10199):672-683.

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Calhoun DA, Lacourci?re Y, Crikelair N, Jia Y, Glazer RD. Effects of demographics on the antihypertensive efficacy of triple therapy with amlodipine, valsartan, and hydrochlorothiazide for moderate to severe hypertension. Curr Med Res Opin. 2013 Aug; 29(8):901-10.

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Ofili EO, Zappe DH, Purkayastha D, Samuel R, Sowers JR. Antihypertensive and metabolic effects of Angiotensin receptor blocker/diuretic combination therapy in obese, hypertensive African American and white patients. Am J Ther. 2013 Jan; 20(1):2-12.

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Ofili EO, Oparil S, Giles T, Pitt B, Purkayastha D, Hilkert R, Samuel R, Sowers JR. Moderate versus intensive treatment of hypertension using amlodipine/valsartan and with the addition of hydrochlorothiazide for patients uncontrolled on angiotensin receptor blocker monotherapy: results in racial/ethnic subgroups. J Am Soc Hypertens. 2011 Jul-Aug; 5(4):249-58.

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Sowers JR, Raij L, Jialal I, Egan BM, Ofili EO, Samuel R, Zappe DH, Purkayastha D, Deedwania PC. Angiotensin receptor blocker/diuretic combination preserves insulin responses in obese hypertensives. J Hypertens. 2010 Aug; 28(8):1761-9.

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Calhoun DA, Crikelair NA, Yen J, Glazer RD. Amlodipine/valsartan/hydrochlorothiazide triple combination therapy in moderate/severe hypertension: Secondary analyses evaluating efficacy and safety. Adv Ther. 2009 Nov; 26(11):1012-23.

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Calhoun DA, Lacourci?re Y, Chiang YT, Glazer RD. Triple antihypertensive therapy with amlodipine, valsartan, and hydrochlorothiazide: a randomized clinical trial. Hypertension. 2009 Jul; 54(1):32-9.

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Ofili EO, Cable G, Neutel JM, Saunders E. Efficacy and safety of fixed combinations of irbesartan/hydrochlorothiazide in hypertensive women: the inclusive trial. J Womens Health (Larchmt). 2008 Jul-Aug; 17(6):931-8.

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Calhoun DA, Glazer RD, Pettyjohn FS, Coenen PD, Zhao Y, Grosso A. Efficacy and tolerability of combination therapy with valsartan/hydrochlorothiazide in the initial treatment of severe hypertension. Curr Med Res Opin. 2008 Aug; 24(8):2303-11.

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White WB, Calhoun DA, Samuel R, Taylor AA, Zappe DH, Purkayastha D. Improving blood pressure control: increase the dose of diuretic or switch to a fixed-dose angiotensin receptor blocker/diuretic? the valsartan hydrochlorothiazide diuretic for initial control and titration to achieve optimal therapeutic effect (Val-DICTATE) trial. J Clin Hypertens (Greenwich). 2008 Jun; 10(6):450-8.

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