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Olivier Le Saux, PhD

Title
Faculty RankAssociate Professor
InstitutionUniversity of Hawaii
DepartmentCell and Molecular Biology
AddressJohn A. Burns School of Medicine
University of Hawaii at Manoa
651 Ilalo Street
Honolulu HI
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    R21HL087289     (LE SAUX, OLIVIER)Jul 1, 2009 - Jun 30, 2012
    NIH/NHLBI
    Pseudoxanthoma elasticum: Elastic fibers alterations and characterization of seru
    Role: Principal Investigator

    R01HL108249     (LE SAUX, OLIVIER)Feb 24, 2012 - Jan 31, 2016
    NIH/NHLBI
    The Role of ABCC6 In Chronic &Acute Cardiovascular Mineralization
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Roberts FL, Rashdan NA, Phadwal K, Markby GR, Dillon S, Zoll J, Berger J, Milne E, Orriss IR, Karsenty G, Le Saux O, Morton NM, Farquharson C, MacRae VE. Osteoblast-specific deficiency of ectonucleotide pyrophosphatase or phosphodiesterase-1 engenders insulin resistance in high-fat diet fed mice. J Cell Physiol. 2020 Dec 10. PMID: 33305372.
      Citations:    
    2. Panee J, Pomozi V, Franke AA, Le Saux O, Gerschenson M. Chronic marijuana use moderates the correlations of serum cholesterol with systemic mitochondrial function and fluid cognition. Mitochondrion. 2020 May; 52:135-143. PMID: 32169611.
      Citations:    Fields:    
    3. Pomozi V, Julian CB, Zoll J, Pham K, Kuo S, Tokési N, Martin L, Váradi A, Le Saux O. Dietary Pyrophosphate Modulates Calcification in a Mouse Model of Pseudoxanthoma Elasticum: Implication for Treatment of Patients. J Invest Dermatol. 2019 05; 139(5):1082-1088. PMID: 30468740.
      Citations: 3     Fields:    Translation:HumansAnimals
    4. De Vilder EYG, Cardoen S, Hosen MJ, Le Saux O, De Zaeytijd J, Leroy BP, De Reuck J, Coucke PJ, De Paepe A, Hemelsoet D, Vanakker OM. Pathogenic variants in the ABCC6 gene are associated with an increased risk for ischemic stroke. Brain Pathol. 2018 11; 28(6):822-831. PMID: 29722917.
      Citations:    Fields:    Translation:HumansAnimals
    5. Letavernier E, Kauffenstein G, Huguet L, Navasiolava N, Bouderlique E, Tang E, Delaitre L, Bazin D, de Frutos M, Gay C, Perez J, Verpont MC, Haymann JP, Pomozi V, Zoll J, Le Saux O, Daudon M, Leftheriotis G, Martin L. ABCC6 Deficiency Promotes Development of Randall Plaque. J Am Soc Nephrol. 2018 09; 29(9):2337-2347. PMID: 29991491.
      Citations: 2     Fields:    Translation:HumansAnimals
    6. Bauer C, le Saux O, Pomozi V, Aherrahrou R, Kriesen R, Stölting S, Liebers A, Kessler T, Schunkert H, Erdmann J, Aherrahrou Z. Etidronate prevents dystrophic cardiac calcification by inhibiting macrophage aggregation. Sci Rep. 2018 04 11; 8(1):5812. PMID: 29643466.
      Citations: 1     Fields:    Translation:AnimalsCells
    7. Kauffenstein G, Yegutkin GG, Khiati S, Pomozi V, Le Saux O, Leftheriotis G, Lenaers G, Henrion D, Martin L. Alteration of Extracellular Nucleotide Metabolism in Pseudoxanthoma Elasticum. J Invest Dermatol. 2018 08; 138(8):1862-1870. PMID: 29501384.
      Citations: 4     Fields:    Translation:HumansAnimals
    8. Dedinszki D, Szeri F, Kozák E, Pomozi V, Tokési N, Mezei TR, Merczel K, Letavernier E, Tang E, Le Saux O, Arányi T, van de Wetering K, Váradi A. Oral administration of pyrophosphate inhibits connective tissue calcification. EMBO Mol Med. 2017 11; 9(11):1463-1470. PMID: 28701330.
      Citations: 16     Fields:    Translation:HumansAnimals
    9. Favre G, Laurain A, Aranyi T, Szeri F, Fulop K, Le Saux O, Duranton C, Kauffenstein G, Martin L, Lefthériotis G. The ABCC6 Transporter: A New Player in Biomineralization. Int J Mol Sci. 2017 Sep 11; 18(9). PMID: 28891970.
      Citations: 8     Fields:    Translation:HumansAnimals
    10. Pomozi V, Brampton C, van de Wetering K, Zoll J, Calio B, Pham K, Owens JB, Marh J, Moisyadi S, Váradi A, Martin L, Bauer C, Erdmann J, Aherrahrou Z, Le Saux O. Pyrophosphate Supplementation Prevents Chronic and Acute Calcification in ABCC6-Deficient Mice. Am J Pathol. 2017 Jun; 187(6):1258-1272. PMID: 28416300.
      Citations: 12     Fields:    Translation:Animals
    11. Pomozi V, Brampton C, Szeri F, Dedinszki D, Kozák E, van de Wetering K, Hopkins H, Martin L, Váradi A, Le Saux O. Functional Rescue of ABCC6 Deficiency by 4-Phenylbutyrate Therapy Reduces Dystrophic Calcification in Abcc6-/- Mice. J Invest Dermatol. 2017 03; 137(3):595-602. PMID: 27826008.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    12. Leftheriotis G, Kauffenstein G, Hamel JF, Abraham P, Le Saux O, Willoteaux S, Henrion D, Martin L. The contribution of arterial calcification to peripheral arterial disease in pseudoxanthoma elasticum. PLoS One. 2014; 9(5):e96003. PMID: 24800819.
      Citations: 5     Fields:    Translation:Humans
    13. Hosen MJ, Coucke PJ, Le Saux O, De Paepe A, Vanakker OM. Perturbation of specific pro-mineralizing signalling pathways in human and murine pseudoxanthoma elasticum. Orphanet J Rare Dis. 2014 Apr 29; 9:66. PMID: 24775865.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    14. Brampton C, Aherrahrou Z, Chen LH, Martin L, Bergen AA, Gorgels TG, Erdmann J, Erdfdi J, Schunkert H, Szabó Z, Váradi A, Le Saux O. The level of hepatic ABCC6 expression determines the severity of calcification after cardiac injury. Am J Pathol. 2014 Jan; 184(1):159-70. PMID: 24479134.
      Citations: 13     Fields:    Translation:HumansAnimals
    15. Pomozi V, Brampton C, Fülöp K, Chen LH, Apana A, Li Q, Uitto J, Le Saux O, Váradi A. Analysis of pseudoxanthoma elasticum-causing missense mutants of ABCC6 in vivo; pharmacological correction of the mislocalized proteins. J Invest Dermatol. 2014 Apr; 134(4):946-953. PMID: 24352041.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    16. Prunier F, Terrien G, Le Corre Y, Apana AL, Bière L, Kauffenstein G, Furber A, Bergen AA, Gorgels TG, Le Saux O, Leftheriotis G, Martin L. Pseudoxanthoma elasticum: cardiac findings in patients and Abcc6-deficient mouse model. PLoS One. 2013; 8(7):e68700. PMID: 23935882.
      Citations: 9     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    17. Pomozi V, Le Saux O, Brampton C, Apana A, Iliás A, Szeri F, Martin L, Monostory K, Paku S, Sarkadi B, Szakács G, Váradi A. ABCC6 is a basolateral plasma membrane protein. Circ Res. 2013 May 24; 112(11):e148-51. PMID: 23625951.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    18. Arányi T, Bacquet C, de Boussac H, Ratajewski M, Pomozi V, Fülöp K, Brampton CN, Pulaski L, Le Saux O, Váradi A. Transcriptional regulation of the ABCC6 gene and the background of impaired function of missense disease-causing mutations. Front Genet. 2013; 4:27. PMID: 23483032.
      Citations:    
    19. Lefthériotis G, Omarjee L, Le Saux O, Henrion D, Abraham P, Prunier F, Willoteaux S, Martin L. The vascular phenotype in Pseudoxanthoma elasticum and related disorders: contribution of a genetic disease to the understanding of vascular calcification. Front Genet. 2013; 4:4. PMID: 23408347.
      Citations:    
    20. Le Saux O, Martin L, Aherrahrou Z, Leftheriotis G, Váradi A, Brampton CN. The molecular and physiological roles of ABCC6: more than meets the eye. Front Genet. 2012; 3:289. PMID: 23248644.
      Citations:    
    21. Le Corre Y, Le Saux O, Froeliger F, Libouban H, Kauffenstein G, Willoteaux S, Leftheriotis G, Martin L. Quantification of the calcification phenotype of Abcc6-deficient mice with microcomputed tomography. Am J Pathol. 2012 Jun; 180(6):2208-13. PMID: 22469843.
      Citations: 15     Fields:    Translation:HumansAnimals
    22. Le Saux O, Fülöp K, Yamaguchi Y, Iliás A, Szabó Z, Brampton CN, Pomozi V, Huszár K, Arányi T, Váradi A. Expression and in vivo rescue of human ABCC6 disease-causing mutants in mouse liver. PLoS One. 2011; 6(9):e24738. PMID: 21935449.
      Citations: 33     Fields:    Translation:HumansAnimals
    23. Lefthériotis G, Abraham P, Le Corre Y, Le Saux O, Henrion D, Ducluzeau PH, Prunier F, Martin L. Relationship between ankle brachial index and arterial remodeling in pseudoxanthoma elasticum. J Vasc Surg. 2011 Nov; 54(5):1390-4. PMID: 21723076.
      Citations: 19     Fields:    Translation:Humans
    24. Brampton C, Yamaguchi Y, Vanakker O, Van Laer L, Chen LH, Thakore M, De Paepe A, Pomozi V, Szabó PT, Martin L, Váradi A, Le Saux O. Vitamin K does not prevent soft tissue mineralization in a mouse model of pseudoxanthoma elasticum. . 2011 Jun 01; 10(11):1810-20. PMID: 21597330.
      Citations:    
    25. Lefthériotis G, Vanakker O, Le Saux O, Martin L. Reply to the article of C. Markello et al. entitled "Vascular pathology of medial arterial calcifications in NT5E deficiency: Implications for the role of adenosine in pseudoxanthoma elasticum". Mol Genet Metab. 2011 Jun; 103(2):199-200. PMID: 21497121.
      Citations: 3     Fields:    Translation:Humans
    26. Martin L, Douet V, VanWart CM, Heller MB, Le Saux O. A mouse model of ß-thalassemia shows a liver-specific down-regulation of Abcc6 expression. Am J Pathol. 2011 Feb; 178(2):774-83. PMID: 21281810.
      Citations: 19     Fields:    Translation:AnimalsCells
    27. Costrop LM, Vanakker OO, Van Laer L, Le Saux O, Martin L, Chassaing N, Guerra D, Pasquali-Ronchetti I, Coucke PJ, De Paepe A. Novel deletions causing pseudoxanthoma elasticum underscore the genomic instability of the ABCC6 region. J Hum Genet. 2010 Feb; 55(2):112-7. PMID: 20075945.
      Citations: 8     Fields:    Translation:Humans
    28. Martin L, Maître F, Bonicel P, Daudon P, Verny C, Bonneau D, Le Saux O, Chassaing N. Heterozygosity for a single mutation in the ABCC6 gene may closely mimic PXE: consequences of this phenotype overlap for the definition of PXE. Arch Dermatol. 2008 Mar; 144(3):301-6. PMID: 18347285.
      Citations: 17     Fields:    Translation:Humans
    29. Douet V, Heller MB, Le Saux O. DNA methylation and Sp1 binding determine the tissue-specific transcriptional activity of the mouse Abcc6 promoter. Biochem Biophys Res Commun. 2007 Mar 02; 354(1):66-71. PMID: 17214963.
      Citations: 35     Fields:    Translation:AnimalsCells
    30. Douet V, VanWart CM, Heller MB, Reinhard S, Le Saux O. HNF4alpha and NF-E2 are key transcriptional regulators of the murine Abcc6 gene expression. Biochim Biophys Acta. 2006 Aug-Sep; 1759(8-9):426-36. PMID: 16997394.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    31. Le Saux O, Bunda S, VanWart CM, Douet V, Got L, Martin L, Hinek A. Serum factors from pseudoxanthoma elasticum patients alter elastic fiber formation in vitro. J Invest Dermatol. 2006 Jul; 126(7):1497-505. PMID: 16543900.
      Citations: 28     Fields:    Translation:HumansCells
    32. Hamlin N, Beck K, Bacchelli B, Cianciulli P, Pasquali-Ronchetti I, Le Saux O. Acquired Pseudoxanthoma elasticum-like syndrome in beta-thalassaemia patients. Br J Haematol. 2003 Sep; 122(5):852-4. PMID: 12930400.
      Citations: 29     Fields:    Translation:Humans
    33. Beck K, Hayashi K, Nishiguchi B, Le Saux O, Hayashi M, Boyd CD. The distribution of Abcc6 in normal mouse tissues suggests multiple functions for this ABC transporter. J Histochem Cytochem. 2003 Jul; 51(7):887-902. PMID: 12810839.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    34. Le Saux O, Beck K, Sachsinger C, Treiber C, Göring HH, Curry K, Johnson EW, Bercovitch L, Marais AS, Terry SF, Viljoen DL, Boyd CD. Evidence for a founder effect for pseudoxanthoma elasticum in the Afrikaner population of South Africa. Hum Genet. 2002 Oct; 111(4-5):331-8. PMID: 12384774.
      Citations: 8     Fields:    Translation:Humans
    35. Iliás A, Urbán Z, Seidl TL, Le Saux O, Sinkó E, Boyd CD, Sarkadi B, Váradi A. Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6). J Biol Chem. 2002 May 10; 277(19):16860-7. PMID: 11880368.
      Citations: 67     Fields:    Translation:HumansAnimalsCells
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