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Olivier Le Saux, PhD

Faculty RankAssociate Professor
InstitutionUniversity of Hawaii
DepartmentCell and Molecular Biology
AddressJohn A. Burns School of Medicine
University of Hawaii at Manoa
651 Ilalo Street
Honolulu HI
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    R21HL087289     (LE SAUX, OLIVIER)Jul 1, 2009 - Jun 30, 2012
    Pseudoxanthoma elasticum: Elastic fibers alterations and characterization of seru
    Role: Principal Investigator

    R01HL108249     (LE SAUX, OLIVIER)Feb 24, 2012 - Jan 31, 2017
    The Role of ABCC6 In Chronic & Acute Cardiovascular Mineralization
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Brampton C, Pomozi V, Le Corre Y, Zoll J, Kauffenstein G, Ma C, Hoffmann PR, Martin L, Le Saux O. Bone Marrow-Derived ABCC6 Is an Essential Regulator of Ectopic Calcification In PXE. J Invest Dermatol. 2024 Feb 15. PMID: 38367909.
      Citations:    Fields:    
    2. Kauffenstein G, Martin L, Le Saux O. The Purinergic Nature of Pseudoxanthoma Elasticum. Biology (Basel). 2024 Jan 26; 13(2). PMID: 38392293.
    3. Leftheriotis G, Navasiolava N, Clotaire L, Duranton C, Le Saux O, Bendahhou S, Laurain A, Rubera I, Martin L. Relationships between Plasma Pyrophosphate, Vascular Calcification and Clinical Severity in Patients Affected by Pseudoxanthoma Elasticum. J Clin Med. 2022 May 05; 11(9). PMID: 35566717.
    4. Shimada BK, Pomozi V, Zoll J, Kuo S, Martin L, Le Saux O. ABCC6, Pyrophosphate and Ectopic Calcification: Therapeutic Solutions. Int J Mol Sci. 2021 Apr 27; 22(9). PMID: 33925341.
      Citations: 18     Fields:    Translation:HumansAnimals
    5. Brampton C, Pomozi V, Chen LH, Apana A, McCurdy S, Zoll J, Boisvert WA, Lambert G, Henrion D, Blanchard S, Kuo S, Leftheriotis G, Martin L, Le Saux O. ABCC6 deficiency promotes dyslipidemia and atherosclerosis. Sci Rep. 2021 02 16; 11(1):3881. PMID: 33594095.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    6. Roberts FL, Rashdan NA, Phadwal K, Markby GR, Dillon S, Zoll J, Berger J, Milne E, Orriss IR, Karsenty G, Le Saux O, Morton NM, Farquharson C, MacRae VE. Osteoblast-specific deficiency of ectonucleotide pyrophosphatase or phosphodiesterase-1 engenders insulin resistance in high-fat diet fed mice. J Cell Physiol. 2021 06; 236(6):4614-4624. PMID: 33305372.
      Citations: 9     Fields:    Translation:AnimalsCells
    7. Panee J, Pomozi V, Franke AA, Le Saux O, Gerschenson M. Chronic marijuana use moderates the correlations of serum cholesterol with systemic mitochondrial function and fluid cognition. Mitochondrion. 2020 05; 52:135-143. PMID: 32169611.
      Citations: 1     Fields:    Translation:HumansCells
    8. Pomozi V, Julian CB, Zoll J, Pham K, Kuo S, Tok?si N, Martin L, V?radi A, Le Saux O. Dietary Pyrophosphate Modulates Calcification in a Mouse Model of Pseudoxanthoma Elasticum: Implication for Treatment of Patients. J Invest Dermatol. 2019 05; 139(5):1082-1088. PMID: 30468740.
      Citations: 17     Fields:    Translation:HumansAnimals
    9. De Vilder EYG, Cardoen S, Hosen MJ, Le Saux O, De Zaeytijd J, Leroy BP, De Reuck J, Coucke PJ, De Paepe A, Hemelsoet D, Vanakker OM. Pathogenic variants in the ABCC6 gene are associated with an increased risk for ischemic stroke. Brain Pathol. 2018 11; 28(6):822-831. PMID: 29722917.
      Citations: 8     Fields:    Translation:HumansAnimals
    10. Letavernier E, Kauffenstein G, Huguet L, Navasiolava N, Bouderlique E, Tang E, Delaitre L, Bazin D, de Frutos M, Gay C, Perez J, Verpont MC, Haymann JP, Pomozi V, Zoll J, Le Saux O, Daudon M, Leftheriotis G, Martin L. ABCC6 Deficiency Promotes Development of Randall Plaque. J Am Soc Nephrol. 2018 09; 29(9):2337-2347. PMID: 29991491.
      Citations: 23     Fields:    Translation:HumansAnimals
    11. Bauer C, le Saux O, Pomozi V, Aherrahrou R, Kriesen R, St?lting S, Liebers A, Kessler T, Schunkert H, Erdmann J, Aherrahrou Z. Etidronate prevents dystrophic cardiac calcification by inhibiting macrophage aggregation. Sci Rep. 2018 04 11; 8(1):5812. PMID: 29643466.
      Citations: 8     Fields:    Translation:AnimalsCells
    12. Kauffenstein G, Yegutkin GG, Khiati S, Pomozi V, Le Saux O, Leftheriotis G, Lenaers G, Henrion D, Martin L. Alteration of Extracellular Nucleotide Metabolism in Pseudoxanthoma Elasticum. J Invest Dermatol. 2018 08; 138(8):1862-1870. PMID: 29501384.
      Citations: 17     Fields:    Translation:HumansAnimals
    13. Dedinszki D, Szeri F, Koz?k E, Pomozi V, Tok?si N, Mezei TR, Merczel K, Letavernier E, Tang E, Le Saux O, Ar?nyi T, van de Wetering K, V?radi A. Oral administration of pyrophosphate inhibits connective tissue calcification. EMBO Mol Med. 2017 11; 9(11):1463-1470. PMID: 28701330.
      Citations: 60     Fields:    Translation:HumansAnimals
    14. Favre G, Laurain A, Aranyi T, Szeri F, Fulop K, Le Saux O, Duranton C, Kauffenstein G, Martin L, Lefth?riotis G. The ABCC6 Transporter: A New Player in Biomineralization. Int J Mol Sci. 2017 Sep 11; 18(9). PMID: 28891970.
      Citations: 25     Fields:    Translation:HumansAnimals
    15. Pomozi V, Brampton C, van de Wetering K, Zoll J, Calio B, Pham K, Owens JB, Marh J, Moisyadi S, V?radi A, Martin L, Bauer C, Erdmann J, Aherrahrou Z, Le Saux O. Pyrophosphate Supplementation Prevents Chronic and Acute Calcification in ABCC6-Deficient Mice. Am J Pathol. 2017 Jun; 187(6):1258-1272. PMID: 28416300.
      Citations: 43     Fields:    Translation:Animals
    16. Pomozi V, Brampton C, Szeri F, Dedinszki D, Koz?k E, van de Wetering K, Hopkins H, Martin L, V?radi A, Le Saux O. Functional Rescue of ABCC6 Deficiency by 4-Phenylbutyrate Therapy Reduces Dystrophic Calcification in Abcc6-/- Mice. J Invest Dermatol. 2017 03; 137(3):595-602. PMID: 27826008.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    17. Leftheriotis G, Kauffenstein G, Hamel JF, Abraham P, Le Saux O, Willoteaux S, Henrion D, Martin L. The contribution of arterial calcification to peripheral arterial disease in pseudoxanthoma elasticum. PLoS One. 2014; 9(5):e96003. PMID: 24800819.
      Citations: 13     Fields:    Translation:Humans
    18. Hosen MJ, Coucke PJ, Le Saux O, De Paepe A, Vanakker OM. Perturbation of specific pro-mineralizing signalling pathways in human and murine pseudoxanthoma elasticum. Orphanet J Rare Dis. 2014 Apr 29; 9:66. PMID: 24775865.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    19. Brampton C, Aherrahrou Z, Chen LH, Martin L, Bergen AA, Gorgels TG, Erdmann J, Erdfdi J, Schunkert H, Szab? Z, V?radi A, Le Saux O. The level of hepatic ABCC6 expression determines the severity of calcification after cardiac injury. Am J Pathol. 2014 Jan; 184(1):159-70. PMID: 24479134.
      Citations: 19     Fields:    Translation:HumansAnimals
    20. Pomozi V, Brampton C, F?l?p K, Chen LH, Apana A, Li Q, Uitto J, Le Saux O, V?radi A. Analysis of pseudoxanthoma elasticum-causing missense mutants of ABCC6 in vivo; pharmacological correction of the mislocalized proteins. J Invest Dermatol. 2014 Apr; 134(4):946-953. PMID: 24352041.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    21. Prunier F, Terrien G, Le Corre Y, Apana AL, Bi?re L, Kauffenstein G, Furber A, Bergen AA, Gorgels TG, Le Saux O, Leftheriotis G, Martin L. Pseudoxanthoma elasticum: cardiac findings in patients and Abcc6-deficient mouse model. PLoS One. 2013; 8(7):e68700. PMID: 23935882.
      Citations: 22     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    22. Pomozi V, Le Saux O, Brampton C, Apana A, Ili?s A, Szeri F, Martin L, Monostory K, Paku S, Sarkadi B, Szak?cs G, V?radi A. ABCC6 is a basolateral plasma membrane protein. Circ Res. 2013 May 24; 112(11):e148-51. PMID: 23625951.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    23. Ar?nyi T, Bacquet C, de Boussac H, Ratajewski M, Pomozi V, F?l?p K, Brampton CN, Pulaski L, Le Saux O, V?radi A. Transcriptional regulation of the ABCC6 gene and the background of impaired function of missense disease-causing mutations. Front Genet. 2013; 4:27. PMID: 23483032.
    24. Lefth?riotis G, Omarjee L, Le Saux O, Henrion D, Abraham P, Prunier F, Willoteaux S, Martin L. The vascular phenotype in Pseudoxanthoma elasticum and related disorders: contribution of a genetic disease to the understanding of vascular calcification. Front Genet. 2013; 4:4. PMID: 23408347.
    25. Le Saux O, Martin L, Aherrahrou Z, Leftheriotis G, V?radi A, Brampton CN. The molecular and physiological roles of ABCC6: more than meets the eye. Front Genet. 2012; 3:289. PMID: 23248644.
    26. Le Corre Y, Le Saux O, Froeliger F, Libouban H, Kauffenstein G, Willoteaux S, Leftheriotis G, Martin L. Quantification of the calcification phenotype of Abcc6-deficient mice with microcomputed tomography. Am J Pathol. 2012 Jun; 180(6):2208-13. PMID: 22469843.
      Citations: 20     Fields:    Translation:HumansAnimals
    27. Le Saux O, F?l?p K, Yamaguchi Y, Ili?s A, Szab? Z, Brampton CN, Pomozi V, Husz?r K, Ar?nyi T, V?radi A. Expression and in vivo rescue of human ABCC6 disease-causing mutants in mouse liver. PLoS One. 2011; 6(9):e24738. PMID: 21935449.
      Citations: 45     Fields:    Translation:HumansAnimals
    28. Lefth?riotis G, Abraham P, Le Corre Y, Le Saux O, Henrion D, Ducluzeau PH, Prunier F, Martin L. Relationship between ankle brachial index and arterial remodeling in pseudoxanthoma elasticum. J Vasc Surg. 2011 Nov; 54(5):1390-4. PMID: 21723076.
      Citations: 22     Fields:    Translation:Humans
    29. Brampton C, Yamaguchi Y, Vanakker O, Van Laer L, Chen LH, Thakore M, De Paepe A, Pomozi V, Szab? PT, Martin L, V?radi A, Le Saux O. Vitamin K does not prevent soft tissue mineralization in a mouse model of pseudoxanthoma elasticum. Cell Cycle. 2011 Jun 01; 10(11):1810-20. PMID: 21597330.
      Citations: 32     Fields:    Translation:Animals
    30. Lefth?riotis G, Vanakker O, Le Saux O, Martin L. Reply to the article of C. Markello et al. entitled "Vascular pathology of medial arterial calcifications in NT5E deficiency: Implications for the role of adenosine in pseudoxanthoma elasticum". Mol Genet Metab. 2011 Jun; 103(2):199-200. PMID: 21497121.
      Citations: 3     Fields:    Translation:Humans
    31. Martin L, Douet V, VanWart CM, Heller MB, Le Saux O. A mouse model of ?-thalassemia shows a liver-specific down-regulation of Abcc6 expression. Am J Pathol. 2011 Feb; 178(2):774-83. PMID: 21281810.
      Citations: 22     Fields:    Translation:AnimalsCells
    32. Costrop LM, Vanakker OO, Van Laer L, Le Saux O, Martin L, Chassaing N, Guerra D, Pasquali-Ronchetti I, Coucke PJ, De Paepe A. Novel deletions causing pseudoxanthoma elasticum underscore the genomic instability of the ABCC6 region. J Hum Genet. 2010 Feb; 55(2):112-7. PMID: 20075945.
      Citations: 12     Fields:    Translation:Humans
    33. Martin L, Ma?tre F, Bonicel P, Daudon P, Verny C, Bonneau D, Le Saux O, Chassaing N. Heterozygosity for a single mutation in the ABCC6 gene may closely mimic PXE: consequences of this phenotype overlap for the definition of PXE. Arch Dermatol. 2008 Mar; 144(3):301-6. PMID: 18347285.
      Citations: 18     Fields:    Translation:Humans
    34. Douet V, Heller MB, Le Saux O. DNA methylation and Sp1 binding determine the tissue-specific transcriptional activity of the mouse Abcc6 promoter. Biochem Biophys Res Commun. 2007 Mar 02; 354(1):66-71. PMID: 17214963.
      Citations: 40     Fields:    Translation:AnimalsCells
    35. Douet V, VanWart CM, Heller MB, Reinhard S, Le Saux O. HNF4alpha and NF-E2 are key transcriptional regulators of the murine Abcc6 gene expression. Biochim Biophys Acta. 2006 Aug-Sep; 1759(8-9):426-36. PMID: 16997394.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    36. Le Saux O, Bunda S, VanWart CM, Douet V, Got L, Martin L, Hinek A. Serum factors from pseudoxanthoma elasticum patients alter elastic fiber formation in vitro. J Invest Dermatol. 2006 Jul; 126(7):1497-505. PMID: 16543900.
      Citations: 37     Fields:    Translation:HumansCells
    37. Hamlin N, Beck K, Bacchelli B, Cianciulli P, Pasquali-Ronchetti I, Le Saux O. Acquired Pseudoxanthoma elasticum-like syndrome in beta-thalassaemia patients. Br J Haematol. 2003 Sep; 122(5):852-4. PMID: 12930400.
      Citations: 33     Fields:    Translation:Humans
    38. Beck K, Hayashi K, Nishiguchi B, Le Saux O, Hayashi M, Boyd CD. The distribution of Abcc6 in normal mouse tissues suggests multiple functions for this ABC transporter. J Histochem Cytochem. 2003 Jul; 51(7):887-902. PMID: 12810839.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    39. Ili?s A, Urb?n Z, Seidl TL, Le Saux O, Sink? E, Boyd CD, Sarkadi B, V?radi A. Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6). J Biol Chem. 2002 May 10; 277(19):16860-7. PMID: 11880368.
      Citations: 82     Fields:    Translation:HumansAnimalsCells
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