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Abhijit Date, PhD

Faculty RankAssistant Professor
InstitutionUniversity of Hawaii
DepartmentPharmaceutical Sciences
AddressThe Daniel K. Inouye College of Pharmacy
University of Hawaii at Hilo
34 Rainbow Drive
Hilo HI 96720
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Sutar Y, Yadavalli T, Paul SK, Mallick S, Koganti R, Chauhan H, Date AA, Shukla D. BX795-Organic Acid Coevaporates: Evaluation of Solid-State Characteristics, In Vitro Cytocompatibility and In Vitro Activity against HSV-1 and HSV-2. Pharmaceutics. 2021 Nov 12; 13(11). PMID: 34834335.
    2. Golla U, Ehudin MA, Annageldiyev C, Zeng Z, Bastihalli Tukaramrao D, Tarren A, Date AA, Elcheva I, Berg A, Amin S, Loughran TP, Kester M, Desai D, Dovat S, Claxton D, Sharma A. DJ4 Targets the Rho-Associated Protein Kinase Pathway and Attenuates Disease Progression in Preclinical Murine Models of Acute Myeloid Leukemia. Cancers (Basel). 2021 Sep 29; 13(19). PMID: 34638385.
    3. Sutar Y, Fulton SR, Paul S, Altamirano S, Mhatre S, Saeed H, Patel P, Mallick S, Bhat R, Patravale VB, Chauhan H, Nielsen K, Date AA. Docusate-Based Ionic Liquids of Anthelmintic Benzimidazoles Show Improved Pharmaceutical Processability, Lipid Solubility, and in Vitro Activity against Cryptococcus neoformans. ACS Infect Dis. 2021 09 10; 7(9):2637-2649. PMID: 34467755.
      Citations:    Fields:    Translation:Animals
    4. Josyula A, Omiadze R, Parikh K, Kanvinde P, Appell MB, Patel P, Saeed H, Sutar Y, Anders N, He P, McDonnell PJ, Hanes J, Date AA, Ensign LM. An ion-paired moxifloxacin nanosuspension eye drop provides improved prevention and treatment of ocular infection. Bioeng Transl Med. 2021 Sep; 6(3):e10238. PMID: 34589607.
    5. Chen WN, Shaikh MF, Bhuvanendran S, Date A, Ansari MT, Radhakrishnan AK, Othman I. Poloxamer 188 (P188), A Potential Polymeric Protective Agent for Central Nervous System Disorders: A Systematic Review. Curr Neuropharmacol. 2021 May 28. PMID: 34077349.
      Citations: 1     Fields:    
    6. Patel P, Pol A, Kalaria D, Date AA, Kalia Y, Patravale V. Microemulsion-based gel for the transdermal delivery of rasagiline mesylate: In vitro and in vivo assessment for Parkinson's therapy. Eur J Pharm Biopharm. 2021 Aug; 165:66-74. PMID: 33971272.
      Citations: 2     Fields:    
    7. Hsueh HT, Kim YC, Pitha I, Shin MD, Berlinicke CA, Chou RT, Kimball E, Schaub J, Quillen S, Leo KT, Han H, Xiao A, Kim Y, Appell M, Rai U, Kwon H, Kolodziejski P, Ogunnaike L, Anders NM, Hemingway A, Jefferys JL, Date AA, Eberhart C, Johnson TV, Quigley HA, Zack DJ, Hanes J, Ensign LM. Ion-Complex Microcrystal Formulation Provides Sustained Delivery of a Multimodal Kinase Inhibitor from the Subconjunctival Space for Protection of Retinal Ganglion Cells. Pharmaceutics. 2021 May 01; 13(5). PMID: 34062883.
    8. Saeed HK, Sutar Y, Patel P, Bhat R, Mallick S, Hatada AE, Koomoa DT, Lange I, Date AA. Synthesis and Characterization of Lipophilic Salts of Metformin to Improve Its Repurposing for Cancer Therapy. ACS Omega. 2021 Feb 02; 6(4):2626-2637. PMID: 33553880.
    9. Date AA, Kates M, Yoshida T, Babu T, Afzal U, Kanvinde P, Baras A, Anders N, He P, Rudek M, Hanes J, Bivalacqua TJ, Ensign LM. Preclinical evaluation of a hypotonic docetaxel nanosuspension formulation for intravesical treatment of non-muscle-invasive bladder cancer. Drug Deliv Transl Res. 2021 Oct; 11(5):2085-2095. PMID: 33164163.
      Citations: 2     Fields:    
    10. Yadavalli T, Mallick S, Patel P, Koganti R, Shukla D, Date AA. Pharmaceutically Acceptable Carboxylic Acid-Terminated Polymers Show Activity and Selectivity against HSV-1 and HSV-2 and Synergy with Antiviral Drugs. ACS Infect Dis. 2020 11 13; 6(11):2926-2937. PMID: 33078609.
      Citations:    Fields:    Translation:HumansCells
    11. Kulkarni M, Potdar S, Date AA, Marfatiya A. In Vitro Release Testing of Acyclovir Topical Formulations Using Immersion Cells. Assay Drug Dev Technol. 2021 Feb-Mar; 19(2):75-84. PMID: 33035072.
      Citations:    Fields:    Translation:HumansCells
    12. Kim YC, Shin MD, Hackett SF, Hsueh HT, Lima E Silva R, Date A, Han H, Kim BJ, Xiao A, Kim Y, Ogunnaike L, Anders NM, Hemingway A, He P, Jun AS, McDonnell PJ, Eberhart C, Pitha I, Zack DJ, Campochiaro PA, Hanes J, Ensign LM. Gelling hypotonic polymer solution for extended topical drug delivery to the eye. Nat Biomed Eng. 2020 11; 4(11):1053-1062. PMID: 32895514.
      Citations: 12     Fields:    Translation:Animals
    13. Jacob J, Tan G, Lange I, Saeed H, Date A, Jarvi S. In vitro efficacy of anthelmintics on Angiostrongylus cantonensis L3 larvae. Parasitology. 2021 02; 148(2):240-250. PMID: 32799943.
      Citations:    Fields:    Translation:Animals
    14. Kulkarni M, Hastak V, Jadhav V, Date AA. Fenugreek Leaf Extract and Its Gel Formulation Show Activity Against Malassezia furfur. Assay Drug Dev Technol. 2020 01; 18(1):45-55. PMID: 31524496.
      Citations: 1     Fields:    Translation:Animals
    15. Kulkarni M, Goge N, Date AA. Development of Nanoemulsion Preconcentrate of Capsanthin with Improved Chemical Stability. Assay Drug Dev Technol. 2020 01; 18(1):34-44. PMID: 31502853.
      Citations:    Fields:    
    16. Kulkarni M, Vishwakarma B, Sen S, Anupuram S, Date AA. Development and evaluation of taste masked dry syrup formulation of potassium chloride. AAPS Open. 2019; 5(1):1. PMID: 30957011.
    17. Hoang T, Zierden H, Date A, Ortiz J, Gumber S, Anders N, He P, Segars J, Hanes J, Mahendroo M, Ensign LM. Development of a mucoinert progesterone nanosuspension for safer and more effective prevention of preterm birth. J Control Release. 2019 02 10; 295:74-86. PMID: 30597245.
      Citations: 7     Fields:    Translation:HumansAnimals
    18. Date AA, Halpert G, Babu T, Ortiz J, Kanvinde P, Dimitrion P, Narayan J, Zierden H, Betageri K, Musmanno O, Wiegand H, Huang X, Gumber S, Hanes J, Ensign LM. Mucus-penetrating budesonide nanosuspension enema for local treatment of inflammatory bowel disease. Biomaterials. 2018 12; 185:97-105. PMID: 30236840.
      Citations: 9     Fields:    Translation:Animals
    19. Hoang T, Date AA, Ortiz JO, Young TW, Bensouda S, Xiao P, Marzinke M, Rohan L, Fuchs EJ, Hendrix C, Gumber S, Villinger F, Cone RA, Hanes J, Ensign LM. Development of rectal enema as microbicide (DREAM): Preclinical progressive selection of a tenofovir prodrug enema. Eur J Pharm Biopharm. 2019 May; 138:23-29. PMID: 29802984.
      Citations: 3     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    20. Xiao P, Gumber S, Marzinke MA, Date AA, Hoang T, Hanes J, Ensign LM, Wang L, Rohan L, Fuchs EJ, Hendrix C, Villinger F. Hypo-osmolar Formulation of Tenofovir (TFV) Enema Promotes Uptake and Metabolism of TFV in Tissues, Leading to Prevention of SHIV/SIV Infection. Antimicrob Agents Chemother. 2018 01; 62(1). PMID: 29084755.
      Citations: 6     Fields:    Translation:AnimalsCellsPHPublic Health
    21. Kates M, Date A, Yoshida T, Afzal U, Kanvinde P, Babu T, Sopko NA, Matsui H, Hahn NM, McConkey DJ, Baras A, Hanes J, Ensign L, Bivalacqua TJ. Preclinical Evaluation of Intravesical Cisplatin Nanoparticles for Non-Muscle-Invasive Bladder Cancer. Clin Cancer Res. 2017 Nov 01; 23(21):6592-6601. PMID: 28808039.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    22. Timbie KF, Afzal U, Date A, Zhang C, Song J, Wilson Miller G, Suk JS, Hanes J, Price RJ. MR image-guided delivery of cisplatin-loaded brain-penetrating nanoparticles to invasive glioma with focused ultrasound. J Control Release. 2017 Oct 10; 263:120-131. PMID: 28288892.
      Citations: 30     Fields:    Translation:AnimalsCells
    23. Date AA, Rais R, Babu T, Ortiz J, Kanvinde P, Thomas AG, Zimmermann SC, Gadiano AJ, Halpert G, Slusher BS, Ensign LM. Local enema treatment to inhibit FOLH1/GCPII as a novel therapy for inflammatory bowel disease. J Control Release. 2017 Oct 10; 263:132-138. PMID: 28159515.
      Citations: 3     Fields:    Translation:Animals
    24. Date AA, Hanes J, Ensign LM. Nanoparticles for oral delivery: Design, evaluation and state-of-the-art. J Control Release. 2016 10 28; 240:504-526. PMID: 27292178.
      Citations: 49     Fields:    Translation:HumansAnimals
    25. Destache CJ, Mandal S, Yuan Z, Kang G, Date AA, Lu W, Shibata A, Pham R, Bruck P, Rezich M, Zhou Y, Vivekanandan R, Fletcher CV, Li Q. Topical Tenofovir Disoproxil Fumarate Nanoparticles Prevent HIV-1 Vaginal Transmission in a Humanized Mouse Model. Antimicrob Agents Chemother. 2016 06; 60(6):3633-9. PMID: 27044548.
      Citations: 18     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    26. Date AA, Destache CJ. Natural polyphenols: potential in the prevention of sexually transmitted viral infections. Drug Discov Today. 2016 Feb; 21(2):333-41. PMID: 26546859.
      Citations: 10     Fields:    Translation:HumansAnimals
    27. Kovarova M, Council OD, Date AA, Long JM, Nochi T, Belshan M, Shibata A, Vincent H, Baker CE, Thayer WO, Kraus G, Lachaud-Durand S, Williams P, Destache CJ, Garcia JV. Correction: Nanoformulations of Rilpivirine for Topical Pericoital and Systemic Coitus-Independent Administration Efficiently Prevent HIV Transmission. PLoS Pathog. 2015 Oct; 11(10):e1005170. PMID: 26474397.
      Citations: 1     Fields:    
    28. Kovarova M, Council OD, Date AA, Long JM, Nochi T, Nochii T, Belshan M, Shibata A, Vincent H, Baker CE, Thayer WO, Kraus G, Lachaud-Durand S, Williams P, Destache CJ, Garcia JV. Nanoformulations of Rilpivirine for Topical Pericoital and Systemic Coitus-Independent Administration Efficiently Prevent HIV Transmission. PLoS Pathog. 2015 Aug; 11(8):e1005075. PMID: 26271040.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    29. Date AA, Shibata A, McMullen E, La Bruzzo K, Bruck P, Belshan M, Zhou Y, Destache CJ. Thermosensitive Gel Containing Cellulose Acetate Phthalate-Efavirenz Combination Nanoparticles for Prevention of HIV-1 Infection. J Biomed Nanotechnol. 2015 Mar; 11(3):416-27. PMID: 26307825.
      Citations: 12     Fields:    Translation:HumansCells
    30. Date AA, Shibata A, Bruck P, Destache CJ. Development and validation of a simple and isocratic reversed-phase HPLC method for the determination of rilpivirine from tablets, nanoparticles and HeLa cell lysates. Biomed Chromatogr. 2015 May; 29(5):709-15. PMID: 25298145.
      Citations: 1     Fields:    Translation:HumansCells
    31. Malkani A, Date AA, Hegde D. Celecoxib nanosuspension: single-step fabrication using a modified nanoprecipitation method and in vivo evaluation. Drug Deliv Transl Res. 2014 Aug; 4(4):365-76. PMID: 25787068.
      Citations: 3     Fields:    
    32. Date AA, Destache CJ. A review of nanotechnological approaches for the prophylaxis of HIV/AIDS. Biomaterials. 2013 Aug; 34(26):6202-28. PMID: 23726227.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    33. Shibata A, McMullen E, Pham A, Belshan M, Sanford B, Zhou Y, Goede M, Date AA, Date AA, Destache CJ. Polymeric nanoparticles containing combination antiretroviral drugs for HIV type 1 treatment. AIDS Res Hum Retroviruses. 2013 May; 29(5):746-54. PMID: 23289671.
      Citations: 24     Fields:    Translation:HumansCells
    34. Date AA, Shibata A, Goede M, Sanford B, La Bruzzo K, Belshan M, Destache CJ. Development and evaluation of a thermosensitive vaginal gel containing raltegravir+efavirenz loaded nanoparticles for HIV prophylaxis. Antiviral Res. 2012 Dec; 96(3):430-6. PMID: 23041201.
      Citations: 25     Fields:    Translation:HumansCells
    35. Ursekar BM, Soni PS, Date AA, Nagarsenker MS. Characterization of soy polysaccharide and its in vitro and in vivo evaluation for application in colon drug delivery. AAPS PharmSciTech. 2012 Sep; 13(3):934-43. PMID: 22739785.
      Citations: 2     Fields:    Translation:Humans
    36. Date AA, Patil RR, Panicucci R, Souto EB, Lee RW. Translating nanotechnology from bench to pharmaceutical market: barriers, success, and promises. J Drug Deliv. 2012; 2012:678910. PMID: 22754698.
    37. Date AA, Srivastava D, Nagarsenker MS, Mulherkar R, Panicker L, Aswal V, Hassan PA, Steiniger F, Thamm J, Fahr A. Lecithin-based novel cationic nanocarriers (LeciPlex) I: fabrication, characterization and evaluation. Nanomedicine (Lond). 2011 Oct; 6(8):1309-25. PMID: 22026377.
      Citations: 4     Fields:    Translation:HumansCells
    38. Jain AS, Date AA, Pissurlenkar RR, Coutinho EC, Nagarsenker MS. Sulfobutyl ether(7) ß-cyclodextrin (SBE(7) ß-CD) carbamazepine complex: preparation, characterization, molecular modeling, and evaluation of in vivo anti-epileptic activity. AAPS PharmSciTech. 2011 Dec; 12(4):1163-75. PMID: 21918921.
      Citations: 14     Fields:    Translation:AnimalsCells
    39. Khachane P, Date AA, Nagarsenker MS. Eudragit EPO nanoparticles: application in improving therapeutic efficacy and reducing ulcerogenicity of meloxicam on oral administration. J Biomed Nanotechnol. 2011 Aug; 7(4):590-7. PMID: 21870464.
      Citations: 4     Fields:    Translation:Animals
    40. Date AA, Vador N, Jagtap A, Nagarsenker MS. Lipid nanocarriers (GeluPearl) containing amphiphilic lipid Gelucire 50/13 as a novel stabilizer: fabrication, characterization and evaluation for oral drug delivery. Nanotechnology. 2011 Jul 08; 22(27):275102. PMID: 21606564.
      Citations: 6     Fields:    Translation:Animals
    41. Date AA, Nagarsenker MS, Patere S, Dhawan V, Gude RP, Hassan PA, Aswal V, Steiniger F, Thamm J, Fahr A. Lecithin-based novel cationic nanocarriers (Leciplex) II: improving therapeutic efficacy of quercetin on oral administration. Mol Pharm. 2011 Jun 06; 8(3):716-26. PMID: 21480639.
      Citations: 17     Fields:    Translation:Animals
    42. Date AA, Desai N, Dixit R, Nagarsenker M. Self-nanoemulsifying drug delivery systems: formulation insights, applications and advances. Nanomedicine (Lond). 2010 Dec; 5(10):1595-616. PMID: 21143036.
      Citations: 61     Fields:    
    43. Bhattacharjee J, Verma G, Aswal VK, Date AA, Nagarsenker MS, Hassan PA. Tween 80-sodium deoxycholate mixed micelles: structural characterization and application in doxorubicin delivery. J Phys Chem B. 2010 Dec 16; 114(49):16414-21. PMID: 21080698.
      Citations: 6     Fields:    Translation:HumansCells
    44. Nagarsenker MS, Amin L, Date AA. Potential of cyclodextrin complexation and liposomes in topical delivery of ketorolac: in vitro and in vivo evaluation. AAPS PharmSciTech. 2008; 9(4):1165-70. PMID: 19016331.
      Citations: 3     Fields:    Translation:Animals
    45. Date AA, Nagarsenker MS. Design and evaluation of microemulsions for improved parenteral delivery of propofol. AAPS PharmSciTech. 2008; 9(1):138-45. PMID: 18446474.
      Citations: 7     Fields:    Translation:AnimalsCells
    46. Date AA, Nagarsenker MS. Parenteral microemulsions: an overview. Int J Pharm. 2008 May 01; 355(1-2):19-30. PMID: 18295991.
      Citations: 25     Fields:    Translation:HumansAnimals
    47. Date AA, Nagarsenker MS. Novel delivery systems of atorvastatin should be evaluated for pharmacodynamics instead of pharmacokinetics. J Pharm Pharmacol. 2007 Nov; 59(11):1583-4. PMID: 17976271.
      Citations: 2     Fields:    Translation:Animals
    48. Shah KA, Date AA, Joshi MD, Patravale VB. Solid lipid nanoparticles (SLN) of tretinoin: potential in topical delivery. Int J Pharm. 2007 Dec 10; 345(1-2):163-71. PMID: 17644288.
      Citations: 31     Fields:    Translation:AnimalsCells
    49. Date AA, Joshi MD, Patravale VB. Parasitic diseases: Liposomes and polymeric nanoparticles versus lipid nanoparticles. Adv Drug Deliv Rev. 2007 Jul 10; 59(6):505-21. PMID: 17574295.
      Citations: 29     Fields:    Translation:HumansAnimals
    50. Date AA, Patravale VB. Microemulsions: applications in transdermal and dermal delivery. Crit Rev Ther Drug Carrier Syst. 2007; 24(6):547-96. PMID: 18298390.
      Citations: 9     Fields:    Translation:HumansAnimals
    51. Date AA, Nagarsenker MS. Design and evaluation of self-nanoemulsifying drug delivery systems (SNEDDS) for cefpodoxime proxetil. Int J Pharm. 2007 Feb 01; 329(1-2):166-72. PMID: 17010543.
      Citations: 50     Fields:    
    52. Mukherjee S, Date A, Patravale V, Korting HC, Roeder A, Weindl G. Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clin Interv Aging. 2006; 1(4):327-48. PMID: 18046911.
      Citations: 70     Fields:    Translation:Humans
    53. Patravale VB, Date AA, Kulkarni RM. Nanosuspensions: a promising drug delivery strategy. J Pharm Pharmacol. 2004 Jul; 56(7):827-40. PMID: 15233860.
      Citations: 115     Fields:    
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