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Mamdooh H Ghoneum, PhD

TitleAssociate Professor
Faculty RankAssociate Professor
InstitutionCharles R. Drew University of Medicine and Science
DepartmentSurgery
Address1731 E. 120th Street, Hawkins Building
1731 E. 120th Street, Hawkins Building
Los Angeles CA 90059
Phone3235635953
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ghoneum MH, El Sayed NS. Protective Effect of Biobran/MGN-3 against Sporadic Alzheimer's Disease Mouse Model: Possible Role of Oxidative Stress and Apoptotic Pathways. Oxid Med Cell Longev. 2021; 2021:8845064. PMID: 33574982.
      Citations:    Fields:    
    2. El Sayed NS, Ghoneum MH. Antia, a Natural Antioxidant Product, Attenuates Cognitive Dysfunction in Streptozotocin-Induced Mouse Model of Sporadic Alzheimer's Disease by Targeting the Amyloidogenic, Inflammatory, Autophagy, and Oxidative Stress Pathways. Oxid Med Cell Longev. 2020; 2020:4386562. PMID: 32655767.
      Citations:    Fields:    
    3. Badr El-Din NK, Shabana SM, Abdulmajeed BA, Ghoneum M. A novel kefir product (PFT) inhibits Ehrlich ascites carcinoma in mice via induction of apoptosis and immunomodulation. BMC Complement Med Ther. 2020 Apr 28; 20(1):127. PMID: 32345289.
      Citations:    
    4. Badr El-Din NK, Ali DA, Othman R, French SW, Ghoneum M. Chemopreventive role of arabinoxylan rice bran, MGN-3/Biobran, on liver carcinogenesis in rats. Biomed Pharmacother. 2020 Jun; 126:110064. PMID: 32278271.
      Citations: 1     Fields:    Translation:Animals
    5. Ghoneum M, Abdulmalek S, Pan D. Reversal of age-associated oxidative stress in mice by PFT, a novel kefir product. Int J Immunopathol Pharmacol. 2020 Jan-Dec; 34:2058738420950149. PMID: 32862733.
      Citations:    Fields:    
    6. Badr El-Din NK, Areida SK, Ahmed KO, Ghoneum M. Arabinoxylan rice bran (MGN-3/Biobran) enhances radiotherapy in animals bearing Ehrlich ascites carcinoma†. J Radiat Res. 2019 Nov 22; 60(6):747-758. PMID: 31504707.
      Citations:    Fields:    Translation:Animals
    7. Ghoneum M, Badr El-Din NK, Mahmoud AZ, Tolentino L, Pan D, Hassan TA. Dietary baker's yeast sensitizes Ehrlich mammary adenocarcinoma to paclitaxel in mice bearing tumor. Oncol Rep. 2019 Jun; 41(6):3155-3166. PMID: 31002367.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    8. Ghoneum MH, Gimzewski JK, Ghoneum AD, Agrawal S. Potential role of MRN-100, an iron-based compound, in upregulating production of cytokine IL-10 in human dendritic cells to promote an anti-inflammatory response in vitro. Int J Immunopathol Pharmacol. 2019 Jan-Dec; 33:2058738419844932. PMID: 30994016.
      Citations:    Fields:    Translation:HumansCells
    9. Ghoneum MH, Gimzewski JK, Ghoneum A, Katano H, Paw U CN, Agrawal A. Inhibition of TRPV1 Channel Activity in Human CD4? T Cells by Nanodiamond and Nanoplatinum Liquid, DPV576. Nanomaterials (Basel). 2018 Sep 29; 8(10). PMID: 30274279.
      Citations:    
    10. Elwakkad A, Ghoneum M, El-Sawi M, Mohamed SI, Gamal El Din AA, Pan D, Elqattan GM. Baker's Yeast Induces Apoptotic Effects and Histopathological Changes on Skin Tumors in Mice. Cogent Med. 2018; 5(1). PMID: 31098389.
      Citations:    
    11. Elsaid AF, Shaheen M, Ghoneum M. Biobran/MGN-3, an arabinoxylan rice bran, enhances NK cell activity in geriatric subjects: A randomized, double-blind, placebo-controlled clinical trial. Exp Ther Med. 2018 Mar; 15(3):2313-2320. PMID: 29456638.
      Citations:    
    12. Ghoneum MH, Ogura T, Gimzewski JK, Ghoneum AD, Henary MC, Agrawal S. Marina crystal minerals (MCM) activate human dendritic cells to induce CD4+ and CD8+ T cell responses in vitro. Int J Immunopathol Pharmacol. 2018 Jan-Dec; 32:2058738418797768. PMID: 30270704.
      Citations:    Fields:    Translation:HumansCells
    13. Badr El-Din NK, Mahmoud AZ, Hassan TA, Ghoneum M. Baker's Yeast Sensitizes Metastatic Breast Cancer Cells to Paclitaxel In Vitro. Integr Cancer Ther. 2018 06; 17(2):542-550. PMID: 29161917.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    14. Ghoneum MH, Katano H, Agrawal S, Ganguly S, Agrawal A. Effect of Nanodiamond and Nanoplatinum Liquid, DPV576, on Human Primary Keratinocytes. J Biomed Nanotechnol. 2017 Jan; 13(1):110-16. PMID: 29373005.
      Citations: 1     Fields:    Translation:HumansCells
    15. Salama H, Medhat E, Shaheen M, Zekri AN, Darwish T, Ghoneum M. Arabinoxylan rice bran (Biobran) suppresses the viremia level in patients with chronic HCV infection: A randomized trial. Int J Immunopathol Pharmacol. 2016 Dec; 29(4):647-653. PMID: 27799299.
      Citations: 3     Fields:    Translation:HumansAnimalsCTClinical Trials
    16. Badr El-Din NK, Ali DA, Alaa El-Dein M, Ghoneum M. Enhancing the Apoptotic Effect of a Low Dose of Paclitaxel on Tumor Cells in Mice by Arabinoxylan Rice Bran (MGN-3/Biobran). Nutr Cancer. 2016 Aug-Sep; 68(6):1010-20. PMID: 27367621.
      Citations: 4     Fields:    Translation:AnimalsCells
    17. Badr El-Din NK, Abdel Fattah SM, Pan D, Tolentino L, Ghoneum M. Chemopreventive Activity of MGN-3/Biobran Against Chemical Induction of Glandular Stomach Carcinogenesis in Rats and Its Apoptotic Effect in Gastric Cancer Cells. Integr Cancer Ther. 2016 12; 15(4):NP26-NP34. PMID: 27151588.
      Citations: 7     Fields:    Translation:AnimalsCells
    18. Ghoneum M, Felo N, Agrawal S, Agrawal A. A novel kefir product (PFT) activates dendritic cells to induce CD4+T and CD8+T cell responses in vitro. Int J Immunopathol Pharmacol. 2015 Dec; 28(4):488-96. PMID: 26384392.
      Citations: 6     Fields:    Translation:HumansCells
    19. Ghoneum M, Felo N. Selective induction of apoptosis in human gastric cancer cells by Lactobacillus kefiri (PFT), a novel kefir product. Oncol Rep. 2015 Oct; 34(4):1659-66. PMID: 26251956.
      Citations: 6     Fields:    Translation:HumansCells
    20. Ghoneum MH, Badr El-Din NK, Abdel Fattah SM, Pan D, Tolentino L. Hydroferrate fluid, MRN-100, provides protection against chemical-induced gastric and esophageal cancer in Wistar rats. Int J Biol Sci. 2015; 11(3):295-303. PMID: 25678848.
      Citations: 4     Fields:    Translation:AnimalsCells
    21. Ghoneum M, Gimzewski J. Apoptotic effect of a novel kefir product, PFT, on multidrug-resistant myeloid leukemia cells via a hole-piercing mechanism. Int J Oncol. 2014 Mar; 44(3):830-7. PMID: 24430613.
      Citations: 9     Fields:    Translation:HumansCells
    22. Ghoneum M, Badr El-Din NK, Ali DA, El-Dein MA. Modified arabinoxylan from rice bran, MGN-3/biobran, sensitizes metastatic breast cancer cells to paclitaxel in vitro. Anticancer Res. 2014 Jan; 34(1):81-7. PMID: 24403447.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    23. Ghoneum M, Elbaghdady HA, El-Shebly AA, Pan D, Assanah E, Lawson G. Protective effect of hydroferrate fluid, MRN-100, against lethality and hematopoietic tissue damage in ?-radiated Nile tilapia, Oreochromis niloticus. J Radiat Res. 2013 Sep; 54(5):852-62. PMID: 23589025.
      Citations: 2     Fields:    Translation:AnimalsPHPublic Health
    24. Ghoneum M, Badr El-Din NK, Abdel Fattah SM, Tolentino L. Arabinoxylan rice bran (MGN-3/Biobran) provides protection against whole-body ?-irradiation in mice via restoration of hematopoietic tissues. J Radiat Res. 2013 May; 54(3):419-29. PMID: 23287771.
      Citations: 11     Fields:    Translation:AnimalsPHPublic Health
    25. Bang MH, Van Riep T, Thinh NT, Song le H, Dung TT, Van Truong L, Van Don L, Ky TD, Pan D, Shaheen M, Ghoneum M. Arabinoxylan rice bran (MGN-3) enhances the effects of interventional therapies for the treatment of hepatocellular carcinoma: a three-year randomized clinical trial. Anticancer Res. 2010 Dec; 30(12):5145-51. PMID: 21187503.
      Citations: 11     Fields:    Translation:Humans
    26. Ghoneum M, Ghoneum A, Gimzewski J. Nanodiamond and nanoplatinum liquid, DPV576, activates human monocyte-derived dendritic cells in vitro. Anticancer Res. 2010 Oct; 30(10):4075-9. PMID: 21036722.
      Citations: 8     Fields:    Translation:HumansCells
    27. Badr El-Din NK, Noaman E, Fattah SM, Ghoneum M. Reversal of age-associated oxidative stress in rats by MRN-100, a hydro-ferrate fluid. In Vivo. 2010 Jul-Aug; 24(4):525-33. PMID: 20668320.
      Citations: 5     Fields:    Translation:AnimalsCells
    28. Ghoneum M, Ghoneum A, Tolentino L, Gimzewski J. Modulation of aged murine T lymphocytes in vivo by DPV576-C, a nanodiamond- and nanoplatinum-coated material. In Vivo. 2010 Mar-Apr; 24(2):141-6. PMID: 20363985.
      Citations: 4     Fields:    Translation:AnimalsCells
    29. Ghoneum M, Tolentino L, Seto Y. Phenotypic correction of Age-associated functional decline in murine immune cells by Thymax, a thymic extract. In Vivo. 2009 Nov-Dec; 23(6):895-902. PMID: 20023230.
      Citations:    Fields:    Translation:AnimalsCells
    30. Ghoneum M, Seto Y, Agrawal S. Activation of human monocyte-derived dendritic cells in vitro by Thymax, a gross thymic extract. Anticancer Res. 2009 Nov; 29(11):4367-71. PMID: 20032380.
      Citations:    Fields:    Translation:HumansCells
    31. Ghoneum M, Gollapudi S. Susceptibility of the human LNCaP prostate cancer cells to the apoptotic effect of marina crystal minerals (MCM) in vitro. Oncol Rep. 2009 Jul; 22(1):155-9. PMID: 19513518.
      Citations: 1     Fields:    Translation:HumansCells
    32. Ghoneum M, Matsuura M, Gollapudi S. An iron-based beverage, HydroFerrate fluid (MRN-100), alleviates oxidative stress in murine lymphocytes in vitro. Nutr J. 2009 May 02; 8:18. PMID: 19409106.
      Citations: 2     Fields:    Translation:AnimalsCells
    33. Ghoneum M, Matsuura M, Braga M, Gollapudi S. S. cerevisiae induces apoptosis in human metastatic breast cancer cells by altering intracellular Ca2+ and the ratio of Bax and Bcl-2. Int J Oncol. 2008 Sep; 33(3):533-9. PMID: 18695883.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    34. Noaman E, Badr El-Din NK, Bibars MA, Abou Mossallam AA, Ghoneum M. Antioxidant potential by arabinoxylan rice bran, MGN-3/biobran, represents a mechanism for its oncostatic effect against murine solid Ehrlich carcinoma. Cancer Lett. 2008 Sep 18; 268(2):348-59. PMID: 18554778.
      Citations: 19     Fields:    Translation:AnimalsCells
    35. Ghoneum M, Seto Y, Sato S, Ghoneum A, Braga M, Gollapudi S. Gross thymic extract, Thymax, induces apoptosis in human breast cancer cells in vitro through the mitochondrial pathway. Anticancer Res. 2008 May-Jun; 28(3A):1603-9. PMID: 18630518.
      Citations: 1     Fields:    Translation:HumansCells
    36. Gollapudi S, Ghoneum M. MGN-3/Biobran, modified arabinoxylan from rice bran, sensitizes human breast cancer cells to chemotherapeutic agent, daunorubicin. Cancer Detect Prev. 2008; 32(1):1-6. PMID: 18406070.
      Citations: 8     Fields:    Translation:HumansCells
    37. Ghoneum M, Shaheen M. MRN-100, an Iron-based Compound, Possesses Anti-HIV Activity In Vitro. Evid Based Complement Alternat Med. 2010 Dec; 7(4):427-32. PMID: 18955328.
      Citations:    
    38. Badr El-Din NK, Noaman E, Ghoneum M. In vivo tumor inhibitory effects of nutritional rice bran supplement MGN-3/Biobran on Ehrlich carcinoma-bearing mice. Nutr Cancer. 2008; 60(2):235-44. PMID: 18444156.
      Citations: 10     Fields:    Translation:AnimalsCells
    39. Ghoneum M, Badr El-Din NK, Noaman E, Tolentino L. Saccharomyces cerevisiae, the Baker's Yeast, suppresses the growth of Ehrlich carcinoma-bearing mice. Cancer Immunol Immunother. 2008 Apr; 57(4):581-92. PMID: 17891396.
      Citations: 5     Fields:    Translation:Animals
    40. Ghoneum M, Wang L, Agrawal S, Gollapudi S. Yeast therapy for the treatment of breast cancer: a nude mice model study. In Vivo. 2007 Mar-Apr; 21(2):251-8. PMID: 17436573.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    41. Ghoneum M, Gollapudi S. Apoptosis of breast cancer MCF-7 cells in vitro is induced specifically by yeast and not by fungal mycelia. Anticancer Res. 2006 May-Jun; 26(3A):2013-22. PMID: 16827138.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    42. Ghoneum M, Gollapudi S. Synergistic role of arabinoxylan rice bran (MGN-3/Biobran) in S. cerevisiae-induced apoptosis of monolayer breast cancer MCF-7 cells. Anticancer Res. 2005 Nov-Dec; 25(6B):4187-96. PMID: 16309215.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    43. Ghoneum M, Gollapudi S. Modified arabinoxylan rice bran (MGN-3/Biobran) enhances yeast-induced apoptosis in human breast cancer cells in vitro. Anticancer Res. 2005 Mar-Apr; 25(2A):859-70. PMID: 15868920.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    44. Ghoneum M, Hamilton J, Brown J, Gollapudi S. Human squamous cell carcinoma of the tongue and colon undergoes apoptosis upon phagocytosis of Saccharomyces cerevisiae, the baker's yeast, in vitro. Anticancer Res. 2005 Mar-Apr; 25(2A):981-9. PMID: 15868937.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    45. Ghoneum M, Abedi S. Enhancement of natural killer cell activity of aged mice by modified arabinoxylan rice bran (MGN-3/Biobran). J Pharm Pharmacol. 2004 Dec; 56(12):1581-8. PMID: 15563765.
      Citations: 19     Fields:    Translation:AnimalsCells
    46. Ghoneum M, Saglie R, Brown J, Regala C. Actinobacillus actinomycetemcomitans suppresses rat natural killer cell activity in vivo. Acta Otolaryngol. 2004 Jun; 124(5):621-7. PMID: 15267183.
      Citations:    Fields:    Translation:AnimalsCells
    47. Ghoneum M, Gollapudi S. Induction of apoptosis in breast cancer cells by Saccharomyces cerevisiae, the baker's yeast, in vitro. Anticancer Res. 2004 May-Jun; 24(3a):1455-63. PMID: 15274310.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    48. Ghoneum M, Gollapudi S. Phagocytosis of Candida albicans by metastatic and non metastatic human breast cancer cell lines in vitro. Cancer Detect Prev. 2004; 28(1):17-26. PMID: 15041073.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    49. Ghoneum M, Gollapudi S. Modified arabinoxylan rice bran (MGN-3/Biobran) sensitizes human T cell leukemia cells to death receptor (CD95)-induced apoptosis. Cancer Lett. 2003 Nov 10; 201(1):41-9. PMID: 14580685.
      Citations: 8     Fields:    Translation:HumansCells
    50. Ghoneum M, Grewal I, Brown J, Osborne R, Elembabi H, Gill G. Phagocytosis of candida albicans by lymphatic tumour cells in vitro. Acta Histochem. 2003; 105(2):127-33. PMID: 12831164.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
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