RCMI Coordinating Center (RCMI CC) Header Logo

Mamdooh H Ghoneum, PhD

TitleAssociate Professor
Faculty RankAssociate Professor
InstitutionCharles R. Drew University of Medicine and Science
Address1731 E. 120th Street, Hawkins Building
1731 E. 120th Street, Hawkins Building
Los Angeles CA 90059
vCardDownload vCard

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kenawy ER, El-Moaty MSA, Ghoneum M, Soliman HMA, El-Shanshory AA, Shendy S. Biobran-loaded core/shell nanofibrous scaffold: a promising wound dressing candidate. RSC Adv. 2024 Jan 31; 14(7):4930-4945. PMID: 38327812.
    2. Ghoneum M, Badr El-Din NK, Alaa El-Dein M. Anti-radiation effect of MRN-100: a hydro-ferrate fluid, in vivo. J Radiat Res. 2024 Jan 21. PMID: 38247158.
      Citations:    Fields:    
    3. Abdou HM, Hamaad FA, Abd Elmageed GM, Ghoneum MH. Efficiency of Biobran/MGN-3, an Arabinoxylan Rice Bran, in Attenuating Diabetes-Induced Cognitive Impairment of the Hippocampus via Oxidative Stress and IR/Akt/NF-?B in Rats. Evid Based Complement Alternat Med. 2023; 2023:8248576. PMID: 37501860.
    4. El-Mahdi MBM, Rabie SA, Hassanine RME, Hassan AA, Abo Elhussien OF, Ghoneum M, El-Gerbed MSA. Molecular Identification, Pathogenesis, and Life Cycle of Sarcocystis cruzi from Cattle (Bos taurus) in New Valley Governorate, Egypt. J Parasitol Res. 2023; 2023:7829290. PMID: 36937557.
    5. Ghoneum M, Abdulmalek S, Fadel HH. Biobran/MGN-3, an Arabinoxylan Rice Bran, Protects against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An In Vitro and In Silico Study. Nutrients. 2023 Jan 15; 15(2). PMID: 36678324.
      Citations: 3     Fields:    
    6. Ghoneum M, Alaa El-Dein M, Badr El-Din NK. Anticancer potential of Marina Crystal Minerals (MCM) against the growth of murine mammary adenocarcinoma cells in vivo. Biomed Pharmacother. 2022 Nov 11; 157:113975. PMID: 36371853.
      Citations:    Fields:    
    7. Abdou HM, Hamaad FA, Ali EY, Ghoneum MH. Antidiabetic efficacy of Trifolium alexandrinum extracts hesperetin and quercetin in ameliorating carbohydrate metabolism and activating IR and AMPK signaling in the pancreatic tissues of diabetic rats. Biomed Pharmacother. 2022 May; 149:112838. PMID: 35344738.
      Citations: 7     Fields:    Translation:AnimalsCells
    8. Badr El-Din NK, Othman AI, Amer ME, Ghoneum M. Thymax, a gross thymic extract, exerts cell cycle arrest and apoptosis in Ehrlich ascites carcinoma in vivo. Heliyon. 2022 Mar; 8(3):e09047. PMID: 35299600.
    9. Elsaid AF, Agrawal S, Agrawal A, Ghoneum M. Dietary Supplementation with Biobran/MGN-3 Increases Innate Resistance and Reduces the Incidence of Influenza-like Illnesses in Elderly Subjects: A Randomized, Double-Blind, Placebo-Controlled Pilot Clinical Trial. Nutrients. 2021 Nov 19; 13(11). PMID: 34836388.
      Citations: 4     Fields:    Translation:HumansCells
    10. Ghoneum M, Abdulmalek S. KDP, a Lactobacilli Product from Kimchi, Enhances Mucosal Immunity by Increasing Secretory IgA in Mice and Exhibits Antimicrobial Activity. Nutrients. 2021 Nov 04; 13(11). PMID: 34836191.
      Citations: 5     Fields:    Translation:AnimalsCells
    11. Ghoneum M, El-Gerbed MSA. Human placental extract ameliorates methotrexate-induced hepatotoxicity in rats via regulating antioxidative and anti-inflammatory responses. Cancer Chemother Pharmacol. 2021 12; 88(6):961-971. PMID: 34505929.
      Citations: 2     Fields:    Translation:AnimalsCells
    12. El Sayed NS, Kandil EA, Ghoneum MH. Enhancement of Insulin/PI3K/Akt Signaling Pathway and Modulation of Gut Microbiome by Probiotics Fermentation Technology, a Kefir Grain Product, in Sporadic Alzheimer's Disease Model in Mice. Front Pharmacol. 2021; 12:666502. PMID: 34366841.
    13. El Sayed NS, Kandil EA, Ghoneum MH. Probiotics Fermentation Technology, a Novel Kefir Product, Ameliorates Cognitive Impairment in Streptozotocin-Induced Sporadic Alzheimer's Disease in Mice. Oxid Med Cell Longev. 2021; 2021:5525306. PMID: 34306309.
      Citations: 9     Fields:    Translation:AnimalsCells
    14. Ghoneum MH, El Sayed NS. Protective Effect of Biobran/MGN-3 against Sporadic Alzheimer's Disease Mouse Model: Possible Role of Oxidative Stress and Apoptotic Pathways. Oxid Med Cell Longev. 2021; 2021:8845064. PMID: 33574982.
      Citations: 12     Fields:    Translation:AnimalsCells
    15. El Sayed NS, Ghoneum MH. Antia, a Natural Antioxidant Product, Attenuates Cognitive Dysfunction in Streptozotocin-Induced Mouse Model of Sporadic Alzheimer's Disease by Targeting the Amyloidogenic, Inflammatory, Autophagy, and Oxidative Stress Pathways. Oxid Med Cell Longev. 2020; 2020:4386562. PMID: 32655767.
      Citations: 17     Fields:    Translation:AnimalsCells
    16. Badr El-Din NK, Shabana SM, Abdulmajeed BA, Ghoneum M. A novel kefir product (PFT) inhibits Ehrlich ascites carcinoma in mice via induction of apoptosis and immunomodulation. BMC Complement Med Ther. 2020 Apr 28; 20(1):127. PMID: 32345289.
      Citations: 7     Fields:    Translation:AnimalsCells
    17. Badr El-Din NK, Ali DA, Othman R, French SW, Ghoneum M. Chemopreventive role of arabinoxylan rice bran, MGN-3/Biobran, on liver carcinogenesis in rats. Biomed Pharmacother. 2020 Jun; 126:110064. PMID: 32278271.
      Citations: 9     Fields:    Translation:Animals
    18. Ghoneum M, Abdulmalek S, Pan D. Reversal of age-associated oxidative stress in mice by PFT, a novel kefir product. Int J Immunopathol Pharmacol. 2020 Jan-Dec; 34:2058738420950149. PMID: 32862733.
      Citations: 11     Fields:    Translation:AnimalsCells
    19. Badr El-Din NK, Areida SK, Ahmed KO, Ghoneum M. Arabinoxylan rice bran (MGN-3/Biobran) enhances radiotherapy in animals bearing Ehrlich ascites carcinoma?. J Radiat Res. 2019 Nov 22; 60(6):747-758. PMID: 31504707.
      Citations: 4     Fields:    Translation:Animals
    20. Ghoneum M, Badr El-Din NK, Mahmoud AZ, Tolentino L, Pan D, Hassan TA. Dietary baker's yeast sensitizes Ehrlich mammary adenocarcinoma to paclitaxel in mice bearing tumor. Oncol Rep. 2019 Jun; 41(6):3155-3166. PMID: 31002367.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    21. Ghoneum MH, Gimzewski JK, Ghoneum AD, Agrawal S. Potential role of MRN-100, an iron-based compound, in upregulating production of cytokine IL-10 in human dendritic cells to promote an anti-inflammatory response in vitro. Int J Immunopathol Pharmacol. 2019 Jan-Dec; 33:2058738419844932. PMID: 30994016.
      Citations: 2     Fields:    Translation:HumansCells
    22. Ghoneum MH, Gimzewski JK, Ghoneum A, Katano H, Paw U CN, Agrawal A. Inhibition of TRPV1 Channel Activity in Human CD4? T Cells by Nanodiamond and Nanoplatinum Liquid, DPV576. Nanomaterials (Basel). 2018 Sep 29; 8(10). PMID: 30274279.
    23. Elwakkad A, Ghoneum M, El-Sawi M, Mohamed SI, Gamal El Din AA, Pan D, Elqattan GM. Baker's Yeast Induces Apoptotic Effects and Histopathological Changes on Skin Tumors in Mice. Cogent Med. 2018; 5(1). PMID: 31098389.
    24. Elsaid AF, Shaheen M, Ghoneum M. Biobran/MGN-3, an arabinoxylan rice bran, enhances NK cell activity in geriatric subjects: A randomized, double-blind, placebo-controlled clinical trial. Exp Ther Med. 2018 Mar; 15(3):2313-2320. PMID: 29456638.
    25. Ghoneum MH, Ogura T, Gimzewski JK, Ghoneum AD, Henary MC, Agrawal S. Marina crystal minerals (MCM) activate human dendritic cells to induce CD4+ and CD8+ T cell responses in vitro. Int J Immunopathol Pharmacol. 2018 Jan-Dec; 32:2058738418797768. PMID: 30270704.
      Citations: 1     Fields:    Translation:HumansCells
    26. Badr El-Din NK, Mahmoud AZ, Hassan TA, Ghoneum M. Baker's Yeast Sensitizes Metastatic Breast Cancer Cells to Paclitaxel In Vitro. Integr Cancer Ther. 2018 06; 17(2):542-550. PMID: 29161917.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    27. Ghoneum MH, Katano H, Agrawal S, Ganguly S, Agrawal A. Effect of Nanodiamond and Nanoplatinum Liquid, DPV576, on Human Primary Keratinocytes. J Biomed Nanotechnol. 2017 Jan; 13(1):110-16. PMID: 29373005.
      Citations: 2     Fields:    Translation:HumansCells
    28. Salama H, Medhat E, Shaheen M, Zekri AN, Darwish T, Ghoneum M. Arabinoxylan rice bran (Biobran) suppresses the viremia level in patients with chronic HCV infection: A randomized trial. Int J Immunopathol Pharmacol. 2016 Dec; 29(4):647-653. PMID: 27799299.
      Citations: 7     Fields:    Translation:HumansAnimalsCTClinical Trials
    29. Badr El-Din NK, Ali DA, Alaa El-Dein M, Ghoneum M. Enhancing the Apoptotic Effect of a Low Dose of Paclitaxel on Tumor Cells in Mice by Arabinoxylan Rice Bran (MGN-3/Biobran). Nutr Cancer. 2016 Aug-Sep; 68(6):1010-20. PMID: 27367621.
      Citations: 9     Fields:    Translation:AnimalsCells
    30. Badr El-Din NK, Abdel Fattah SM, Pan D, Tolentino L, Ghoneum M. Chemopreventive Activity of MGN-3/Biobran Against Chemical Induction of Glandular Stomach Carcinogenesis in Rats and Its Apoptotic Effect in Gastric Cancer Cells. Integr Cancer Ther. 2016 12; 15(4):NP26-NP34. PMID: 27151588.
      Citations: 14     Fields:    Translation:AnimalsCells
    31. Ghoneum M, Felo N, Agrawal S, Agrawal A. A novel kefir product (PFT) activates dendritic cells to induce CD4+T and CD8+T cell responses in vitro. Int J Immunopathol Pharmacol. 2015 Dec; 28(4):488-96. PMID: 26384392.
      Citations: 11     Fields:    Translation:HumansCells
    32. Ghoneum M, Felo N. Selective induction of apoptosis in human gastric cancer cells by Lactobacillus kefiri (PFT), a novel kefir product. Oncol Rep. 2015 Oct; 34(4):1659-66. PMID: 26251956.
      Citations: 14     Fields:    Translation:HumansCells
    33. Ghoneum MH, Badr El-Din NK, Abdel Fattah SM, Pan D, Tolentino L. Hydroferrate fluid, MRN-100, provides protection against chemical-induced gastric and esophageal cancer in Wistar rats. Int J Biol Sci. 2015; 11(3):295-303. PMID: 25678848.
      Citations: 5     Fields:    Translation:AnimalsCells
    34. Ghoneum M, Gimzewski J. Apoptotic effect of a novel kefir product, PFT, on multidrug-resistant myeloid leukemia cells via a hole-piercing mechanism. Int J Oncol. 2014 Mar; 44(3):830-7. PMID: 24430613.
      Citations: 20     Fields:    Translation:HumansCells
    35. Ghoneum M, Badr El-Din NK, Ali DA, El-Dein MA. Modified arabinoxylan from rice bran, MGN-3/biobran, sensitizes metastatic breast cancer cells to paclitaxel in vitro. Anticancer Res. 2014 Jan; 34(1):81-7. PMID: 24403447.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    36. Ghoneum M, Elbaghdady HA, El-Shebly AA, Pan D, Assanah E, Lawson G. Protective effect of hydroferrate fluid, MRN-100, against lethality and hematopoietic tissue damage in ?-radiated Nile tilapia, Oreochromis niloticus. J Radiat Res. 2013 Sep; 54(5):852-62. PMID: 23589025.
      Citations: 3     Fields:    Translation:AnimalsPHPublic Health
    37. Ghoneum M, Badr El-Din NK, Abdel Fattah SM, Tolentino L. Arabinoxylan rice bran (MGN-3/Biobran) provides protection against whole-body ?-irradiation in mice via restoration of hematopoietic tissues. J Radiat Res. 2013 May; 54(3):419-29. PMID: 23287771.
      Citations: 16     Fields:    Translation:AnimalsPHPublic Health
    38. Bang MH, Van Riep T, Thinh NT, Song le H, Dung TT, Van Truong L, Van Don L, Ky TD, Pan D, Shaheen M, Ghoneum M. Arabinoxylan rice bran (MGN-3) enhances the effects of interventional therapies for the treatment of hepatocellular carcinoma: a three-year randomized clinical trial. Anticancer Res. 2010 Dec; 30(12):5145-51. PMID: 21187503.
      Citations: 18     Fields:    Translation:Humans
    39. Ghoneum M, Ghoneum A, Gimzewski J. Nanodiamond and nanoplatinum liquid, DPV576, activates human monocyte-derived dendritic cells in vitro. Anticancer Res. 2010 Oct; 30(10):4075-9. PMID: 21036722.
      Citations: 11     Fields:    Translation:HumansCells
    40. Badr El-Din NK, Noaman E, Fattah SM, Ghoneum M. Reversal of age-associated oxidative stress in rats by MRN-100, a hydro-ferrate fluid. In Vivo. 2010 Jul-Aug; 24(4):525-33. PMID: 20668320.
      Citations: 6     Fields:    Translation:AnimalsCells
    41. Ghoneum M, Ghoneum A, Tolentino L, Gimzewski J. Modulation of aged murine T lymphocytes in vivo by DPV576-C, a nanodiamond- and nanoplatinum-coated material. In Vivo. 2010 Mar-Apr; 24(2):141-6. PMID: 20363985.
      Citations: 5     Fields:    Translation:AnimalsCells
    42. Ghoneum M, Tolentino L, Seto Y. Phenotypic correction of Age-associated functional decline in murine immune cells by Thymax, a thymic extract. In Vivo. 2009 Nov-Dec; 23(6):895-902. PMID: 20023230.
      Citations: 1     Fields:    Translation:AnimalsCells
    43. Ghoneum M, Seto Y, Agrawal S. Activation of human monocyte-derived dendritic cells in vitro by Thymax, a gross thymic extract. Anticancer Res. 2009 Nov; 29(11):4367-71. PMID: 20032380.
      Citations: 1     Fields:    Translation:HumansCells
    44. Ghoneum M, Gollapudi S. Susceptibility of the human LNCaP prostate cancer cells to the apoptotic effect of marina crystal minerals (MCM) in vitro. Oncol Rep. 2009 Jul; 22(1):155-9. PMID: 19513518.
      Citations: 2     Fields:    Translation:HumansCells
    45. Ghoneum M, Matsuura M, Gollapudi S. An iron-based beverage, HydroFerrate fluid (MRN-100), alleviates oxidative stress in murine lymphocytes in vitro. Nutr J. 2009 May 02; 8:18. PMID: 19409106.
      Citations: 3     Fields:    Translation:AnimalsCells
    46. Ghoneum M, Matsuura M, Braga M, Gollapudi S. S. cerevisiae induces apoptosis in human metastatic breast cancer cells by altering intracellular Ca2+ and the ratio of Bax and Bcl-2. Int J Oncol. 2008 Sep; 33(3):533-9. PMID: 18695883.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    47. Noaman E, Badr El-Din NK, Bibars MA, Abou Mossallam AA, Ghoneum M. Antioxidant potential by arabinoxylan rice bran, MGN-3/biobran, represents a mechanism for its oncostatic effect against murine solid Ehrlich carcinoma. Cancer Lett. 2008 Sep 18; 268(2):348-59. PMID: 18554778.
      Citations: 28     Fields:    Translation:AnimalsCells
    48. Ghoneum M, Seto Y, Sato S, Ghoneum A, Braga M, Gollapudi S. Gross thymic extract, Thymax, induces apoptosis in human breast cancer cells in vitro through the mitochondrial pathway. Anticancer Res. 2008 May-Jun; 28(3A):1603-9. PMID: 18630518.
      Citations: 3     Fields:    Translation:HumansCells
    49. Gollapudi S, Ghoneum M. MGN-3/Biobran, modified arabinoxylan from rice bran, sensitizes human breast cancer cells to chemotherapeutic agent, daunorubicin. Cancer Detect Prev. 2008; 32(1):1-6. PMID: 18406070.
      Citations: 13     Fields:    Translation:HumansCells
    50. Ghoneum M, Shaheen M. MRN-100, an Iron-based Compound, Possesses Anti-HIV Activity In Vitro. Evid Based Complement Alternat Med. 2010 Dec; 7(4):427-32. PMID: 18955328.
    51. Badr El-Din NK, Noaman E, Ghoneum M. In vivo tumor inhibitory effects of nutritional rice bran supplement MGN-3/Biobran on Ehrlich carcinoma-bearing mice. Nutr Cancer. 2008; 60(2):235-44. PMID: 18444156.
      Citations: 23     Fields:    Translation:AnimalsCells
    52. Ghoneum M, Badr El-Din NK, Noaman E, Tolentino L. Saccharomyces cerevisiae, the Baker's Yeast, suppresses the growth of Ehrlich carcinoma-bearing mice. Cancer Immunol Immunother. 2008 Apr; 57(4):581-92. PMID: 17891396.
      Citations: 9     Fields:    Translation:Animals
    53. Ghoneum M, Wang L, Agrawal S, Gollapudi S. Yeast therapy for the treatment of breast cancer: a nude mice model study. In Vivo. 2007 Mar-Apr; 21(2):251-8. PMID: 17436573.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    54. Ghoneum M, Gollapudi S. Apoptosis of breast cancer MCF-7 cells in vitro is induced specifically by yeast and not by fungal mycelia. Anticancer Res. 2006 May-Jun; 26(3A):2013-22. PMID: 16827138.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    55. Ghoneum M, Gollapudi S. Synergistic role of arabinoxylan rice bran (MGN-3/Biobran) in S. cerevisiae-induced apoptosis of monolayer breast cancer MCF-7 cells. Anticancer Res. 2005 Nov-Dec; 25(6B):4187-96. PMID: 16309215.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    56. Ghoneum M, Gollapudi S. Modified arabinoxylan rice bran (MGN-3/Biobran) enhances yeast-induced apoptosis in human breast cancer cells in vitro. Anticancer Res. 2005 Mar-Apr; 25(2A):859-70. PMID: 15868920.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    57. Ghoneum M, Hamilton J, Brown J, Gollapudi S. Human squamous cell carcinoma of the tongue and colon undergoes apoptosis upon phagocytosis of Saccharomyces cerevisiae, the baker's yeast, in vitro. Anticancer Res. 2005 Mar-Apr; 25(2A):981-9. PMID: 15868937.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    58. Ghoneum M, Abedi S. Enhancement of natural killer cell activity of aged mice by modified arabinoxylan rice bran (MGN-3/Biobran). J Pharm Pharmacol. 2004 Dec; 56(12):1581-8. PMID: 15563765.
      Citations: 25     Fields:    Translation:AnimalsCells
    59. Ghoneum M, Saglie R, Brown J, Regala C. Actinobacillus actinomycetemcomitans suppresses rat natural killer cell activity in vivo. Acta Otolaryngol. 2004 Jun; 124(5):621-7. PMID: 15267183.
      Citations:    Fields:    Translation:AnimalsCells
    60. Ghoneum M, Gollapudi S. Induction of apoptosis in breast cancer cells by Saccharomyces cerevisiae, the baker's yeast, in vitro. Anticancer Res. 2004 May-Jun; 24(3a):1455-63. PMID: 15274310.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    61. Ghoneum M, Gollapudi S. Phagocytosis of Candida albicans by metastatic and non metastatic human breast cancer cell lines in vitro. Cancer Detect Prev. 2004; 28(1):17-26. PMID: 15041073.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    62. Ghoneum M, Gollapudi S. Modified arabinoxylan rice bran (MGN-3/Biobran) sensitizes human T cell leukemia cells to death receptor (CD95)-induced apoptosis. Cancer Lett. 2003 Nov 10; 201(1):41-9. PMID: 14580685.
      Citations: 11     Fields:    Translation:HumansCells
    63. Ghoneum M, Grewal I, Brown J, Osborne R, Elembabi H, Gill G. Phagocytosis of candida albicans by lymphatic tumour cells in vitro. Acta Histochem. 2003; 105(2):127-33. PMID: 12831164.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    Ghoneum's Networks
    Click the
    buttons for more information and interactive visualizations!
    Concepts (268)
    Co-Authors (3)
    Similar People (60)
    Same Department Expand Description
    RCMI CC is supported by the National Institute on Minority Health and Health Disparities, National Institutes of Health (NIH), through Grant Number U24MD015970. The contents of this site are solely the responsibility of the authors and do not necessarily represent the official views of the NIH

    For technical support please contact support