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One or more keywords matched the following properties of Sobin, Christina
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overview My laboratory studies brain and behavior during development. In child studies, we examine cognitive concomitants and sequelae of genetic variants and medical conditions; these provide a natural manipulation of brain mechanisms that may be unrecognized as critical for key mental functions, particularly visual attention, working memory, inhibitory control, and motor dexterity. Our work is translational and we use results from child studies to guide the development of new animal models. Currently, we are studying the effects on brain and behavior of early chronic low-level lead exposure. In child studies, we have provided new evidence of a genetic variant (hPEPT2) that increases low blood lead burden and predicts unique working memory and motor deficits in young males exposed to low-level lead. In mouse low-level lead exposure studies, we have begun to characterize memory deficits using a novel odor recognition task and quantified loss of microglia in dentate gyrus following early chronic low-level lead exposure. As we attempt to replicate these first results, future studies, will test effects in an hPEPT2 transgenic mouse model.
One or more keywords matched the following items that are connected to Sobin, Christina
Item TypeName
Academic Article Polymorphisms of delta-aminolevulinic acid dehydratase (ALAD) and peptide transporter 2 (PEPT2) genes in children with low-level lead exposure.
Academic Article d-Aminolevulinic acid dehydratase single nucleotide polymorphism 2 and peptide transporter 2*2 haplotype may differentially mediate lead exposure in male children.
Academic Article A Bland-Altman comparison of the Lead Care® System and inductively coupled plasma mass spectrometry for detecting low-level lead in child whole blood samples.
Academic Article d-Aminolevulinic acid dehydratase single nucleotide polymorphism 2 (ALAD2) and peptide transporter 2*2 haplotype (hPEPT2*2) differently influence neurobehavior in low-level lead exposed children.
Academic Article A Comparison of Child Blood Lead Levels in Urban and Rural Children Ages 5-12 Years Living in the Border Region of El Paso, Texas.
Academic Article A comparison of arsenic exposure in young children and home water arsenic in two rural West Texas communities.
Academic Article Early, non-psychotic deviant behavior in schizophrenia: a possible endophenotypic marker for genetic studies.
Academic Article Phenotypic differences in early- and late-onset obsessive-compulsive disorder.
Academic Article Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophrenia.
Academic Article Lower prepulse inhibition in children with the 22q11 deletion syndrome.
Academic Article Olfactory disorder in children with 22q11 deletion syndrome.
Academic Article Neuromotor deficits in children with the 22q11 deletion syndrome.
Academic Article Networks of attention in children with the 22q11 deletion syndrome.
Academic Article Associations between prepulse inhibition and executive visual attention in children with the 22q11 deletion syndrome.
Academic Article Neuropsychological characteristics of children with the 22q11 Deletion Syndrome: a descriptive analysis.
Academic Article Social skills and executive function deficits in children with the 22q11 Deletion Syndrome.
Academic Article Sex differences in the behavior of children with the 22q11 deletion syndrome.
Concept Child
Concept Child Behavior
Concept Child Behavior Disorders
Concept Child, Preschool
Grant Attention in Children with the 22q11 Deletion Syndrome
Grant Lead, Genes, and Cognition in Underserved Children
Search Criteria
  • Children
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