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Jerry Guyden

TitleRCMI Program PI, Professor of Biology
InstitutionCity College, CUNY
AddressCity College of New York
160 Convent Avenue
Attention RCMI Program
New York NY 10031
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    Dr. Guyden is a molecular immunologist whose research interests center on the function of thymic nurse cells (TNCs) - specialized epithelial cells that contain T cells completely enclosed in intra-cytoplasmic vacuoles. Recent research in his lab indicates that TNCs may house the MHC restriction process. Dr. Guyden is the Principal Investigator (PI), RCMI (Research Centers in Minority Institutions) at City College.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Guyden JC, Martinez M, Chilukuri RV, Reid V, Kelly F, Samms MO. Thymic Nurse Cells Participate in Heterotypic Internalization and Repertoire Selection of Immature Thymocytes; Their Removal from the Thymus of Autoimmune Animals May be Important to Disease Etiology. Curr Mol Med. 2015; 15(9):828-35. PMID: 26511706.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    2. Chilukuri RV, Patel VK, Martinez M, Guyden JC, Samms MD. The Antigenic Determinant That Defines Thymic Nurse Cells Is Expressed by Thymic Epithelial Progenitor Cells. Front Cell Dev Biol. 2014 Apr 28; 2(13). PMID: 25340052.
    3. Guyden JC. A different kind of quarterback. Mol Biol Cell. 2011 Nov; 22(21):3926-8. PMID: 22039064.
      Citations:    Fields:    
    4. Hendrix TM, Chilukuri RV, Martinez M, Olushoga Z, Blake A, Brohi M, Walker C, Samms M, Guyden JC. Thymic nurse cells exhibit epithelial progenitor phenotype and create unique extra-cytoplasmic membrane space for thymocyte selection. Cell Immunol. 2010; 261(2):81-92. PMID: 20035931.
      Citations: 12     Fields:    Translation:AnimalsCells
    5. Martinez M, Samms M, Hendrix TM, Adeosun O, Pezzano M, Guyden JC. Thymic nurse cell multicellular complexes in HY-TCR transgenic mice demonstrate their association with MHC restriction. Exp Biol Med (Maywood). 2007 Jun; 232(6):780-8. PMID: 17526770.
      Citations: 5     Fields:    Translation:AnimalsCells
    6. Webb O, Kelly F, Benitez J, Li J, Parker M, Martinez M, Samms M, Blake A, Pezzano M, Guyden JC. The identification of thymic nurse cells in vivo and the role of cytoskeletal proteins in thymocyte internalization. Cell Immunol. 2004 Apr; 228(2):119-29. PMID: 15219463.
      Citations: 4     Fields:    Translation:AnimalsCells
    7. Guyden JC, Pezzano M. Thymic nurse cells: a microenvironment for thymocyte development and selection. Int Rev Cytol. 2003; 223:1-37. PMID: 12641209.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    8. Pezzano M, Samms M, Martinez M, Guyden J. Questionable thymic nurse cell. Microbiol Mol Biol Rev. 2001 Sep; 65(3):390-403, table of contents. PMID: 11528002.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    9. Samms M, Martinez M, Fousse S, Pezzano M, Guyden JC. Circulating macrophages as well as developing thymocytes are enclosed within thymic nurse cells. Cell Immunol. 2001 Aug 25; 212(1):16-23. PMID: 11716525.
      Citations: 3     Fields:    Translation:AnimalsCells
    10. Pezzano M, Samms M, Guyden JC. TNF and Fas-induced apoptosis during negative selection in thymic nurse cells. Ethn Dis. 2001; 11(1):154-6. PMID: 11289237.
      Citations: 3     Fields:    Translation:HumansCells
    11. Lee SK, Pestano GA, Riley J, Hasan AS, Pezzano M, Samms M, Park KJ, Guyden J, Boto WM. A single point mutation in HIV-1 V3 loop alters the immunogenic properties of rgp120. Arch Virol. 2000; 145(10):2087-103. PMID: 11087093.
      Citations: 1     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    12. Samms M, Philp D, Emanus F, Osuji O, Pezzano M, Guyden JC. Lysosomal-mediated degradation of apoptotic thymocytes within thymic nurse cells. Cell Immunol. 1999 Nov 01; 197(2):108-15. PMID: 10607428.
      Citations: 8     Fields:    Translation:AnimalsCells
    13. Pezzano M, King KD, Philp DD, Adeyemi A, Gardiner B, Yang J, Samms M, Boto W, Guyden JC. A thymic nurse cell-specific monoclonal antibody. Cell Immunol. 1998 May 01; 185(2):123-33. PMID: 9636690.
      Citations: 4     Fields:    Translation:AnimalsCells
    14. Xie JM, Pestano GA, Samms M, Lee SK, Guyden J, Boto WM. Immunogenic potential of rgp120 from African HIV-1 subtype A. Vaccine. 1996 Jul; 14(10):993-1000. PMID: 8873394.
      Citations:    Fields:    Translation:AnimalsCells
    15. Pezzano M, Philp D, Stephenson S, Li Y, Reid V, Maitta R, Guyden JC. Positive selection by thymic nurse cells requires IL-1 beta and is associated with an increased Bcl-2 expression. Cell Immunol. 1996 May 01; 169(2):174-84. PMID: 8620545.
      Citations: 7     Fields:    Translation:AnimalsCells
    16. Pezzano M, Li Y, Philp D, Omene C, Cantey M, Saunders G, Guyden JC. Thymic nurse cell rescue of early CD4+CD8+ thymocytes from apoptosis. Cell Mol Biol (Noisy-le-grand). 1995 Dec; 41(8):1099-111. PMID: 8747091.
      Citations: 7     Fields:    Translation:AnimalsCells
    17. Riley JP, Pestano GA, Harewood K, Alfred LJ, Guyden J, Boto WM. Distribution of linear antigenic epitopes on GP120 encoded in sibling clones of novel New York HIV-1 subtype B isolates. Cell Mol Biol (Noisy-le-grand). 1995; 41 Suppl 1:S83-91. PMID: 8574151.
      Citations: 1     Fields:    Translation:HumansCells
    18. Riley JP, Pestano GA, Hosford K, Francis C, Xie JM, Mugyenyi P, Kataaha P, Katongole-Mbidde E, Anokbonggo WW, Guyden J, et al. Relative reactivity of the V3 loop PND of HIV-1 subtypes A, B, C, D, and F with sera from selected Ugandan localities. Arch Virol. 1995; 140(8):1393-404. PMID: 7544970.
      Citations:    Fields:    Translation:HumansCells
    19. Pestano G, Prince A, Guyden J, Ntambi JM, Atkin A, Boto WM. Independent divergences in the CD4 binding site and V3 loop encoded in two seroprevalent Ugandan HIV-1 clinical isolates. J Acquir Immune Defic Syndr (1988). 1993 Aug; 6(8):872-80. PMID: 7686222.
    20. Philp D, Pezzano M, Li Y, Omene C, Boto W, Guyden J. The binding, internalization, and release of thymocytes by thymic nurse cells. Cell Immunol. 1993 May; 148(2):301-15. PMID: 8495496.
      Citations: 6     Fields:    Translation:AnimalsCells
    21. Li Y, Pezzano M, Philp D, Reid V, Guyden J. Thymic nurse cells exclusively bind and internalize CD4+CD8+ thymocytes. Cell Immunol. 1992 Apr; 140(2):495-506. PMID: 1544171.
      Citations: 6     Fields:    Translation:AnimalsCells
    22. Pezzano M, Li Y, Yang YM, Guyden J. The immortalization of thymic nurse cells by SV40 virus. Cell Immunol. 1991 Apr 01; 133(2):434-45. PMID: 1849801.
      Citations: 4     Fields:    Translation:AnimalsCells
    23. Rogers P, Fisher R, Guyden J. Neutral selection of transfected mammalian cells using tissue plasminogen activator gene expression. Gene. 1989 Sep 01; 81(1):151-8. PMID: 2553537.
      Citations:    Fields:    Translation:HumansAnimalsCells
    24. Guyden J, Godfrey W, Doe B, Ousley F, Wofsy L. Immunospecific vesicle targeting facilitates fusion with selected cell populations. Ciba Found Symp. 1984; 103:239-53. PMID: 6561136.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    25. Guyden JC, Martin GS. Transformation parameters of chick embryo fibroblasts transformed by Fujinami, PRCII, PRCII-p, and Y73 avian sarcoma viruses. Virology. 1982 Oct 15; 122(1):71-83. PMID: 6291237.
      Citations: 5     Fields:    Translation:AnimalsCells
    26. Pawson T, Guyden J, Kung TH, Radke K, Gilmore T, Martin GS. A strain of Fujinami sarcoma virus which is temperature-sensitive in protein phosphorylation and cellular transformation. Cell. 1980 Dec; 22(3):767-75. PMID: 6257397.
      Citations: 64     Fields:    Translation:AnimalsCells
    27. Busbee DL, Guyden J, Kingston T, Rose FL, Cantrell ET. Metabolism of benzo(a)pyrene in animals with high aryl hydrocarbon hydroxylase levels and high rates of spontaneous cancer. Cancer Lett. 1978 Feb; 4(2):61-7. PMID: 647652.
      Citations: 1     Fields:    Translation:AnimalsCells
    28. Cantrell ET, Abreu-Greenberg M, Guyden J, Busbee DL. Metabolism of diphenyloxazole (PPO) by mouse liver microsomes. Life Sci. 1975 Aug 01; 17(3):317-21. PMID: 240097.
      Citations: 4     Fields:    Translation:AnimalsCells
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