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Shafiq A. Khan

TitleProfessor of Biological Sciences; GRA Eminent Scholar
Faculty RankProfessor
InstitutionClark Atlanta University
DepartmentCenter for Cancer Research and Therapeutic Development
AddressClark Atlanta University
Center for Cancer Research and Theraputic Development
223 James P. Brawley Drive, S.W.
Atlanta GA 30314
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    Dr. Khan is the Scientific Director of the Clark Atlanta University Center for Cancer Research and Therapeutic Development (CCRTD), a University Center of Excellence that focuses on research in prostate cancer and is an Eminent Scholar in Cancer Cell Biology, an endowed chair funded by the Georgia Research Alliance. He is also Professor in the Department of Biological Sciences and serves as PI/Program Director of the NIH/NIMHD Center of Excellence for Prostate Cancer Research, Education and Community Services and the NIH/NIMHD/RCMI programs at Clark Atlanta University.

    Dr. Khan earned his Master’s degree in Biological Sciences in 1976 from Quaid-i-Azam University in Islamabad, Pakistan, and his Doctorate in Reproductive Endocrinology in 1985 from the Karolinska Institute in Sweden. He was an Associate Professor in the Department of Cell Biology and Biochemistry at Texas Tech University, where he also served as the Director of Basic Research of the Southwest Cancer Center. Prior to this, he was affiliated with the University of Muenster in Germany, the University of Toronto and the University of Kansas Medical Center. Dr. Khan has provided services to the World Health Organization (WHO) through numerous collaborations with researchers from London, Stockholm, and Muenster.

    His research focus is on understanding the role of growth factors and cytokines in the regulation of prostate cancer and the regulation of AR function in androgen-independent prostate cancer cells. During his tenure as a scientist and Director of CCRTD, he has mentored 6 junior faculty members, 15 postdoctoral scientists, 21 doctoral graduate students, 29 undergraduate students and 3 medical students. Along with his administrative and research activities, Dr. Khan continues to teach and mentor undergraduate and graduate students in biomedical sciences. Although admired and respected for his research contributions, he particularly enjoys teaching and advising undergraduates and feels that proper mentoring at this level is critical to students’ success as future scientists. His career includes more than 30 years of experience in areas of reproductive endocrinology and cancer research. As a researcher, he has published over 80 journal articles and several book chapters and has 2 patents.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Thompson-Elliott B, Johnson R, Khan SA. Alterations in TGFß signaling during prostate cancer progression. Am J Clin Exp Urol. 2021; 9(4):318-328. PMID: 34541030.
    2. Hedges JR, Soliman KFA, Southerland WM, D'Amour G, Fernández-Repollet E, Khan SA, Kumar D, Shikuma CM, Rivers BM, Yates CC, Yanagihara R, Thompson WE, Bond VC, Harris-Hooker S, McClure SA, Ofili EO. Strengthening and Sustaining Inter-Institutional Research Collaborations and Partnerships. Int J Environ Res Public Health. 2021 03 08; 18(5). PMID: 33800316.
      Citations:    Fields:    Translation:Humans
    3. Caggia S, Tapadar S, Wu B, Venugopal SV, Garrett AS, Kumar A, Stiffend JS, Davis JS, Oyelere AK, Khan SA. Small Molecule Inhibitors Targeting Gai2 Protein Attenuate Migration of Cancer Cells. Cancers (Basel). 2020 Jun 19; 12(6). PMID: 32575572.
    4. Cinar B, Al-Mathkour MM, Khan SA, Moreno CS. Androgen attenuates the inactivating phospho-Ser-127 modification of yes-associated protein 1 (YAP1) and promotes YAP1 nuclear abundance and activity. J Biol Chem. 2020 06 19; 295(25):8550-8559. PMID: 32376689.
      Citations: 3     Fields:    Translation:HumansCells
    5. Venugopal SV, Caggia S, Gambrell-Sanders D, Khan SA. Differential roles and activation of mammalian target of rapamycin complexes 1 and 2 during cell migration in prostate cancer cells. Prostate. 2020 04; 80(5):412-423. PMID: 31995655.
      Citations: 4     Fields:    Translation:HumansCells
    6. Caggia S, Chunduri H, Millena AC, Perkins JN, Venugopal SV, Vo BT, Li C, Tu Y, Khan SA. Novel role of Gia2 in cell migration: Downstream of PI3-kinase-AKT and Rac1 in prostate cancer cells. J Cell Physiol. 2018 01; 234(1):802-815. PMID: 30078221.
      Citations: 8     Fields:    Translation:HumansCells
    7. Kimbrough-Allah MN, Millena AC, Khan SA. Differential role of PTEN in transforming growth factor ß (TGF-ß) effects on proliferation and migration in prostate cancer cells. Prostate. 2018 04; 78(5):377-389. PMID: 29341212.
      Citations: 8     Fields:    Translation:HumansCells
    8. Barrett CS, Millena AC, Khan SA. TGF-ß Effects on Prostate Cancer Cell Migration and Invasion Require FosB. Prostate. 2017 01; 77(1):72-81. PMID: 27604827.
      Citations: 33     Fields:    Translation:HumansCells
    9. Millena AC, Vo BT, Khan SA. JunD Is Required for Proliferation of Prostate Cancer Cells and Plays a Role in Transforming Growth Factor-ß (TGF-ß)-induced Inhibition of Cell Proliferation. J Biol Chem. 2016 08 19; 291(34):17964-76. PMID: 27358408.
      Citations: 15     Fields:    Translation:HumansCells
    10. Vo BT, Morton D, Komaragiri S, Millena AC, Leath C, Khan SA. TGF-ß effects on prostate cancer cell migration and invasion are mediated by PGE2 through activation of PI3K/AKT/mTOR pathway. Endocrinology. 2013 May; 154(5):1768-79. PMID: 23515290.
      Citations: 88     Fields:    Translation:HumansCells
    11. Strong N, Millena AC, Walker L, Chaudhary J, Khan SA. Inhibitor of differentiation 1 (Id1) and Id3 proteins play different roles in TGFß effects on cell proliferation and migration in prostate cancer cells. Prostate. 2013 May; 73(6):624-33. PMID: 23060149.
      Citations: 20     Fields:    Translation:HumansCells
    12. Zhong M, Clarke S, Vo BT, Khan SA. The essential role of Gia2 in prostate cancer cell migration. Mol Cancer Res. 2012 Oct; 10(10):1380-8. PMID: 22936789.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    13. Vo BT, Cody B, Cao Y, Khan SA. Differential role of Sloan-Kettering Institute (Ski) protein in Nodal and transforming growth factor-beta (TGF-ß)-induced Smad signaling in prostate cancer cells. Carcinogenesis. 2012 Nov; 33(11):2054-64. PMID: 22843506.
      Citations: 13     Fields:    Translation:HumansCells
    14. Darrington E, Zhong M, Vo BH, Khan SA. Vascular endothelial growth factor A, secreted in response to transforming growth factor-ß1 under hypoxic conditions, induces autocrine effects on migration of prostate cancer cells. Asian J Androl. 2012 Sep; 14(5):745-51. PMID: 22705563.
      Citations: 23     Fields:    Translation:HumansCells
    15. Walker L, Millena AC, Strong N, Khan SA. Expression of TGFß3 and its effects on migratory and invasive behavior of prostate cancer cells: involvement of PI3-kinase/AKT signaling pathway. Clin Exp Metastasis. 2013 Jan; 30(1):13-23. PMID: 22678424.
      Citations: 25     Fields:    Translation:HumansCells
    16. Vo BT, Khan SA. Expression of nodal and nodal receptors in prostate stem cells and prostate cancer cells: autocrine effects on cell proliferation and migration. Prostate. 2011 Jul; 71(10):1084-96. PMID: 21557273.
      Citations: 26     Fields:    Translation:HumansCells
    17. Zhong M, Boseman ML, Millena AC, Khan SA. Oxytocin induces the migration of prostate cancer cells: involvement of the Gi-coupled signaling pathway. Mol Cancer Res. 2010 Aug; 8(8):1164-72. PMID: 20663860.
      Citations: 27     Fields:    Translation:HumansCells
    18. Dillard PR, Lin MF, Khan SA. Androgen-independent prostate cancer cells acquire the complete steroidogenic potential of synthesizing testosterone from cholesterol. Mol Cell Endocrinol. 2008 Nov 25; 295(1-2):115-20. PMID: 18782595.
      Citations: 93     Fields:    Translation:HumansCells
    19. Jo Y, King SR, Khan SA, Stocco DM. Involvement of protein kinase C and cyclic adenosine 3',5'-monophosphate-dependent kinase in steroidogenic acute regulatory protein expression and steroid biosynthesis in Leydig cells. Biol Reprod. 2005 Aug; 73(2):244-55. PMID: 15814901.
      Citations: 39     Fields:    Translation:AnimalsCells
    20. Karri S, Johnson H, Hendry WJ, Williams SC, Khan SA. Neonatal exposure to diethylstilbestrol leads to impaired action of androgens in adult male hamsters. Reprod Toxicol. 2004 Nov; 19(1):53-63. PMID: 15336712.
      Citations: 4     Fields:    Translation:Animals
    21. Millena AC, Reddy SC, Bowling GH, Khan SA. Autocrine regulation of steroidogenic function of Leydig cells by transforming growth factor-alpha. Mol Cell Endocrinol. 2004 Sep 30; 224(1-2):29-39. PMID: 15353178.
      Citations: 12     Fields:    Translation:AnimalsCells
    22. Oduru S, Campbell JL, Karri S, Hendry WJ, Khan SA, Williams SC. Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs. BMC Genomics. 2003 Jun 03; 4(1):22. PMID: 12783626.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    23. Dickson C, Webster DR, Johnson H, Cecilia Millena A, Khan SA. Transforming growth factor-beta effects on morphology of immature rat Leydig cells. Mol Cell Endocrinol. 2002 Sep 30; 195(1-2):65-77. PMID: 12354673.
      Citations: 4     Fields:    Translation:AnimalsCells
    24. Khan SA, Ndjountche L, Pratchard L, Spicer LJ, Davis JS. Follicle-stimulating hormone amplifies insulin-like growth factor I-mediated activation of AKT/protein kinase B signaling in immature rat Sertoli cells. Endocrinology. 2002 Jun; 143(6):2259-67. PMID: 12021190.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
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