Our research focus is to understand molecular basis of prostate cancer development and progression. We currently have two projects in this area. The first project is focused on understanding the role of Inhibitor of differentiation 4 (Id4) in prostate development, castration resistant prostate cancer and chemo-sensitivity around the p53/ PTEN pathway. The second, project addresses how inflammation and infection causes prostate cancer. The observation that body’s failure to effectively fight inflammation or infection causes cancer is the basis of this project. Our group is looking at molecular signatures in genes (SNP and expression) that cause inflammation that we hope will indicate if a person has increased susceptibility to prostate cancer. Our overall hypothesis is that body’s inflammatory response, under the genetic control and influenced by race, environment and dietary habits is a major determinant of prostate cancer.