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Guangdi Wang

TitleRCMI Program Director
Faculty RankProfessor
InstitutionXavier University of Louisiana
AddressXavier University of Louisiana
1 Drexel Drive
New Orleans LA 70125
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    Collapse Research 
    Collapse research activities and funding
    R03DA017141     (WANG, GUANGDI)Sep 15, 2004 - Jul 31, 2007
    Role: Principal Investigator

    G12MD007595     (D'AMOUR, GENE)Sep 24, 2009 - Mar 31, 2019
    Xavier RCMI Center for Cancer Research
    Role: Co-Principal Investigator

    U54MD007595     (WANG, GUANGDI)Sep 24, 2009 - Dec 31, 2023
    Xavier RCMI Renewal Application-Overall
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zheng S, Liu J, Wu Y, Huang TL, Wang G. Small-molecule inhibitors of Wnt signaling pathway: towards novel anticancer therapeutics. Future Med Chem. 2015; 7(18):2485-505. PMID: 26670195.
      Citations: 4     Fields:    Translation:HumansCells
    2. Zhong Q, Zhang C, Zhang Q, Miele L, Zheng S, Wang G. Boronic prodrug of 4-hydroxytamoxifen is more efficacious than tamoxifen with enhanced bioavailability independent of CYP2D6 status. BMC Cancer. 2015 Sep 09; 15:625. PMID: 26354796.
      Citations: 11     Fields:    Translation:AnimalsCells
    3. Liu J, Pham PT, Skripnikova EV, Zheng S, Lovings LJ, Wang Y, Goyal N, Bellow SM, Mensah LM, Chatters AJ, Bratton MR, Wiese TE, Zhao M, Wang G, Foroozesh M. A Ligand-Based Drug Design. Discovery of 4-Trifluoromethyl-7,8-pyranocoumarin as a Selective Inhibitor of Human Cytochrome P450 1A2. J Med Chem. 2015 Aug 27; 58(16):6481-93. PMID: 26222195.
      Citations: 6     Fields:    Translation:HumansCells
    4. Zhao LM, Ma FY, Jin HS, Zheng S, Zhong Q, Wang G. Design and synthesis of novel hydroxyanthraquinone nitrogen mustard derivatives as potential anticancer agents via a bioisostere approach. Eur J Med Chem. 2015 Sep 18; 102:303-9. PMID: 26291039.
      Citations: 2     Fields:    Translation:HumansCells
    5. Zhang C, Zhong Q, Zhang Q, Zheng S, Miele L, Wang G. Boronic prodrug of endoxifen as an effective hormone therapy for breast cancer. Breast Cancer Res Treat. 2015 Jul; 152(2):283-91. PMID: 26071758.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    6. Wang R, Chen C, Zhang X, Zhang C, Zhong Q, Chen G, Zhang Q, Zheng S, Wang G, Chen QH. Structure-Activity Relationship and Pharmacokinetic Studies of 1,5-Diheteroarylpenta-1,4-dien-3-ones: A Class of Promising Curcumin-Based Anticancer Agents. J Med Chem. 2015 Jun 11; 58(11):4713-26. PMID: 25961334.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    7. Washington C, Maxwell J, Stevenson J, Malone G, Lowe EW, Zhang Q, Wang G, McIntyre NR. Mechanistic studies of the tyrosinase-catalyzed oxidative cyclocondensation of 2-aminophenol to 2-aminophenoxazin-3-one. Arch Biochem Biophys. 2015 Jul; 577-578:24-34. PMID: 25982123.
      Citations: 3     Fields:    Translation:AnimalsCells
    8. Mottamal M, Zheng S, Huang TL, Wang G. Histone deacetylase inhibitors in clinical studies as templates for new anticancer agents. Molecules. 2015 Mar 02; 20(3):3898-941. PMID: 25738536.
      Citations: 226     Fields:    Translation:HumansAnimals
    9. Xiong P, Wang R, Zhang X, DeLa Torre E, Leon F, Zhang Q, Zheng S, Wang G, Chen QH. Design, Synthesis, and Evaluation of Genistein Analogues as Anti-Cancer Agents. Anticancer Agents Med Chem. 2015; 15(9):1197-203. PMID: 25991428.
      Citations: 5     Fields:    Translation:HumansCells
    10. Parajuli KR, Zhang Q, Liu S, Patel NK, Lu H, Zeng SX, Wang G, Zhang C, You Z. Methoxyacetic acid suppresses prostate cancer cell growth by inducing growth arrest and apoptosis. Am J Clin Exp Urol. 2014; 2(4):300-12. PMID: 25606576.
    11. Strong AL, Ohlstein JF, Jiang Q, Zhang Q, Zheng S, Boue SM, Elliott S, Gimble JM, Burow ME, Wang G, Bunnell BA. Novel daidzein analogs enhance osteogenic activity of bone marrow-derived mesenchymal stem cells and adipose-derived stromal/stem cells through estrogen receptor dependent and independent mechanisms. Stem Cell Res Ther. 2014 Aug 28; 5(4):105. PMID: 25168698.
      Citations: 7     Fields:    Translation:HumansCells
    12. Zheng S, Zhong Q, Xi Y, Mottamal M, Zhang Q, Schroeder RL, Sridhar J, He L, McFerrin H, Wang G. Modification and biological evaluation of thiazole derivatives as novel inhibitors of metastatic cancer cell migration and invasion. J Med Chem. 2014 Aug 14; 57(15):6653-67. PMID: 25007006.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    13. Zheng S, Zhong Q, Mottamal M, Zhang Q, Zhang C, Lemelle E, McFerrin H, Wang G. Design, synthesis, and biological evaluation of novel pyridine-bridged analogues of combretastatin-A4 as anticancer agents. J Med Chem. 2014 Apr 24; 57(8):3369-81. PMID: 24669888.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    14. Scarritt ME, Bonvillain RW, Burkett BJ, Wang G, Glotser EY, Zhang Q, Sammarco MC, Betancourt AM, Sullivan DE, Bunnell BA. Hypertensive rat lungs retain hallmarks of vascular disease upon decellularization but support the growth of mesenchymal stem cells. Tissue Eng Part A. 2014 May; 20(9-10):1426-43. PMID: 24378017.
      Citations: 10     Fields:    Translation:AnimalsCells
    15. Samaan N, Zhong Q, Fernandez J, Chen G, Hussain AM, Zheng S, Wang G, Chen QH. Design, synthesis, and evaluation of novel heteroaromatic analogs of curcumin as anti-cancer agents. Eur J Med Chem. 2014 Mar 21; 75:123-31. PMID: 24531225.
      Citations: 16     Fields:    Translation:HumansCells
    16. Strong AL, Jiang Q, Zhang Q, Zheng S, Boue SM, Elliott S, Burow ME, Bunnell BA, Wang G. Design, synthesis, and osteogenic activity of daidzein analogs on human mesenchymal stem cells. ACS Med Chem Lett. 2014 Feb 13; 5(2):143-8. PMID: 24900787.
    17. Zhou W, Wang G, Guo S. Regulation of angiogenesis via Notch signaling in breast cancer and cancer stem cells. Biochim Biophys Acta. 2013 Dec; 1836(2):304-20. PMID: 24183943.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    18. Guo S, Zou J, Wang G. Advances in the proteomic discovery of novel therapeutic targets in cancer. Drug Des Devel Ther. 2013; 7:1259-71. PMID: 24187485.
      Citations: 9     Fields:    Translation:HumansCells
    19. Kode NR, Vanden Eynde JJ, Mayence A, Wang G, Huang TL. Design and synthesis of N¹,N5-bis[4-(5-alkyl-1,2,4-oxadiazol-3-yl)phenyl]glutaramides as potential antifungal prodrugs. Molecules. 2013 Sep 12; 18(9):11250-63. PMID: 24036514.
      Citations: 2     Fields:    Translation:AnimalsCells
    20. Rider MA, Zou J, Vanlandingham D, Nuckols JT, Higgs S, Zhang Q, Lacey M, Kim J, Wang G, Hong YS. Quantitative proteomic analysis of the Anopheles gambiae (Diptera: Culicidae) midgut infected with o'nyong-nyong virus. J Med Entomol. 2013 Sep; 50(5):1077-88. PMID: 24180113.
      Citations: 8     Fields:    Translation:AnimalsCells
    21. Jiang Q, Zheng S, Wang G. Development of new estrogen receptor-targeting therapeutic agents for tamoxifen-resistant breast cancer. Future Med Chem. 2013 Jun; 5(9):1023-35. PMID: 23734685.
      Citations: 9     Fields:    Translation:Humans
    22. Tilghman SL, Townley I, Zhong Q, Carriere PP, Zou J, Llopis SD, Preyan LC, Williams CC, Skripnikova E, Bratton MR, Zhang Q, Wang G. Proteomic signatures of acquired letrozole resistance in breast cancer: suppressed estrogen signaling and increased cell motility and invasiveness. Mol Cell Proteomics. 2013 Sep; 12(9):2440-55. PMID: 23704778.
      Citations: 33     Fields:    Translation:HumansCells
    23. Patel AR, Chougule MB, I T, Patlolla R, Wang G, Singh M. Efficacy of aerosolized celecoxib encapsulated nanostructured lipid carrier in non-small cell lung cancer in combination with docetaxel. Pharm Res. 2013 May; 30(5):1435-46. PMID: 23361589.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    24. Zheng S, Zhong Q, Jiang Q, Mottamal M, Zhang Q, Zhu N, Burow ME, Worthylake RA, Wang G. Discovery of a Series of Thiazole Derivatives as Novel Inhibitors of Metastatic Cancer Cell Migration and Invasion. ACS Med Chem Lett. 2013 Feb 14; 4(2):191-196. PMID: 23526571.
    25. Liu M, Wang G, Gomez-Fernandez CR, Guo S. GREB1 functions as a growth promoter and is modulated by IL6/STAT3 in breast cancer. PLoS One. 2012; 7(10):e46410. PMID: 23056300.
      Citations: 20     Fields:    Translation:HumansCells
    26. Bonvillain RW, Danchuk S, Sullivan DE, Betancourt AM, Semon JA, Eagle ME, Mayeux JP, Gregory AN, Wang G, Townley IK, Borg ZD, Weiss DJ, Bunnell BA. A nonhuman primate model of lung regeneration: detergent-mediated decellularization and initial in vitro recellularization with mesenchymal stem cells. Tissue Eng Part A. 2012 Dec; 18(23-24):2437-52. PMID: 22764775.
      Citations: 69     Fields:    Translation:AnimalsCells
    27. Abbaraju NV, Boutaghou MN, Townley IK, Zhang Q, Wang G, Cole RB, Rees BB. Analysis of tissue proteomes of the Gulf killifish, Fundulus grandis, by 2D electrophoresis and MALDI-TOF/TOF mass spectrometry. Integr Comp Biol. 2012 Nov; 52(5):626-35. PMID: 22537935.
      Citations: 3     Fields:    Translation:AnimalsCellsPHPublic Health
    28. Jiang Q, Zhong Q, Zhang Q, Zheng S, Wang G. Boron-Based 4-Hydroxytamoxifen Bioisosteres for Treatment of de Novo Tamoxifen Resistant Breast Cancer. ACS Med Chem Lett. 2012 Apr 06; 3(5):392-396. PMID: 23864928.
    29. Wang G, Ma P, Zhang Q, Lewis J, Lacey M, Furukawa Y, O'Reilly SE, Meaux S, McLachlan J, Zhang S. Endocrine disrupting chemicals in New Orleans surface waters and Mississippi Sound sediments. J Environ Monit. 2012 May; 14(5):1353-64. PMID: 22438038.
      Citations: 6     Fields:    Translation:PHPublic Health
    30. Zhou C, Zhong Q, Rhodes LV, Townley I, Bratton MR, Zhang Q, Martin EC, Elliott S, Collins-Burow BM, Burow ME, Wang G. Proteomic analysis of acquired tamoxifen resistance in MCF-7 cells reveals expression signatures associated with enhanced migration. Breast Cancer Res. 2012 Mar 14; 14(2):R45. PMID: 22417809.
      Citations: 62     Fields:    Translation:HumansCells
    31. Guo S, Liu M, Wang G, Torroella-Kouri M, Gonzalez-Perez RR. Oncogenic role and therapeutic target of leptin signaling in breast cancer and cancer stem cells. Biochim Biophys Acta. 2012 Apr; 1825(2):207-22. PMID: 22289780.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    32. Rhodes LV, Tilghman SL, Boue SM, Wang S, Khalili H, Muir SE, Bratton MR, Zhang Q, Wang G, Burow ME, Collins-Burow BM. Glyceollins as novel targeted therapeutic for the treatment of triple-negative breast cancer. Oncol Lett. 2012 Jan; 3(1):163-171. PMID: 22740874.
    33. Jiang Q, Payton-Stewart F, Elliott S, Driver J, Rhodes LV, Zhang Q, Zheng S, Bhatnagar D, Boue SM, Collins-Burow BM, Sridhar J, Stevens C, McLachlan JA, Wiese TE, Burow ME, Wang G. Effects of 7-O substitutions on estrogenic and anti-estrogenic activities of daidzein analogues in MCF-7 breast cancer cells. J Med Chem. 2010 Aug 26; 53(16):6153-63. PMID: 20669983.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    34. Zhang Q, Ma P, Cole RB, Wang G. In vitro metabolism of indomethacin morpholinylamide (BML-190), an inverse agonist for the peripheral cannabinoid receptor (CB(2)) in rat liver microsomes. Eur J Pharm Sci. 2010 Sep 11; 41(1):163-72. PMID: 20542112.
      Citations:    Fields:    Translation:AnimalsCells
    35. Zhou C, Nitschke AM, Xiong W, Zhang Q, Tang Y, Bloch M, Elliott S, Zhu Y, Bazzone L, Yu D, Weldon CB, Schiff R, McLachlan JA, Beckman BS, Wiese TE, Nephew KP, Shan B, Burow ME, Wang G. Proteomic analysis of tumor necrosis factor-alpha resistant human breast cancer cells reveals a MEK5/Erk5-mediated epithelial-mesenchymal transition phenotype. Breast Cancer Res. 2008; 10(6):R105. PMID: 19087274.
      Citations: 59     Fields:    Translation:Humans
    36. Liebl AL, Granados LH, Zhang Q, Wang G, Mielke HW, Gonzales CR, Ennis DG, Rees BB. Effects of post-Hurricane Katrina New Orleans (LA, USA) sediments on early development of the Japanese medaka (Oryzias latipes). Environ Toxicol Chem. 2008 Dec; 27(12):2557-64. PMID: 18620474.
      Citations: 2     Fields:    Translation:Animals
    37. Huang TL, Bacchi CJ, Kode NR, Zhang Q, Wang G, Yartlet N, Rattendi D, Londono I, Mazumder L, Vanden Eynde JJ, Mayence A, Donkor IO. Trypanocidal activity of piperazine-linked bisbenzamidines and bisbenzamidoxime, an orally active prodrug. Int J Antimicrob Agents. 2007 Dec; 30(6):555-61. PMID: 17920820.
      Citations: 6     Fields:    Translation:HumansAnimals
    38. Zhang Q, Ma P, Cole RB, Wang G. Identification of in vitro metabolites of JWH-015, an aminoalkylindole agonist for the peripheral cannabinoid receptor (CB2) by HPLC-MS/MS. Anal Bioanal Chem. 2006 Nov; 386(5):1345-55. PMID: 16955257.
      Citations: 14     Fields:    Translation:Cells
    39. Painter RG, Valentine VG, Lanson NA, Leidal K, Zhang Q, Lombard G, Thompson C, Viswanathan A, Nauseef WM, Wang G, Wang G. CFTR Expression in human neutrophils and the phagolysosomal chlorination defect in cystic fibrosis. Biochemistry. 2006 Aug 29; 45(34):10260-9. PMID: 16922501.
      Citations: 108     Fields:    Translation:HumansCells
    40. Zhang S, Zhang Q, Darisaw S, Ehie O, Wang G. Simultaneous quantification of polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), and pharmaceuticals and personal care products (PPCPs) in Mississippi river water, in New Orleans, Louisiana, USA. Chemosphere. 2007 Jan; 66(6):1057-69. PMID: 16884762.
      Citations: 25     Fields:    Translation:PHPublic Health
    41. Wang W, Hua Y, Wang G, Cole RB. Characterization of rat liver microsomal and hepatocytal metabolites of brevetoxins by liquid chromatography-electrospray tandem mass spectrometry. Anal Bioanal Chem. 2005 Sep; 383(1):67-75. PMID: 16059676.
      Citations: 2     Fields:    Translation:AnimalsCells
    42. Zhang Q, Ma P, Wang W, Cole RB, Wang G. In vitro metabolism of diarylpyrazoles, a novel group of cannabinoid receptor ligands. Drug Metab Dispos. 2005 Apr; 33(4):508-17. PMID: 15616153.
      Citations: 3     Fields:    Translation:AnimalsCells
    43. Mielke HW, Wang G, Gonzales CR, Powell ET, Le B, Quach VN. PAHs and metals in the soils of inner-city and suburban New Orleans, Louisiana, USA. Environ Toxicol Pharmacol. 2004 Dec; 18(3):243-7. PMID: 21782755.
      Citations: 25     Fields:    
    44. Zhang Q, Ma P, Wang W, Cole RB, Wang G. Characterization of rat liver microsomal metabolites of AM-630, a potent cannabinoid receptor antagonist, by high-performance liquid chromatography/electrospray ionization tandem mass spectrometry. J Mass Spectrom. 2004 Jun; 39(6):672-81. PMID: 15236306.
      Citations: 7     Fields:    Translation:AnimalsCells
    45. Zhang Q, Ma P, Iszard M, Cole RB, Wang W, Wang G. In vitro metabolism of R(+)-[2,3-dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo [1,2,3-de]1,4-benzoxazinyl]-(1-naphthalenyl) methanone mesylate, a cannabinoid receptor agonist. Drug Metab Dispos. 2002 Oct; 30(10):1077-86. PMID: 12228183.
      Citations: 10     Fields:    Translation:AnimalsCells
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