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Jennifer L. Barreto-Estrada

Faculty RankAssociate Professor
InstitutionUniversity of Puerto Rico
DepartmentSchool of Medicine
AddressUPR- Medical Sciences Campus
San Juan PR 936
Phone7877582525 Ext 2562
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    Dr. Jennifer L. Barreto is an Associate Professor in the Department of Anatomy and Neurobiology, School of Medicine, University of Puerto Rico Medical Sciences Campus.

    Dr. Barreto received her bachelor’s and doctoral degrees in biology from the University of Puerto Rico, Rio Piedras Campus. She conducted postdoctoral studies in neuroendocrinology at the University of Puerto Rico, Medical Sciences Campus.

    Dr. Barreto’s research studies focuses on the hormonal regulation of molecular and cellular substrates underlying socio-sexual behaviors and anxiety-related behaviors. In particular, how the abuse of anabolic androgenic steroids (AAS) affect the expression of peptidergic neuromodulators that are found in the central nervous system and that are known to be associated with different domains of behavior. Other studies seek to determine the hedonic and rewarding properties of the different classes of AAS, as well as determine the misuse and prevalence of AAS abuse among athletes and young adolescents in Puerto Rico.

    Regarding classical drugs of abuse, Dr. Barreto's laboratory studies the effect of deep brain stimulation (DBS) in morphine place preference.

    Dr. Barreto’s research has been supported by grants from the National Institutes of Health, including the NCRR-RCMI Program (2G12-RR003051and 8G12-MD007600 (RCMI: Center for Collaborative Research in Health Disparities), the NIH-NIGMS/NCRR-Clinical Research Infrastructure Initiative (P20GM103475 / P20RR016470), the RTRN Corebucks (U54MD008149) and the EARDA program (G11HD046326).

    Research Areas: Behavioral Neuroendocrinology and Addiction Biology

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Martínez-Rivera FJ, Martínez NA, Martínez M, Ayala-Pagán RN, Silva WI, Barreto-Estrada JL. Neuroplasticity transcript profile of the ventral striatum in the extinction of opioid-induced conditioned place preference. Neurobiol Learn Mem. 2019 09; 163:107031. PMID: 31173919.
      Citations: 2     Fields:    Translation:AnimalsCells
    2. Martínez-Rivera FJ, Pérez-Laspiur J, Santiago-Gascot ME, Alemán-Reyes AG, García-Santiago E, Rodríguez-Pérez Y, Calo-Guadalupe C, Otero-Pagán I, Ayala-Pagán RN, Martínez M, Cantres-Rosario YM, Meléndez LM, Barreto-Estrada JL. Differential protein expression profile in the hypothalamic GT1-7 cell line after exposure to anabolic androgenic steroids. PLoS One. 2017; 12(7):e0180409. PMID: 28719635.
      Citations:    Fields:    Translation:AnimalsCells
    3. Martínez-Rivera FJ, Barreto-Estrada JL. Reply to: Does High-Frequency Deep Brain Stimulation in Dorsal Regions of the Ventral Striatum Impair Extinction of Morphine-Induced Place Preference? Biol Psychiatry. 2018 01 01; 83(1):e21. PMID: 28673441.
      Citations:    Fields:    
    4. Martínez-Rivera FJ, Rodriguez-Romaguera J, Lloret-Torres ME, Do Monte FH, Quirk GJ, Barreto-Estrada JL. Bidirectional Modulation of Extinction of Drug Seeking by Deep Brain Stimulation of the Ventral Striatum. Biol Psychiatry. 2016 11 01; 80(9):682-690. PMID: 27449798.
      Citations: 12     Fields:    Translation:Animals
    5. Martínez-Rivera FJ, Natal-Albelo EJ, Martínez NA, Orozco-Vega RA, Muñiz-Seda OA, Barreto-Estrada JL. The effect of the anabolic steroid, nandrolone, in conditioned place preference and D1 dopamine receptor expression in adolescent and adult mice. Behav Processes. 2015 Apr; 113:81-5. PMID: 25612844.
      Citations: 4     Fields:    Translation:Animals
    6. Ramos-Pratts K, Rosa-González D, Pérez-Acevedo NL, Cintrón-López D, Barreto-Estrada JL. Sex-specific effect of the anabolic steroid, 17a-methyltestosterone, on inhibitory avoidance learning in periadolescent rats. Behav Processes. 2013 Oct; 99:73-80. PMID: 23792034.
      Citations: 4     Fields:    Translation:Animals
    7. Acevedo P, Jorge JC, Cruz-Sánchez A, Amy E, Barreto-Estrada JL. A ten-year assessment of anabolic steroid misuse among competitive athletes in Puerto Rico. West Indian Med J. 2011 Oct; 60(5):531-5. PMID: 22519228.
      Citations:    Fields:    Translation:HumansPHPublic Health
    8. Sánchez Montoya EL, Hernández L, Barreto-Estrada JL, Ortiz JG, Jorge JC. The testosterone metabolite 3a-diol enhances female rat sexual motivation when infused in the nucleus accumbens shell. J Sex Med. 2010 Nov; 7(11):3598-609. PMID: 20646182.
      Citations: 4     Fields:    Translation:Animals
    9. Parrilla-Carrero J, Figueroa O, Lugo A, García-Sosa R, Brito-Vargas P, Cruz B, Rivera M, Barreto-Estrada JL. The anabolic steroids testosterone propionate and nandrolone, but not 17alpha-methyltestosterone, induce conditioned place preference in adult mice. Drug Alcohol Depend. 2009 Feb 01; 100(1-2):122-7. PMID: 19028026.
      Citations: 12     Fields:    Translation:Animals
    10. Barreto-Estrada JL, Parrilla-Carrero J, Jorge JC. Exposure to an anabolic steroid changes female mice's sexual responses according to sex partner. J Sex Med. 2007 Jul; 4(4 Pt 1):878-85. PMID: 17419814.
      Citations: 1     Fields:    Translation:Animals
    11. Barreto-Estrada JL, Barreto J, Fortis-Santiago Y, Rivera-Ramos I, Fortis-Santiago A, Jorge JC. Modulation of affect after chronic exposure to the anabolic steroid 17alpha-methyltestosterone in adult mice. Behav Neurosci. 2004 Oct; 118(5):1071-9. PMID: 15506889.
      Citations: 15     Fields:    Translation:Animals
    12. Barreto-Estrada JL, Medina-Ortíz WE, García-Arrarás JE. The morphological and biochemical response of avian embryonic sympathoadrenal cells to nerve growth factor is developmentally regulated. Brain Res Dev Brain Res. 2003 Aug 12; 144(1):1-8. PMID: 12888213.
      Citations: 3     Fields:    Translation:AnimalsCells
    13. Ramírez-Ordóñez R, Barreto-Estrada JL, García-Arrarás JE. Growth factors effects on the expression of morphological and biochemical properties of avian embryonic sympathetic cells. Emphasis on NGF. Brain Res Dev Brain Res. 1999 Apr 12; 114(1):27-36. PMID: 10209239.
      Citations:    Fields:    Translation:AnimalsCells
    14. Barreto-Estrada JL, Medina-Vera L, De Jesús-Escobar JM, Garcia-Arrarás JE. Development of galanin- and enkephalin-like immunoreactivities in the sympathoadrenal lineage of the avian embryo. In vivo and in vitro studies. Dev Neurosci. 1997; 19(4):328-36. PMID: 9215878.
      Citations: 1     Fields:    Translation:Animals
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