My main area of interest is the mechanisms by which cancer cells become resistant to chemotherapy. My ultimate goal is to design and test small interference RNA (siRNA)-and microRNA-based therapies for advanced cancers that are resistant to current standard chemotherapy regimens.
• MicroRNA expression profiles in brain tumor patients
• Role of c-MYC in drug resistance
• Role of microRNAs in drug resistance
• Nanoliposome formulations for siRNA and miRNA-based molecules