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Eliud Hernandez

Faculty RankAssociate Professor
InstitutionUniversity of Puerto Rico
DepartmentSchool of Pharmacy
AddressUPR- Medical Sciences Campus, School of Pharmacy
Department of Pharmaceutical Sciences
San Juan PR 936
Phone7877582525 ext 5436, 1236 (lab)
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    Collapse Biography 
    Collapse awards and honors
    2013 - 2014New Investigator Award, AACP
    2017 - 20201SC2GM116712-01A1, NIH/NIGMS

    Collapse Overview 
    Collapse overview
    Dr. Hernandez-O’Farrill is Assistant Professor of Medicinal Chemistry, University of Puerto Rico, School
    of Pharmacy.
    Dr. Hernandez-O’Farrill received his BS from the Interamerican University in 1998, a PhD from University of
    Puerto Rico, Rio Piedras Campus on 2006. Post-doctoral research in Drug Discovery: Medicinal Chemistry,
    University of Puerto Rico, Medical Sciences Campus, School of Pharmacy.
    Research efforts target the synthesis of small molecule inhibitors of Rac1 as anti-invasive breast cancer
    compounds. Rho family GTPases are molecular switches that control signaling pathways regulating a myriad of cellular functions. Rac1, a Rho family member, plays a critical role in several aspects of tumorigenesis
    and cancer progression, and has been associated with the increased proliferation and invasion of several
    breast cancer cell lines. Since the activation of Rho GTPases is controlled by guanine nucleotide exchange
    factors (GEFs), inhibition of the interaction of Rac with its GEFs is a targeted strategy for blocking Rac activation.
    Dr. Hernández-O’Farrill’s research is supported by institutional matching funds from the NCRR-RCMI Program at the UPR-Medical Sciences Campus for the project: “Small Molecule Inhibitors of Rac1 as AntiInvasive Breast Cancer Compounds”.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mendez B, Reyes J, Conde I, Ramos Z, Lozada E, Cruz AM, Asencio G, Carvajal A, Dharmawardhane S, Piñero-Cruz DM, Hernández E, Vivas P, Ospina CA. Simalikalactone D, a Potential Anticancer Compound from Simarouba tulae, an Endemic Plant of Puerto Rico. Plants (Basel). 2020 Jan 11; 9(1). PMID: 31940804.
    2. Maldonado MDM, Rosado-González G, Bloom J, Duconge J, Ruiz-Calderón JF, Hernández-O'Farrill E, Vlaar C, Rodríguez-Orengo JF, Dharmawardhane S. Pharmacokinetics of the Rac/Cdc42 Inhibitor MBQ-167 in Mice by Supercritical Fluid Chromatography-Tandem Mass Spectrometry. ACS Omega. 2019 Nov 05; 4(19):17981-17989. PMID: 31720502.
    3. Claudio-Campos K, Moneró-Paredes M, Hernández E, Renta J, Duconge J. Low-frequency variants at the CYP2C9 locus among Puerto Rican patients on warfarin: in silico predictions of functionality and conservation. Pharmacogenomics. 2019 08; 20(12):891-902. PMID: 31453773.
      Citations:    Fields:    Translation:HumansCTClinical Trials
    4. Butler-Fernández KM, Ramos Z, Francis-Malavé AM, Bloom J, Dharmawardhane S, Hernández E. Synthesis, Anti-Cancer and Anti-Migratory Evaluation of 3,6-Dibromocarbazole and 5-Bromoindole Derivatives. Molecules. 2019 Jul 24; 24(15). PMID: 31344865.
      Citations:    Fields:    Translation:HumansCells
    5. Vlaar CP, Castillo-Pichardo L, Medina JI, Marrero-Serra CM, Vélez E, Ramos Z, Hernández E. Design, synthesis and biological evaluation of new carbazole derivatives as anti-cancer and anti-migratory agents. Bioorg Med Chem. 2018 02 15; 26(4):884-890. PMID: 29358027.
      Citations: 1     Fields:    Translation:HumansCells
    6. Humphries-Bickley T, Castillo-Pichardo L, Hernandez-O'Farrill E, Borrero-Garcia LD, Forestier-Roman I, Gerena Y, Blanco M, Rivera-Robles MJ, Rodriguez-Medina JR, Cubano LA, Vlaar CP, Dharmawardhane S. Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer. . 2017 05; 16(5):805-818. PMID: 28450422.
    7. Humphries-Bickley T, Castillo-Pichardo L, Corujo-Carro F, Duconge J, Hernandez-O'Farrill E, Vlaar C, Rodriguez-Orengo JF, Cubano L, Dharmawardhane S. Pharmacokinetics of Rac inhibitor EHop-016 in mice by ultra-performance liquid chromatography tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Feb 15; 981-982:19-26. PMID: 25594952.
      Citations: 9     Fields:    Translation:Animals
    8. Castillo-Pichardo L, Humphries-Bickley T, De La Parra C, Forestier-Roman I, Martinez-Ferrer M, Hernandez E, Vlaar C, Ferrer-Acosta Y, Washington AV, Cubano LA, Rodriguez-Orengo J, Dharmawardhane S. The Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model. Transl Oncol. 2014 Oct; 7(5):546-55. PMID: 25389450.
    9. Dharmawardhane S, Hernandez E, Vlaar C. Development of EHop-016: a small molecule inhibitor of Rac. Enzymes. 2013; 33 Pt A:117-46. PMID: 25033803.
      Citations: 7     Fields:    Translation:HumansAnimals
    10. Suranganie Dharmawardhane, Eliud Hernández, Cornelis P. Vlaar. Development of EHop-016: A Small Molecule Inhibitor of Rac. The Enzymes. 2013; Vol. 33:117-146. View Publication.
    11. Eliud Hernandez, Cornelis Vlaar and Suranganie Dharmawardhane. Novel Small-Molecule Inhibitors of Rac1 in Metastatic Breast Cancer. 2013.
    12. Montalvo-Ortiz BL, Castillo-Pichardo L, Hernández E, Humphries-Bickley T, De la Mota-Peynado A, Cubano LA, Vlaar CP, Dharmawardhane S. Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase. J Biol Chem. 2012 Apr 13; 287(16):13228-38. PMID: 22383527.
      Citations: 77     Fields:    Translation:HumansCells
    13. Hernández E, De La Mota-Peynado A, Dharmawardhane S, Vlaar CP. Novel inhibitors of Rac1 in metastatic breast cancer. P R Health Sci J. 2010 Dec; 29(4):348-56. PMID: 21261173.
      Citations: 16     Fields:    Translation:HumansCells
    14. Hernández E, Vélez JM, Vlaar CP. Synthesis of 1,4-dihydro-benzo[d][1,3]oxazin-2-ones from phthalides via an aminolysis-Hofmann rearrangement protocol. Tetrahedron Lett. 2007 Dec 17; 48(51):8972-8975. PMID: 19096499.
      Citations: 1     Fields:    
    15. Hernandez E, Burgos CH, Alicea E, Soderquist JA. B-allenyl- and B-(gamma-trimethylsilylpropargyl)-10-phenyl-9-borabicyclo[3.3.2]decanes: asymmetric synthesis of propargyl and alpha-allenyl 3-degree-carbinols from ketones. Org Lett. 2006 Aug 31; 8(18):4089-91. PMID: 16928081.
      Citations: 9     Fields:    Translation:Cells
    16. Canales E, Hernandez E, Soderquist JA. Nonracemic 3 degrees-carbamines from the asymmetric allylboration of N-trimethylsilyl ketimines with B-allyl-10-phenyl-9-borabicyclo[3.3.2]decanes. J Am Chem Soc. 2006 Jul 12; 128(27):8712-3. PMID: 16819848.
      Citations: 4     Fields:    Translation:Cells
    17. Hernandez E, Soderquist JA. Nonracemic alpha-allenyl carbinols from asymmetric propargylation with the 10-trimethylsilyl-9-borabicyclo[3.3.2]decanes. Org Lett. 2005 Nov 24; 7(24):5397-400. PMID: 16288515.
      Citations: 4     Fields:    Translation:Cells
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