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Walter I. Silva- Ortiz

Faculty RankProfessor
InstitutionUniversity of Puerto Rico
DepartmentSchool of Medicine
AddressUPR-Medical Sciences Campus, School of Medicine
San Juan PR 936
Phone7877582525 ext. 1608
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    In general terms my laboratory is interested in the cellular and molecular physiology of vascular and brain cells. Using cultured cells from vascular and brain tissue as models systems, we are focusing our efforts in understanding the role of subcellular transport vesicles in the transport of neuropeptide processing enzymes, and in the cellular level effects of the polyether marine toxins (brevetoxins, saxitoxins, ciguatoxins, and maitotoxins). In addition, the laboratory also studies the role of the recently characterized caveolae and their constituent caveolins in the differentiation of cultured vascular smooth muscle cells, and C6 glial cells. In the first area of interest the fundamental premise is forwarded that the peripheral and central effects of these marine neurotoxins are intimately linked to subcellular transport pathways and the signal transduction compartments that these define, i.e. the caveolar signal transduction compartment. This subcellular level approach shall provide an enhanced understanding of the mechanisms of action and the pathophysiology of the toxicity ensued by these toxins. On the second hand, the possibility is explored that the peripheral and central actions of neuropeptides (NP) are intimately linked to the expression of NP processing enzymes (NPE) in two coated vesicular transport organelles, clathrin coated vesicles (CCV) and caveolae (CAV). The main trust of this project rests on the opportunity to expand our fundamental knowledge on neuropeptide expression and function, and in providing a groundwork for understanding the subcellular basis of the regulation of NPE expression, both centrally and peripherally. Last but not least, our laboratory has recently succeeded in the initial characterization of caveolae and caveolins in C6 glial cells. These findings are particularly significant in relationship to the establishment of a model system to study the relevance of the caveolae compartment to signal transduction pathways in glial cells, and their fundamental relevance to the differentiation of these brain cells.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Santiago JM, Torrado AI, Arocho LC, Rosas OR, Rodríguez AE, Toro FK, Salgado IK, Torres YA, Silva WI, Miranda JD. Expression profile of flotillin-2 and its pathophysiological role after spinal cord injury. J Mol Neurosci. 2013 Feb; 49(2):347-59. PMID: 22878913.
      Citations: 1     Fields:    Translation:AnimalsCells
    2. Salgado IK, Serrano M, García JO, Martínez NA, Maldonado HM, Báez-Pagán CA, Lasalde-Dominicci JA, Silva WI. SorLA in glia: shared subcellular distribution patterns with caveolin-1. Cell Mol Neurobiol. 2012 Apr; 32(3):409-21. PMID: 22127416.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    3. Nieves-Cintrón M, Caballero-Rivera D, Silva WI, Navedo MF, Lasalde-Dominicci JA. Functional contribution of alpha3L8' to the neuronal nicotinic alpha3 receptor. J Neurosci Res. 2008 Oct; 86(13):2884-94. PMID: 18615639.
      Citations:    Fields:    Translation:AnimalsCells
    4. Báez-Pagán CA, Martínez-Ortiz Y, Otero-Cruz JD, Salgado-Villanueva IK, Velázquez G, Ortiz-Acevedo A, Quesada O, Silva WI, Lasalde-Dominicci JA. Potential role of caveolin-1-positive domains in the regulation of the acetylcholine receptor's activatable pool: implications in the pathogenesis of a novel congenital myasthenic syndrome. Channels (Austin). 2008 May-Jun; 2(3):180-90. PMID: 18836288.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    5. Sanabria P, Ross E, Ramirez E, Colon K, Hernandez M, Maldonado HM, Silva WI, Jimenez-Rivera CA, Gonzalez FA. P2Y2 receptor desensitization on single endothelial cells. Endothelium. 2008 Jan-Feb; 15(1):43-51. PMID: 18568944.
      Citations:    Fields:    Translation:HumansAnimalsCells
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