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José R. Rodríguez-Medina

Faculty RankProfessor and Chair
InstitutionUniversity of Puerto Rico
DepartmentSchool of Medicine
AddressUPR-Medical Sciences Campus, School of Medicine
San Juan PR 936
Phone7877582525 ext 2299
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    José R. Rodríguez-Medina has been an independent investigator in the field of molecular biology of yeast for the past 27 years while serving as a member of the Department of Biochemistry at the University of Puerto Rico Medical Sciences Campus (UPR-MSC) in San Juan, P.R. He currently serves Professor and Chair of the Department of Biochemistry and as Associate Director of Research, Compliance and Development for the UPR Medical Sciences Campus. He is also Program Director of the NIGMS Puerto Rico IDeA Networks for Biomedical Research Excellence (PR-INBRE) and supervises several instrumentation cores for the NIMHD RCMI Program and the Puerto Rico Clinical and Translational Research Consortium (PRCTRC) at UPR-MSC. His research has been focused on topics related to myosin type II and associated cell wall phenotypes of myosin II-deficient (myo1delta) yeast strains, gene expression profiling of these strains, and the mechanism of stress signaling, particularly through the PKC1 pathway, in the response to heat shock and cell wall stress. He has supervised 11 Ph.D. student dissertations during his 27-year career.

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Martínez-Matías N, Chorna N, González-Crespo S, Villanueva L, Montes-Rodríguez I, Melendez-Aponte LM, Roche-Lima A, Carrasquillo-Carrión K, Santiago-Cartagena E, Rymond BC, Babu M, Stagljar I, Rodríguez-Medina JR. Toward the discovery of biological functions associated with the mechanosensor Mtl1p of Saccharomyces cerevisiae via integrative multi-OMICs analysis. Sci Rep. 2021 Apr 01; 11(1):7411. PMID: 33795741.
      Citations:    Fields:    
    2. Vélez-Segarra V, González-Crespo S, Santiago-Cartagena E, Vázquez-Quiñones LE, Martínez-Matías N, Otero Y, Zayas JJ, Siaca R, Del Rosario J, Mejías I, Aponte JJ, Collazo NC, Lasso FJ, Snider J, Jessulat M, Aoki H, Rymond BC, Babu M, Stagljar I, Rodríguez-Medina JR. Protein Interactions of the Mechanosensory Proteins Wsc2 and Wsc3 for Stress Resistance in Saccharomyces cerevisiae. G3 (Bethesda). 2020 09 02; 10(9):3121-3135. PMID: 32641451.
      Citations: 1     Fields:    
    3. Santiago-Cartagena E, González-Crespo S, Vélez V, Martínez N, Snider J, Jessulat M, Aoki H, Minic Z, Akamine P, Mejías I, Pérez LM, Rymond BC, Babu M, Stagljar I, Rodríguez-Medina JR. Identification and Functional Testing of Novel Interacting Protein Partners for the Stress Sensors Wsc1p and Mid2p of Saccharomyces cerevisiae. G3 (Bethesda). 2019 04 09; 9(4):1085-1102. PMID: 30733383.
      Citations: 2     Fields:    Translation:AnimalsCells
    4. Vélez-Segarra V, Carrasquillo-Carrión K, Santini-González JJ, Ramos-Valerio YA, Vázquez-Quiñones LE, Roche-Lima A, Rodríguez-Medina JR, Parés-Matos EI. Modelling and molecular docking studies of the cytoplasmic domain of Wsc-family, full-length Ras2p, and therapeutic antifungal compounds. Comput Biol Chem. 2019 Feb; 78:338-352. PMID: 30654316.
      Citations:    Fields:    Translation:Animals
    5. Martínez-Matías N, Rodríguez-Medina JR. Fundamental Concepts of Azole Compounds and Triazole Antifungals: A Beginner's Review. P R Health Sci J. 2018 09; 37(3):135-142. PMID: 30188556.
      Citations: 4     Fields:    Translation:HumansAnimals
    6. Rivera-Robles MJ, Medina-Velázquez J, Asencio-Torres GM, González-Crespo S, Rymond BC, Rodríguez-Medina J, Dharmawardhane S. Targeting Cdc42 with the anticancer compound MBQ-167 inhibits cell polarity and growth in the budding yeast S. cerevisiae. Small GTPases. 2020 11; 11(6):430-440. PMID: 29969362.
      Citations: 2     Fields:    
    7. Santiago E, Akamine P, Snider J, Wong V, Jessulat M, Deineko V, Gagarinova A, Aoki H, Minic Z, Phanse S, San Antonio A, Cubano LA, Rymond BC, Babu M, Stagljar I, Rodriguez-Medina JR. Novel Interactome of Saccharomyces cerevisiae Myosin Type II Identified by a Modified Integrated Membrane Yeast Two-Hybrid (iMYTH) Screen. G3 (Bethesda). 2016 05 03; 6(5):1469-74. PMID: 26921299.
      Citations: 1     Fields:    Translation:Animals
    8. Morales-Vásquez L, Miranda-Avalo EI, Rodríguez-Medina JR, Quiñones-Badillo Y, Marqués-Lespier J, Muñoz-Acabá J, Pastrana R, Pérez-Cardona CM, Yamamura Y, Torres EA. Demographics, clinical characteristics, IFNL3- and IFNL4- polymorphisms in a cohort of hepatitis C patients from Puerto Rico. P R Health Sci J. 2014 Dec; 33(4):177-83. PMID: 25563035.
      Citations: 1     Fields:    Translation:Humans
    9. Pagán-Mercado G, Santiago-Cartagena E, Akamine P, Rodríguez-Medina JR. Functional and genetic interactions of TOR in the budding yeast Saccharomyces cerevisiae with myosin type II-deficiency (myo1?). BMC Cell Biol. 2012 May 30; 13:13. PMID: 22646158.
      Citations: 1     Fields:    Translation:AnimalsCells
    10. Rivera-Ruiz ME, Rodríguez-Quiñones JF, Akamine P, Rodríguez-Medina JR. Post-transcriptional regulation in the myo1? mutant of Saccharomyces cerevisiae. BMC Genomics. 2010 Dec 02; 11:690. PMID: 21126371.
      Citations: 4     Fields:    Translation:AnimalsCells
    11. Franco HL, Casasnovas J, Rodríguez-Medina JR, Cadilla CL. Redundant or separate entities?--roles of Twist1 and Twist2 as molecular switches during gene transcription. Nucleic Acids Res. 2011 Mar; 39(4):1177-86. PMID: 20935057.
      Citations: 63     Fields:    Translation:AnimalsCells
    12. Pagán-Mercado G, Rivera-Ruiz ME, Segarra-Román F, Rodríguez-Medina JR. Antifungal research strategies aiming for new targets. P R Health Sci J. 2009 Sep; 28(3):220-6. PMID: 19715114.
      Citations: 2     Fields:    Translation:AnimalsCells
    13. Rodríguez-Quiñones JF, Rodríguez-Medina JR. Differential gene expression signatures for cell wall integrity found in chitin synthase II (chs2Delta) and myosin II (myo1Delta) deficient cytokinesis mutants of Saccharomyces cerevisiae. BMC Res Notes. 2009 May 09; 2:87. PMID: 19426543.
      Citations: 5     Fields:    
    14. Rodríguez-Quiñones JF, Irizarry RA, Díaz-Blanco NL, Rivera-Molina FE, Gómez-Garzón D, Rodríguez-Medina JR. Global mRNA expression analysis in myosin II deficient strains of Saccharomyces cerevisiae reveals an impairment of cell integrity functions. BMC Genomics. 2008 Jan 23; 9:34. PMID: 18215314.
      Citations: 10     Fields:    Translation:AnimalsCells
    15. Díaz-Blanco NL, Rodríguez-Medina JR. Dosage rescue by UBC4 restores cell wall integrity in Saccharomyces cerevisiae lacking the myosin type II gene MYO1. Yeast. 2007 Apr; 24(4):343-55. PMID: 17397110.
      Citations: 7     Fields:    Translation:AnimalsCells
    16. Rivera-Molina FE, González-Crespo S, Maldonado-De la Cruz Y, Ortiz-Betancourt JM, Rodríguez-Medina JR. 2,3-Butanedione monoxime increases sensitivity to Nikkomycin Z in the budding yeast Saccharomyces cerevisiae. World J Microbiol Biotechnol. 2006 Mar; 22(3):255-260. PMID: 25382940.
      Citations: 4     Fields:    
    17. F. E. Rivera-Molina, Y. Maldonado-De la Cruz, J. M. Ortiz-Betancourt and J.R. Rodríguez-Medina. 2,3-butanedione monoxime increases sensitivity to nikkomycin Z in the budding yeast Saccharomyces cerevisiae. World J Microbiol Biotechnol. 2006; 3(22):255-260.
    18. F. E. Rivera-Molina, N. L. Díaz-Blanco, J. F. Rodríguez-Quiñones, and J. R. Rodríguez-Medina. Interplay between the protein recycling pathway and susceptibility to nikkomycin Z in the budding yeast Saccharomyces cerevisiae. Recent Res. Devel. Mol. and Cell. Biol., 6:109-120, ISBN:81-308-0131-0. 2006; 3:109-120.
    19. Santana JL, Rodríguez-Medina JR, Rodríguez-Orengo JF. Clinical challenges and controversies in the management of HIV/ HCV-coinfected individuals. P R Health Sci J. 2004 Jun; 23(2 Suppl):35-40. PMID: 16929585.
      Citations: 2     Fields:    Translation:Humans
    20. Jiang L, Whiteway M, Ramos Cw, Rodriguez-Medina JR, Shen SH. The YHR076w gene encodes a type 2C protein phosphatase and represents the seventh PP2C gene in budding yeast. FEBS Lett. 2002 Sep 11; 527(1-3):323-5. PMID: 12220683.
      Citations: 7     Fields:    Translation:Cells
    21. Espino AM, Rodríguez Medina JR, Hillyer GV. Isolation and immunological characterization of fatty acid binding protein isoforms from Fasciola hepatica. J Parasitol. 2001 Oct; 87(5):1028-33. PMID: 11695360.
      Citations: 6     Fields:    Translation:Animals
    22. Cruz JA, Garcia R, Rodriguez-Orengo JF, Rodriguez-Medina JR. Increased chitin synthesis in response to type II myosin deficiency in Saccharomyces cerevisiae. Mol Cell Biol Res Commun. 2000 Jan; 3(1):20-5. PMID: 10683313.
      Citations: 5     Fields:    Translation:AnimalsCells
    23. Castro F, Santaella M, Torres EA, Rodriguez-Medina JR, González-Keelan C. Sustained response to interferon in a patient with common variable immunodeficiency and hepatitis C. Am J Gastroenterol. 1997 Sep; 92(9):1557-8. PMID: 9317087.
      Citations:    Fields:    Translation:HumansCellsPHPublic Health
    24. Negron JA, Gonzalez S, Rodriguez-Medina JR. In vivo phosphorylation of type II myosin in Saccharomyces cerevisiae. Biochem Biophys Res Commun. 1996 Apr 25; 221(3):515-20. PMID: 8629993.
      Citations: 3     Fields:    Translation:AnimalsCells
    25. Muro A, Martin FS, Rodriguez-Medina JR, Hillyer GV. Identification of genes that encode Fasciola-specific arc 2 antigens. Am J Trop Med Hyg. 1994 Nov; 51(5):684-9. PMID: 7985762.
      Citations:    Fields:    Translation:Animals
    26. Rodriguez-Medina JR, Rymond BC. Prevalence and distribution of introns in non-ribosomal protein genes of yeast. Mol Gen Genet. 1994 Jun 03; 243(5):532-9. PMID: 7911556.
      Citations: 9     Fields:    Translation:AnimalsCells
    27. Muro A, Rodriguez-Medina JR, Hillyer GV. Sequence analysis of a Fasciola hepatica glutathione S-transferase cDNA clone. Am J Trop Med Hyg. 1993 Mar; 48(3):457-63. PMID: 7682383.
      Citations: 1     Fields:    Translation:AnimalsCells
    28. Rodriguez JR, Paterson BM. Yeast myosin heavy chain mutant: maintenance of the cell type specific budding pattern and the normal deposition of chitin and cell wall components requires an intact myosin heavy chain gene. Cell Motil Cytoskeleton. 1990; 17(4):301-8. PMID: 2076546.
      Citations: 45     Fields:    Translation:AnimalsCells
    29. Jacquier A, Rodriguez JR, Rosbash M. A quantitative analysis of the effects of 5' junction and TACTAAC box mutants and mutant combinations on yeast mRNA splicing. Cell. 1985 Dec; 43(2 Pt 1):423-30. PMID: 3935321.
      Citations: 53     Fields:    Translation:AnimalsCells
    30. Rodriguez JR, Pikielny CW, Rosbash M. In vivo characterization of yeast mRNA processing intermediates. Cell. 1984 Dec; 39(3 Pt 2):603-10. PMID: 6096013.
      Citations: 53     Fields:    Translation:AnimalsCells
    31. Teem JL, Rodriguez JR, Tung L, Rosbash M. The rna2 mutation of yeast affects the processing of actin mRNA as well as ribosomal protein mRNAs. Mol Gen Genet. 1983; 192(1-2):101-3. PMID: 6358792.
      Citations: 10     Fields:    Translation:AnimalsCells
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