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Carlos Jiménez

Faculty RankAssociate Professor
InstitutionUniversity of Puerto Rico
DepartmentSchool of Medicine
AddressUPR-Medical Sciences Campus, School of Medicine
San Juan PR 936
Phone7877582525 ext. 1676
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    My laboratory is interested in the role of the central synaptic and intrinsic neuronal properties in cocaine addiction. Our recent work investigates the role of the protein kinase M zeta (PKM) and the Ih current in the development of cocaine sensitization, a progressive and lasting enhancement in the motor stimulant effect induced by a subsequent drug challenge. Experiments include the use of animal models, western blots, systemic and intracranial administration of agonists and antagonists together with in vivo behavioral recordings. Whole cell patch clamp neurophysiologic recording techniques in in vitro brain slices are also employed to understand the basic biophysical mechanisms of cocaine addiction. The completion of these investigations will provide important information of whether a dysfunction of these modulatory properties are important factosr in the development of cocaine addiction and could suggest possible avenues for therapeutic pharmacological interventions.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Monzón Daza G, Meneses Macías C, Forero AM, Rodríguez J, Aragón M, Jiménez C, Ramos FA, Castellanos L. Identification of a-Amylase and a-Glucosidase Inhibitors and Ligularoside A, a New Triterpenoid Saponin from Passiflora ligularis Juss (Sweet Granadilla) Leaves, by a Nuclear Magnetic Resonance-Based Metabolomic Study. J Agric Food Chem. 2021 Mar 10; 69(9):2919-2931. PMID: 33621072.
      Citations:    Fields:    
    2. Galvis F, Ageitos L, Martínez-Matamoros D, Barja JL, Rodríguez J, Lemos ML, Jiménez C, Balado M. The marine bivalve molluscs pathogen Vibrio neptunius produces the siderophore amphibactin, which is widespread in molluscs microbiota. Environ Microbiol. 2020 12; 22(12):5467-5482. PMID: 33169914.
      Citations:    Fields:    Translation:AnimalsCells
    3. París-Coderch L, Soriano A, Jiménez C, Erazo T, Muñoz-Guardiola P, Masanas M, Antonelli R, Boloix A, Alfón J, Pérez-Montoyo H, Yeste-Velasco M, Domènech C, Roma J, Sánchez de Toledo J, Moreno L, Lizcano JM, Gallego S, Segura MF. The antitumour drug ABTL0812 impairs neuroblastoma growth through endoplasmic reticulum stress-mediated autophagy and apoptosis. Cell Death Dis. 2020 09 17; 11(9):773. PMID: 32943619.
      Citations:    Fields:    
    4. Antonelli R, Jiménez C, Riley M, Servidei T, Riccardi R, Soriano A, Roma J, Martínez-Saez E, Martini M, Ruggiero A, Moreno L, Sánchez de Toledo J, Gallego S, Bové J, Hooker JM, Segura MF. CN133, a Novel Brain-Penetrating Histone Deacetylase Inhibitor, Hampers Tumor Growth in Patient-Derived Pediatric Posterior Fossa Ependymoma Models. Cancers (Basel). 2020 Jul 16; 12(7). PMID: 32708733.
    5. Vargas MB, Cárdenas DE, Jiménez C, García AE. WITHDRAWN: Noncaseating granuloma as first manifestation of rheumatoid arthritis: a case report. Reumatol Clin. 2020 Jul 15. PMID: 32819854.
      Citations:    Fields:    
    6. Barreiro E, Jiménez C, García de Pedro J, Ramírez Prieto MT. COVID-19 and xxi Century Pulmonology: Challenge or Opportunity? Arch Bronconeumol. 2020 07; 56(7):411-412. PMID: 32405135.
      Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
    7. Boloix A, Masanas M, Jiménez C, Antonelli R, Soriano A, Roma J, Sánchez de Toledo J, Gallego S, Segura MF. Long Non-coding RNA PVT1 as a Prognostic and Therapeutic Target in Pediatric Cancer. Front Oncol. 2019; 9:1173. PMID: 31781490.
    8. Ruiz P, Balado M, Fuentes-Monteverde JC, Toranzo AE, Rodríguez J, Jiménez C, Avendaño-Herrera R, Lemos ML. The Fish Pathogen Vibrio ordalii Under Iron Deprivation Produces the Siderophore Piscibactin. Microorganisms. 2019 Sep 03; 7(9). PMID: 31484388.
    9. Majem B, Parrilla A, Jiménez C, Suárez-Cabrera L, Barber M, Marín A, Castellví J, Tamayo G, Moreno-Bueno G, Ponce J, Matias-Guiu X, Alameda F, Romero I, Sánchez JL, Pérez-Benavente A, Moran S, Esteller M, Reventós J, Rigau M, Gil-Moreno A, Segura MF, Santamaría A. MicroRNA-654-5p suppresses ovarian cancer development impacting on MYC, WNT and AKT pathways. Oncogene. 2019 08; 38(32):6035-6050. PMID: 31278368.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    10. Pérez-Sáez MJ, Lafuente Covarrubias O, Hernández D, Moreso F, Melilli E, Juega J, de Sousa E, López-Sánchez P, Rodríguez-Ferrero ML, Maruri-Kareaga N, Navarro MD, Valero R, Mazuecos MA, Llamas F, Martín-Moreno P, Fernández-García A, Espí J, Jiménez C, Ramos A, Gavela E, Pascual J, Portolés JM. Early outcomes of kidney transplantation from elderly donors after circulatory death (GEODAS study). BMC Nephrol. 2019 06 26; 20(1):233. PMID: 31242927.
      Citations: 1     Fields:    Translation:Humans
    11. Soriano A, Masanas M, Boloix A, Masiá N, París-Coderch L, Piskareva O, Jiménez C, Henrich KO, Roma J, Westermann F, Stallings RL, Sábado C, de Toledo JS, Santamaria A, Gallego S, Segura MF. Functional high-throughput screening reveals miR-323a-5p and miR-342-5p as new tumor-suppressive microRNA for neuroblastoma. Cell Mol Life Sci. 2019 Jun; 76(11):2231-2243. PMID: 30770954.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    12. Puig-Gay N, Jacobs-Cacha C, Sellarès J, Guirado L, González Roncero F, Jiménez C, Zárraga S, Paul J, Lauzurica R, Alonso Á, Fernández A, Beneyto I, Mazuecos A, Hernández D, Rodriguez-Benot A, Franco A, Jimeno L, Crespo M, Meseguer A, Moreso F, Seron D, Lopez-Hellin J, Cantarell C. Apolipoprotein A-Ib as a biomarker of focal segmental glomerulosclerosis recurrence after kidney transplantation: diagnostic performance and assessment of its prognostic value - a multi-centre cohort study. Transpl Int. 2019 03; 32(3):313-322. PMID: 30411406.
      Citations: 7     Fields:    Translation:Humans
    13. Jubierre L, Jiménez C, Rovira E, Soriano A, Sábado C, Gros L, Llort A, Hladun R, Roma J, Toledo JS, Gallego S, Segura MF. Targeting of epigenetic regulators in neuroblastoma. Exp Mol Med. 2018 04 27; 50(4):1-12. PMID: 29700278.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    14. Lara GAG, Zúñiga JO, Pérez OC, Solís SH, Jiménez CEP, Méndez MC. Predictors of suicidal ideation and depressive symptoms among adolescents in Chiapas, Mexico. Cien Saude Colet. 2018 Apr; 23(4):1089-1096. PMID: 29694595.
      Citations: 1     Fields:    Translation:Humans
    15. Bernal CA, Castellanos L, Aragón DM, Martínez-Matamoros D, Jiménez C, Baena Y, Ramos FA. Peruvioses A to F, sucrose esters from the exudate of Physalis peruviana fruit as a-amylase inhibitors. Carbohydr Res. 2018 May 22; 461:4-10. PMID: 29549750.
      Citations: 2     Fields:    Translation:Animals
    16. Gasulla F, Barreno E, Parages ML, Cámara J, Jiménez C, Dörmann P, Bartels D. The Role of Phospholipase D and MAPK Signaling Cascades in the Adaption of Lichen Microalgae to Desiccation: Changes in Membrane Lipids and Phosphoproteome. Plant Cell Physiol. 2016 Sep; 57(9):1908-20. PMID: 27335354.
      Citations: 5     Fields:    Translation:AnimalsCells
    17. Jiménez C, Ellahioui Y, Álvarez R, Aramburu L, Riesco A, González M, Vicente A, Dahdouh A, Ibn Mansour A, Jiménez C, Martín D, Sarmiento RG, Medarde M, Caballero E, Peláez R. Exploring the size adaptability of the B ring binding zone of the colchicine site of tubulin with para-nitrogen substituted isocombretastatins. Eur J Med Chem. 2015 Jul 15; 100:210-22. PMID: 26092446.
      Citations: 1     Fields:    Translation:HumansCells
    18. Figueroa L, Jiménez C, Rodríguez J, Areche C, Chávez R, Henríquez M, de la Cruz M, Díaz C, Segade Y, Vaca I. 3-Nitroasterric Acid Derivatives from an Antarctic Sponge-Derived Pseudogymnoascus sp. Fungus. J Nat Prod. 2015 Apr 24; 78(4):919-23. PMID: 25732560.
      Citations: 11     Fields:    Translation:AnimalsCells
    19. Núñez-Pons L, Nieto RM, Avila C, Jiménez C, Rodríguez J. Mass spectrometry detection of minor new meridianins from the Antarctic colonial ascidians Aplidium falklandicum and Aplidium meridianum. J Mass Spectrom. 2015 Jan; 50(1):103-11. PMID: 25601681.
      Citations: 2     Fields:    Translation:AnimalsCells
    20. Gordillo FJ, Aguilera J, Wiencke C, Jiménez C. Ocean acidification modulates the response of two Arctic kelps to ultraviolet radiation. . 2015 Jan 15; 173:41-50. PMID: 25462077.
    21. Velásquez-Martínez MC, Vázquez-Torres R, Rojas LV, Sanabria P, Jiménez-Rivera CA. Alpha-1 adrenoreceptors modulate GABA release onto ventral tegmental area dopamine neurons. Neuropharmacology. 2015 Jan; 88:110-21. PMID: 25261018.
      Citations: 9     Fields:    Translation:AnimalsCells
    22. Pardo-Vargas A, de Barcelos Oliveira I, Stephens PR, Cirne-Santos CC, de Palmer Paixão IC, Ramos FA, Jiménez C, Rodríguez J, Resende JA, Teixeira VL, Castellanos L. Dolabelladienols A-C, new diterpenes isolated from Brazilian brown alga Dictyota pfaffii. Mar Drugs. 2014 Jul 23; 12(7):4247-59. PMID: 25056631.
      Citations: 6     Fields:    Translation:AnimalsCells
    23. Rodríguez J, Nieto RM, Blanco M, Valeriote FA, Jiménez C, Crews P. Thelepamide: an unprecedented ketide-amino acid from Thelepus crispus, a marine annelid worm. Org Lett. 2014 Jan 17; 16(2):464-7. PMID: 24359301.
      Citations:    Fields:    Translation:HumansAnimalsCells
    24. Pascual J, Jiménez C, Franco A, Gil M, Obrador-Mulet AR, Gentil MA, Romero R, Grinyó JM, Hernández D, Morales JM, Pallardó LM, Serón D, Arias M, Campistol JM. Early-onset anemia after kidney transplantation is an independent factor for graft loss: a multicenter, observational cohort study. Transplantation. 2013 Oct 27; 96(8):717-25. PMID: 23896555.
      Citations: 2     Fields:    Translation:Humans
    25. Vélez-Hernández ME, Vázquez-Torres R, Velasquez-Martinez MC, Jiménez L, Báez F, Sacktor TC, Jiménez-Rivera CA. Inhibition of Protein kinase Mzeta (PKM?) in the mesolimbic system alters cocaine sensitization in rats. J Drug Alcohol Res. 2013 Jul 01; 2:235669. PMID: 24729912.
    26. Inyushin MU, Arencibia-Albite F, de la Cruz A, Vázquez-Torres R, Colon K, Sanabria P, Jiménez-Rivera CA. New method to visualize neurons with DAT in slices of rat VTA using fluorescent substrate for DAT, ASP+ J Neurosci Neuroeng. 2013 Apr; 2(2):98-103. PMID: 24052926.
    27. Santos-Vera B, Vázquez-Torres R, Marrero HG, Acevedo JM, Arencibia-Albite F, Vélez-Hernández ME, Miranda JD, Jiménez-Rivera CA. Cocaine sensitization increases I h current channel subunit 2 (HCN2) protein expression in structures of the mesocorticolimbic system. J Mol Neurosci. 2013 May; 50(1):234-45. PMID: 23203153.
      Citations: 4     Fields:    Translation:Animals
    28. Souto A, Montaos MA, Balado M, Osorio CR, Rodríguez J, Lemos ML, Jiménez C. Synthesis and antibacterial activity of conjugates between norfloxacin and analogues of the siderophore vanchrobactin. Bioorg Med Chem. 2013 Jan 01; 21(1):295-302. PMID: 23182214.
      Citations: 4     Fields:    Translation:AnimalsCells
    29. Jiménez-Rivera CA, Figueroa J, Vázquez-Torres R, Vélez-Hernandez ME, Schwarz D, Velásquez-Martinez MC, Arencibia-Albite F. Presynaptic inhibition of glutamate transmission by a2 receptors in the VTA. Eur J Neurosci. 2012 May; 35(9):1406-15. PMID: 22564071.
      Citations: 11     Fields:    Translation:AnimalsCells
    30. Conde E, Alegre L, Blanco-Sánchez I, Sáenz-Morales D, Aguado-Fraile E, Ponte B, Ramos E, Sáiz A, Jiménez C, Ordoñez A, López-Cabrera M, del Peso L, de Landázuri MO, Liaño F, Selgas R, Sanchez-Tomero JA, García-Bermejo ML. Hypoxia inducible factor 1-alpha (HIF-1 alpha) is induced during reperfusion after renal ischemia and is critical for proximal tubule cell survival. PLoS One. 2012; 7(3):e33258. PMID: 22432008.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    31. Arencibia-Albite F, Vázquez R, Velásquez-Martinez MC, Jiménez-Rivera CA. Cocaine sensitization inhibits the hyperpolarization-activated cation current Ih and reduces cell size in dopamine neurons of the ventral tegmental area. J Neurophysiol. 2012 Apr; 107(8):2271-82. PMID: 22262829.
      Citations: 10     Fields:    Translation:AnimalsCells
    32. Iglesias E, Brandariz I, Jiménez C, Soengas RG. Iron(III) complexation by Vanchrobactin, a siderophore of the bacterial fish pathogen Vibrio anguillarum. Metallomics. 2011 May 01; 3(5):521-8. PMID: 21494744.
      Citations: 3     Fields:    Translation:AnimalsCells
    33. Ardá A, Nieto MI, Blanco M, Jiménez C, Rodríguez J. Low-temperature NMR j-based configurational analysis of flexible acyclic systems. J Org Chem. 2010 Nov 05; 75(21):7227-32. PMID: 20879784.
      Citations:    Fields:    
    34. Moreso F, Calvo N, Pascual J, Anaya F, Jiménez C, Del Castillo D, Sánchez-Plumed J, Serón D. Early statin use is an independent predictor of long-term graft survival. NDT Plus. 2010 Jun; 3(Suppl_2):ii26-ii31. PMID: 20508861.
    35. Cortés J, Jiménez CE, Fonseca AC, Alvarado JJ. Status and conservation of coral reefs in Costa Rica. Rev Biol Trop. 2010 May; 58 Suppl 1:33-50. PMID: 20873039.
      Citations: 3     Fields:    Translation:AnimalsPHPublic Health
    36. Magno P, Jiménez CE, Ortiz Z, Torres EA. Recombinant human granulocyte-macrophage colony stimulating factor (sargramostim) as an alternative therapy for fistulizing Crohn's disease. P R Health Sci J. 2010 Mar; 29(1):60-5. PMID: 20222336.
      Citations: 2     Fields:    Translation:Humans
    37. Poza JJ, Rodríguez J, Jiménez C. Synthesis of a new cytotoxic cephalostatin/ritterazine analogue from hecogenin and 22-epi-hippuristanol. Bioorg Med Chem. 2010 Jan 01; 18(1):58-63. PMID: 19948408.
      Citations: 4     Fields:    Translation:HumansCells
    38. Chaves-Fonnegra A, Castellanos L, Zea S, Duque C, Rodríguez J, Jiménez C. Clionapyrrolidine A--a metabolite from the encrusting and excavating sponge Cliona tenuis that kills coral tissue upon contact. J Chem Ecol. 2008 Dec; 34(12):1565-74. PMID: 19023625.
      Citations: 2     Fields:    Translation:Animals
    39. Poza JJ, Fernández R, Reyes F, Rodríguez J, Jiménez C. Isolation, biological significance, synthesis, and cytotoxic evaluation of new natural parathiosteroids A-C and analogues from the soft coral Paragorgia sp. J Org Chem. 2008 Oct 17; 73(20):7978-84. PMID: 18795787.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    40. Cañizares P, Jiménez C, Martínez F, Rodrigo MA, Sáez C. The pH as a key parameter in the choice between coagulation and electrocoagulation for the treatment of wastewaters. J Hazard Mater. 2009 Apr 15; 163(1):158-64. PMID: 18674858.
      Citations: 2     Fields:    Translation:PHPublic Health
    41. Ardá A, G Soengas R, Nieto MI, Jiménez C, Rodríguez J. Total synthesis of (-)-dysithiazolamide. Org Lett. 2008 Jun 05; 10(11):2175-8. PMID: 18459798.
      Citations: 1     Fields:    
    42. Soengas RG, Larrosa M, Balado M, Rodríguez J, Lemos ML, Jiménez C. Synthesis and biological activity of analogues of vanchrobactin, a siderophore from Vibrio anguillarum serotype O2. Org Biomol Chem. 2008 Apr 07; 6(7):1278-87. PMID: 18362969.
      Citations: 3     Fields:    Translation:Cells
    43. Sanabria P, Ross E, Ramirez E, Colon K, Hernandez M, Maldonado HM, Silva WI, Jimenez-Rivera CA, Gonzalez FA. P2Y2 receptor desensitization on single endothelial cells. Endothelium. 2008 Jan-Feb; 15(1):43-51. PMID: 18568944.
      Citations:    Fields:    Translation:HumansAnimalsCells
    44. Cañizares P, Martínez F, Jiménez C, Sáez C, Rodrigo MA. Coagulation and electrocoagulation of oil-in-water emulsions. J Hazard Mater. 2008 Feb 28; 151(1):44-51. PMID: 17583426.
      Citations: 7     Fields:    Translation:CellsPHPublic Health
    45. Poza J, Rega M, Paz V, Alonso B, Rodríguez J, Salvador N, Fernández A, Jiménez C. Synthesis and evaluation of new 6-hydroximinosteroid analogs as cytotoxic agents. Bioorg Med Chem. 2007 Jul 15; 15(14):4722-40. PMID: 17531494.
      Citations: 5     Fields:    Translation:HumansCells
    46. Rega M, Jiménez C, Rodríguez J. 6E-hydroximinosteroid homodimerization by cross-metathesis processes. Steroids. 2007 Oct; 72(11-12):729-35. PMID: 17692350.
      Citations: 3     Fields:    Translation:HumansCells
    47. Cañizares P, Martínez F, Jiménez C, Lobato J, Rodrigo MA. Coagulation and electrocoagulation of wastes polluted with dyes. Environ Sci Technol. 2006 Oct 15; 40(20):6418-24. PMID: 17120574.
      Citations: 3     Fields:    Translation:PHPublic Health
    48. Castellanos L, Duque C, Zea S, Espada A, Rodríguez J, Jiménez C. Isolation and synthesis of (-)-(5S)-2-imino-1-methylpyrrolidine-5- carboxylic acid from Cliona tenuis: structure revision of pyrostatins. Org Lett. 2006 Oct 12; 8(21):4967-70. PMID: 17020348.
      Citations: 5     Fields:    Translation:AnimalsCells
    49. Jiménez-Rivera CA, Feliu-Mojer M, Vázquez-Torres R. Alpha-noradrenergic receptors modulate the development and expression of cocaine sensitization. Ann N Y Acad Sci. 2006 Aug; 1074:390-402. PMID: 17105937.
      Citations: 21     Fields:    Translation:Animals
    50. Gordillo FJ, Aguilera J, Jiménez C. The response of nutrient assimilation and biochemical composition of Arctic seaweeds to a nutrient input in summer. J Exp Bot. 2006; 57(11):2661-71. PMID: 16829547.
      Citations: 7     Fields:    Translation:Animals
    51. Mejías-Aponte CA, Jiménez-Rivera CA, Segarra AC. Sex differences in models of temporal lobe epilepsy: role of testosterone. Brain Res. 2002 Jul 19; 944(1-2):210-8. PMID: 12106683.
      Citations: 25     Fields:    Translation:AnimalsCells
    52. Febo M, Jiménez-Rivera CA, Segarra AC. Estrogen and opioids interact to modulate the locomotor response to cocaine in the female rat. Brain Res. 2002 Jul 05; 943(1):151-61. PMID: 12088849.
      Citations: 13     Fields:    Translation:Animals
    53. González N, Rodríguez J, Jiménez C. Didemniserinolipids A-C, Unprecedented Serinolipids from the Tunicate Didemnumsp. J Org Chem. 1999 Jul 23; 64(15):5705-5707. PMID: 11674645.
      Citations: 7     Fields:    
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