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María J. Crespo

Faculty RankProfessor
InstitutionUniversity of Puerto Rico
DepartmentSchool of Medicine
AddressUPR-Medical Sciences Campus, School of Medicine
San Juan PR 936
Phone7877582525 ext. 5078, 1913
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    My research interests are in the area of cardiovascular Physiology and Pharmacology, especially in pathophysiological conditions such as hypertension and congestive heart failure. In particular, I am interested in understanding the mechanism underlying endothelial dysfunction and the vascular modifications present in these conditions. We study alterations in the nitric oxide (NO) signal transduction pathway and in the renin-angiotensin system (RAS) using animal models of hypertension and heart failure.

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Román M, Ramírez JM, Morales M, Crespo MJ. Significant reduction of vascular reactivity with dantrolene and nimodipine in diabetic rats: a potential approach to cerebral vasospasm management in diabetes. Pharmacol Rep. 2020 Feb; 72(1):126-134. PMID: 32016838.
      Citations:    Fields:    Translation:Animals
    2. Crespo M, León-Navarro DA, Martín M. Cerebellar oxidative stress and fine motor impairment in adolescent rats exposed to hyperthermia-induced seizures is prevented by maternal caffeine intake during gestation and lactation. Eur J Pharmacol. 2018 Mar 05; 822:186-198. PMID: 29360435.
      Citations:    Fields:    Translation:HumansAnimals
    3. Crespo MJ, Quidgley J. Simvastatin, atorvastatin, and pravastatin equally improve the hemodynamic status of diabetic rats. World J Diabetes. 2015 Aug 25; 6(10):1168-78. PMID: 26322162.
    4. Hernández-Gil de Lamadrid J, Nieves-Rivera JJ, Mora L, Corretjer L, Altieri PI, Suárez A, Banchs HL, Muñiz J, Soto MI, Escobales N, Crespo M. Metabolic Changes After Roux-N-Y Bariatric Surgery In Hispanics. Bol Asoc Med P R. 2015 Jul-Sep; 107(3):66-9. PMID: 26742199.
      Citations: 1     Fields:    Translation:Humans
    5. Altieri PI, Marcial JM, Banchs HL, Escobales N, Crespo M, González W. Coronary levels of angiotensin-II and endothelin-I in diabetic patients with and without coronary artery disease. Bol Asoc Med P R. 2015 Jan-Mar; 107(1):5-7. PMID: 26035976.
      Citations:    Fields:    Translation:Humans
    6. González W, Altieri PI, Alvarado E, Banchs HL, Colón E, Escobales N, Crespo M. Celiac trunk and branches dissection due to energy drink consumption and heavy resistance exercise: case report and review of literature. Bol Asoc Med P R. 2015 Jan-Mar; 107(1):38-40. PMID: 26035983.
      Citations: 2     Fields:    Translation:HumansAnimals
    7. Quidgley J, Cruz N, Crespo MJ. Atorvastatin improves systolic function, but does not prevent the development of dilated cardiomyopathy in streptozotocin-induced diabetic rats. Ther Adv Cardiovasc Dis. 2014 Aug; 8(4):133-144. PMID: 24759610.
      Citations: 5     Fields:    
    8. Crespo MJ, Cruz N, Quidgley J, Torres H, Hernandez C, Casiano H, Rivera K. Daily administration of atorvastatin and simvastatin for one week improves cardiac function in type 1 diabetic rats. Pharmacology. 2014; 93(1-2):84-91. PMID: 24556594.
      Citations: 2     Fields:    Translation:Animals
    9. Bou E, Hernández P, Cerezo L, Altieri PI, Gurrea CM, Figueroa R, García P, González-Cancel IF, Defendini E, Escobales N, Crespo M, Banchs HL. Heart tumors in Puerto Rico de novo atrial fibrillation as clinical presentation in a subgroup of patients. P R Health Sci J. 2013 Mar; 32(1):14-7. PMID: 23556261.
      Citations: 1     Fields:    Translation:Humans
    10. González W, Altieri PI, Alvarado S, Banchs HL, Escobales N, Crespo M, Borges W. Magnesium: the forgotten electrolyte. Bol Asoc Med P R. 2013; 105(3):17-20. PMID: 24282915.
      Citations: 3     Fields:    Translation:Humans
    11. Altieri PI, Marcial JM, Banchs H, Escobales N, Crespo M. Ethnicity and genetics are more important than diabetes mellitus and hypertension in producing cardiovascular events in patients with the metabolic syndrome: emphasis in the Puerto Rico population. Bol Asoc Med P R. 2013; 105(3):56-63. PMID: 24282924.
      Citations: 1     Fields:    Translation:Humans
    12. Crespo MJ, Cangiano JL, Altieri PI, Escobales N. Aliskiren improves left ventricular dysfunction and reduces cardiac dilation in Syrian cardiomyopathic hamsters. J Cardiovasc Pharmacol. 2012 Jun; 59(6):547-52. PMID: 22370958.
      Citations: 1     Fields:    Translation:Animals
    13. Altieri PI, Figueroa Y, Banchs HL, de Lamadrid JH, Escobales N, Crespo M. Higher incidence of atrial fibrillation in the metabolic syndrome: a Hispanic population study. Bol Asoc Med P R. 2011 Oct-Dec; 103(4):24-7. PMID: 22737826.
      Citations: 1     Fields:    Translation:Humans
    14. Crespo MJ, Marrero M, Cruz N, Quidgley J, Creagh O, Torres H, Rivera K. Diabetes alters cardiovascular responses to anaesthetic induction agents in STZ-diabetic rats. Diab Vasc Dis Res. 2011 Oct; 8(4):299-302. PMID: 21933844.
      Citations: 3     Fields:    Translation:Animals
    15. Marcial JM, Altieri PI, Banchs H, Escobales N, Crespo M. Metabolic syndrome among Puerto Ricans and other Hispanic populations. P R Health Sci J. 2011 Sep; 30(3):145-51. PMID: 21932717.
      Citations: 3     Fields:    Translation:Humans
    16. Crespo MJ, Cruz N, Altieri PI, Escobales N. Chronic treatment with N-acetylcysteine improves cardiac function but does not prevent progression of cardiomyopathy in Syrian cardiomyopathic hamsters. J Cardiovasc Pharmacol Ther. 2011 Jun; 16(2):197-204. PMID: 21149830.
      Citations: 3     Fields:    Translation:Animals
    17. Prat M, Fernández D, Buil MA, Crespo MI, Casals G, Ferrer M, Tort L, Castro J, Monleón JM, Gavaldà A, Miralpeix M, Ramos I, Doménech T, Vilella D, Antón F, Huerta JM, Espinosa S, López M, Sentellas S, González M, Albertí J, Segarra V, Cárdenas A, Beleta J, Ryder H. Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinol esters as potent and long-acting muscarinic antagonists with potential for minimal systemic exposure after inhaled administration: identification of (3R)-3-{[hydroxy(di-2-thienyl)acetyl]oxy}-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide (aclidinium bromide). J Med Chem. 2009 Aug 27; 52(16):5076-92. PMID: 19653626.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    18. Escobales N, Ramos JA, Santacana GE, Crespo MJ. Hemodynamic alterations in the coronary circulation of cardiomyopathic hamsters: age and Ang II-dependent mechanisms. J Card Fail. 2009 Dec; 15(10):929-38. PMID: 19944371.
      Citations: 2     Fields:    Translation:Animals
    19. Escobales N, Crespo MJ. Early pathophysiological alterations in experimental cardiomyopathy: the Syrian cardiomyopathic hamster. P R Health Sci J. 2008 Dec; 27(4):307-14. PMID: 19069355.
      Citations: 4     Fields:    Translation:Animals
    20. Crespo MJ, Cruz N, Altieri PI, Escobales N. Enalapril and losartan are more effective than carvedilol in preventing dilated cardiomyopathy in the Syrian cardiomyopathic hamster. J Cardiovasc Pharmacol Ther. 2008 Sep; 13(3):199-206. PMID: 18593848.
      Citations: 3     Fields:    Translation:Animals
    21. Crespo MJ, Zalacaín J, Dunbar DC, Cruz N, Arocho L. Cardiac oxidative stress is elevated at the onset of dilated cardiomyopathy in streptozotocin-diabetic rats. J Cardiovasc Pharmacol Ther. 2008 Mar; 13(1):64-71. PMID: 18287592.
      Citations: 9     Fields:    Translation:Animals
    22. Figueroa Y, Altieri PI, Banchs H, Hernández J, López JC, Escobales N, Crespo MJ. Syncope in Puerto Rico. Bol Asoc Med P R. 2007 Jul-Sep; 99(3):207-10. PMID: 19610576.
      Citations:    Fields:    Translation:Humans
    23. Cruz N, Arocho L, Rosario L, Crespo MJ. Chronic administration of carvedilol improves cardiac function in 6-month-old Syrian cardiomyopathic hamsters. Pharmacology. 2007; 80(2-3):144-50. PMID: 17534124.
      Citations: 3     Fields:    Translation:Animals
    24. Figueroa Y, Altieri PI, Banchs H, Escobales N, Crespo M, Defendini E, González-Cancel I. Coronary artery abnormalities in Puerto Rico. P R Health Sci J. 2006 Sep; 25(3):225-7. PMID: 17203792.
      Citations: 1     Fields:    Translation:Humans
    25. Crespo MJ, Quidgley J, Dunbar DC. Differential regulation of the left and right coronary arteries of swine. Pharmacology. 2006; 77(3):137-43. PMID: 16763381.
      Citations:    Fields:    Translation:Animals
    26. Crespo MJ, Altieri PI, Escobales N. Increased vascular angiotensin II binding capacity and ET-1 release in young cardiomyopathic hamsters. Vascul Pharmacol. 2006 Apr; 44(4):247-52. PMID: 16503205.
      Citations: 1     Fields:    Translation:AnimalsCells
    27. Crespo MJ, Quidgley JA. Statins decrease serotonin-induced contractions in coronary arteries of swine in vitro. Pharmacology. 2006; 76(3):141-7. PMID: 16428899.
      Citations: 1     Fields:    Translation:HumansAnimals
    28. Escobales N, Crespo MJ. Oxidative-nitrosative stress in hypertension. Curr Vasc Pharmacol. 2005 Jul; 3(3):231-46. PMID: 16026320.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    29. Guerra J, De Jesus A, Santiago-Borrero P, Roman-Franco A, Rodríguez E, Crespo MJ. Plasma nitric oxide levels used as an indicator of doxorubicin-induced cardiotoxicity in rats. Hematol J. 2005; 5(7):584-8. PMID: 15692604.
      Citations: 8     Fields:    Translation:Animals
    30. González-Pérez J, Crespo MJ. Chronic effects of toremifene on the vasculature of menopause-induced rats. Vascul Pharmacol. 2003 Dec; 40(5):261-8. PMID: 15259793.
      Citations:    Fields:    Translation:Animals
    31. González-Pérez J, Crespo MJ. Acute effects of toremifene on the vasculature of intact and menopause-induced rats. Vascul Pharmacol. 2003 Nov; 40(4):205-11. PMID: 14746827.
      Citations:    Fields:    Translation:Animals
    32. Crespo MJ, Moreta S, González J. Cardiovascular deterioration in STZ-diabetic rats: possible role of vascular RAS. Pharmacology. 2003 May; 68(1):1-8. PMID: 12660473.
      Citations: 4     Fields:    Translation:Animals
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