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Leng Chee Chang, PhD

Title
Faculty RankAssociate Professor
InstitutionUniversity of Hawaii
DepartmentPharmaceutical Sciences
AddressThe Daniel K. Inouye College of Pharmacy
University of Hawaii at Hilo
34 Rainbow Drive
Hilo HI 96720
Phone8089332951; 808-981-8018
Fax8089332974
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    Other Positions
    TitleAssociate Member
    InstitutionUniversity of Hawaii Cancer Center


    Collapse Biography 
    Collapse awards and honors
    1997Van Doren Scholar Award, College of Pharmacy, University of Illinois at Chicago, Chicago, IL
    1998Kilmer Prize, American Society of Pharmacognosy, Orlando, Florida
    2004Travel Grant for Active Members, ASP, Phoenix, Arizona
    2006D. John Faulkner Travel Award, American Society of Pharmacognosy, Arlington, Virginia
    2008Faculty Travel Award, Office of Research, University of Hawaii Hilo
    2011Excellence in Teaching Award for Pharmaceutical Sciences, College of Pharmacy, U Hawaii at Hilo
    2013Excellence in Teaching Award for Pharmaceutical Sciences, College of Pharmacy, U Hawaii at Hilo

    Collapse Overview 
    Collapse overview
    Leng Chee Chang, Assistant Professor of the Department of Pharmaceutical Sciences, College of Pharmacy, University of Hawaii at Hilo, HI, USA, investigates new cancer chemotherapeutic and cancer chemopreventative agents from plant and microbial natural products. She earned her Ph.D. degree in Natural Products at the University of Illinois at Chicago. During her Ph.D. study, she worked on a research project investigating new cancer chemopreventive agents which were derived from plants. This project was funded as Program Project (P01) grant entitled “Natural Inhibitors of Carcinogenesis” by the National Cancer Institute to Professors A. D. Kinghorn and John M. Pezzuto. She received further training as an Intramural Research Training Award fellow with Dr. Carole A. Bewley, LBC, NIDDK, NIH. Thirteen promising bioactive marine natural products were isolated during her fellowship, nine having novel structures.

    Her current research has focused on the evaluation of natural products as cancer chemopreventive and chemotherapeutic agents, where promising bioactive natural products may serve as lead compounds for drug design. She have established collaborations with Director of Natural Products and Therapeutic Program, UH Cancer Center, Dr. James Turkson, in the area of STAT3 as cancer therapeutic target; Dean College of Pharmacy, Dr. John M. Pezzuto, in the area of plant-derived cancer chemopreventative agents.

    She has more than fifteen years of experience as a researcher in natural products chemistry. Her research results have appeared in: Journal of Natural Products, Organic Letters, Planta Medica, Tetrahedron, and Bioorganic Medicinal Chemistry Letters.



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Li X, Liu R, Wang Z, Wu M, Chang L, Yuan H, Zhuang F, Song Y, Liu Z. MicroRNA-7 regulates the proliferation and metastasis of human papillary carcinoma cells by targeting Bcl-2. Am J Transl Res. 2020; 12(9):5772-5780. PMID: 33042456.
      Citations:    
    2. Gao C, Fan YL, Zhao F, Ren QC, Wu X, Chang L, Gao F. Quinolone derivatives and their activities against methicillin-resistant Staphylococcus aureus (MRSA). Eur J Med Chem. 2018 Sep 05; 157:1081-1095. PMID: 30179746.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    3. Zhang S, Xu Z, Gao C, Ren QC, Chang L, Lv ZS, Feng LS. Triazole derivatives and their anti-tubercular activity. Eur J Med Chem. 2017 Sep 29; 138:501-513. PMID: 28692915.
      Citations: 12     Fields:    Translation:HumansCells
    4. Youn UJ, Park EJ, Kondratyuk TP, Sripisut T, Laphookhieo S, Pezzuto JM, Chang LC. Anti-inflammatory triterpenes from the apical bud of Gardenia sootepensis. Fitoterapia. 2016 Oct; 114:92-97. PMID: 27575322.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    5. Youn UJ, Park EJ, Kondratyuk TP, Sang-Ngern M, Wall MM, Wei Y, Pezzuto JM, Chang LC. Anti-inflammatory and Quinone Reductase Inducing Compounds from Fermented Noni (Morinda citrifolia) Juice Exudates. J Nat Prod. 2016 06 24; 79(6):1508-13. PMID: 27196335.
      Citations: 5     Fields:    Translation:AnimalsCells
    6. Park EJ, Sang-Ngern M, Chang LC, Pezzuto JM. Induction of cell cycle arrest and apoptosis with downregulation of Hsp90 client proteins and histone modification by 4ß-hydroxywithanolide E isolated from Physalis peruviana. Mol Nutr Food Res. 2016 06; 60(6):1482-500. PMID: 27006100.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    7. Chang L, Wang G, Jia T, Zhang L, Li Y, Han Y, Zhang K, Lin G, Zhang R, Li J, Wang L. Armored long non-coding RNA MEG3 targeting EGFR based on recombinant MS2 bacteriophage virus-like particles against hepatocellular carcinoma. Oncotarget. 2016 Apr 26; 7(17):23988-4004. PMID: 26992211.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    8. Sang-Ngern M, Youn UJ, Park EJ, Kondratyuk TP, Simmons CJ, Wall MM, Ruf M, Lorch SE, Leong E, Pezzuto JM, Chang LC. Withanolides derived from Physalis peruviana (Poha) with potential anti-inflammatory activity. Bioorg Med Chem Lett. 2016 Jun 15; 26(12):2755-2759. PMID: 27210437.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    9. Miklossy G, Youn UJ, Yue P, Zhang M, Chen CH, Hilliard TS, Paladino D, Li Y, Choi J, Sarkaria JN, Kawakami JK, Wongwiwatthananukit S, Chen Y, Sun D, Chang LC, Turkson J. Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importin a-2 Expression, and Induce Antitumor Effects against Human Glioma. J Med Chem. 2015 Oct 08; 58(19):7734-48. PMID: 26331426.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    10. Youn UJ, Sripisut T, Park EJ, Kondratyuk TP, Fatima N, Simmons CJ, Wall MM, Sun D, Pezzuto JM, Chang LC. Determination of the absolute configuration of chaetoviridins and other bioactive azaphilones from the endophytic fungus Chaetomium globosum. Bioorg Med Chem Lett. 2015 Nov 01; 25(21):4719-4723. PMID: 26343828.
      Citations: 2     Fields:    Translation:AnimalsCells
    11. Marholz LJ, Chang L, Old WM, Wang X. Development of substrate-selective probes for affinity pulldown of histone demethylases. ACS Chem Biol. 2015 Jan 16; 10(1):129-37. PMID: 25335116.
      Citations:    Fields:    Translation:Cells
    12. Saleem S, Jafri L, ul Haq I, Chang LC, Calderwood D, Green BD, Mirza B. Plants Fagonia cretica L. and Hedera nepalensis K. Koch contain natural compounds with potent dipeptidyl peptidase-4 (DPP-4) inhibitory activity. J Ethnopharmacol. 2014 Oct 28; 156:26-32. PMID: 25169215.
      Citations: 9     Fields:    Translation:Animals
    13. Yong Y, Pan L, Ren Y, Fatima N, Ahmed S, Chang LC, Zhang X, Kinghorn AD, Swanson SM, Carcache de Blanco EJ. Assay development for the discovery of semaphorin 3B inducing agents from natural product sources. Fitoterapia. 2014 Oct; 98:184-91. PMID: 25016954.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    14. Chang L, Podoll JD, Wang W, Walls S, O'Rourke CP, Wang X. Structure-activity relationship studies of the tricyclic indoline resistance-modifying agent. J Med Chem. 2014 May 08; 57(9):3803-17. PMID: 24694192.
      Citations: 7     Fields:    Translation:HumansCells
    15. Chai X, Youn UJ, Sun D, Dai J, Williams P, Kondratyuk TP, Borris RP, Davies J, Villanueva IG, Pezzuto JM, Chang LC. Herbicidin congeners, undecose nucleosides from an organic extract of Streptomyces sp. L-9-10. J Nat Prod. 2014 Feb 28; 77(2):227-33. PMID: 24533857.
      Citations: 2     Fields:    Translation:HumansCells
    16. Youn UJ, Miklossy G, Chai X, Wongwiwatthananukit S, Toyama O, Songsak T, Turkson J, Chang LC. Bioactive sesquiterpene lactones and other compounds isolated from Vernonia cinerea. Fitoterapia. 2014 Mar; 93:194-200. PMID: 24370662.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    17. Podoll JD, Liu Y, Chang L, Walls S, Wang W, Wang X. Bio-inspired synthesis yields a tricyclic indoline that selectively resensitizes methicillin-resistant Staphylococcus aureus (MRSA) to ß-lactam antibiotics. Proc Natl Acad Sci U S A. 2013 Sep 24; 110(39):15573-8. PMID: 24019472.
      Citations: 21     Fields:    Translation:HumansCells
    18. Sun Z, Wang HQ, Liu ZH, Chang L, Chen YF, Zhang YZ, Zhang WL, Gao Y, Wan ZY, Che L, Liu X, Samartzis D, Luo ZJ. Down-regulated CK8 expression in human intervertebral disc degeneration. Int J Med Sci. 2013; 10(8):948-56. PMID: 23801880.
      Citations: 15     Fields:    Translation:HumansCells
    19. Youn UJ, Chai X, Park EJ, Kondratyuk TP, Simmons CJ, Borris RP, Mirza B, Pezzuto JM, Chang LC. Biologically active withanolides from Withania coagulans. J Nat Prod. 2013 Jan 25; 76(1):22-8. PMID: 23316950.
      Citations: 6     Fields:    Translation:AnimalsCells
    20. Youn UJ, Park EJ, Kondratyuk TP, Simmons CJ, Borris RP, Tanamatayarat P, Wongwiwatthananukit S, Toyama O, Songsak T, Pezzuto JM, Chang LC. Anti-inflammatory sesquiterpene lactones from the flower of Vernonia cinerea. Bioorg Med Chem Lett. 2012 Sep 01; 22(17):5559-62. PMID: 22850207.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    21. Park EJ, Cheenpracha S, Chang LC, Pezzuto JM. Suppression of cyclooxygenase-2 and inducible nitric oxide synthase expression by epimuqubilin A via IKK/I?B/NF-?B pathways in lipopolysaccharide-stimulated RAW 264.7 cells. Phytochem Lett. 2011 Dec 01; 4(4):426-431. PMID: 22180763.
      Citations:    
    22. Park EJ, Cheenpracha S, Chang LC, Kondratyuk TP, Pezzuto JM. Inhibition of lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression by 4-[(2'-O-acetyl-a-L-rhamnosyloxy)benzyl]isothiocyanate from Moringa oleifera. Nutr Cancer. 2011; 63(6):971-82. PMID: 21774591.
      Citations: 19     Fields:    Translation:AnimalsCells
    23. Cheenpracha S, Park EJ, Yoshida WY, Barit C, Wall M, Pezzuto JM, Chang LC. Potential anti-inflammatory phenolic glycosides from the medicinal plant Moringa oleifera fruits. Bioorg Med Chem. 2010 Sep 01; 18(17):6598-602. PMID: 20685125.
      Citations: 26     Fields:    Translation:Animals
    24. Cheenpracha S, Park EJ, Rostama B, Pezzuto JM, Chang LC. Inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-activated murine macrophage RAW 264.7 cells by the norsesterterpene peroxide, epimuqubilin A. Mar Drugs. 2010 Mar 01; 8(3):429-37. PMID: 20411107.
      Citations: 12     Fields:    Translation:AnimalsCells
    25. Barker LP, Lien BA, Brun OS, Schaak DD, McDonough KA, Chang LC. A Mycobacterium marinum zone of inhibition assay as a method for screening potential antimycobacterial compounds from marine extracts. Planta Med. 2007 Jun; 73(6):559-63. PMID: 17534789.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    26. Kinghorn AD, Su BN, Jang DS, Chang LC, Lee D, Gu JQ, Carcache-Blanco EJ, Pawlus AD, Lee SK, Park EJ, Cuendet M, Gills JJ, Bhat K, Park HS, Mata-Greenwood E, Song LL, Jang M, Pezzuto JM. Natural inhibitors of carcinogenesis. Planta Med. 2004 Aug; 70(8):691-705. PMID: 15326546.
      Citations: 30     Fields:    Translation:HumansAnimals
    27. Su BN, Chang LC, Park EJ, Cuendet M, Santarsiero BD, Mesecar AD, Mehta RG, Fong HH, Pezzuto JM, Kinghorn AD. Bioactive constituents of the seeds of Brucea javanica. Planta Med. 2002 Aug; 68(8):730-3. PMID: 12221597.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    28. Chang LC, Song LL, Park EJ, Luyengi L, Lee KJ, Farnsworth NR, Pezzuto JM, Kinghorn AD. Bioactive constituents of Thuja occidentalis. J Nat Prod. 2000 Sep; 63(9):1235-8. PMID: 11000026.
      Citations: 9     Fields:    Translation:AnimalsCells
    29. Chang LC, Gerhäuser C, Song L, Farnsworth NR, Pezzuto JM, Kinghorn AD. Activity-guided isolation of constituents of Tephrosia purpurea with the potential to induce the phase II enzyme, quinone reductase. J Nat Prod. 1997 Sep; 60(9):869-73. PMID: 9322358.
      Citations: 5     Fields:    Translation:AnimalsCells
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