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Takashi Matsui, MD, PhD

TitleChair
Faculty RankProfessor
InstitutionUniversity of Hawaii
DepartmentAnatomy, Biochemistry & Physiology
AddressJohn A. Burns School of Medicine
University of Hawaii at Manoa
651 Ilalo Street
Honolulu HI 96813
Phone8086921554
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    Collapse Biography 
    Collapse awards and honors
    1997 - 1999American Heart Association Fellowship Award , American Heart Association,
    1997The Japan Heart Foundation Investigator Award, Pfizer Pharmaceutical Grant for Research on Coronary Artery Disease,
    1999Calderwood Prize, Division of Cardiac Surgery, Massachusetts General Hospital,
    2000 - 2005Mentored Clinical Scientist Development Award (K08), NIH, NHLBI,
    2000The Young Investigator Award, Heart Failure Society of America,
    2001Trainee Abstract award at the Annual Scientific Session, American Heart Association,
    20122011 Star Reviewer, American Journal of Physiology Heart and Circulatory Physiology,

    Collapse Overview 
    Collapse overview
    We focus on understanding the mechanism and signal transduction pathway underlying cardiac dysfunction that arises from myocardial infarction and cardiac hypertrophy, apparent risk factors for heart failure. Specifically, our interests center around the role of the mechanistic target of rapamycin (mTOR), which is intimately related to the insulin/phosphatidylinositol 3-kinase (PI3K)/Akt signal transduction pathway. In order to investigate the role of mTOR in the heart, we utilize a variety of in vitro, in vivo, and ex vivo models. Recombinant DNA is employed in both cells via the use of gene transfer and animals via the generation of transgenic mice. We are studying mice engineered with cardiac-specific overexpression of mTOR in order to see if changes in disease processes related to heart failure occur. While mTOR inhibitor rapamycin is known to prevent cardiac hypertrophy induced by pathological stresses such as pressure-overload, the role of cardiac mTOR on cardiac function under the models of cardiac diseases has not been fully defined. My laboratory reported that mTOR attenuates the inflammatory response in cardiomyocytes and prevents cardiac dysfunction in pathological hypertrophy. Recently our study using the transgenic mice has demonstrated that overexpression of cardiac mTOR is sufficient to protect the heart against ischemia-reperfusion injury in both in vivo and ex vivo models. These findings strongly suggest that the mTOR signaling pathway plays an important role in cardioprotection under multiple stresses such as myocardial infarction.
    The second major target in my laboratory is heart failure in diabetic mellitus. Diabetes is an independent risk factor for both heart failure and ischemic heart disease. After myocardial infarction, heart failure develops at twice the rate in diabetic patients as in nondiabetic patients. Type 2 (non-insulin-dependent) diabetes occurs more commonly than type 1 (insulin-dependent) diabetes and comprises more than 90% of all case of diabetes. In addition, rising rates of obesity and physical inactivity are increasing the prevalence of type 2 diabetes, especially in Hawaii. These considerations have led us to focus on type 2 diabetes in order to find efficient therapies to reduce mortality of cardiac disease in diabetes. As mentioned above, since mTOR is one of important molecules in insulin signaling pathway, my laboratory focuses on determining the role of mTOR in diabetic hearts and exploring the mTOR signaling pathway with the idea that it may present a novel therapeutic target for treatment of heart failure in diabetes.
    In order to investigate the role of mTOR in the heart, my laboratory utilizes a variety of in vitro, in vivo, and ex vivo models of heart failure with genetically manipulated models of mTOR such as transgenic and knockout mice. Hopefully, an enhanced comprehension of the mechanism underlying cardiac dysfunction will lead to the identification of novel therapeutic targets along the mTOR signal transduction pathway for the treatment of heart failure.

    Collapse webpage

    Collapse Research 
    Collapse research activities and funding
    K08HL004250     (MATSUI, TAKASHI)Feb 1, 2000 - May 31, 2005
    NIH
    ROLE OF PI 3-KINASE AND AKT IN CARDIOMYOCYTE APOPTOSIS
    Role: Principal Investigator

    R01HL098423     (MATSUI, TAKASHI)Jul 1, 2010 - May 31, 2016
    NIH
    Role of mTOR in the diabetic heart
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Shimada BK, Yorichika N, Higa JK, Baba Y, Kobayashi M, Aoyagi T, Suhara T, Matsui T. mTOR-mediated calcium transients affect cardiac function in ex vivo ischemia-reperfusion injury. Physiol Rep. 2021 Mar; 9(6):e14807. PMID: 33769701.
      Citations:    Fields:    
    2. Mishra PK, Adameova A, Hill JA, Baines CP, Kang PM, Downey JM, Narula J, Takahashi M, Abbate A, Piristine HC, Kar S, Su S, Higa JK, Kawasaki NK, Matsui T. Guidelines for evaluating myocardial cell death. Am J Physiol Heart Circ Physiol. 2019 11 01; 317(5):H891-H922. PMID: 31418596.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    3. Yorichika N, Baba Y, Shimada BK, Thakore M, Wong SM, Kobayashi M, Higa JK, Matsui T. The effects of Tel2 on cardiomyocyte survival. Life Sci. 2019 Sep 01; 232:116665. PMID: 31323273.
      Citations:    Fields:    Translation:AnimalsCells
    4. Kobayashi M, Higa JK, Matsui T. The role of ubiquitin in cardiac ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2019 Mar 01; 316(3):H583-H585. PMID: 30657725.
      Citations:    Fields:    Translation:Humans
    5. Soya M, Jesmin S, Shima T, Matsui T, Soya H. Dysregulation of Glycogen Metabolism with Concomitant Spatial Memory Dysfunction in Type 2 Diabetes: Potential Beneficial Effects of Chronic Exercise. Adv Neurobiol. 2019; 23:363-383. PMID: 31667816.
      Citations:    Fields:    Translation:HumansCells
    6. Kobayashi M, Suhara T, Baba Y, Kawasaki NK, Higa JK, Matsui T. Pathological Roles of Iron in Cardiovascular Disease. Curr Drug Targets. 2018; 19(9):1068-1076. PMID: 29874997.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    7. Baba Y, Higa JK, Shimada BK, Horiuchi KM, Suhara T, Kobayashi M, Woo JD, Aoyagi H, Marh KS, Kitaoka H, Matsui T. Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2018 03 01; 314(3):H659-H668. PMID: 29127238.
      Citations: 38     Fields:    Translation:AnimalsCells
    8. Suhara T, Baba Y, Shimada BK, Higa JK, Matsui T. The mTOR Signaling Pathway in Myocardial Dysfunction in Type 2 Diabetes Mellitus. Curr Diab Rep. 2017 06; 17(6):38. PMID: 28434143.
      Citations: 12     Fields:    Translation:HumansCells
    9. Matsui T, Kodama T, Mori T, Tadakoshi T, Noguchi H, Abe I, Morita H. 2-Alkylquinolone alkaloid biosynthesis in the medicinal plant Evodia rutaecarpa involves collaboration of two novel type III polyketide synthases. J Biol Chem. 2017 06 02; 292(22):9117-9135. PMID: 28411241.
      Citations: 2     Fields:    Translation:AnimalsCells
    10. Pineles SL, Repka MX, Yu F, Lum F, Coleman AL. Evaluating the impact of strabismus surgery on the association of musculoskeletal injuries, fractures, and falls with disorders of binocular vision in medicare beneficiaries. J AAPOS. 2017 Jun; 21(3):239-241.e3. PMID: 15582322.
      Citations: 60     Fields:    Translation:AnimalsCells
    11. Shima T, Jesmin S, Matsui T, Soya M, Soya H. Differential effects of type 2 diabetes on brain glycometabolism in rats: focus on glycogen and monocarboxylate transporter 2. J Physiol Sci. 2018 Jan; 68(1):69-75. PMID: 27987117.
      Citations: 4     Fields:    Translation:AnimalsCells
    12. Shima T, Matsui T, Jesmin S, Okamoto M, Soya M, Inoue K, Liu YF, Torres-Aleman I, McEwen BS, Soya H. Moderate exercise ameliorates dysregulated hippocampal glycometabolism and memory function in a rat model of type 2 diabetes. Diabetologia. 2017 03; 60(3):597-606. PMID: 27928614.
      Citations: 8     Fields:    Translation:Animals
    13. Fernandez AM, Hernandez-Garzón E, Perez-Domper P, Perez-Alvarez A, Mederos S, Matsui T, Santi A, Trueba-Saiz A, García-Guerra L, Pose-Utrilla J, Fielitz J, Olson EN, Fernandez de la Rosa R, Garcia Garcia L, Pozo MA, Iglesias T, Araque A, Soya H, Perea G, Martin ED, Torres Aleman I. Insulin Regulates Astrocytic Glucose Handling Through Cooperation With IGF-I. Diabetes. 2017 Jan; 66(1):64-74. PMID: 27999108.
      Citations: 22     Fields:    Translation:AnimalsCells
    14. Chang CW, Atkinson G, Gandhi N, Farrell ML, Labrash S, Smith AB, Norton NS, Matsui T, Lozanoff S. Cone beam computed tomography of plastinated hearts for instruction of radiological anatomy. Surg Radiol Anat. 2016 Sep; 38(7):843-53. PMID: 26905076.
      Citations: 1     Fields:    Translation:Humans
    15. Aoyagi T, Higa JK, Aoyagi H, Yorichika N, Shimada BK, Matsui T. Cardiac mTOR rescues the detrimental effects of diet-induced obesity in the heart after ischemia-reperfusion. . 2015 Jun 15; 308(12):H1530-9. PMID: 25888508.
      Citations:    
    16. Mori T, Yang D, Matsui T, Hashimoto M, Morita H, Fujii I, Abe I. Structural basis for the formation of acylalkylpyrones from two ß-ketoacyl units by the fungal type III polyketide synthase CsyB. J Biol Chem. 2015 Feb 20; 290(8):5214-5225. PMID: 25564614.
      Citations: 7     Fields:    Translation:AnimalsCells
    17. Hoffmann PR, Panigada M, Soprana E, Terry F, Bandar IS, Napolitano A, Rose AH, Hoffmann FW, Ndhlovu LC, Belcaid M, Moise L, De Groot AS, Carbone M, Gaudino G, Matsui T, Siccardi A, Bertino P. Preclinical development of HIvax: Human survivin highly immunogenic vaccines. Hum Vaccin Immunother. 2015; 11(7):1585-95. PMID: 26042612.
      Citations: 9     Fields:    Translation:HumansCellsPHPublic Health
    18. Katz MY, Kusakari Y, Aoyagi H, Higa JK, Xiao CY, Abdelkarim AZ, Marh K, Aoyagi T, Rosenzweig A, Lozanoff S, Matsui T. Three-dimensional myocardial scarring along myofibers after coronary ischemia-reperfusion revealed by computerized images of histological assays. Physiol Rep. 2014 Jul 16; 2(7). PMID: 25347856.
      Citations: 3     Fields:    
    19. Matsui T, Han X, Yu J, Yao M, Tanaka I. Structural change in FtsZ Induced by intermolecular interactions between bound GTP and the T7 loop. J Biol Chem. 2014 Feb 07; 289(6):3501-9. PMID: 24347164.
      Citations: 21     Fields:    Translation:Cells
    20. Dai J, Matsui T, Abel ED, Dedhar S, Gerszten RE, Seidman CE, Seidman JG, Rosenzweig A. Deep sequence analysis of gene expression identifies osteopontin as a downstream effector of integrin-linked kinase (ILK) in cardiac-specific ILK knockout mice. Circ Heart Fail. 2014 Jan; 7(1):184-93. PMID: 24319095.
      Citations: 6     Fields:    Translation:AnimalsCells
    21. Mori T, Shimokawa Y, Matsui T, Kinjo K, Kato R, Noguchi H, Sugio S, Morita H, Abe I. Cloning and structure-function analyses of quinolone- and acridone-producing novel type III polyketide synthases from Citrus microcarpa. J Biol Chem. 2013 Oct 04; 288(40):28845-58. PMID: 23963450.
      Citations: 9     Fields:    Translation:AnimalsCells
    22. Fujikawa T, Hirata T, Hosoo S, Nakajima K, Wada A, Yurugi Y, Soya H, Matsui T, Yamaguchi A, Ogata M, Nishibe S. Asperuloside stimulates metabolic function in rats across several organs under high-fat diet conditions, acting like the major ingredient of Eucommia leaves with anti-obesity activity. J Nutr Sci. 2012; 1:e10. PMID: 25191539.
      Citations: 5     Fields:    
    23. Aoyagi T, Kusakari Y, Xiao CY, Inouye BT, Takahashi M, Scherrer-Crosbie M, Rosenzweig A, Hara K, Matsui T. Cardiac mTOR protects the heart against ischemia-reperfusion injury. . 2012 Jul; 303(1):H75-85. PMID: 22561297.
      Citations:    
    24. Aoyagi T, Matsui T. The Cardiomyocyte as a Source of Cytokines in Cardiac Injury. J Cell Sci Ther. 2011 Dec 01; 2012(S5). PMID: 23493668.
      Citations:    
    25. Matsui T, Ishikawa T, Ito H, Okamoto M, Inoue K, Lee MC, Fujikawa T, Ichitani Y, Kawanaka K, Soya H. Brain glycogen supercompensation following exhaustive exercise. J Physiol. 2012 Feb 01; 590(3):607-16. PMID: 22063629.
      Citations: 31     Fields:    Translation:Animals
    26. Lv H, Havari E, Pinto S, Gottumukkala RV, Cornivelli L, Raddassi K, Matsui T, Rosenzweig A, Bronson RT, Smith R, Fletcher AL, Turley SJ, Wucherpfennig K, Kyewski B, Lipes MA. Impaired thymic tolerance to a-myosin directs autoimmunity to the heart in mice and humans. J Clin Invest. 2011 Apr; 121(4):1561-73. PMID: 21436590.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    27. Aoyagi T, Matsui T. Phosphoinositide-3 kinase signaling in cardiac hypertrophy and heart failure. Curr Pharm Des. 2011; 17(18):1818-24. PMID: 21631421.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    28. Song X, Kusakari Y, Xiao CY, Kinsella SD, Rosenberg MA, Scherrer-Crosbie M, Hara K, Rosenzweig A, Matsui T. mTOR attenuates the inflammatory response in cardiomyocytes and prevents cardiac dysfunction in pathological hypertrophy. . 2010 Dec; 299(6):C1256-66. PMID: 20861467.
      Citations:    
    29. Koyama M, Izutani Y, Goda AE, Matsui TA, Horinaka M, Tomosugi M, Fujiwara J, Nakamura Y, Wakada M, Yogosawa S, Sowa Y, Sakai T. Histone deacetylase inhibitors and 15-deoxy-Delta12,14-prostaglandin J2 synergistically induce apoptosis. Clin Cancer Res. 2010 Apr 15; 16(8):2320-32. PMID: 20371690.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    30. Shirasugi I, Kamada M, Matsui T, Sakakibara Y, Liu MC, Suiko M. Sulforaphane inhibited melanin synthesis by regulating tyrosinase gene expression in B16 mouse melanoma cells. Biosci Biotechnol Biochem. 2010; 74(3):579-82. PMID: 20208349.
      Citations: 10     Fields:    Translation:AnimalsCells
    31. Cook SA, Varela-Carver A, Mongillo M, Kleinert C, Khan MT, Leccisotti L, Strickland N, Matsui T, Das S, Rosenzweig A, Punjabi P, Camici PG. Abnormal myocardial insulin signalling in type 2 diabetes and left-ventricular dysfunction. Eur Heart J. 2010 Jan; 31(1):100-11. PMID: 19797329.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    32. Kusakari Y, Xiao CY, Himes N, Kinsella SD, Takahashi M, Rosenzweig A, Matsui T. Myocyte injury along myofibers in left ventricular remodeling after myocardial infarction. Interact Cardiovasc Thorac Surg. 2009 Dec; 9(6):951-5. PMID: 19776081.
      Citations: 5     Fields:    Translation:AnimalsCells
    33. Sosnovik DE, Nahrendorf M, Panizzi P, Matsui T, Aikawa E, Dai G, Li L, Reynolds F, Dorn GW, Weissleder R, Josephson L, Rosenzweig A. Molecular MRI detects low levels of cardiomyocyte apoptosis in a transgenic model of chronic heart failure. Circ Cardiovasc Imaging. 2009 Nov; 2(6):468-75. PMID: 19920045.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    34. Matsui T, Nunomura S, Shimokawa T, Yoshimaru T, Ra C. Functionality of the IgA Fc receptor (FcalphaR, CD89) is down-regulated by extensive engagement of FcepsilonRI. Clin Immunol. 2008 Oct; 129(1):155-62. PMID: 18700185.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    35. Matsui TA, Murata H, Sakabe T, Sowa Y, Horie N, Nakanishi R, Sakai T, Kubo T. Sulforaphane induces cell cycle arrest and apoptosis in murine osteosarcoma cells in vitro and inhibits tumor growth in vivo. Oncol Rep. 2007 Nov; 18(5):1263-8. PMID: 17914583.
      Citations: 18     Fields:    Translation:HumansAnimals
    36. Matsui TA, Sowa Y, Murata H, Takagi K, Nakanishi R, Aoki S, Yoshikawa M, Kobayashi M, Sakabe T, Kubo T, Sakai T. The plant alkaloid cryptolepine induces p21WAF1/CIP1 and cell cycle arrest in a human osteosarcoma cell line. Int J Oncol. 2007 Oct; 31(4):915-22. PMID: 17786325.
      Citations: 9     Fields:    Translation:HumansCells
    37. Yang H, Yang T, Baur JA, Perez E, Matsui T, Carmona JJ, Lamming DW, Souza-Pinto NC, Bohr VA, Rosenzweig A, de Cabo R, Sauve AA, Sinclair DA. Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell. 2007 Sep 21; 130(6):1095-107. PMID: 17889652.
      Citations: 401     Fields:    Translation:HumansAnimalsCells
    38. Lee KH, Bae JS, Lee SC, Paik JY, Matsui T, Jung KH, Ko BH, Kim BT. Evidence that myocardial Na/I symporter gene imaging does not perturb cardiac function. J Nucl Med. 2006 Nov; 47(11):1851-7. PMID: 17079819.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    39. Morissette MR, Cook SA, Foo S, McKoy G, Ashida N, Novikov M, Scherrer-Crosbie M, Li L, Matsui T, Brooks G, Rosenzweig A. Myostatin regulates cardiomyocyte growth through modulation of Akt signaling. Circ Res. 2006 Jul 07; 99(1):15-24. PMID: 16763166.
      Citations: 62     Fields:    Translation:AnimalsCells
    40. Matsui TA, Sowa Y, Yoshida T, Murata H, Horinaka M, Wakada M, Nakanishi R, Sakabe T, Kubo T, Sakai T. Sulforaphane enhances TRAIL-induced apoptosis through the induction of DR5 expression in human osteosarcoma cells. Carcinogenesis. 2006 Sep; 27(9):1768-77. PMID: 16571651.
      Citations: 15     Fields:    Translation:HumansCells
    41. Matsui T, Nagoshi T, Hong EG, Luptak I, Hartil K, Li L, Gorovits N, Charron MJ, Kim JK, Tian R, Rosenzweig A. Effects of chronic Akt activation on glucose uptake in the heart. Am J Physiol Endocrinol Metab. 2006 May; 290(5):E789-97. PMID: 16352665.
      Citations: 28     Fields:    Translation:AnimalsCells
    42. Sosnovik DE, Schellenberger EA, Nahrendorf M, Novikov MS, Matsui T, Dai G, Reynolds F, Grazette L, Rosenzweig A, Weissleder R, Josephson L. Magnetic resonance imaging of cardiomyocyte apoptosis with a novel magneto-optical nanoparticle. Magn Reson Med. 2005 Sep; 54(3):718-24. PMID: 16086367.
      Citations: 75     Fields:    Translation:AnimalsCells
    43. Nagoshi T, Matsui T, Aoyama T, Leri A, Anversa P, Li L, Ogawa W, del Monte F, Gwathmey JK, Grazette L, Hemmings BA, Hemmings B, Kass DA, Champion HC, Rosenzweig A. PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury. J Clin Invest. 2005 Aug; 115(8):2128-38. PMID: 16007268.
      Citations: 91     Fields:    Translation:HumansAnimalsCells
    44. Arany Z, He H, Lin J, Hoyer K, Handschin C, Toka O, Ahmad F, Matsui T, Chin S, Wu PH, Rybkin II, Shelton JM, Manieri M, Cinti S, Schoen FJ, Bassel-Duby R, Rosenzweig A, Ingwall JS, Spiegelman BM. Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle. Cell Metab. 2005 Apr; 1(4):259-71. PMID: 16054070.
      Citations: 271     Fields:    Translation:AnimalsCells
    45. Lee KH, Kim HK, Paik JY, Matsui T, Choe YS, Choi Y, Kim BT. Accuracy of myocardial sodium/iodide symporter gene expression imaging with radioiodide: evaluation with a dual-gene adenovirus vector. J Nucl Med. 2005 Apr; 46(4):652-7. PMID: 15809488.
      Citations: 8     Fields:    Translation:AnimalsCells
    46. Aoyama T, Matsui T, Novikov M, Park J, Hemmings B, Rosenzweig A. Serum and glucocorticoid-responsive kinase-1 regulates cardiomyocyte survival and hypertrophic response. Circulation. 2005 Apr 05; 111(13):1652-9. PMID: 15795328.
      Citations: 41     Fields:    Translation:AnimalsCells
    47. Matsui T, Rosenzweig A. Convergent signal transduction pathways controlling cardiomyocyte survival and function: the role of PI 3-kinase and Akt. J Mol Cell Cardiol. 2005 Jan; 38(1):63-71. PMID: 15623422.
      Citations: 75     Fields:    Translation:HumansAnimalsCells
    48. Miki N, Ikuta M, Matsui T. Hypoxia-induced activation of the retinoic acid receptor-related orphan receptor alpha4 gene by an interaction between hypoxia-inducible factor-1 and Sp1. J Biol Chem. 2004 Apr 09; 279(15):15025-31. PMID: 14742449.
      Citations: 28     Fields:    Translation:HumansCells
    49. Suzuki Y, Yoshimaru T, Matsui T, Inoue T, Niide O, Nunomura S, Ra C. Fc epsilon RI signaling of mast cells activates intracellular production of hydrogen peroxide: role in the regulation of calcium signals. J Immunol. 2003 Dec 01; 171(11):6119-27. PMID: 14634127.
      Citations: 17     Fields:    Translation:AnimalsCells
    50. Cook SA, Novikov MS, Ahn Y, Matsui T, Rosenzweig A. A20 is dynamically regulated in the heart and inhibits the hypertrophic response. Circulation. 2003 Aug 12; 108(6):664-7. PMID: 12900338.
      Citations: 18     Fields:    Translation:AnimalsCells
    51. Yasuhara S, Zhu Y, Matsui T, Tipirneni N, Yasuhara Y, Kaneki M, Rosenzweig A, Martyn JA. Comparison of comet assay, electron microscopy, and flow cytometry for detection of apoptosis. J Histochem Cytochem. 2003 Jul; 51(7):873-85. PMID: 12810838.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    52. Matsui T, Rosenzweig A. Targeting ischemic cardiac dysfunction through gene transfer. Curr Atheroscler Rep. 2003 May; 5(3):191-5. PMID: 12667431.
      Citations:    Fields:    Translation:HumansCells
    53. Matsui T, Nagoshi T, Rosenzweig A. Akt and PI 3-kinase signaling in cardiomyocyte hypertrophy and survival. . 2003 May-Jun; 2(3):220-3. PMID: 12734428.
      Citations:    
    54. Chao W, Matsui T, Novikov MS, Tao J, Li L, Liu H, Ahn Y, Rosenzweig A. Strategic advantages of insulin-like growth factor-I expression for cardioprotection. J Gene Med. 2003 Apr; 5(4):277-86. PMID: 12692862.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    55. Hajjar RJ, Huq F, Matsui T, Rosenzweig A. Genetic editing of dysfunctional myocardium. Med Clin North Am. 2003 Mar; 87(2):553-67. PMID: 12693739.
      Citations:    Fields:    Translation:HumansCells
    56. Miyakura Y, Sugano K, Konishi F, Fukayama N, Igarashi S, Kotake K, Matsui T, Koyama Y, Maekawa M, Nagai H. Methylation profile of the MLH1 promoter region and their relationship to colorectal carcinogenesis. Genes Chromosomes Cancer. 2003 Jan; 36(1):17-25. PMID: 12461746.
      Citations: 3     Fields:    Translation:HumansCells
    57. Suzuki Y, Yoshimaru T, Matsui T, Ra C. Silver activates calcium signals in rat basophilic leukemia-2H3 mast cells by a mechanism that differs from the Fc epsilon RI-activated response. J Immunol. 2002 Oct 01; 169(7):3954-62. PMID: 12244196.
      Citations: 1     Fields:    Translation:AnimalsCells
    58. Cook SA, Matsui T, Li L, Rosenzweig A. Transcriptional effects of chronic Akt activation in the heart. J Biol Chem. 2002 Jun 21; 277(25):22528-33. PMID: 11956204.
      Citations: 62     Fields:    Translation:AnimalsCells
    59. Matsui T, Li L, Wu JC, Cook SA, Nagoshi T, Picard MH, Liao R, Rosenzweig A. Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart. J Biol Chem. 2002 Jun 21; 277(25):22896-901. PMID: 11943770.
      Citations: 162     Fields:    Translation:AnimalsCells
    60. Meiler SE, Hung RR, Gerszten RE, Gianetti J, Li L, Matsui T, Gimbrone MA, Rosenzweig A. Endothelial IKK beta signaling is required for monocyte adhesion under laminar flow conditions. J Mol Cell Cardiol. 2002 Mar; 34(3):349-59. PMID: 11945026.
      Citations: 6     Fields:    Translation:HumansCells
    61. Matsui T, Tao J, del Monte F, Lee KH, Li L, Picard M, Force TL, Franke TF, Hajjar RJ, Rosenzweig A. Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo. Circulation. 2001 Jul 17; 104(3):330-5. PMID: 11457753.
      Citations: 196     Fields:    Translation:AnimalsCells
    62. Gerszten RE, Friedrich EB, Matsui T, Hung RR, Li L, Force T, Rosenzweig A. Role of phosphoinositide 3-kinase in monocyte recruitment under flow conditions. J Biol Chem. 2001 Jul 20; 276(29):26846-51. PMID: 11278864.
      Citations: 12     Fields:    Translation:HumansCells
    63. Matsui T, Li L, Fukui Y, Franke TF, Hajjar RJ, Rosenzweig A. Adenoviral gene transfer of activated phosphatidylinositol 3'-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro. Circulation. 1999 Dec 07; 100(23):2373-9. PMID: 10587343.
      Citations: 104     Fields:    Translation:AnimalsCells
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