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Ralph V. Shohet, MD

Faculty RankProfessor
InstitutionUniversity of Hawaii
AddressCOBRE Center for Cardiovascular Research
John A. Burns School of Medicine
651 Ilalo Street, Bio-Sciences Building 311
Honolulu HI 96813
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    I spent my first 15 years on the faculty at the University of Texas Southwestern Medical Center where I pursued molecular investigations of cardiovascular biology. There I developed my interests in hypoxia and technology development which are presently the central efforts of my lab. I moved to the University of Hawaii in December 2005 to help JABSOM fulfill its promise to become an advanced biomedical research institution. We established a Center for Cardiovascular Research and with the support of a renewed COBRE grant, and substantial institutional support, we have created a sustainable, nationally competitive effort in cardiovascular basic science. We work closely with the other infrastructure programs, including the other COBREs, RCMI, and R-CTR efforts, to develop complementary Core resources, provide mentored career development opportunities for young investigators, enhance biomedical education, and discover new understanding of medically important biology.

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Anderson CD, Walton CB, Shohet RV. A Comparison of Focused and Unfocused Ultrasound for Microbubble-Mediated Gene Delivery. Ultrasound Med Biol. 2021 Mar 31. PMID: 33812691.
      Citations:    Fields:    
    2. Williams AL, Khadka VS, Anagaran MCT, Lee K, Avelar A, Deng Y, Shohet RV. miR-125 family regulates XIRP1 and FIH in response to myocardial infarction. Physiol Genomics. 2020 08 01; 52(8):358-368. PMID: 32716698.
      Citations:    Fields:    
    3. Baldassari AR, Sitlani CM, Highland HM, Arking DE, Buyske S, Darbar D, Gondalia R, Graff M, Guo X, Heckbert SR, Hindorff LA, Hodonsky CJ, Ida Chen YD, Kaplan RC, Peters U, Post W, Reiner AP, Rotter JI, Shohet RV, Seyerle AA, Sotoodehnia N, Tao R, Taylor KD, Wojcik GL, Yao J, Kenny EE, Lin HJ, Soliman EZ, Whitsel EA, North KE, Kooperberg C, Avery CL. Multi-Ethnic Genome-Wide Association Study of Decomposed Cardioelectric Phenotypes Illustrates Strategies to Identify and Characterize Evidence of Shared Genetic Effects for Complex Traits. Circ Genom Precis Med. 2020 08; 13(4):e002680. PMID: 32602732.
      Citations: 1     Fields:    
    4. Ching LL, Nerurkar VR, Lim E, Shohet RV, Melish ME, Bratincsak A. Elevated Levels of Pentraxin 3 Correlate With Neutrophilia and Coronary Artery Dilation During Acute Kawasaki Disease. Front Pediatr. 2020; 8:295. PMID: 32670996.
    5. Schunke KJ, Walton CB, Veal DR, Mafnas CT, Anderson CD, Williams AL, Shohet RV. Protein kinase C binding protein 1 inhibits hypoxia-inducible factor-1 in the heart. Cardiovasc Res. 2019 07 01; 115(8):1332-1342. PMID: 30395227.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    6. Marcinko MC, Darrow AL, Tuia AJ, Shohet RV. Sex influences susceptibility to methamphetamine cardiomyopathy in mice. Physiol Rep. 2019 03; 7(6):e14036. PMID: 30891941.
      Citations: 3     Fields:    Translation:AnimalsCells
    7. Williams AL, Walton CB, MacCannell KA, Avelar A, Shohet RV. HIF-1 regulation of miR-29c impairs SERCA2 expression and cardiac contractility. Am J Physiol Heart Circ Physiol. 2019 03 01; 316(3):H554-H565. PMID: 30575439.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    8. Lam L, Ahn HJ, Okajima K, Schoenman K, Seto TB, Shohet RV, Miyamura J, Sentell TL, Nakagawa K. Gender Differences in the Rate of 30-Day Readmissions after Percutaneous Coronary Intervention for Acute Coronary Syndrome. Womens Health Issues. 2019 Jan - Feb; 29(1):17-22. PMID: 30482594.
      Citations: 1     Fields:    Translation:Humans
    9. Akram KM, Moyo NA, Leeming GH, Bingle L, Jasim S, Hussain S, Schorlemmer A, Kipar A, Digard P, Tripp RA, Shohet RV, Bingle CD, Stewart JP. An innate defense peptide BPIFA1/SPLUNC1 restricts influenza A virus infection. Mucosal Immunol. 2018 05; 11(3):1008. PMID: 29845976.
      Citations: 2     Fields:    
    10. Williams AL, Khadka V, Tang M, Avelar A, Schunke KJ, Menor M, Shohet RV. HIF1 mediates a switch in pyruvate kinase isoforms after myocardial infarction. Physiol Genomics. 2018 07 01; 50(7):479-494. PMID: 29652636.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    11. Bratincsak A, Limm-Chan BN, Nerurkar VR, Ching LL, Reddy VD, Lim E, Shohet RV, Melish ME. Study design and rationale to assess Doxycycline Efficacy in preventing coronary Artery Lesions in children with Kawasaki disease (DEAL trial) - A phase II clinical trial. Contemp Clin Trials. 2018 02; 65:33-38. PMID: 29313803.
      Citations: 1     Fields:    Translation:HumansCTClinical Trials
    12. Krepp JM, Roman MJ, Devereux RB, Bruce A, Prakash SK, Morris SA, Milewicz DM, Holmes KW, Ravekes W, Shohet RV, Pyeritz RE, Maslen CL, Kroner BL, Eagle KA, Preiss L, Asch FM. Bicuspid and unicuspid aortic valves: Different phenotypes of the same disease? Insight from the GenTAC Registry. Congenit Heart Dis. 2017 Dec; 12(6):740-745. PMID: 28805011.
      Citations: 3     Fields:    Translation:Humans
    13. Roman MJ, Pugh NL, Devereux RB, Eagle KA, Holmes K, LeMaire SA, Milewski RK, Morris SA, Prakash SK, Pyeritz RE, Ravekes WJ, Shohet RV, Song HK, Asch FM. Aortic Dilatation Associated With Bicuspid Aortic Valve: Relation to Sex, Hemodynamics, and Valve Morphology (the National Heart Lung and Blood Institute-Sponsored National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions). Am J Cardiol. 2017 Oct 01; 120(7):1171-1175. PMID: 28802510.
      Citations: 8     Fields:    Translation:Humans
    14. Roman MJ, Devereux RB, Preiss LR, Asch FM, Eagle KA, Holmes KW, LeMaire SA, Maslen CL, Milewicz DM, Morris SA, Prakash SK, Pyeritz RE, Ravekes WJ, Shohet RV, Song HK, Weinsaft JW. Associations of Age and Sex With Marfan Phenotype: The National Heart, Lung, and Blood Institute GenTAC (Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions) Registry. Circ Cardiovasc Genet. 2017 Jun; 10(3). PMID: 28600386.
      Citations: 12     Fields:    Translation:Humans
    15. Akram KM, Moyo NA, Leeming GH, Bingle L, Jasim S, Hussain S, Schorlemmer A, Kipar A, Digard P, Tripp RA, Shohet RV, Bingle CD, Stewart JP. An innate defense peptide BPIFA1/SPLUNC1 restricts influenza A virus infection. Mucosal Immunol. 2018 01; 11(1):71-81. PMID: 28513596.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    16. Lum CJ, Nakagawa K, Shohet RV, Seto TB, Taira DA. The Cost-Benefit Balance of Statins in Hawai'i: A Moving Target. Hawaii J Med Public Health. 2017 04; 76(4):99-102. PMID: 28428922.
      Citations:    Fields:    Translation:Humans
    17. Avery CL, Wassel CL, Richard MA, Highland HM, Bien S, Zubair N, Soliman EZ, Fornage M, Bielinski SJ, Tao R, Seyerle AA, Shah SJ, Lloyd-Jones DM, Buyske S, Rotter JI, Post WS, Rich SS, Hindorff LA, Jeff JM, Shohet RV, Sotoodehnia N, Lin DY, Whitsel EA, Peters U, Haiman CA, Crawford DC, Kooperberg C, North KE. Fine mapping of QT interval regions in global populations refines previously identified QT interval loci and identifies signals unique to African and Hispanic descent populations. Heart Rhythm. 2017 04; 14(4):572-580. PMID: 27988371.
      Citations: 11     Fields:    Translation:Humans
    18. Evans DS, Avery CL, Nalls MA, Li G, Barnard J, Smith EN, Tanaka T, Butler AM, Buxbaum SG, Alonso A, Arking DE, Berenson GS, Bis JC, Buyske S, Carty CL, Chen W, Chung MK, Cummings SR, Deo R, Eaton CB, Fox ER, Heckbert SR, Heiss G, Hindorff LA, Hsueh WC, Isaacs A, Jamshidi Y, Kerr KF, Liu F, Liu Y, Lohman KK, Magnani JW, Maher JF, Mehra R, Meng YA, Musani SK, Newton-Cheh C, North KE, Psaty BM, Redline S, Rotter JI, Schnabel RB, Schork NJ, Shohet RV, Singleton AB, Smith JD, Soliman EZ, Srinivasan SR, Taylor HA, Van Wagoner DR, Wilson JG, Young T, Zhang ZM, Zonderman AB, Evans MK, Ferrucci L, Murray SS, Tranah GJ, Whitsel EA, Reiner AP, Sotoodehnia N. Fine-mapping, novel loci identification, and SNP association transferability in a genome-wide association study of QRS duration in African Americans. Hum Mol Genet. 2016 10 01; 25(19):4350-4368. PMID: 27577874.
      Citations: 10     Fields:    Translation:Humans
    19. Roman MJ, Pugh NL, Hendershot TP, Devereux RB, Dietz H, Holmes K, Eagle KA, LeMaire SA, Milewicz DM, Morris SA, Pyeritz RE, Ravekes WJ, Shohet RV, Silberbach M. Aortic Complications Associated With Pregnancy in Marfan Syndrome: The NHLBI National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC). J Am Heart Assoc. 2016 08 11; 5(8). PMID: 27515814.
      Citations: 7     Fields:    Translation:Humans
    20. Weinsaft JW, Devereux RB, Preiss LR, Feher A, Roman MJ, Basson CT, Geevarghese A, Ravekes W, Dietz HC, Holmes K, Habashi J, Pyeritz RE, Bavaria J, Milewski K, LeMaire SA, Morris S, Milewicz DM, Prakash S, Maslen C, Song HK, Silberbach GM, Shohet RV, McDonnell N, Hendershot T, Eagle KA, Asch FM. Aortic Dissection in Patients With Genetically Mediated Aneurysms: Incidence and Predictors in the GenTAC Registry. J Am Coll Cardiol. 2016 06 14; 67(23):2744-2754. PMID: 27282895.
      Citations: 16     Fields:    Translation:Humans
    21. Anderson CD, Moisyadi S, Avelar A, Walton CB, Shohet RV. Ultrasound-targeted hepatic delivery of factor IX in hemophiliac mice. Gene Ther. 2016 06; 23(6):510-9. PMID: 26960037.
      Citations: 7     Fields:    Translation:HumansAnimals
    22. Sun Z, Schriewer J, Tang M, Marlin J, Taylor F, Shohet RV, Konorev EA. The TGF-ß pathway mediates doxorubicin effects on cardiac endothelial cells. J Mol Cell Cardiol. 2016 Jan; 90:129-38. PMID: 26686989.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    23. Darrow AL, Shohet RV. Galectin-3 deficiency exacerbates hyperglycemia and the endothelial response to diabetes. Cardiovasc Diabetol. 2015 Jun 06; 14:73. PMID: 26047815.
      Citations: 14     Fields:    Translation:AnimalsCells
    24. Wu J, Bond C, Chen P, Chen M, Li Y, Shohet RV, Wright G. HIF-1a in the heart: remodeling nucleotide metabolism. J Mol Cell Cardiol. 2015 May; 82:194-200. PMID: 25681585.
      Citations: 4     Fields:    Translation:Animals
    25. Regan JN, Lim J, Shi Y, Joeng KS, Arbeit JM, Shohet RV, Long F. Up-regulation of glycolytic metabolism is required for HIF1a-driven bone formation. Proc Natl Acad Sci U S A. 2014 Jun 10; 111(23):8673-8. PMID: 24912186.
      Citations: 45     Fields:    Translation:AnimalsCells
    26. Dumitrescu L, Carty CL, Franceschini N, Hindorff LA, Cole SA, Bužková P, Schumacher FR, Eaton CB, Goodloe RJ, Duggan DJ, Haessler J, Cochran B, Henderson BE, Cheng I, Johnson KC, Carlson CS, Love SA, Brown-Gentry K, Nato AQ, Quibrera M, Shohet RV, Ambite JL, Wilkens LR, Le Marchand L, Haiman CA, Buyske S, Kooperberg C, North KE, Fornage M, Crawford DC. No evidence of interaction between known lipid-associated genetic variants and smoking in the multi-ethnic PAGE population. Hum Genet. 2013 Dec; 132(12):1427-31. PMID: 24100633.
      Citations: 3     Fields:    Translation:Humans
    27. Anderson CD, Urschitz J, Khemmani M, Owens JB, Moisyadi S, Shohet RV, Walton CB. Ultrasound directs a transposase system for durable hepatic gene delivery in mice. Ultrasound Med Biol. 2013 Dec; 39(12):2351-61. PMID: 24035623.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    28. Walton CB, Ecker J, Anderson CD, Outten JT, Allison RZ, Shohet RV. Cardiac angiogenesis directed by stable Hypoxia Inducible Factor-1. Vasc Cell. 2013 Aug 29; 5(1):15. PMID: 23987100.
    29. Won S, Hong RA, Shohet RV, Seto TB, Parikh NI. Methamphetamine-associated cardiomyopathy. Clin Cardiol. 2013 Dec; 36(12):737-42. PMID: 24037954.
      Citations: 28     Fields:    Translation:HumansAnimals
    30. Wu J, Chen P, Li Y, Ardell C, Der T, Shohet R, Chen M, Wright GL. HIF-1a in heart: protective mechanisms. . 2013 Sep 15; 305(6):H821-8. PMID: 23873797.
    31. Dumitrescu L, Carty CL, Franceschini N, Hindorff LA, Cole SA, Bužková P, Schumacher FR, Eaton CB, Goodloe RJ, Duggan DJ, Haessler J, Cochran B, Henderson BE, Cheng I, Johnson KC, Carlson CS, Love SA, Brown-Gentry K, Nato AQ, Quibrera M, Anderson G, Shohet RV, Ambite JL, Wilkens LR, Marchand LL, Haiman CA, Buyske S, Kooperberg C, North KE, Fornage M, Crawford DC. Post-genome-wide association study challenges for lipid traits: describing age as a modifier of gene-lipid associations in the Population Architecture using Genomics and Epidemiology (PAGE) study. Ann Hum Genet. 2013 Sep; 77(5):416-25. PMID: 23808484.
      Citations: 3     Fields:    Translation:Humans
    32. Darrow AL, Maresh JG, Shohet RV. Mouse models and techniques for the isolation of the diabetic endothelium. ISRN Endocrinol. 2013; 2013:165397. PMID: 23840960.
    33. Taylor KC, Carty CL, Dumitrescu L, Bužková P, Cole SA, Hindorff L, Schumacher FR, Wilkens LR, Shohet RV, Quibrera PM, Johnson KC, Henderson BE, Haessler J, Franceschini N, Eaton CB, Duggan DJ, Cochran B, Cheng I, Carlson CS, Brown-Gentry K, Anderson G, Ambite JL, Haiman C, Le Marchand L, Kooperberg C, Crawford DC, Buyske S, North KE, Fornage M. Investigation of gene-by-sex interactions for lipid traits in diverse populations from the population architecture using genomics and epidemiology study. BMC Genet. 2013 May 01; 14:33. PMID: 23634756.
      Citations: 10     Fields:    Translation:Humans
    34. Yanagihara AA, Shohet RV. Cubozoan venom-induced cardiovascular collapse is caused by hyperkalemia and prevented by zinc gluconate in mice. PLoS One. 2012; 7(12):e51368. PMID: 23251508.
      Citations: 22     Fields:    Translation:Animals
    35. Avery CL, Sethupathy P, Buyske S, He Q, Lin DY, Arking DE, Carty CL, Duggan D, Fesinmeyer MD, Hindorff LA, Jeff JM, Klein L, Patton KK, Peters U, Shohet RV, Sotoodehnia N, Young AM, Kooperberg C, Haiman CA, Mohlke KL, Whitsel EA, North KE. Fine-mapping and initial characterization of QT interval loci in African Americans. PLoS Genet. 2012; 8(8):e1002870. PMID: 22912591.
      Citations: 12     Fields:    Translation:Humans
    36. Darrow AL, Shohet RV, Maresh JG. Transcriptional analysis of the endothelial response to diabetes reveals a role for galectin-3. Physiol Genomics. 2011 Oct 20; 43(20):1144-52. PMID: 21791638.
      Citations: 14     Fields:    Translation:AnimalsCells
    37. Oladipupo S, Hu S, Kovalski J, Yao J, Santeford A, Sohn RE, Shohet R, Maslov K, Wang LV, Arbeit JM. VEGF is essential for hypoxia-inducible factor-mediated neovascularization but dispensable for endothelial sprouting. Proc Natl Acad Sci U S A. 2011 Aug 09; 108(32):13264-9. PMID: 21784979.
      Citations: 62     Fields:    Translation:AnimalsCells
    38. Dumitrescu L, Carty CL, Taylor K, Schumacher FR, Hindorff LA, Ambite JL, Anderson G, Best LG, Brown-Gentry K, Bužková P, Carlson CS, Cochran B, Cole SA, Devereux RB, Duggan D, Eaton CB, Fornage M, Franceschini N, Haessler J, Howard BV, Johnson KC, Laston S, Kolonel LN, Lee ET, MacCluer JW, Manolio TA, Pendergrass SA, Quibrera M, Shohet RV, Wilkens LR, Haiman CA, Le Marchand L, Buyske S, Kooperberg C, North KE, Crawford DC. Genetic determinants of lipid traits in diverse populations from the population architecture using genomics and epidemiology (PAGE) study. PLoS Genet. 2011 Jun; 7(6):e1002138. PMID: 21738485.
      Citations: 88     Fields:    Translation:Humans
    39. Walton CB, Anderson CD, Boulay R, Shohet RV. Introduction to the ultrasound targeted microbubble destruction technique. J Vis Exp. 2011 Jun 12; (52). PMID: 21694693.
      Citations: 8     Fields:    Translation:Animals
    40. Miyasato SK, Loeffler J, Shohet R, Zhang J, Lindsey M, Le Saux CJ. Caveolin-1 modulates TGF-ß1 signaling in cardiac remodeling. Matrix Biol. 2011 Jun; 30(5-6):318-29. PMID: 21641995.
      Citations: 26     Fields:    Translation:AnimalsCells
    41. Hoffmann FW, Hashimoto AS, Lee BC, Rose AH, Shohet RV, Hoffmann PR. Specific antioxidant selenoproteins are induced in the heart during hypertrophy. Arch Biochem Biophys. 2011 Aug 01; 512(1):38-44. PMID: 21621505.
      Citations: 12     Fields:    Translation:AnimalsCells
    42. Oladipupo SS, Hu S, Santeford AC, Yao J, Kovalski JR, Shohet RV, Maslov K, Wang LV, Arbeit JM. Conditional HIF-1 induction produces multistage neovascularization with stage-specific sensitivity to VEGFR inhibitors and myeloid cell independence. Blood. 2011 Apr 14; 117(15):4142-53. PMID: 21307392.
      Citations: 35     Fields:    Translation:AnimalsCells
    43. MacCannell KA, Shohet RV. Toward a holistic view of transcriptional regulation. Circ Cardiovasc Genet. 2011 Feb; 4(1):2-3. PMID: 21325161.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    44. Maresh JG, Campen MJ, Reed MD, Darrow AL, Shohet RV. Hypercholesterolemia potentiates aortic endothelial response to inhaled diesel exhaust. Inhal Toxicol. 2011 Jan; 23(1):1-10. PMID: 21222557.
      Citations: 3     Fields:    Translation:AnimalsPHPublic Health
    45. Chun SG, Yee NS, Holland JM, Shohet RV, Palalay MP, Bryant-Greenwood PK. Pancreatic Adenocarcinoma Associated With Werner's Syndrome (Adult-Onset Progeria). Gastrointest Cancer Res. 2011 Jan; 4(1):24-8. PMID: 21464868.
    46. Artaza JN, Contreras S, Garcia LA, Mehrotra R, Gibbons G, Shohet R, Martins D, Norris KC. Vitamin D and cardiovascular disease: potential role in health disparities. J Health Care Poor Underserved. 2011; 22(4 Suppl):23-38. PMID: 22102304.
      Citations: 9     Fields:    Translation:Humans
    47. Bekeredjian R, Walton CB, MacCannell KA, Ecker J, Kruse F, Outten JT, Sutcliffe D, Gerard RD, Bruick RK, Shohet RV. Conditional HIF-1alpha expression produces a reversible cardiomyopathy. PLoS One. 2010 Jul 21; 5(7):e11693. PMID: 20657781.
      Citations: 41     Fields:    Translation:Animals
    48. Chun SG, Armstrong JA, Pang DK, Lau J, Shohet RV. Giant coronary artery aneurysms in a Japanese octogenarian - The oldest case of Kawasaki Disease? J Cardiol Cases. 2010 Apr 01; 1(2):e80-e83. PMID: 23997839.
    49. Walton CB, Shohet RV. Tiny bubbles and endocytosis? Circ Res. 2009 Mar 13; 104(5):563-5. PMID: 19286610.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    50. Schorlemmer A, Matter ML, Shohet RV. Cardioprotective signaling by endothelin. Trends Cardiovasc Med. 2008 Oct; 18(7):233-9. PMID: 19232951.
      Citations: 20     Fields:    Translation:HumansAnimals
    51. Maresh JG, Shohet RV. In vivo endothelial gene regulation in diabetes. Cardiovasc Diabetol. 2008 Apr 19; 7:8. PMID: 18423039.
      Citations: 7     Fields:    Translation:Animals
    52. Le Saux CJ, Teeters K, Miyasato SK, Hoffmann PR, Bollt O, Douet V, Shohet RV, Broide DH, Tam EK. Down-regulation of caveolin-1, an inhibitor of transforming growth factor-beta signaling, in acute allergen-induced airway remodeling. J Biol Chem. 2008 Feb 29; 283(9):5760-8. PMID: 18056268.
      Citations: 26     Fields:    Translation:AnimalsCells
    53. Shohet RV, Garcia JA. Keeping the engine primed: HIF factors as key regulators of cardiac metabolism and angiogenesis during ischemia. J Mol Med (Berl). 2007 Dec; 85(12):1309-15. PMID: 18026917.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    54. Chun SG, Harada GL, Kuriyama DK, Nywening TM, Shohet RV. Broken heart syndrome--a critical review of transient left ventricular apical ballooning. Hawaii Med J. 2007 Oct; 66(10):265-7. PMID: 18065123.
      Citations:    Fields:    Translation:Humans
    55. Lund AK, Knuckles TL, Obot Akata C, Shohet R, McDonald JD, Gigliotti A, Seagrave JC, Campen MJ. Gasoline exhaust emissions induce vascular remodeling pathways involved in atherosclerosis. Toxicol Sci. 2007 Feb; 95(2):485-94. PMID: 17065432.
      Citations: 38     Fields:    Translation:AnimalsCells
    56. Zhao XS, Pan W, Bekeredjian R, Shohet RV. Endogenous endothelin-1 is required for cardiomyocyte survival in vivo. Circulation. 2006 Aug 22; 114(8):830-7. PMID: 16908774.
      Citations: 25     Fields:    Translation:AnimalsCells
    57. Chen S, Ding JH, Bekeredjian R, Yang BZ, Shohet RV, Johnston SA, Hohmeier HE, Newgard CB, Grayburn PA. Efficient gene delivery to pancreatic islets with ultrasonic microbubble destruction technology. Proc Natl Acad Sci U S A. 2006 May 30; 103(22):8469-74. PMID: 16709667.
      Citations: 63     Fields:    Translation:HumansAnimals
    58. Flood EM, Kumar RS, Shah R, Amos Q, Wren JD, Shohet RV, Garner HR. Melatonin administration does not affect isoproterenol-induced LVH. IEEE Eng Med Biol Mag. 2006 May-Jun; 25(3):84-7. PMID: 16764435.
      Citations: 1     Fields:    Translation:HumansAnimals
    59. Shohet RV, Grayburn PA. Potential bioeffects of ultrasonic destruction of microbubble contrast agents. J Am Coll Cardiol. 2006 Apr 04; 47(7):1469-70. PMID: 16580538.
      Citations: 3     Fields:    Translation:Animals
    60. Mineo C, Gormley AK, Yuhanna IS, Osborne-Lawrence S, Gibson LL, Hahner L, Shohet RV, Black S, Salmon JE, Samols D, Karp DR, Thomas GD, Shaul PW. FcgammaRIIB mediates C-reactive protein inhibition of endothelial NO synthase. Circ Res. 2005 Nov 25; 97(11):1124-31. PMID: 16269657.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    61. Yi X, Bekeredjian R, DeFilippis NJ, Siddiquee Z, Fernandez E, Shohet RV. Transcriptional analysis of doxorubicin-induced cardiotoxicity. . 2006 Mar; 290(3):H1098-102. PMID: 16243910.
    62. Korpanty G, Chen S, Shohet RV, Ding J, Yang B, Frenkel PA, Grayburn PA. Targeting of VEGF-mediated angiogenesis to rat myocardium using ultrasonic destruction of microbubbles. Gene Ther. 2005 Sep; 12(17):1305-12. PMID: 15829992.
      Citations: 34     Fields:    Translation:AnimalsCells
    63. Korpanty G, Grayburn PA, Shohet RV, Brekken RA. Targeting vascular endothelium with avidin microbubbles. Ultrasound Med Biol. 2005 Sep; 31(9):1279-83. PMID: 16176794.
      Citations: 25     Fields:    Translation:AnimalsCells
    64. Bekeredjian R, Chen S, Grayburn PA, Shohet RV. Augmentation of cardiac protein delivery using ultrasound targeted microbubble destruction. Ultrasound Med Biol. 2005 May; 31(5):687-91. PMID: 15866418.
      Citations: 29     Fields:    Translation:Animals
    65. Maresh JG, Xu H, Jiang N, Gairola CG, Shohet RV. Tobacco smoke dysregulates endothelial vasoregulatory transcripts in vivo. Physiol Genomics. 2005 May 11; 21(3):308-13. PMID: 15728332.
      Citations: 10     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    66. Bekeredjian R, Grayburn PA, Shohet RV. Use of ultrasound contrast agents for gene or drug delivery in cardiovascular medicine. J Am Coll Cardiol. 2005 Feb 01; 45(3):329-35. PMID: 15680708.
      Citations: 62     Fields:    Translation:Humans
    67. Maresh JG, Xu H, Jiang N, Shohet RV. In vivo transcriptional response of cardiac endothelium to lipopolysaccharide. Arterioscler Thromb Vasc Biol. 2004 Oct; 24(10):1836-41. PMID: 15319271.
      Citations: 1     Fields:    Translation:AnimalsCells
    68. Bekeredjian R, Chen S, Pan W, Grayburn PA, Shohet RV. Effects of ultrasound-targeted microbubble destruction on cardiac gene expression. Ultrasound Med Biol. 2004 Apr; 30(4):539-43. PMID: 15121256.
      Citations: 7     Fields:    Translation:Animals
    69. Bekeredjian R, Shohet RV. Cardiovascular gene therapy: angiogenesis and beyond. Am J Med Sci. 2004 Mar; 327(3):139-48. PMID: 15090752.
      Citations: 1     Fields:    Translation:Humans
    70. Shohet RV, Kisanuki YY, Zhao XS, Siddiquee Z, Franco F, Yanagisawa M. Mice with cardiomyocyte-specific disruption of the endothelin-1 gene are resistant to hyperthyroid cardiac hypertrophy. Proc Natl Acad Sci U S A. 2004 Feb 17; 101(7):2088-93. PMID: 14764893.
      Citations: 25     Fields:    Translation:AnimalsCells
    71. Wren JD, Bekeredjian R, Stewart JA, Shohet RV, Garner HR. Knowledge discovery by automated identification and ranking of implicit relationships. Bioinformatics. 2004 Feb 12; 20(3):389-98. PMID: 14960466.
      Citations: 78     Fields:    
    72. Bekeredjian R, Chen S, Frenkel PA, Grayburn PA, Shohet RV. Ultrasound-targeted microbubble destruction can repeatedly direct highly specific plasmid expression to the heart. Circulation. 2003 Aug 26; 108(8):1022-6. PMID: 12912823.
      Citations: 79     Fields:    Translation:AnimalsCells
    73. Chen S, Shohet RV, Bekeredjian R, Frenkel P, Grayburn PA. Optimization of ultrasound parameters for cardiac gene delivery of adenoviral or plasmid deoxyribonucleic acid by ultrasound-targeted microbubble destruction. J Am Coll Cardiol. 2003 Jul 16; 42(2):301-8. PMID: 12875768.
      Citations: 49     Fields:    Translation:AnimalsCells
    74. Wu H, Gallardo T, Olson EN, Williams RS, Shohet RV. Transcriptional analysis of mouse skeletal myofiber diversity and adaptation to endurance exercise. J Muscle Res Cell Motil. 2003; 24(8):587-92. PMID: 14870974.
      Citations: 10     Fields:    Translation:AnimalsCells
    75. Zhao XS, Gallardo TD, Lin L, Schageman JJ, Shohet RV. Transcriptional mapping and genomic analysis of the cardiac atria and ventricles. Physiol Genomics. 2002 Dec 26; 12(1):53-60. PMID: 12502795.
      Citations: 15     Fields:    Translation:AnimalsCells
    76. Chen S, Kroll MH, Shohet RV, Frenkel P, Mayer SA, Grayburn PA. Bioeffects of myocardial contrast microbubble destruction by echocardiography. Echocardiography. 2002 Aug; 19(6):495-500. PMID: 12356345.
      Citations: 12     Fields:    Translation:Animals
    77. Frenkel PA, Chen S, Thai T, Shohet RV, Grayburn PA. DNA-loaded albumin microbubbles enhance ultrasound-mediated transfection in vitro. Ultrasound Med Biol. 2002 Jun; 28(6):817-22. PMID: 12113794.
      Citations: 31     Fields:    Translation:AnimalsCells
    78. Shohet RV, Vega GL, Bersot TP, Mahley RW, Grundy SM, Guerra R, Cohen JC. Sources of variability in genetic association studies: insights from the analysis of hepatic lipase (LIPC). Hum Mutat. 2002 May; 19(5):536-42. PMID: 11968086.
      Citations: 6     Fields:    Translation:Humans
    79. Schageman JJ, Basit M, Gallardo TD, Garner HR, Shohet RV. MarC-V: a spreadsheet-based tool for analysis, normalization, and visualization of single cDNA microarray experiments. Biotechniques. 2002 Feb; 32(2):338-40, 342, 344. PMID: 11848411.
      Citations: 3     Fields:    
    80. Moore LG, Zamudio S, Zhuang J, Droma T, Shohet RV. Analysis of the myoglobin gene in Tibetans living at high altitude. High Alt Med Biol. 2002; 3(1):39-47. PMID: 12006163.
      Citations: 9     Fields:    Translation:Humans
    81. Fernandez E, Siddiquee Z, Shohet RV. Apoptosis and proliferation in the neonatal murine heart. Dev Dyn. 2001 Jul; 221(3):302-10. PMID: 11458390.
      Citations: 19     Fields:    Translation:Animals
    82. Wren JD, Forgacs E, Fondon JW, Pertsemlidis A, Cheng SY, Gallardo T, Williams RS, Shohet RV, Minna JD, Garner HR. Repeat polymorphisms within gene regions: phenotypic and evolutionary implications. Am J Hum Genet. 2000 Aug; 67(2):345-56. PMID: 10889045.
      Citations: 53     Fields:    Translation:HumansCells
    83. Shohet RV, Chen S, Zhou YT, Wang Z, Meidell RS, Unger RH, Grayburn PA. Echocardiographic destruction of albumin microbubbles directs gene delivery to the myocardium. Circulation. 2000 Jun 06; 101(22):2554-6. PMID: 10840004.
      Citations: 70     Fields:    Translation:Animals
    84. Kukanskis KA, Siddiquee Z, Shohet RV, Garner HR. Mix of sequencing technologies for sequence closure: an example. Biotechniques. 2000 Apr; 28(4):630-2, 634. PMID: 10769739.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    85. Shohet RV, Vega GL, Anwar A, Cigarroa JE, Grundy SM, Cohen JC. Hepatic lipase (LIPC) promoter polymorphism in men with coronary artery disease. Allele frequency and effects on hepatic lipase activity and plasma HDL-C concentrations. Arterioscler Thromb Vasc Biol. 1999 Aug; 19(8):1975-8. PMID: 10446080.
      Citations: 9     Fields:    Translation:Humans
    86. Shohet RV, Anwar A, Johnston JM, Cohen JC. Plasma platelet-activating factor acetylhydrolase activity is not associated with premature coronary atherosclerosis. Am J Cardiol. 1999 Jan 01; 83(1):109-11, A8-9. PMID: 10073795.
      Citations: 3     Fields:    Translation:Humans
    87. Yan Z, DeGregori J, Shohet R, Leone G, Stillman B, Nevins JR, Williams RS. Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells. Proc Natl Acad Sci U S A. 1998 Mar 31; 95(7):3603-8. PMID: 9520412.
      Citations: 88     Fields:    Translation:HumansAnimalsCells
    88. Franco F, Dubois SK, Peshock RM, Shohet RV. Magnetic resonance imaging accurately estimates LV mass in a transgenic mouse model of cardiac hypertrophy. Am J Physiol. 1998 02; 274(2):H679-83. PMID: 9486274.
      Citations: 28     Fields:    Translation:AnimalsCells
    89. Williams RS, Shohet RV, Stillman B. A human protein related to yeast Cdc6p. Proc Natl Acad Sci U S A. 1997 Jan 07; 94(1):142-7. PMID: 8990175.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    90. Fernandez E, Duke A, Sevrioukova I, Shohet RV. Analysis of the myoglobin gene in heart disease. Hum Mutat. 1997; 9(5):426-30. PMID: 9143922.
      Citations:    Fields:    Translation:Humans
    91. O'Brien PJ, Duke AL, Shen H, Shohet RV. Myocardial mRNA content and stability, and enzyme activities of Ca-cycling and aerobic metabolism in canine dilated cardiomyopathies. Mol Cell Biochem. 1995 Jan 26; 142(2):139-50. PMID: 7770066.
      Citations: 2     Fields:    Translation:AnimalsCells
    92. Shohet RV, Spitzer S, Madison EL, Bassel-Duby R, Gething MJ, Sambrook JF. Inhibitor-resistant tissue-type plasminogen activator: an improved thrombolytic agent in vitro. Thromb Haemost. 1994 Jan; 71(1):124-8. PMID: 8165630.
      Citations:    Fields:    Translation:HumansAnimalsCells
    93. Bassel-Duby R, Jiang NY, Bittick T, Madison E, McGookey D, Orth K, Shohet R, Sambrook J, Gething MJ. Tyrosine 67 in the epidermal growth factor-like domain of tissue-type plasminogen activator is important for clearance by a specific hepatic receptor. J Biol Chem. 1992 May 15; 267(14):9668-77. PMID: 1315765.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    94. Shohet RV, Conti MA, Kawamoto S, Preston YA, Brill DA, Adelstein RS. Cloning of the cDNA encoding the myosin heavy chain of a vertebrate cellular myosin. Proc Natl Acad Sci U S A. 1989 Oct; 86(20):7726-30. PMID: 2813355.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
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