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James Porter

Faculty RankProfessor
AddressP.O. Box 7030
Ponce PR 00742
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    Functional imaging studies in PTSD patients suggest that reduced activation of the medial prefrontal cortex (mPFC) contributes to the excessive fear response seen in these patients. To understand why the mPFC is less activated in PTSD patients, we need to understand the mechanisms by which fear conditioning and extinction alter mPFC excitability. Patch-clamp recordings of infralimbic (IL) neurons in the mPFC revealed that the intrinsic excitability of IL neurons was depressed by fear conditioning in rats. The depressed IL excitability could reduce IL activation and enhance conditioned fear responses. Consistent with this, reducing IL intrinsic excitability enhances conditioned fear response. These findings imply that intrinsic plasticity in IL contributes to the consolidation of the conditioned fear memory. Currently we are working to extend these results by examining the mechanisms and circuits involved in this fear conditioning-induced depression of IL intrinsic excitability. A better understanding of the mechanisms leading to intrinsic plasticity in this brain structure may provide direction for the development of novel treatments for PTSD.

    Rather than erase fear memory, extinction is thought to form a new memory that signals safety. The goal of this project is to understand how extinction memory is encoded at the level of single neurons. Since a growing body of literature implicates enhanced activity in the infralimbic region (IL) of the medial prefrontal cortex in the retention of fear extinction, we are examining the intrinsic and synaptic mechanisms that mediate the enhanced activity of the IL neurons after extinction training. We are applying a multidisciplinary approach combining patch-clamp electrophysiology in brain slices, histology, behavioral training, molecular techniques, optogenetics and in vitro and in vivo neuropharmacology.

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    R15MH101700     (PORTER, JAMES T.)Aug 1, 2013 - Jul 31, 2017
    Fear Modulation of IL excitability
    Role: Principal Investigator

    R15MH116345     (PORTER, JAMES T.)Sep 1, 2018 - Aug 31, 2021
    Fkbp5 modulation of prefrontal function.
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Boulle A, Davies MA, Hussey H, Ismail M, Morden E, Vundle Z, Zweigenthal V, Mahomed H, Paleker M, Pienaar D, Tembo Y, Lawrence C, Isaacs W, Mathema H, Allen D, Allie T, Bam JL, Buddiga K, Dane P, Heekes A, Matlapeng B, Mutemaringa T, Muzarabani L, Phelanyane F, Pienaar R, Rode C, Smith M, Tiffin N, Zinyakatira N, Cragg C, Marais F, Mudaly V, Voget J, Davids J, Roodt F, van Zyl Smit N, Vermeulen A, Adams K, Audley G, Bateman K, Beckwith P, Bernon M, Blom D, Boloko L, Botha J, Boutall A, Burmeister S, Cairncross L, Calligaro G, Coccia C, Corin C, Daroowala R, Dave JA, De Bruyn E, De Villiers M, Deetlefs M, Dlamini S, Du Toit T, Endres W, Europa T, Fieggan G, Figaji A, Frankenfeld P, Gatley E, Gina P, Govender E, Grobler R, Gule MV, Hanekom C, Held M, Heynes A, Hlatswayo S, Hodkinson B, Holtzhausen J, Hoosain S, Jacobs A, Kahn M, Kahn T, Khamajeet A, Khan J, Khan R, Khwitshana A, Knight L, Kooverjee S, Krogscheepers R, Jacque Kruger J, Kuhn S, Laubscher K, Lazarus J, Le Roux J, Lee Jones S, Levin D, Maartens G, Majola T, Manganyi R, Marais D, Marais S, Maritz F, Maughan D, Mazondwa S, Mbanga L, Mbatani N, Mbena B, Meintjes G, Mendelson M, Möller E, Moore A, Ndebele B, Nortje M, Ntusi N, Nyengane F, Ofoegbu C, Papavarnavas N, Peter J, Pickard H, Pluke K, Raubenheimer PJ, Robertson G, Rozmiarek J, Sayed A, Scriba M, Sekhukhune H, Singh P, Smith E, Soldati V, Stek C, van den Berg R, van der Merwe LR, Venter P, Vermooten B, Viljoen G, Viranna S, Vogel J, Vundla N, Wasserman S, Zitha E, Lomas-Marais V, Lombard A, Stuve K, Viljoen W, Basson V, Le Roux S, Linden-Mars E, Victor L, Wates M, Zwanepoel E, Ebrahim N, Lahri S, Mnguni A, Crede T, de Man M, Evans K, Hendrikse C, Naude J, Parak M, Szymanski P, Van Koningsbruggen C, Abrahams R, Allwood B, Botha C, Henndrik Botha M, Broadhurst A, Claasen D, Daniel C, Dawood R, du Preez M, Du Toit N, Erasmus K, Koegelenberg CFN, Gabriel S, Hugo S, Jardine T, Johannes C, Karamchand S, Lalla U, Langenegger E, Louw E, Mashigo B, Mhlana N, Mnqwazi C, Moodley A, Moodley D, Moolla S, Mowlana A, Nortje A, Olivier E, Parker A, Paulsen C, Prozesky H, Rood J, Sabela T, Schrueder N, Sithole N, Sithole S, Taljaard JJ, Titus G, Van Der Merwe T, van Schalkwyk M, Vazi L, Viljoen AJ, Yazied Chothia M, Naidoo V, Alan Wallis L, Abbass M, Arendse J, Armien R, Bailey R, Bello M, Carelse R, Forgus S, Kalawe N, Kariem S, Kotze M, Lucas J, McClaughlin J, Murie K, Najjaar L, Petersen L, Porter J, Shaw M, Stapar D, Williams M, Aldum L, Berkowitz N, Girran R, Lee K, Naidoo L, Neumuller C, Anderson K, Begg K, Boerlage L, Cornell M, de Waal R, Dudley L, English R, Euvrard J, Groenewald P, Jacob N, Jaspan H, Kalk E, Levitt N, Malaba T, Nyakato P, Patten G, Schneider H, Shung King M, Tsondai P, Van Duuren J, van Schaik N, Blumberg L, Cohen C, Govender N, Jassat W, Kufa T, McCarthy K, Morris L, Hsiao NY, Marais R, Ambler J, Ngwenya O, Osei-Yeboah R, Johnson L, Kassanjee R, Tamuhla T. Risk factors for COVID-19 death in a population cohort study from the Western Cape Province, South Africa. Clin Infect Dis. 2020 Aug 29. PMID: 32860699.
      Citations: 35     Fields:    
    2. Porter JT, Sepulveda-Orengo MT. Learning-induced intrinsic and synaptic plasticity in the rodent medial prefrontal cortex. Neurobiol Learn Mem. 2020 03; 169:107117. PMID: 31765801.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Mateo Z, Porter JT. Developmental decline in modulation of glutamatergic synapses in layer IV of the barrel cortex by group II metabotropic glutamate receptors. Neuroscience. 2015 Apr 02; 290:41-8. PMID: 25595969.
      Citations: 2     Fields:    Translation:AnimalsCells
    4. Pacheco WI, Noel RJ, Porter JT, Appleyard CB. Beyond the GRE: using a composite score to predict ?the success of Puerto Rican students in a biomedical ?PhD program. CBE Life Sci Educ. 2015; 14(2). PMID: 25828404.
      Citations: 3     Fields:    Translation:Humans
    5. Cruz E, López AV, Porter JT. Spontaneous recovery of fear reverses extinction-induced excitability of infralimbic neurons. PLoS One. 2014; 9(8):e103596. PMID: 25089624.
      Citations: 10     Fields:    Translation:AnimalsCells
    6. Vázquez-Santiago FJ, Noel RJ, Porter JT, Rivera-Amill V. Glutamate metabolism and HIV-associated neurocognitive disorders. J Neurovirol. 2014 Aug; 20(4):315-31. PMID: 24867611.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    7. Criado-Marrero M, Santini E, Porter JT. Modulating fear extinction memory by manipulating SK potassium channels in the infralimbic cortex. Front Behav Neurosci. 2014; 8:96. PMID: 24715857.
    8. Sepulveda-Orengo MT, Lopez AV, Soler-Cedeño O, Porter JT. Fear extinction induces mGluR5-mediated synaptic and intrinsic plasticity in infralimbic neurons. J Neurosci. 2013 Apr 24; 33(17):7184-93. PMID: 23616528.
      Citations: 36     Fields:    Translation:AnimalsCells
    9. Chompre G, Cruz E, Maldonado L, Rivera-Amill V, Porter JT, Noel RJ. Astrocytic expression of HIV-1 Nef impairs spatial and recognition memory. Neurobiol Dis. 2013 Jan; 49:128-36. PMID: 22926191.
      Citations: 28     Fields:    Translation:AnimalsCells
    10. Santini E, Sepulveda-Orengo M, Porter JT. Muscarinic receptors modulate the intrinsic excitability of infralimbic neurons and consolidation of fear extinction. Neuropsychopharmacology. 2012 Aug; 37(9):2047-56. PMID: 22510723.
      Citations: 37     Fields:    Translation:AnimalsCells
    11. Santini E, Porter JT. M-type potassium channels modulate the intrinsic excitability of infralimbic neurons and regulate fear expression and extinction. J Neurosci. 2010 Sep 15; 30(37):12379-86. PMID: 20844133.
      Citations: 40     Fields:    Translation:AnimalsCells
    12. Fontanez-Nuin DE, Santini E, Quirk GJ, Porter JT. Memory for fear extinction requires mGluR5-mediated activation of infralimbic neurons. Cereb Cortex. 2011 Mar; 21(3):727-35. PMID: 20705895.
      Citations: 51     Fields:    Translation:AnimalsCells
    13. Shavali S, Brown-Borg HM, Ebadi M, Porter J. Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells. Neurosci Lett. 2008 Jul 11; 439(2):125-8. PMID: 18514418.
      Citations: 59     Fields:    Translation:HumansCells
    14. Santini E, Quirk GJ, Porter JT. Fear conditioning and extinction differentially modify the intrinsic excitability of infralimbic neurons. J Neurosci. 2008 Apr 09; 28(15):4028-36. PMID: 18400902.
      Citations: 122     Fields:    Translation:AnimalsCells
    15. Mueller D, Porter JT, Quirk GJ. Noradrenergic signaling in infralimbic cortex increases cell excitability and strengthens memory for fear extinction. J Neurosci. 2008 Jan 09; 28(2):369-75. PMID: 18184779.
      Citations: 116     Fields:    Translation:AnimalsCells
    16. Mateo Z, Porter JT. Group II metabotropic glutamate receptors inhibit glutamate release at thalamocortical synapses in the developing somatosensory cortex. Neuroscience. 2007 May 25; 146(3):1062-72. PMID: 17418955.
      Citations: 23     Fields:    Translation:AnimalsCells
    17. Kooncumchoo P, Sharma S, Porter J, Govitrapong P, Ebadi M. Coenzyme Q(10) provides neuroprotection in iron-induced apoptosis in dopaminergic neurons. J Mol Neurosci. 2006; 28(2):125-41. PMID: 16679553.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    18. Fontanez DE, Porter JT. Adenosine A1 receptors decrease thalamic excitation of inhibitory and excitatory neurons in the barrel cortex. Neuroscience. 2006; 137(4):1177-84. PMID: 16343787.
      Citations: 25     Fields:    Translation:AnimalsCells
    19. Porter JT, Nieves D. Presynaptic GABAB receptors modulate thalamic excitation of inhibitory and excitatory neurons in the mouse barrel cortex. J Neurophysiol. 2004 Nov; 92(5):2762-70. PMID: 15254073.
      Citations: 33     Fields:    Translation:AnimalsCells
    20. Porter JT, Johnson CK, Agmon A. Diverse types of interneurons generate thalamus-evoked feedforward inhibition in the mouse barrel cortex. J Neurosci. 2001 Apr 15; 21(8):2699-710. PMID: 11306623.
      Citations: 114     Fields:    Translation:AnimalsCells
    21. Wells JE, Porter JT, Agmon A. GABAergic inhibition suppresses paroxysmal network activity in the neonatal rodent hippocampus and neocortex. J Neurosci. 2000 Dec 01; 20(23):8822-30. PMID: 11102490.
      Citations: 10     Fields:    Translation:AnimalsCells
    22. Cauli B, Porter JT, Tsuzuki K, Lambolez B, Rossier J, Quenet B, Audinat E. Classification of fusiform neocortical interneurons based on unsupervised clustering. Proc Natl Acad Sci U S A. 2000 May 23; 97(11):6144-9. PMID: 10823957.
      Citations: 103     Fields:    Translation:AnimalsCells
    23. Porter JT, Cauli B, Tsuzuki K, Lambolez B, Rossier J, Audinat E. Selective excitation of subtypes of neocortical interneurons by nicotinic receptors. J Neurosci. 1999 Jul 01; 19(13):5228-35. PMID: 10377334.
      Citations: 93     Fields:    Translation:AnimalsCells
    24. Porter JT, Cauli B, Staiger JF, Lambolez B, Rossier J, Audinat E. Properties of bipolar VIPergic interneurons and their excitation by pyramidal neurons in the rat neocortex. Eur J Neurosci. 1998 Dec; 10(12):3617-28. PMID: 9875341.
      Citations: 58     Fields:    Translation:AnimalsCells
    25. Porter JT, McCarthy KD. Astrocytic neurotransmitter receptors in situ and in vivo. Prog Neurobiol. 1997 Mar; 51(4):439-55. PMID: 9106901.
      Citations: 101     Fields:    Translation:HumansAnimalsCells
    26. Porter JT, McCarthy KD. Hippocampal astrocytes in situ respond to glutamate released from synaptic terminals. J Neurosci. 1996 Aug 15; 16(16):5073-81. PMID: 8756437.
      Citations: 178     Fields:    Translation:AnimalsCells
    27. Porter JT, McCarthy KD. Adenosine receptors modulate [Ca2+]i in hippocampal astrocytes in situ. J Neurochem. 1995 Oct; 65(4):1515-23. PMID: 7561845.
      Citations: 16     Fields:    Translation:AnimalsCells
    28. Porter JT, McCarthy KD. GFAP-positive hippocampal astrocytes in situ respond to glutamatergic neuroligands with increases in [Ca2+]i. Glia. 1995 Feb; 13(2):101-12. PMID: 7544323.
      Citations: 29     Fields:    Translation:AnimalsCells
    29. Shao Y, Porter JT, McCarthy KD. Neuroligand receptor heterogeneity among astroglia. Perspect Dev Neurobiol. 1994; 2(3):205-15. PMID: 7850353.
      Citations: 9     Fields:    Translation:AnimalsCells
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