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Felicite Noubissi

Faculty RankAssistant Professor
InstitutionJackson State University
Address1400 J. R. Lynch St.
John A. People's Building, Room 429
Jackson MS 39217
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    My research program is focused on the investigation of the cellular and molecular mechanisms underlying tumor development with the goal of identifying new therapeutic targets for cancer treatment.

    -My previous research uncovered an RNA-binding protein, CRD-BP (coding region determinant-binding protein) which is a Wnt/Bcatenin target. It seems to play a critical role in cancer development and metastasis. CRD-BP also mediates a cross talk between Wnt and Hh signaling pathways in colorectal cancer development. The role of CRD-BP in the cross talk between Wnt and Hh appears critical for basal cell carcinoma development as suggested the basal cell carcinoma cell line UW-BCC1 that we generated. Using this cell line, my lab continues to study the role of Wnt and CRD-BP in basal cell carcinoma developement.

    -My research has expanded on investigating mechanisms of cancer metastasis and drug resistance. Identifying mechanisms of cancer heterogeneity leading to drug resistance and metastasis are some aspects of my current research program. We previously demonstrated that breast tumor cells fuse with mesenchymal stem/stromal cells (MSCs) spontaneously and fusion products showed increased metastatic potential. We also observed that fusion between non metastatic breast cancer cells and MSCs was enhanced with hypoxia by a mechanism involving apoptosis. My lab is investigating cellular and molecular aspects of cancer cell fusion-driven heterogeneity and metastasis.

    Collapse Research 
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    R21CA153102     (NOUBISSI, FELICITE K)Sep 1, 2010 - Aug 31, 2013
    Role of CRD-BP in Basal Cell Carcinoma Development
    Role: Principal Investigator

    R03CA223099     (NOUBISSI, FELICITE K)Aug 1, 2018 - Jul 31, 2021
    A novel approach in Basal Cell Carcinoma treatment; targeting CRD-BP
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mbemi AT, Sims JN, Yedjou CG, Noubissi FK, Gomez CR, Tchounwou PB. Vernonia calvoana Shows Promise towards the Treatment of Ovarian Cancer. Int J Mol Sci. 2020 Jun 22; 21(12). PMID: 32580345.
      Citations:    Fields:    
    2. Yedjou CG, Mbemi AT, Noubissi F, Tchounwou SS, Tsabang N, Payton M, Miele L, Tchounwou PB. Prostate Cancer Disparity, Chemoprevention, and Treatment by Specific Medicinal Plants. Nutrients. 2019 Feb 04; 11(2). PMID: 30720759.
      Citations: 4     Fields:    Translation:HumansAnimals
    3. Yedjou CG, Sims JN, Miele L, Noubissi F, Lowe L, Fonseca DD, Alo RA, Payton M, Tchounwou PB. Health and Racial Disparity in Breast Cancer. Adv Exp Med Biol. 2019; 1152:31-49. PMID: 31456178.
      Citations: 8     Fields:    Translation:Humans
    4. Tchounwou PB, Yedjou CG, Udensi UK, Pacurari M, Stevens JJ, Patlolla AK, Noubissi F, Kumar S. State of the science review of the health effects of inorganic arsenic: Perspectives for future research. Environ Toxicol. 2019 Feb; 34(2):188-202. PMID: 30511785.
      Citations: 1     Fields:    Translation:HumansAnimals
    5. Chitwood CA, Dietzsch C, Jacobs G, McArdle T, Freeman BT, Banga A, Noubissi FK, Ogle BM. Breast tumor cell hybrids form spontaneously in vivo and contribute to breast tumor metastases. APL Bioeng. 2018 Sep; 2(3):031907. PMID: 31069316.
    6. Rady I, Bloch MB, Chamcheu RN, Banang Mbeumi S, Anwar MR, Mohamed H, Babatunde AS, Kuiate JR, Noubissi FK, El Sayed KA, Whitfield GK, Chamcheu JC. Anticancer Properties of Graviola (Annona muricata): A Comprehensive Mechanistic Review. Oxid Med Cell Longev. 2018; 2018:1826170. PMID: 30151067.
      Citations: 3     Fields:    Translation:HumansAnimals
    7. Noubissi FK, Yedjou CG, Spiegelman VS, Tchounwou PB. Cross-Talk between Wnt and Hh Signaling Pathways in the Pathology of Basal Cell Carcinoma. Int J Environ Res Public Health. 2018 07 09; 15(7). PMID: 29987229.
      Citations: 6     Fields:    Translation:AnimalsCells
    8. Chamcheu JC, Rady I, Chamcheu RN, Siddique AB, Bloch MB, Banang Mbeumi S, Babatunde AS, Uddin MB, Noubissi FK, Jurutka PW, Liu YY, Spiegelman VS, Whitfield GK, El Sayed KA. Graviola (Annona muricata) Exerts Anti-Proliferative, Anti-Clonogenic and Pro-Apoptotic Effects in Human Non-Melanoma Skin Cancer UW-BCC1 and A431 Cells In Vitro: Involvement of Hedgehog Signaling. Int J Mol Sci. 2018 Jun 16; 19(6). PMID: 29914183.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    9. McArdle TJ, Ogle BM, Noubissi FK. Moving Upwards: A Simple and Flexible In Vitro Three-dimensional Invasion Assay Protocol. J Vis Exp. 2018 03 12; (133). PMID: 29578529.
      Citations:    Fields:    Translation:HumansAnimalsCells
    10. McArdle TJ, Ogle BM, Noubissi FK. An In Vitro Inverted Vertical Invasion Assay to Avoid Manipulation of Rare or Sensitive Cell Types. J Cancer. 2016; 7(15):2333-2340. PMID: 27994672.
    11. Noubissi FK, Ogle BM. Cancer Cell Fusion: Mechanisms Slowly Unravel. Int J Mol Sci. 2016 Sep 21; 17(9). PMID: 27657058.
      Citations: 11     Fields:    
    12. Hamilton KE, Chatterji P, Lundsmith ET, Andres SF, Giroux V, Hicks PD, Noubissi FK, Spiegelman VS, Rustgi AK. Loss of Stromal IMP1 Promotes a Tumorigenic Microenvironment in the Colon. Mol Cancer Res. 2015 Nov; 13(11):1478-86. PMID: 26194191.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    13. Noubissi FK, Harkness T, Alexander CM, Ogle BM. Apoptosis-induced cancer cell fusion: a mechanism of breast cancer metastasis. FASEB J. 2015 Sep; 29(9):4036-45. PMID: 26085132.
      Citations: 28     Fields:    Translation:HumansCells
    14. Chamcheu JC, Pal HC, Siddiqui IA, Adhami VM, Ayehunie S, Boylan BT, Noubissi FK, Khan N, Syed DN, Elmets CA, Wood GS, Afaq F, Mukhtar H. Prodifferentiation, anti-inflammatory and antiproliferative effects of delphinidin, a dietary anthocyanidin, in a full-thickness three-dimensional reconstituted human skin model of psoriasis. Skin Pharmacol Physiol. 2015; 28(4):177-88. PMID: 25620035.
      Citations: 11     Fields:    Translation:HumansCells
    15. Noubissi FK, Kim T, Kawahara TN, Aughenbaugh WD, Berg E, Longley BJ, Athar M, Spiegelman VS. Role of CRD-BP in the growth of human basal cell carcinoma cells. J Invest Dermatol. 2014 Jun; 134(6):1718-1724. PMID: 24468749.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    16. Hamilton KE, Noubissi FK, Katti PS, Hahn CM, Davey SR, Lundsmith ET, Klein-Szanto AJ, Rhim AD, Spiegelman VS, Rustgi AK. IMP1 promotes tumor growth, dissemination and a tumor-initiating cell phenotype in colorectal cancer cell xenografts. Carcinogenesis. 2013 Nov; 34(11):2647-54. PMID: 23764754.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    17. Mongroo PS, Noubissi FK, Cuatrecasas M, Kalabis J, King CE, Johnstone CN, Bowser MJ, Castells A, Spiegelman VS, Rustgi AK. IMP-1 displays cross-talk with K-Ras and modulates colon cancer cell survival through the novel proapoptotic protein CYFIP2. Cancer Res. 2011 Mar 15; 71(6):2172-82. PMID: 21252116.
      Citations: 41     Fields:    Translation:HumansCells
    18. Noubissi FK, Nikiforov MA, Colburn N, Spiegelman VS. Transcriptional Regulation of CRD-BP by c-myc: Implications for c-myc Functions. Genes Cancer. 2010 Oct; 1(10):1074-82. PMID: 21779431.
    19. Noubissi FK, Goswami S, Sanek NA, Kawakami K, Minamoto T, Moser A, Grinblat Y, Spiegelman VS. Wnt signaling stimulates transcriptional outcome of the Hedgehog pathway by stabilizing GLI1 mRNA. Cancer Res. 2009 Nov 15; 69(22):8572-8. PMID: 19887615.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    20. Elcheva I, Goswami S, Noubissi FK, Spiegelman VS. CRD-BP protects the coding region of betaTrCP1 mRNA from miR-183-mediated degradation. Mol Cell. 2009 Jul 31; 35(2):240-6. PMID: 19647520.
      Citations: 84     Fields:    Translation:HumansCells
    21. Noubissi FK, Elcheva I, Bhatia N, Shakoori A, Ougolkov A, Liu J, Minamoto T, Ross J, Fuchs SY, Spiegelman VS. CRD-BP mediates stabilization of betaTrCP1 and c-myc mRNA in response to beta-catenin signalling. Nature. 2006 Jun 15; 441(7095):898-901. PMID: 16778892.
      Citations: 101     Fields:    Translation:HumansAnimalsCells
    22. Bhat A, Noubissi FK, Vyas M, Kasbekar DP. Genetic analysis of wild-isolated Neurospora crassa strains identified as dominant suppressors of repeat-induced point mutation. Genetics. 2003 Jul; 164(3):947-61. PMID: 12871906.
      Citations: 11     Fields:    Translation:AnimalsCells
    23. Noubissi FK, Aparna K, McCluskey K, Kasbekar DP. Evidence for dominant suppression of repeat-induced point mutation (RIP) in crosses with the wild-isolated Neurospora crassa strains Sugartown and Adiopodoume-7. J Genet. 2001 Aug; 80(2):55-61. PMID: 11910125.
      Citations: 4     Fields:    Translation:AnimalsCells
    24. Noubissi FK, McCluskey K, Kasbekar DP. Repeat-induced point mutation (RIP) in crosses with wild-isolated strains of Neurospora crassa: evidence for dominant reduction of RIP. Fungal Genet Biol. 2000 Nov; 31(2):91-7. PMID: 11170738.
      Citations: 10     Fields:    Translation:AnimalsCells
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