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Pradeep Karla

TitleAssistant Professor
Faculty RankAssistant Professor
InstitutionHoward University
DepartmentPharmaceutical Sciences
AddressHoward University
College of Pharmacy
2300 4th Street NW
Washington DC 20059
Phone2028066543
Fax2028064636
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    Collapse Biography 
    Collapse awards and honors
    2011 - 2013Nanotherapeutic Mediated Efflux Modulation for Improved Ocular Drug Disposition , NIH
    2012 - 2013MRP Drug Efflux Inhibition as a Strategy for Improved Ocular Drug Delivery, American Association of Colleges of Pharmacy

    Collapse Overview 
    Collapse overview
    Personal Statement:

    Dr. Pradeep K. Karla is an Assistant Professor in Pharmaceutical Sciences at Howard University, College of Pharmacy. The significance of Dr. Karla's research involves the discovery of new drug efflux transporters on human ocular tissue, Cornea, which forms the primary barrier for topical ocular drug delivery. Dr. Karla's research demonstrated for the first time that the Multidrug Resistance associated Protein (MRP) class of efflux transporters play a vital role in decreased bioavailability of drugs employed for chronic disease states, glaucoma and ocular herpes. Current research in Dr. Karla’s laboratory involves the screening of multiple ocular / HIV drugs for possible efflux by MRP efflux transporters and designing formulation strategies (Nano-encapsulation / Pro-drug) for efflux bypass and improved bioavailability. Further, Dr. Karla's research group in collaboration with HIV research pioneers (Dr. Michel Bukrinsky, Dr. Leonid Margolis and Dr. Mary Young) is working on developing a microbicidal nano-gel drug delivery strategy to achieve a complete prevention of HIV sexual transmission. Dr. Karla's research on drug efflux transporters has been cited by American Association of Colleges of Pharmacy (AACP) as one of the eight outstanding research contributions that have the potential to achieve a therapeutic cure for glaucoma associated blindness. Apart from research, Dr. Karla is interested in implementing new technologies for promoting active learning in classroom. Dr. Karla's research in teaching method development involves integrating tablet touch interface of faculty and students via Wi-Fi network to create a real time interactive platform during the classroom lecture.

    Positions:
    2009 - Current Assistant Professor - Howard University, College of Pharmacy

    Courses taught: Pharmaceutics, Pharmaceutical Compounding Lab,
    Biopharmaceutics, Pharmacokinetics, Pharmaceutical Sciences Lab (Coordinator),
    Introduction to Pharmacy (Coordinator), Novel Drug Delivery Strategies (Graduate
    Course - Coordinator) and Pharmaceutical Care

    Post-Doctoral Mentor: Daniel Oyugi, Ph.D. (10/10/2012 – Current)
    Ramesh Chandra Nagarwal Ph.D. (01/23/2013 – Current)

    Ph.D. Mentor: Ann-Marie Ako-Adounvo, B.S.

    Class Advisor: Pharm.D. 2013 class
    2012 Session Chair for Scientific Tracks: OTC Drug Products and Medicines, Safety and
    Quality Regulation, Pharmaceutical Business and Education – International
    Conference of Pharmaceutical Regulatory Affairs
    2011-Current NIH Clinical and Translational Research Scholar Award (K12 Grant)
    2011-Current Editor - Pharmaceutical Sciences – Chronicles of Young Scientists Journal
    2010-Current Editorial Board Member - Archives of Pharmacy Practice, Pharmaceutics & Novel Drug
    Delivery Systems and Journal of Autocoids
    2008-Current Reviewer - Journal of Controlled Release, Pharmaceutical Research, Journal of Ocular
    Pharmacology and Therapeutics, Current Eye Research and Drug Dev. and Industrial
    Pharmacy, Clinical Research and Regulatory Affairs
    2004-2007 Graduate Teaching Assistant - University of Missouri-Kansas City, USA
    Courses taught: Novel Drug Delivery Systems and Pharmaceutics Lab
    2003-2008 NIH Graduate Research Assistant - University of Missouri-Kansas City, USA

    Honors:

    2012 Teaching with Technology Award by Center for Excellence in Teaching, Learning, and
    Assessment (CETLA)
    2012 Appreciation Award – Excellent Teacher - Pharmaceutics - Pharm.D. Class 2015,
    College of Pharmacy, Howard University
    2011 Professor of the Year Award – Pharm.D. Class 2014, College of Pharmacy,
    Howard University
    2011 First Place for Best Research Presentation in Faculty Research – Howard
    University Health Sciences Research Day
    2010 Appreciation Award – Excellence in Teaching, Mentoring and Enhancing
    Pharmacy Education – Pharm.D. Class of 2013, College of Pharmacy, Howard
    University
    2010 Appreciation Award – Valuable Contributions to Pharmacy Education – Pharm.D.
    Class of 2012, College of Pharmacy, Howard University
    2009 American Association of Colleges of Pharmacy (AACP) Outstanding research
    recognition – Recent top discoveries in Pharmaceutical Research
    2007 Scientific Sessions organizing committee Co-chair, PGSRM Annual Meeting 2007


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Bachu RD, Chowdhury P, Al-Saedi ZHF, Karla PK, Boddu SHS. Ocular Drug Delivery Barriers-Role of Nanocarriers in the Treatment of Anterior Segment Ocular Diseases. Pharmaceutics. 2018 Feb 27; 10(1). PMID: 29495528.
      Citations:    
    2. Basant N, Lin X, Reid TE, Karla PK, Wang XS. Discovery of a Novel HDAC2 Inhibitor by a Scaffold-Merging Hybrid Query. Comb Chem High Throughput Screen. 2015; 18(7):693-700. PMID: 26144283.
      Citations: 1     Fields:    Translation:HumansCells
    3. Ako-Adounvo AM, Nagarwal RC, Oliveira L, Boddu SH, Wang XS, Dey S, Karla PK. Recent patents on ophthalmic nanoformulations and therapeutic implications. Recent Pat Drug Deliv Formul. 2014; 8(3):193-201. PMID: 25262835.
      Citations: 3     Fields:    Translation:HumansAnimals
    4. Bonam SP, Bhargav P, Islam Y, Karla PK*, Boddu SH*. (* - Corresponding Authors) . Polymeric Nano-Carriers: for Pharmaceutical Applications. Polyamide Polymers for Drug Delivery. 2013; (Accepted As-Is).
    5. Karla PK, Boddu SH, Patel A, Ako-Adouno AM, Mitra AK. Treatise on Drug Delivery. Novel Strategies to Enhance Ocular Bioavailability. 2013; (Accepted).
    6. Karla PK, Durga P, Nanda MK, Mitra AK. The Biomedical Engineering Handbook. Recent findings and Pharmaceutical Applications for Noninvasive delivery systems for proteins. 2013; (Accepted As-Is).
    7. Karla PK, Ako-Adouno AM. Recent Patents in Naomedicine. Advances in Ocular Iontophoresis. 2012; 1(2):1-6. View Publication.
    8. Debebe Z, Nekhai S, Ashenafi M, Lovejoy DB, Kalinowski DS, Gordeuk VR, Byrnes WM, Richardson DR, Karla PK. Development of a sensitive HPLC method to measure in vitro permeability of E- and Z-isomeric forms of thiosemicarbazones in Caco-2 monolayers. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Oct 01; 906:25-32. PMID: 22954966.
      Citations: 4     Fields:    Translation:HumansCells
    9. North H, Wutoh K, Odoom MK, Karla P, Scott KR, Butcher RJ. 3-(4-Chloro-anilino)-2,5-dimethyl-cyclo-hex-2-en-1-one. Acta Crystallogr Sect E Struct Rep Online. 2011 May 01; 67(Pt 5):o1283-4. PMID: 21754564.
      Citations:    
    10. North H, Wutoh K, Odoom MK, Karla P, Scott KR, Butcher RJ. 2,5-Dimethyl-3-[4-(trifluoro-meth-oxy)anilino]-cyclo-hex-2-enone. Acta Crystallogr Sect E Struct Rep Online. 2011 Feb 12; 67(Pt 3):o603-4. PMID: 21522361.
      Citations:    
    11. Boddu SH, Jwala J, Vaishya R, Earla R, Karla PK, Pal D, Mitra AK. Novel nanoparticulate gel formulations of steroids for the treatment of macular edema. J Ocul Pharmacol Ther. 2010 Feb; 26(1):37-48. PMID: 20148659.
      Citations: 11     Fields:    Translation:AnimalsCells
    12. Karla PK, Quinn TL, Herndon BL, Thomas P, Pal D, Mitra A. Expression of multidrug resistance associated protein 5 (MRP5) on cornea and its role in drug efflux. J Ocul Pharmacol Ther. 2009 Apr; 25(2):121-32. PMID: 19323627.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    13. Karla PK, Earla R, Boddu SH, Johnston TP, Pal D, Mitra A. Molecular expression and functional evidence of a drug efflux pump (BCRP) in human corneal epithelial cells. Curr Eye Res. 2009 Jan; 34(1):1-9. PMID: 19172464.
      Citations: 18     Fields:    Translation:HumansCells
    14. Karla PK, Deep K, Gaudana R, Mitra AK. Modified Release Drug Delivery Technology. Nasal Drug Delivery. 2008; 2(32):427-450. View Publication.
    15. Karla PK, Pal D, Quinn T, Mitra AK. Molecular evidence and functional expression of a novel drug efflux pump (ABCC2) in human corneal epithelium and rabbit cornea and its role in ocular drug efflux. Int J Pharm. 2007 May 04; 336(1):12-21. PMID: 17156953.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    16. Karla PK, Pal D, Mitra AK. Molecular evidence and functional expression of multidrug resistance associated protein (MRP) in rabbit corneal epithelial cells. Exp Eye Res. 2007 Jan; 84(1):53-60. PMID: 17083930.
      Citations: 13     Fields:    Translation:AnimalsCells
    17. Warrier B, Mallipeddi R, Karla PK, Lee CH. The functional role of C-reactive protein in aortic wall calcification. Cardiology. 2005; 104(2):57-64. PMID: 16020921.
      Citations: 6     Fields:    Translation:HumansAnimals
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