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Jesus A. Angulo

TitleProfessor of Biology
Faculty RankProfessor
InstitutionHunter College, CUNY
DepartmentBiological Sciences
AddressRoom 927 HN, Hunter College, CUNY
695 Park Avenue
New York NY 10065
Phone212 772-5232
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    Collapse Biography 
    Collapse awards and honors
    1989 - 1991Young Investigator Award, National Alliance for Research on Schizophrenia and Depression
    1994 - 1996Professional Staff Congress of the City University of New York Research Award, City University of New York
    2000 - 2005Specialized Neuroscience Research Program, NINDS/NIH

    Collapse Overview 
    Collapse overview
    For nearly two decades my laboratory has investigated the role of dopamine on neuropeptide expression in the nigrostriatal and mesolimbic pathways of the rodent brain. Our research and that of others has demonstrated that dopaminergic transmission exerts dynamic regulation on the levels of expression and utilization of striatal neuropeptides. During the last ten years, we have investigated the novel hypothesis that neuropeptides modulate the methamphetamine-induced damage to striatal dopamine terminals and the apoptosis of some striatal neurons. My laboratory has extensive background in biochemistry, molecular and histochemical methods involving the brains of rats and mice. The proposed research is an extension of an R01-funded project from NIDA to demonstrate the role of the neuronal neurokinin-1 receptor (substance P is the natural ligand) on the methamphetamine-induced production of striatal nitric oxide and the neuroprotection afforded by neurokinin-1 receptor antagonists on the neuronal apoptosis induced by methamphetamine. This research has advanced our knowledge of the role played by neuropeptides in the methamphetamine-induced striatal injury. Recently, we are investigating the role of other striatal neuropeptides such as neuropeptide Y and somatostatin on the cellular mechanisms of methamphetamine-induced neural damage. Interestingly, we are finding that substance P is pro-damage while neuropeptide Y and somatostatin are neuroprotective. This research is novel because it is demonstrating that endogenous neuropeptides play key regulatory roles on survival of neurons in this part of the brain, a surprising finding with therapeutic potential. It is of high significance to elucidate the involvement of striatal neuropeptides in the methamphetamine-induced neural damage because these neuropeptides are expressed and utilized by the healthy brain. In summary, I have extensive experience and demonstrated productivity in the area of neuropeptides and dopaminergic transmission in nigrostriatal and mesolimbic pathways. This area of investigation is highly relevant to the field of drug abuse research and to the mission of the National Institute on Drug Abuse. I am the Principal Investigator/Program Director of the Research Centers in Minority Institutions (RCMI, NIMHD) Program at Hunter College. The RCMI Program maintains and expands the research infrastructure for the researchers of the Center for Translational and Basic Research of Hunter College. The Center is comprised of 45 faculty researchers in the areas of neuroscience/behavior, cancer and bioinformatics. The Center researchers are located in the departments of Chemistry, Biology and Psychology. The Center fosters and develops new generations of minority scientists and helps to encourage the participation of other ethnic minority groups in the biomedical workforce pipeline. The research conducted by the Center addresses health disparities in our population. In addition to the basic/translational research, the Center participates in community engagement projects in collaboration with the Hunter College School of Nursing, Public Health and the Weill Cornell CTSC.

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Martin KC, Tricomi J, Corzana F, García-García A, Ceballos-Laita L, Hicks T, Monaco S, Angulo J, Hurtado-Guerrero R, Richichi B, Sackstein R. Fucosyltransferase-specific inhibition via next generation of fucose mimetics. Chem Commun (Camb). 2021 Jan 28; 57(9):1145-1148. PMID: 33411866.
      Citations:    Fields:    
    2. Latorre-Muro P, Baeza J, Hurtado-Guerrero R, Hicks T, Delso I, Hernández-Ruiz C, Velazquez-Campoy A, Lawton AJ, Angulo J, Denu JM, Carrodeguas JA. Self-acetylation at the active site of phosphoenolpyruvate carboxykinase (PCK1) controls enzyme activity. J Biol Chem. 2020 Dec 17. PMID: 33334880.
      Citations:    Fields:    
    3. Hall JL, Sohail A, Cabrita EJ, Macdonald C, Stockner T, Sitte HH, Angulo J, MacMillan F. Saturation transfer difference NMR on the integral trimeric membrane transport protein GltPh determines cooperative substrate binding. Sci Rep. 2020 10 05; 10(1):16483. PMID: 33020522.
      Citations: 1     Fields:    Translation:AnimalsCells
    4. Monaco S, Walpole S, Doukani H, Nepravishta R, Martínez-Bailén M, Carmona AT, Ramos-Soriano J, Bergström M, Robina I, Angulo J. Exploring Multi-Subsite Binding Pockets in Proteins: DEEP-STD NMR Fingerprinting and Molecular Dynamics Unveil a Cryptic Subsite at the GM1 Binding Pocket of Cholera Toxin B. Chemistry. 2020 Aug 06; 26(44):10024-10034. PMID: 32449563.
      Citations:    Fields:    Translation:Cells
    5. Bell A, Severi E, Lee M, Monaco S, Latousakis D, Angulo J, Thomas GH, Naismith JH, Juge N. Uncovering a novel molecular mechanism for scavenging sialic acids in bacteria. J Biol Chem. 2020 10 02; 295(40):13724-13736. PMID: 32669363.
      Citations: 2     Fields:    Translation:HumansCells
    6. Wu H, Rebello O, Crost EH, Owen CD, Walpole S, Bennati-Granier C, Ndeh D, Monaco S, Hicks T, Colvile A, Urbanowicz PA, Walsh MA, Angulo J, Spencer DIR, Juge N. Fucosidases from the human gut symbiont Ruminococcus gnavus. Cell Mol Life Sci. 2021 Jan; 78(2):675-693. PMID: 32333083.
      Citations: 2     Fields:    Translation:HumansCells
    7. Pan AL, Hasalliu E, Hasalliu M, Angulo JA. Epigallocatechin Gallate Mitigates the Methamphetamine-Induced Striatal Dopamine Terminal Toxicity by Preventing Oxidative Stress in the Mouse Brain. Neurotox Res. 2020 Apr; 37(4):883-892. PMID: 32080803.
      Citations: 2     Fields:    Translation:Animals
    8. Watt JE, Hughes GR, Walpole S, Monaco S, Stephenson GR, Bulman Page PC, Hemmings AM, Angulo J, Chantry A. Discovery of Small Molecule WWP2 Ubiquitin Ligase Inhibitors. Chemistry. 2018 Dec 03; 24(67):17677-17680. PMID: 30207403.
      Citations: 6     Fields:    Translation:HumansCells
    9. Park JB, Kim YH, Yoo Y, Kim J, Jun SH, Cho JW, El Qaidi S, Walpole S, Monaco S, García-García AA, Wu M, Hays MP, Hurtado-Guerrero R, Angulo J, Hardwidge PR, Shin JS, Cho HS. Structural basis for arginine glycosylation of host substrates by bacterial effector proteins. Nat Commun. 2018 10 16; 9(1):4283. PMID: 30327479.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    10. Walpole S, Monaco S, Nepravishta R, Angulo J. STD NMR as a Technique for Ligand Screening and Structural Studies. Methods Enzymol. 2019; 615:423-451. PMID: 30638536.
      Citations: 3     Fields:    Translation:HumansCells
    11. Owen CD, Tailford LE, Monaco S, Šuligoj T, Vaux L, Lallement R, Khedri Z, Yu H, Lecointe K, Walshaw J, Tribolo S, Horrex M, Bell A, Chen X, Taylor GL, Varki A, Angulo J, Juge N. Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus. Nat Commun. 2017 12 19; 8(1):2196. PMID: 29259165.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    12. Monaco S, Tailford LE, Juge N, Angulo J. Differential Epitope Mapping by STD NMR Spectroscopy To Reveal the Nature of Protein-Ligand Contacts. Angew Chem Int Ed Engl. 2017 11 27; 56(48):15289-15293. PMID: 28977722.
      Citations: 14     Fields:    Translation:Cells
    13. Pineles SL, Repka MX, Yu F, Lum F, Coleman AL. Evaluating the impact of strabismus surgery on the association of musculoskeletal injuries, fractures, and falls with disorders of binocular vision in medicare beneficiaries. J AAPOS. 2017 Jun; 21(3):239-241.e3. PMID: 21886567.
      Citations: 8     Fields:    
    14. Liu Q, Hazan A, Grinman E, Angulo JA. Pharmacological activation of the neurotensin receptor 1 abrogates the methamphetamine-induced striatal apoptosis in the mouse brain. Brain Res. 2017 03 15; 1659:148-155. PMID: 28130052.
      Citations: 1     Fields:    Translation:AnimalsCells
    15. Tulloch IK, Afanador L, Baker L, Ordonez D, Payne H, Mexhitaj I, Olivares E, Chowdhury A, Angulo JA. Methamphetamine induces low levels of neurogenesis in striatal neuron subpopulations and differential motor performance. Neurotox Res. 2014 Aug; 26(2):115-29. PMID: 24549503.
      Citations: 7     Fields:    Translation:AnimalsCells
    16. Afanador L, Mexhitaj I, Diaz C, Ordonez D, Baker L, Angulo JA. The role of the neuropeptide somatostatin on methamphetamine and glutamate-induced neurotoxicity in the striatum of mice. Brain Res. 2013 May 13; 1510:38-47. PMID: 23524190.
      Citations: 2     Fields:    Translation:Animals
    17. Yarosh HL, Angulo JA. Modulation of methamphetamine-induced nitric oxide production by neuropeptide Y in the murine striatum. Brain Res. 2012 Nov 05; 1483:31-8. PMID: 22982589.
      Citations: 1     Fields:    Translation:Animals
    18. Afanador L, Yarosh H, Wang J, Ali SF, Angulo JA. Contrasting Effects of the Neuropeptides Substance P, Somatostatin, and Neuropeptide Y on the Methamphetamine-Induced Production of Striatal Nitric Oxide in Mice. J Drug Alcohol Res. 2012; 1. PMID: 25383232.
      Citations:    
    19. Tulloch I, Afanador L, Mexhitaj I, Ghazaryan N, Garzagongora AG, Angulo JA. A single high dose of methamphetamine induces apoptotic and necrotic striatal cell loss lasting up to 3 months in mice. Neuroscience. 2011 Oct 13; 193:162-9. PMID: 21771641.
      Citations: 7     Fields:    Translation:Animals
    20. Tulloch I, Ghazaryan N, Mexhitaj I, Ordonez D, Angulo JA. Role of neurokinin-1 and dopamine receptors on the striatal methamphetamine-induced proliferation of new cells in mice. Brain Res. 2011 Jul 05; 1399:33-9. PMID: 21652034.
      Citations: 5     Fields:    Translation:Animals
    21. Wang J, Angulo JA. Synergism between methamphetamine and the neuropeptide substance P on the production of nitric oxide in the striatum of mice. Brain Res. 2011 Jan 19; 1369:131-9. PMID: 21075091.
      Citations: 13     Fields:    Translation:Animals
    22. Wang J, Angulo JA. Methamphetamine induces striatal neurokinin-1 receptor endocytosis primarily in somatostatin/NPY/NOS interneurons and the role of dopamine receptors in mice. Synapse. 2011 Apr; 65(4):300-8. PMID: 20730802.
      Citations: 6     Fields:    Translation:AnimalsCells
    23. Zhu J, Xu W, Wang J, Ali SF, Angulo JA. The neurokinin-1 receptor modulates the methamphetamine-induced striatal apoptosis and nitric oxide formation in mice. J Neurochem. 2009 Nov; 111(3):656-68. PMID: 19682209.
      Citations: 11     Fields:    Translation:Animals
    24. Wang J, Xu W, Ali SF, Angulo JA. Connection between the striatal neurokinin-1 receptor and nitric oxide formation during methamphetamine exposure. Ann N Y Acad Sci. 2008 Oct; 1139:164-71. PMID: 18991860.
      Citations: 9     Fields:    Translation:AnimalsCells
    25. Zhu JP, Xu W, Angulo JA. Distinct mechanisms mediating methamphetamine-induced neuronal apoptosis and dopamine terminal damage share the neuropeptide substance p in the striatum of mice. Ann N Y Acad Sci. 2006 Aug; 1074:135-48. PMID: 17105911.
      Citations: 7     Fields:    Translation:AnimalsCells
    26. Zhu JP, Xu W, Angulo JA. Methamphetamine-induced cell death: selective vulnerability in neuronal subpopulations of the striatum in mice. Neuroscience. 2006 Jun 30; 140(2):607-22. PMID: 16650608.
      Citations: 55     Fields:    Translation:AnimalsCells
    27. Xu W, Zhu JP, Angulo JA. Induction of striatal pre- and postsynaptic damage by methamphetamine requires the dopamine receptors. Synapse. 2005 Nov; 58(2):110-21. PMID: 16088948.
      Citations: 35     Fields:    Translation:AnimalsCells
    28. Zhu JP, Xu W, Angulo N, Angulo JA. Methamphetamine-induced striatal apoptosis in the mouse brain: comparison of a binge to an acute bolus drug administration. Neurotoxicology. 2006 Jan; 27(1):131-6. PMID: 16165214.
      Citations: 34     Fields:    Translation:Animals
    29. Zhu JP, Xu W, Angulo JA. Disparity in the temporal appearance of methamphetamine-induced apoptosis and depletion of dopamine terminal markers in the striatum of mice. Brain Res. 2005 Jul 12; 1049(2):171-81. PMID: 16043139.
      Citations: 33     Fields:    Translation:AnimalsCells
    30. Angulo JA, Angulo N, Yu J. Antagonists of the neurokinin-1 or dopamine D1 receptors confer protection from methamphetamine on dopamine terminals of the mouse striatum. Ann N Y Acad Sci. 2004 Oct; 1025:171-80. PMID: 15542715.
      Citations: 5     Fields:    Translation:AnimalsCells
    31. Yu J, Wang J, Cadet JL, Angulo JA. Histological evidence supporting a role for the striatal neurokinin-1 receptor in methamphetamine-induced neurotoxicity in the mouse brain. Brain Res. 2004 May 08; 1007(1-2):124-31. PMID: 15064143.
      Citations: 18     Fields:    Translation:Animals
    32. Loonam TM, Noailles PA, Yu J, Zhu JP, Angulo JA. Substance P and cholecystokinin regulate neurochemical responses to cocaine and methamphetamine in the striatum. Life Sci. 2003 Jun 27; 73(6):727-39. PMID: 12801594.
      Citations: 14     Fields:    Translation:Animals
    33. Yu J, Cadet JL, Angulo JA. Neurokinin-1 (NK-1) receptor antagonists abrogate methamphetamine-induced striatal dopaminergic neurotoxicity in the murine brain. J Neurochem. 2002 Nov; 83(3):613-22. PMID: 12390523.
      Citations: 21     Fields:    Translation:AnimalsCells
    34. Yu J, Allison S, Ibrahim D, Cadet JL, Angulo JA. Ontogeny of neurokinin-1 receptor mediation of methamphetamine neurotoxicity in the striatum of the mouse brain. Ann N Y Acad Sci. 2002 Jun; 965:247-53. PMID: 12105100.
      Citations:    Fields:    Translation:AnimalsCells
    35. Noailles PA, Angulo JA. Neurokinin receptors modulate the neurochemical actions of cocaine. Ann N Y Acad Sci. 2002 Jun; 965:267-73. PMID: 12105102.
      Citations: 3     Fields:    Translation:Animals
    36. Kraft M, Ahluwahlia S, Angulo JA. Neurokinin-1 receptor antagonists block acute cocaine-induced horizontal locomotion. Ann N Y Acad Sci. 2001 Jun; 937:132-9. PMID: 11458534.
      Citations: 5     Fields:    Translation:Animals
    37. Kraft M, Noailles P, Angulo JA. Substance P modulates cocaine-evoked dopamine overflow in the striatum of the rat brain. Ann N Y Acad Sci. 2001 Jun; 937:121-31. PMID: 11458533.
      Citations: 6     Fields:    Translation:Animals
    38. Zhang Y, Loonam TM, Noailles PA, Angulo JA. Comparison of cocaine- and methamphetamine-evoked dopamine and glutamate overflow in somatodendritic and terminal field regions of the rat brain during acute, chronic, and early withdrawal conditions. Ann N Y Acad Sci. 2001 Jun; 937:93-120. PMID: 11458542.
      Citations: 49     Fields:    Translation:Animals
    39. Datta U, Noailles PA, Kraft M, Zhang Y, Angulo JA. Concurrent elevation of the levels of expression of striatal preproenkephalin and preprodynorphin mRNA in the rat brain by chronic treatment with caffeine. Neurosci Lett. 1997 Aug 01; 231(1):29-32. PMID: 9280160.
      Citations:    Fields:    Translation:Animals
    40. Zhang Y, Landas K, Mueller H, Angulo JA. Progressive augmentation of striatal and accumbal preprotachykinin mRNA levels by chronic treatment with methamphetamine and effect of concurrent administration of the N-methyl-D-aspartate receptor antagonist MK-801. Neuropharmacology. 1997 Mar; 36(3):325-34. PMID: 9175611.
      Citations: 2     Fields:    Translation:Animals
    41. Datta U, Noailles PA, Rodriguez M, Kraft M, Zhang Y, Angulo JA. Accumulation of tyrosine hydroxylase messenger RNA molecules in the rat mesencephalon by chronic caffeine treatment. Neurosci Lett. 1996 Dec 13; 220(2):77-80. PMID: 8981477.
      Citations: 4     Fields:    Translation:Animals
    42. Zhang Y, Angulo JA. Contrasting effects of repeated treatment vs. withdrawal of methamphetamine on tyrosine hydroxylase messenger RNA levels in the ventral tegmental area and substantia nigra zona compacta of the rat brain. Synapse. 1996 Nov; 24(3):218-23. PMID: 8923661.
      Citations: 2     Fields:    Translation:Animals
    43. Noailles PA, Villegas M, Ledoux M, Lucas LR, McEwen BS, Angulo JA. Acute treatment with the N-methyl-D-aspartate receptor antagonist MK-801: effect of concurrent administration of haloperidol or scopolamine on preproenkephalin mRNA levels of the striatum and nucleus accumbens of the rat brain. Neurosci Lett. 1996 Jan 05; 202(3):165-68. PMID: 8848257.
      Citations:    Fields:    Translation:AnimalsCells
    44. Villegas M, Angulo JA. Attenuation of neostriatal preproenkephalin and preprotachykinin mRNA abundance by chronic treatment with the kainate/quisqualate receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione in the rat brain. Neurosci Lett. 1995 May 19; 191(1-2):51-4. PMID: 7659290.
      Citations:    Fields:    Translation:AnimalsCells
    45. Angulo JA, Williams A, Ledoux M, Watanabe Y, McEwen BS. Elevation of striatal and accumbal preproenkephalin, preprotachykinin and preprodynorphin mRNA abundance subsequent to N-methyl-D-aspartate receptor blockade with MK-801. Brain Res Mol Brain Res. 1995 Mar; 29(1):15-22. PMID: 7769991.
      Citations: 2     Fields:    Translation:AnimalsCells
    46. Angulo JA, McEwen BS. Molecular aspects of neuropeptide regulation and function in the corpus striatum and nucleus accumbens. Brain Res Brain Res Rev. 1994 Jan; 19(1):1-28. PMID: 7909470.
      Citations: 35     Fields:    Translation:Animals
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