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Itzhak Mano

Faculty RankAssociate Medical Professor
InstitutionCity College, CUNY
DepartmentMol. Cell & Biomed Sci., CUNY School of Medicine
Address85 St. Nicholas Terrace
CDI building room 3-382
New York NY 10031
Phone212 650 7965
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    Collapse Biography 
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    1991 - 1996The Erwin and Claire Weiner Scholarship, The Weizmann Institute of Science
    1997 - 1999Human Frontier Science Program Fellow, France
    2010 - 2014Sinsheimer Scholar, The Alexandrine and Alexander L. Sinsheimer Fund, NY

    Collapse Overview 
    Collapse overview
    I study neuronal communication that uses the key excitatory neurotransmitter Glutamate, and the process of excitotoxicity, the neuronal cell death process that happen when the brain is flooded with too much glutamate. Excessive glutamate signaling triggers the neurodegeneration seen in prevalent neurodegenerative conditions such as stroke and diseases like ALS/Lau Gehrig’s disease. We understand very little about this form of neuronal cell death, and although the gradual progression of brain damage leaves a window of opportunity for clinical intervention, physicians have no effective therapies to treat it. Minority populations are especially at high risk, as African-Americans at 4 times more likely than Caucasians to suffer a stroke in middle age. I examine normal and pathological glutamatergic neurotransmission in the microscopic free-living nematode C. elegans, because of the strong genetic research tools available in this model system. The basic premise is that although we look very different from nematodes, we share a great similarity at the cellular and molecular levels. Therefore, if we understand basic processes of normal physiology and Glutamate-induced pathologies in nematodes, it might give us clues as to possible similar processes in people. Trained as a neuroscientist and experienced in molecular biology, electrophysiology and model-system genetics, I analyze structure-function relations in transport proteins to learn how excess Glutamate is removed from the nervous system. I use genetic tools to study what are the molecular steps that lead from Glutamate over-excitation to neurodegeneration, and I study the ability to interfere with evolutionary-conserved signaling pathways (such as cell stress or autophagy) to protect the nervous system from Glutamate-induced neurodegeneration.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mendelowitz ZZ, Idrizi A, Mano I. Live Animal Imaging and Cell Sorting Methods for Investigating Neurodegeneration in a C. elegans Excitotoxic Necrosis Model. J Vis Exp. 2021 01 22; (167). PMID: 33554967.
      Citations:    Fields:    Translation:AnimalsCells
    2. Feldmann KG, Chowdhury A, Becker JL, McAlpin N, Ahmed T, Haider S, Richard Xia JX, Diaz K, Mehta MG, Mano I. Non-canonical activation of CREB mediates neuroprotection in a Caenorhabditis elegans model of excitotoxic necrosis. J Neurochem. 2019 02; 148(4):531-549. PMID: 30447010.
      Citations: 3     Fields:    Translation:AnimalsCells
    3. Del Rosario JS, Feldmann KG, Ahmed T, Amjad U, Ko B, An J, Mahmud T, Salama M, Mei S, Asemota D, Mano I. Death Associated Protein Kinase (DAPK) -mediated neurodegenerative mechanisms in nematode excitotoxicity. BMC Neurosci. 2015 Apr 23; 16:25. PMID: 25899010.
      Citations: 8     Fields:    Translation:AnimalsCells
    4. Tehrani N, Del Rosario J, Dominguez M, Kalb R, Mano I. The insulin/IGF signaling regulators cytohesin/GRP-1 and PIP5K/PPK-1 modulate susceptibility to excitotoxicity in C. elegans. PLoS One. 2014; 9(11):e113060. PMID: 25422944.
      Citations: 3     Fields:    Translation:AnimalsCells
    5. Mojsilovic-Petrovic J, Nedelsky N, Boccitto M, Mano I, Georgiades SN, Zhou W, Liu Y, Neve RL, Taylor JP, Driscoll M, Clardy J, Merry D, Kalb RG. FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases. J Neurosci. 2009 Jun 24; 29(25):8236-47. PMID: 19553463.
      Citations: 46     Fields:    Translation:AnimalsCells
    6. Mano I, Driscoll M. Caenorhabditis elegans glutamate transporter deletion induces AMPA-receptor/adenylyl cyclase 9-dependent excitotoxicity. J Neurochem. 2009 Mar; 108(6):1373-84. PMID: 19054279.
      Citations: 8     Fields:    Translation:AnimalsCells
    7. Mano I, Straud S, Driscoll M. Caenorhabditis elegans glutamate transporters influence synaptic function and behavior at sites distant from the synapse. J Biol Chem. 2007 Nov 23; 282(47):34412-9. PMID: 17681948.
      Citations: 16     Fields:    Translation:AnimalsCells
    8. Hong K, Mano I, Driscoll M. In vivo structure-function analyses of Caenorhabditis elegans MEC-4, a candidate mechanosensory ion channel subunit. J Neurosci. 2000 Apr 01; 20(7):2575-88. PMID: 10729338.
      Citations: 20     Fields:    Translation:AnimalsCells
    9. Mano I, Driscoll M. DEG/ENaC channels: a touchy superfamily that watches its salt. Bioessays. 1999 Jul; 21(7):568-78. PMID: 10472184.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    10. Mano I, Teichberg VI. A tetrameric subunit stoichiometry for a glutamate receptor-channel complex. Neuroreport. 1998 Jan 26; 9(2):327-31. PMID: 9507977.
      Citations: 27     Fields:    Translation:AnimalsCells
    11. Mano I, Lamed Y, Teichberg VI. A venus flytrap mechanism for activation and desensitization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors. J Biol Chem. 1996 Jun 28; 271(26):15299-302. PMID: 8663365.
      Citations: 14     Fields:    Translation:AnimalsCells
    12. Gregor P, Yang X, Mano I, Takemura M, Teichberg VI, Uhl GR. Organization and expression of the gene encoding chick kainate binding protein, a member of the glutamate receptor family. Brain Res Mol Brain Res. 1992 Dec; 16(3-4):179-86. PMID: 1337927.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    13. Teichberg VI, Eshhar N, Maoz I, Mano I, Ornstein D, Ortega A, Gregor P. Molecular characterization, ultrastructural localization and gene cloning of the chick cerebellar kainate receptor. Adv Exp Med Biol. 1990; 268:73-8. PMID: 1963755.
      Citations: 1     Fields:    Translation:AnimalsCells
    14. Gregor P, Mano I, Maoz I, McKeown M, Teichberg VI. Molecular structure of the chick cerebellar kainate-binding subunit of a putative glutamate receptor. Nature. 1989 Dec 07; 342(6250):689-92. PMID: 2480525.
      Citations: 15     Fields:    Translation:AnimalsCells
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