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Shawn Goodwin

TitlePhD, Director of the Morphology Core and Technologies and Resources
Faculty RankAssociate Professor
InstitutionMeharry Medical College
DepartmentBiochem, Cancer Biology, Neuroscience & Pharmacology
Address1005 Dr. DB Todd Jr Blvd
3109 West Basic Sciences
Nashville TN 37208
Phone6153276686
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    Collapse Affiliation 

    Collapse Biography 
    Collapse awards and honors
    1998 - 2002Mississippi Academy of Science
    1999 - 2009American Chemical Society
    2000Biophysical Society
    2006Society for Neuroscience
    2009Review Committee, NIH Shared Instrumentation Grant: Microscopy and Imaging (ZRG1OBT-A 30)
    2010Experimental Biology
    2011Review Committee, NIH Shared Instrumentation Grant: Microscopy and Imaging (ZRG1 CB-N 30)
    2012NIH Review Committee, Shared Instrument Grant (S10): Bioengineering Sciences and Technologies (BST-T 30)
    2013 Review Committee , NIH Shared Instrumentation Grant (S10): Microscopy and Imaging (ZRG1 CB-P (30)

    Collapse Overview 
    Collapse overview
    As the current activity director of the Technologies and Resources for Core (TRC) Laboratories within the Meharry Translational Research Center, Director of the MMC Morphology Core and an Associate Professor in the Department of Biochemistry and Cancer Biology, I am uniquely qualified to provide managerial and logistical oversight for the TRC. Under the umbrella of the TRC, my team and I established the Proteomics Core Facility, which previously did not exist at Meharry. Additionally, in 2006, I successfully implemented the Meharry Morphology Core, and it is has become the model on which we base the Proteomics Core operations. For the second round of funding we are proposing to add the Morphology Core and the Microarray-Bioinformatics Core to the TRC, while continuing with the success of the Proteomics Core and strengthening our collaborative efforts inside and outside the institution. With the addition of the Morphology Core to the TRC, I will bring with me 16 years of microscopy experience. In addition to my current duties with the TRC, I will be involved in consultation on experimental design, training on microscopes, data analysis, troubleshooting technical difficulties, overseeing educational workshops and seminars relating to microscopy. In addition, I will be consulting with investigators and their trainees as they plan microscopy based experiments to insure proper technological approaches and data analysis methods. Moreover, I will be instrumental in the planning, data acquisition, and data analysis stages of the supported projects, with an emphasis on the elements that relate to microscopy. This effort is necessary to ensure quick and reliable data acquisition and analysis for grants and publications. The TRC provides an invaluable resource to Meharry and will also allow my team and I to keep our internal research community up to date with the latest technology via seminars, journal clubs, and monthly round-table meetings.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Butler B, Goodwin S, Saha K, Becker J, Sambo D, Davari P, Khoshbouei H. Dopamine Transporter Activity Is Modulated by a-synuclein. J Biol Chem. 2015 Jun 05. PMID: 26048988.
      Citations: 1     Fields:    
    2. Ho MH, Chen CH, Goodwin JS, Wang BY, Xie H. Functional Advantages of Porphyromonas gingivalis Vesicles. PLoS One. 2015; 10(4):e0123448. PMID: 25897780.
      Citations: 34     Fields:    Translation:HumansCells
    3. Mantri CK, Chen CH, Dong X, Goodwin JS, Pratap S, Paromov V, Xie H. Fimbriae-mediated outer membrane vesicle production and invasion of Porphyromonas gingivalis. Microbiologyopen. 2015 Feb; 4(1):53-65. PMID: 25524808.
      Citations: 22     Fields:    Translation:HumansCells
    4. Nangami G, Koumangoye R, Shawn Goodwin J, Sakwe AM, Marshall D, Higginbotham J, Ochieng J. Fetuin-A associates with histones intracellularly and shuttles them to exosomes to promote focal adhesion assembly resulting in rapid adhesion and spreading in breast carcinoma cells. Exp Cell Res. 2014 Nov 01; 328(2):388-400. PMID: 25194507.
      Citations: 14     Fields:    Translation:HumansCells
    5. Mantri CK, Chen C, Dong X, Goodwin JS, Xie H. Porphyromonas gingivalis-mediated Epithelial Cell Entry of HIV-1. J Dent Res. 2014 Aug; 93(8):794-800. PMID: 24874702.
      Citations: 7     Fields:    Translation:HumansCells
    6. Rana T, Hasan RJ, Nowicki S, Venkatarajan MS, Singh R, Urvil PT, Popov V, Braun WA, Popik W, Goodwin JS, Nowicki BJ. Complement protective epitopes and CD55-microtubule complexes facilitate the invasion and intracellular persistence of uropathogenic Escherichia coli. J Infect Dis. 2014 Apr 01; 209(7):1066-76. PMID: 24259524.
      Citations: 7     Fields:    Translation:AnimalsCells
    7. Malloy MT, McIntosh DJ, Walters TS, Flores A, Goodwin JS, Arinze IJ. Trafficking of the transcription factor Nrf2 to promyelocytic leukemia-nuclear bodies: implications for degradation of NRF2 in the nucleus. J Biol Chem. 2013 May 17; 288(20):14569-14583. PMID: 23543742.
      Citations: 31     Fields:    Translation:HumansCells
    8. Swant J, Goodwin JS, North A, Ali AA, Gamble-George J, Chirwa S, Khoshbouei H. a-Synuclein stimulates a dopamine transporter-dependent chloride current and modulates the activity of the transporter. J Biol Chem. 2011 Dec 23; 286(51):43933-43943. PMID: 21990355.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    9. Koumangoye RB, Sakwe AM, Goodwin JS, Patel T, Ochieng J. Detachment of breast tumor cells induces rapid secretion of exosomes which subsequently mediate cellular adhesion and spreading. PLoS One. 2011; 6(9):e24234. PMID: 21915303.
      Citations: 80     Fields:    Translation:HumansCells
    10. Cooper J, Liu L, Woodruff EA, Taylor HE, Goodwin JS, D'Aquila RT, Spearman P, Hildreth JE, Dong X. Filamin A protein interacts with human immunodeficiency virus type 1 Gag protein and contributes to productive particle assembly. J Biol Chem. 2011 Aug 12; 286(32):28498-510. PMID: 21705339.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    11. Halder SK, Goodwin JS, Al-Hendy A. 1,25-Dihydroxyvitamin D3 reduces TGF-beta3-induced fibrosis-related gene expression in human uterine leiomyoma cells. J Clin Endocrinol Metab. 2011 Apr; 96(4):E754-62. PMID: 21289245.
      Citations: 56     Fields:    Translation:HumansCells
    12. Sakwe AM, Koumangoye R, Goodwin SJ, Ochieng J. Fetuin-A ({alpha}2HS-glycoprotein) is a major serum adhesive protein that mediates growth signaling in breast tumor cells. J Biol Chem. 2010 Dec 31; 285(53):41827-35. PMID: 20956534.
      Citations: 25     Fields:    Translation:HumansCells
    13. Nayyar T, Bubser M, Ferguson MC, Neely MD, Shawn Goodwin J, Montine TJ, Deutch AY, Ansah TA. Cortical serotonin and norepinephrine denervation in parkinsonism: preferential loss of the beaded serotonin innervation. Eur J Neurosci. 2009 Jul; 30(2):207-16. PMID: 19659923.
      Citations: 11     Fields:    Translation:HumansAnimals
    14. Mines MA, Goodwin JS, Limbird LE, Cui FF, Fan GH. Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation. J Biol Chem. 2009 Feb 27; 284(9):5742-52. PMID: 19106094.
      Citations: 44     Fields:    Translation:HumansCells
    15. Goodwin JS, Larson GA, Swant J, Sen N, Javitch JA, Zahniser NR, De Felice LJ, Khoshbouei H. Amphetamine and methamphetamine differentially affect dopamine transporters in vitro and in vivo. J Biol Chem. 2009 Jan 30; 284(5):2978-2989. PMID: 19047053.
      Citations: 81     Fields:    Translation:HumansAnimalsCells
    16. Ding Y, Qiao A, Wang Z, Goodwin JS, Lee ES, Block ML, Allsbrook M, McDonald MP, Fan GH. Retinoic acid attenuates beta-amyloid deposition and rescues memory deficits in an Alzheimer's disease transgenic mouse model. J Neurosci. 2008 Nov 05; 28(45):11622-34. PMID: 18987198.
      Citations: 80     Fields:    Translation:HumansAnimalsCells
    17. Wu D, Yang H, Zhao Y, Sharan C, Goodwin JS, Zhou L, Guo Y, Guo Z. 2-Aminopurine inhibits lipid accumulation induced by apolipoprotein E-deficient lipoprotein in macrophages: potential role of eukaryotic initiation factor-2alpha phosphorylation in foam cell formation. J Pharmacol Exp Ther. 2008 Aug; 326(2):395-405. PMID: 18463320.
      Citations: 2     Fields:    Translation:AnimalsCells
    18. Ding Y, Zhang L, Goodwin JS, Wang Z, Liu B, Zhang J, Fan GH. Plectin regulates the signaling and trafficking of the HIV-1 co-receptor CXCR4 and plays a role in HIV-1 infection. Exp Cell Res. 2008 Feb 01; 314(3):590-602. PMID: 18155192.
      Citations: 12     Fields:    Translation:HumansCells
    19. Wu D, Sharan C, Yang H, Goodwin JS, Zhou L, Grabowski GA, Du H, Guo Z. Apolipoprotein E-deficient lipoproteins induce foam cell formation by downregulation of lysosomal hydrolases in macrophages. J Lipid Res. 2007 Dec; 48(12):2571-8. PMID: 17720994.
      Citations: 14     Fields:    Translation:AnimalsCells
    20. Brown LA, Khousbouei H, Goodwin JS, Irvin-Wilson CV, Ramesh A, Sheng L, McCallister MM, Jiang GC, Aschner M, Hood DB. Down-regulation of early ionotrophic glutamate receptor subunit developmental expression as a mechanism for observed plasticity deficits following gestational exposure to benzo(a)pyrene. Neurotoxicology. 2007 Sep; 28(5):965-78. PMID: 17606297.
      Citations: 44     Fields:    Translation:AnimalsCells
    21. Goodwin JS, Kenworthy AK. Photobleaching approaches to investigate diffusional mobility and trafficking of Ras in living cells. Methods. 2005 Oct; 37(2):154-64. PMID: 16288889.
      Citations: 40     Fields:    Translation:AnimalsCells
    22. Goodwin JS, Drake KR, Rogers C, Wright L, Lippincott-Schwartz J, Philips MR, Kenworthy AK. Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway. J Cell Biol. 2005 Jul 18; 170(2):261-72. PMID: 16027222.
      Citations: 130     Fields:    Translation:AnimalsCells
    23. Goodwin JS, Drake KR, Remmert CL, Kenworthy AK. Ras diffusion is sensitive to plasma membrane viscosity. Biophys J. 2005 Aug; 89(2):1398-410. PMID: 15923235.
      Citations: 44     Fields:    Translation:AnimalsCells
    24. Stroud PA, Goodwin JS, Butko P, Cannon GC, McCormick CL. Experimental evidence for multiple assembled states of Sc3 from Schizophyllum commune. Biomacromolecules. 2003 Jul-Aug; 4(4):956-67. PMID: 12857079.
      Citations: 3     Fields:    Translation:Animals
    25. Butko P, Buford JP, Goodwin JS, Stroud PA, McCormick CL, Cannon GC. Spectroscopic evidence for amyloid-like interfacial self-assembly of hydrophobin Sc3. Biochem Biophys Res Commun. 2001 Jan 12; 280(1):212-5. PMID: 11162501.
      Citations: 20     Fields:    Translation:AnimalsCells
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