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SAKINA E ELTOM

Faculty RankProfessor
AddressDr. D.B. Todd BLVD.,
WEST BASIC SCIENCES Bldg., Room 2130
Nashville TN 37208
Phone6153275713
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    Dr. Sakina Elzebair Eltom is an Associate Professor in the Department of Biochemistry and Cancer Biology at Meharry Medical College in Nashville, TN. Her education includes a professional degree in Veterinary Medicine where she was trained in large animal medicine and surgery in University of Khartoum in Sudan, with further training in University of Liverpool, England and Veterinary School of Hannover, Germany. Dr. Eltom went on to earn a Masters of Science and a Ph.D. in Pharmacology from Cornell University in Ithaca NY.
    Her postdoctoral research experience includes training in chemical carcinogenesis at the McArdle Laboratory for Cancer Research, and training in environmental and molecular toxicology at the Center for Environmental Toxicology at University of Wisconsin-Madison. She held numerous academic positions at Cornell University and University of Wisconsin-Madison. She also ventured in the biotechnology world, where she held a Senior Scientist position in Paracelsian Inc., an IPO Biotech Company in Upstate NY. Before joining the faculty at Meharry, she was an Assistant Scientist in the Department of Pharmacology at the University of Wisconsin Medical School in Madison.
    Dr. Eltom’s research is investigating the molecular mechanisms of carcinogenesis induced by exposure to environmental Organochlorines and polyaromatic hydrocarbons. The major emphasis is on characterizing the role of the aryl hydrocarbon receptor in the development and progression of breast carcinoma. Another research area in her laboratory is investigating the role of environmental endocrine disruptors in breast cancer of pre-menopausal women and how the gene-environment interaction contributes as a risk factor to the high incidence of breast cancer in pre-menopausal African American women.
    In addition to research, Dr. Eltom has a vast interest in graduate education, contributing as a trainer for Ph.D. students in biomedical sciences. She served as the inaugural director of graduate studies in pharmacology, and she set the foundation on the curriculum for the training program in pharmacology and toxicology at Meharry Medical College.
    Dr. Eltom has served on several review panels at the NIH, DOD and Philip Morris External Research Program and she is currently a chartered member of the Cancer Etiology Study section until 2018. Dr. Eltom is author of several peer-reviewed Publications. She served as a member of ASPET Committee on Diversity (2006-2010), and on the Advisory Committee for organizing the National Meetings of the Directors of Graduate Studies in Pharmacology (2005- ).


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wang X, Zhang L, Dai Q, Si H, Zhang L, Eltom SE, Si H. Combined Luteolin and Indole-3-Carbinol Synergistically Constrains ERa-Positive Breast Cancer by Dual Inhibiting Estrogen Receptor Alpha and Cyclin-Dependent Kinase 4/6 Pathway in Cultured Cells and Xenograft Mice. Cancers (Basel). 2021 Apr 27; 13(9). PMID: 33925607.
      Citations:    
    2. Goodson WH, Lowe L, Carpenter DO, Gilbertson M, Manaf Ali A, Lopez de Cerain Salsamendi A, Lasfar A, Carnero A, Azqueta A, Amedei A, Charles AK, Collins AR, Ward A, Salzberg AC, Colacci A, Olsen AK, Berg A, Barclay BJ, Zhou BP, Blanco-Aparicio C, Baglole CJ, Dong C, Mondello C, Hsu CW, Naus CC, Yedjou C, Curran CS, Laird DW, Koch DC, Carlin DJ, Felsher DW, Roy D, Brown DG, Ratovitski E, Ryan EP, Corsini E, Rojas E, Moon EY, Laconi E, Marongiu F, Al-Mulla F, Chiaradonna F, Darroudi F, Martin FL, Van Schooten FJ, Goldberg GS, Wagemaker G, Nangami GN, Calaf GM, Williams G, Wolf GT, Koppen G, Brunborg G, Lyerly HK, Krishnan H, Ab Hamid H, Yasaei H, Sone H, Kondoh H, Salem HK, Hsu HY, Park HH, Koturbash I, Miousse IR, Scovassi AI, Klaunig JE, Vondrácek J, Raju J, Roman J, Wise JP, Whitfield JR, Woodrick J, Christopher JA, Ochieng J, Martinez-Leal JF, Weisz J, Kravchenko J, Sun J, Prudhomme KR, Narayanan KB, Cohen-Solal KA, Moorwood K, Gonzalez L, Soucek L, Jian L, D'Abronzo LS, Lin LT, Li L, Gulliver L, McCawley LJ, Memeo L, Vermeulen L, Leyns L, Zhang L, Valverde M, Khatami M, Romano MF, Chapellier M, Williams MA, Wade M, Manjili MH, Lleonart ME, Xia M, Gonzalez MJ, Karamouzis MV, Kirsch-Volders M, Vaccari M, Kuemmerle NB, Singh N, Cruickshanks N, Kleinstreuer N, van Larebeke N, Ahmed N, Ogunkua O, Krishnakumar PK, Vadgama P, Marignani PA, Ghosh PM, Ostrosky-Wegman P, Thompson PA, Dent P, Heneberg P, Darbre P, Sing Leung P, Nangia-Makker P, Cheng QS, Robey RB, Al-Temaimi R, Roy R, Andrade-Vieira R, Sinha RK, Mehta R, Vento R, Di Fiore R, Ponce-Cusi R, Dornetshuber-Fleiss R, Nahta R, Castellino RC, Palorini R, Abd Hamid R, Langie SA, Eltom SE, Brooks SA, Ryeom S, Wise SS, Bay SN, Harris SA, Papagerakis S, Romano S, Pavanello S, Eriksson S, Forte S, Casey SC, Luanpitpong S, Lee TJ, Otsuki T, Chen T, Massfelder T, Sanderson T, Guarnieri T, Hultman T, Dormoy V, Odero-Marah V, Sabbisetti V, Maguer-Satta V, Rathmell WK, Engström W, Decker WK, Bisson WH, Rojanasakul Y, Luqmani Y, Chen Z, Hu Z. Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead. Carcinogenesis. 2015 Jun; 36 Suppl 1:S254-96. PMID: 26106142.
      Citations: 57     Fields:    Translation:HumansAnimalsPHPublic Health
    3. Ochieng J, Nangami GN, Ogunkua O, Miousse IR, Koturbash I, Odero-Marah V, McCawley LJ, Nangia-Makker P, Ahmed N, Luqmani Y, Chen Z, Papagerakis S, Wolf GT, Dong C, Zhou BP, Brown DG, Colacci AM, Hamid RA, Mondello C, Raju J, Ryan EP, Woodrick J, Scovassi AI, Singh N, Vaccari M, Roy R, Forte S, Memeo L, Salem HK, Amedei A, Al-Temaimi R, Al-Mulla F, Bisson WH, Eltom SE. The impact of low-dose carcinogens and environmental disruptors on tissue invasion and metastasis. Carcinogenesis. 2015 Jun; 36 Suppl 1:S128-59. PMID: 26106135.
      Citations: 9     Fields:    Translation:HumansAnimalsPHPublic Health
    4. Humphrey-Johnson A, Abukalam R, Eltom SE. Stability of the aryl hydrocarbon receptor and its regulated genes in the low activity variant of Hepa-1 cell line. Toxicol Lett. 2015 Mar 04; 233(2):59-67. PMID: 25637755.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    5. Goode G, Pratap S, Eltom SE. Depletion of the aryl hydrocarbon receptor in MDA-MB-231 human breast cancer cells altered the expression of genes in key regulatory pathways of cancer. PLoS One. 2014; 9(6):e100103. PMID: 24932473.
      Citations: 10     Fields:    Translation:HumansCells
    6. Powell JB, Goode GD, Eltom SE. The Aryl Hydrocarbon Receptor: A Target for Breast Cancer Therapy. J Cancer Ther. 2013 Sep; 4(7):1177-1186. PMID: 25068070.
      Citations:    
    7. Goode GD, Ballard BR, Manning HC, Freeman ML, Kang Y, Eltom SE. Knockdown of aberrantly upregulated aryl hydrocarbon receptor reduces tumor growth and metastasis of MDA-MB-231 human breast cancer cell line. Int J Cancer. 2013 Dec 15; 133(12):2769-80. PMID: 23733406.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    8. Brooks J, Eltom SE. Malignant transformation of mammary epithelial cells by ectopic overexpression of the aryl hydrocarbon receptor. Curr Cancer Drug Targets. 2011 Jun; 11(5):654-69. PMID: 21486221.
      Citations: 27     Fields:    Translation:HumansCells
    9. Dale Y, Eltom SE. The induction of CYP1A1 by oltipraz is mediated through calcium-dependent-calpain. Toxicol Lett. 2006 Oct 10; 166(2):150-9. PMID: 16891067.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    10. Dale YR, Eltom SE. Calpain mediates the dioxin-induced activation and down-regulation of the aryl hydrocarbon receptor. Mol Pharmacol. 2006 Nov; 70(5):1481-7. PMID: 16891617.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    11. Brown KA, Aakre ME, Gorska AE, Price JO, Eltom SE, Pietenpol JA, Moses HL. Induction by transforming growth factor-beta1 of epithelial to mesenchymal transition is a rare event in vitro. Breast Cancer Res. 2004; 6(3):R215-31. PMID: 15084245.
      Citations: 84     Fields:    Translation:HumansAnimalsCells
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