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Shyam Reddy

Title
Faculty RankProfessor
InstitutionMorehouse School of Medicine
DepartmentObstetrics and Gynecology
Address80 Jesse Hill Jr.
Atlanta GA 30303
Phone7704899991
Fax6786235999
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    Other Positions
    TitleAdjunct Senior Scientist, Tumor Biology Program
    InstitutionUAB

    TitleProfessor and Director, Cancer Biology Program,
    InstitutionMorehouse School of Medicine
    DepartmentMicrobiology & Immunology

    TitleAdjunct Senior Scientist at Women’s Program (secondary appointment),Tumor Biology Program
    InstitutionUAB


    Collapse Biography 
    Collapse awards and honors
    1980First Margaret Grant Memorial Fellowship of the United Kingdom , First Margaret Grant Memorial Fellowship of UK
    1980Indian National Science Academy Young Scientist Award from the Prime Minister of India, Indian National Science Academy
    1980Kothari Scientific and Research Institute award to Young scientists, Kothari Scientific and Research Institute award
    1983 - 1984Swebelius Cancer Research Award, Swebelius Cancer Research Award of Yale University
    1984 - 1985Swebelius Cancer Research Award, Swebelius Cancer Research Award of Yale University
    1987 - 1988W.W. Smith Foundation Charitable Trust Award, W.W. Smith Foundation Charitable Trust
    1991General Motors Cancer Research Foundation nominating member, General Motors Cancer Research Foundation
    2000Outstanding Grantsmanship Award and induction into the million dollars club of Drexel University, Drexel University (MCP Hahnemann University)
    2003 - 2012Georgia Cancer Coalition Distinguished Cancer Scholar award, Georgia cancer Coalition (received from the Governor of Georgia)
    2006Excellence in Science, American Telugu Association (ATA)
    2007Dean’s recognition award for Research, Morehouse School of Medicine
    2011Bharat Gaurav Award, International Friendship Society’s (IIFS) Global Friendship Day
    2011Center for Prostate Disease Research (CPDR), Center for Prostate Disease Research Saturday Distinguished Visiting Professor 2011 Recognition Awa
    2011TAMA award for outstanding efforts, services and leadership in the field of Medicine, Telugu Association of Metro Atlanta (TAMA)
    2012BEST PERSONALITIES of INDIA Award and Gold Medal, Frirndship Forum of India
    2012Bharat Award for Excellence, Friendship Forum of India
    2012BHARAT EXCELLENCE Award and Gold Medal, Friendship Forum of India
    2012Glory of India award, India International Friendship Society
    2012INTERNATIONAL GOLDSTAR AWARD, India International Friendship Society
    2012MAHATMA GANDHI PRAVASI GOLD MEDAL , India International Friendship Society
    2012Mother Teresa Excellence Award, Integrated Council for Socio-Economic Progress
    2012RASHTRYA JEWEL AWARD” and GOLD MEDAL, Friendship Forum of India
    2012SUPER ACHIEVERS of INDIA Award and Gold Medal, Friendship Forum of India
    2013LIFETIME ACHIEVEMENT AWARD, India International Friendship Society
    2013RAJIV GANDHI ARCH FOR EXCELLENCE AWARD” And GOLD MEDAL , Friendship Forum of India

    Collapse Overview 
    Collapse overview
    Function Based Therapeutic Strategies to Human cancers (Functionotherapeutics): Study of the Functional Role of ETS-fusion genes in Prostate cancer, Ewing Sarcoma, Breast cancer, Melanoma and leukemias

    We have discovered and cloned several oncogenes and studied their functions (close to twenty genes). The most notable genes discovered include ERG-1, ERG-2 and ERG-3 genes (we have named the gene as ETS Related Gene, published in prestegious Science and PNAS journals). This gene is involved in 40-80% of Prostate cancers, Ewing sarcoma and also leukemias (AML). Other notable genes discovered and studied by Dr Reddy include human Fli-1 (involved in Leukemias), EWS-Fli-1 (involved in Ewing Sarcoma) , EWS-erg (involved in Ewing Sarcoma), TLS-erg (involved in Acute Myeloid Leukemia), EWS (involved in multiple cancers), TLS/FUS (involved in multiple cancers), ELK-1 (ETS Like Gene, published in prestegious Science journal, involved in breast and ovarian cancers), BRCA2a (involved in breast, ovarian and prostate cancers) and EWS-ATF-1 (involved in malignant Melanoma of Soft Parts). We have identified the DNA binding, trans-activation domains and other regulatory domains of ERG, ELK-1, Fli-1, EWS-Fli-1, EWS-erg, TLS-erg, EWS-ATF-1, etc. We have successfully targeted EWS-fusion proteins and shown that this approach can be used as a therapy for Ewing family of tumors. Dr Reddy and his colleagues are identifying the function of these oncogenes and also developing strategies to target these oncoproteins or their functions to develop novel targeted therapeutic agents. Using this Function based therapeutic strategy, we have developed several novel drugs (patent being submitted) that target Prostate, Ewing Sarcoma, Breast cancer (triple negative breast cancer), Pancreatic cancer, Ovarian, cervical cancers and colorectal cancers. Dr Reddy and his colleagues have identified ERG/ETS-target genes and are studying the novel mechanism by which it regulates the signaling pathways. These studies will revolutionize our understanding of tumorigenesis and provide new approaches to therapeutic intervention.

    Dr Reddy and his colleagues have also shown that anti-epileptic drug Valproic acid (VPA) targets ERG-positive Prostate cancers and Ewing Sarcoma and identified the molecular mechanism of action of VPA on ERG/Fli-1 associated cancers. Recently, they have identified novel ways by which ERG/ETS oncoproteins target different signaling pathways that leads to prostate and other cancers (leukemias, lymphomas and sarcomas). Dr Reddy and his colleagues have identified novel molecular mechanism of activation of TGF beta–signaling pathway by ERG oncoprotein in prostate cancer. Recently, Dr Reddy and his colleagues have shown that ETV1 onco-protein induces certain kinases in cancer cells which deregulate the critical Wnt/beta catenin pathway. They have also identified therapeutic agent that interferes with this process. They have also demonstrated that this therapeutic agent targets these cancer cells effectively (manuscript in press, 2016). These therapeutic agents will have a profound impact on prevention and treatment of prostate cancer which may help to reduce health disparity seen in minority prostate cancer patients. Recently, Dr Reddy’s group decoded non-coding DNA and it’s non-coding RNA, which will revolutionize the future biology (manuscript In press, 2016). (Please see www.reddyesp.com)


    We have recently discovered novel post-translational mechanism in Breast cancer cells that will have global effect on the gene expression, differentiation, protein turnover, cell death, cancer and other Human diseases. Majority of N-linked glycosylation of proteins occurs in secretary and membrane proteins. This typical N-glycosylation of a protein takes place upon entry of the protein into the lumen of endoplasmic reticulum (ER) where, there is a transfer of carbohydrate moiety to asparagine residue present in the protein. In bacteria, N-glycosylation can occur independent of this protein translocation (Science, 314, 1148, 2006). Here, Dr Reddy and his group find that such protein modifications (protein translocation-independent N-glycosylation) can also occur even in eukaryotic cells. They show that transcriptional cofactor CBP interacts with BRCA2 protein (involved in breast cancer, ovarian cancer and prostate cancer) and mediates its N-glycosylation both in vitro and in vivo. This is the first report that a transcription cofactor like CBP may be involved in protein translocation-independent N-glycosylation.

    Dr Reddy predicts that this CBP/p300-mediated post-translational modification may be a signal for the regulation of CBP interacting proteins. Interestingly, BRCA2 protein is known to be ubiquitinated and degraded by the proteosomal pathway in breast cancer cells. Dr Reddy is presently testing this hypothesis. Since CBP/p300 cofactor interacts with many onco-proteins, tumor suppressors and transcription factors, such a signal may be vital to regulate the expression of these interacting proteins which play an important role in cell growth, differentiation and cell death. Therefore, this post-translational N-glycosylation can have global effect on gene function, cell growth and differentiation.

    Dr Reddy conducted Cancer Colloquiums to teach MD and Ph.D. students. He also taught and trained Ph.D. students, MD students, residents, MPH students, undergraduate students and also high school students in cancer research.

    Dr Reddy received many personal distinguished awards such as LIFETIME ACHIEVEMENT AWARD by IIFS; prestigious MAHATMA GANDHI PRAVASI GOLD MEDAL at the HOUSE OF LORDS, PARLIAMENT, LONDON; Outstanding Advisor Ph. D. class of 2014, Morehouse School of Medicine, "MOTHER TERESA EXCELLENCE AWARD" by ICSEP; "BHARAT AWARD for EXCELLENCE", “RASHTRYA JEWEL AWARD” and GOLD MEDAL, prestigious INTERNATIONAL GOLDSTAR AWARD 2012, prestigious BEST PERSONALITIES OF INDIA AWARD and Gold Medal, Super achievers of India Award with Gold medal, BHARAT EXCELLENCE AWARD with Gold Medal 2012, CPDR Distinguished Visiting Professor Recognition Award 2011, Prestigious BHARAT GAURAV AWARD (Pride of India award) (Previous winners of this honor - Late Mother Teresa, Noble Laureate, actor Dev Anand, Lord Parekh, S. Gavaskar), TAMA award for outstanding efforts and leadership in medicine 2011, GCC Distinguished Cancer Scholar Award from the Governor, Georgia, USA, chosen to receive the prestigious Glory of India award, ATA Outstanding Science Achievement award, USA, MSM Dean's Outstanding Research award, Outstanding Grantsmanship Award and induction into the million dollars club of Drexel – University, INSA Young Scientist award from the Prime Minister of India, several NIH RO1 grants, PO1 awards, DOD Prostate Cancer idea awards, DOD Breast Cancer idea awards, DOD Breast Cancer concept award (blind review), Twice recipient of Swebelius Cancer Research Award, Yale University, First Margaret Memorial award, UK and W.W. Smith Foundation Charitable Trust award. Dr Reddy is also appointed as Editor of Journal of Pharmaceutical Sciences and Pharmacology, and editorial member of seven journals. 1. American Journal of Cancer Science; 2. American Journal of Cancer Biology; 3. American Journal of Cancer Review; 4. Speciality Editor Cancer on WebmedCentral plus Cancer; 5. Gastroenterology and Hepatology (GH), CSC Canada; 6. J. Hematology & Thromboembolic Diseases; 7. British Biotechnology Journal.

    Dr Reddy is also chosen as Board of Director of Carcinogenesis Foundation.

    WEB: www.reddyesp.com

    http://www.linkedin.com/pub/e-shyam-p-reddy/22/b99/3a


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Nimmanagoti R, Nandan S, Kulkarni PG, Reddy SP, Keerthi M, Pupala G. Protein 53, B-Cell Lymphoma-2, Cyclooxygenase-2, and CD105 Reactivity in Keratocystic Odontogenic Tumors: An Immunohistochemical Analysis. Int J Appl Basic Med Res. 2019 Jan-Mar; 9(1):27-31. PMID: 30820416.
      Citations:    
    2. Sheelam S, Reddy SP, Kulkarni PG, Nandan S, Keerthi M, Raj GS. Role of cell proliferation and vascularity in malignant transformation of potentially malignant disorders. J Oral Maxillofac Pathol. 2018 May-Aug; 22(2):281. PMID: 30158789.
      Citations:    
    3. VanValkenburg ME, Pruitt GI, Brill IK, Costa L, Ehtsham M, Justement IT, Innis-Shelton RD, Salzman D, Reddy ES, Godby KN, Mikhail FM, Carroll AJ, Reddy VB, Sanderson RD, Justement LB, Sanders PW, Brown EE. Family history of hematologic malignancies and risk of multiple myeloma: differences by race and clinical features. Cancer Causes Control. 2016 Jan; 27(1):81-91. PMID: 26596855.
      Citations: 7     Fields:    Translation:Humans
    4. okko C, Turner J, Yoo w, Wood D, Clark K, Childs Ed, Rao VN, Reddy ES, Clark C. J Can Epi Treat . Anal Squamous Cell Carcinoma in African Americans with and without HIV: A Comparative Study. 2015; 1(1):6-10.
    5. Fang J, Xu H, Yang C, Morsalin S, Kayarthodi S, Rungsrisuriyachai K, Gunnal U, Mckenzie B, Rao VN, Reddy ES. Ets Related Gene and Smad3 Proteins Collaborate to Activate Transforming Growth Factor-Beta Mediated Signaling Pathway in ETS Related Gene-Positive Prostate Cancer Cells. J Pharm Sci Pharmacol. 2014 Sep 01; 1(3):175-181. PMID: 25745638.
      Citations:    
    6. Kayarthodi S, Fujimura Y, Fang J, Morsalin S, Rao VN, Reddy ES. Anti-Epileptic Drug Targets Ewing Sarcoma. J Pharm Sci Pharmacol. 2014 Jun 01; 1(2):87-100. PMID: 25664332.
      Citations:    
    7. Reddy SP, Prakash AP, Keerthi M, Rao BJ. Myositis ossificans traumatica of temporalis and medial pterygoid muscle. J Oral Maxillofac Pathol. 2014 May; 18(2):271-5. PMID: 25328311.
      Citations:    
    8. Fang J, Xu H, Yang C, Kayarthodi S, Matthews R, Rao VN, Reddy ES. Molecular Mechanism of Activation of Transforming Growth Factor Beta/Smads Signaling Pathway in Ets Related Gene-Positive Prostate Cancers. J Pharm Sci Pharmacol. 2014 Mar; 1(1):82-85. PMID: 25679011.
      Citations:    
    9. Xu J, Agyemang S, Qin Y, Aysola K, Giles M, Oprea G, O'Regan RM, Partridge EE, Harris-Hooker S, Rice VM, Reddy ES, Rao VN. A Novel Pathway that Links Caveolin-1 Down-Regulation to BRCA1 Dysfunction in Serous Epithelial Ovarian Cancer Cells. Enliven Chall Cancer Detect Ther. 2014; 1(1). PMID: 25594072.
      Citations:    
    10. Reddy SP, Ramani P, Nainani P. Confocal microscopy and exfoliative cytology. J Oral Maxillofac Pathol. 2013 May; 17(2):217-21. PMID: 24250082.
      Citations:    
    11. Aysola K, Desai A, Welch C, Xu J, Qin Y, Reddy V, Matthews R, Owens C, Okoli J, Beech DJ, Piyathilake CJ, Reddy SP, Rao VN. Triple Negative Breast Cancer - An Overview. Hereditary Genet. 2013; 2013(Suppl 2). PMID: 25285241.
      Citations:    
    12. Qin Y, Xu J, Aysola K, Oprea G, Reddy A, Matthews R, Okoli J, Cantor A, Grizzle WE, Partridge EE, Reddy ES, Landen C, Rao VN. BRCA1 proteins regulate growth of ovarian cancer cells by tethering Ubc9. Am J Cancer Res. 2012; 2(5):540-8. PMID: 22957306.
      Citations:    
    13. Qin Y, Xu J, Aysola K, Begum N, Reddy V, Chai Y, Grizzle WE, Partridge EE, Reddy ES, Rao VN. Ubc9 mediates nuclear localization and growth suppression of BRCA1 and BRCA1a proteins. J Cell Physiol. 2011 Dec; 226(12):3355-67. PMID: 21344391.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    14. Fortson WS, Kayarthodi S, Fujimura Y, Xu H, Matthews R, Grizzle WE, Rao VN, Bhat GK, Reddy ES. Histone deacetylase inhibitors, valproic acid and trichostatin-A induce apoptosis and affect acetylation status of p53 in ERG-positive prostate cancer cells. Int J Oncol. 2011 Jul; 39(1):111-9. PMID: 21519790.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    15. Siddique H, Rao VN, Reddy ES. CBP-mediated post-translational N-glycosylation of BRCA2. Int J Oncol. 2009 Aug; 35(2):387-91. PMID: 19578754.
      Citations:    Fields:    Translation:HumansCells
    16. Maniccia AW, Lewis C, Begum N, Xu J, Cui J, Chipitsyna G, Aysola K, Reddy V, Bhat G, Fujimura Y, Henderson B, Reddy ES, Rao VN. Mitochondrial localization, ELK-1 transcriptional regulation and growth inhibitory functions of BRCA1, BRCA1a, and BRCA1b proteins. J Cell Physiol. 2009 Jun; 219(3):634-41. PMID: 19170108.
      Citations: 19     Fields:    Translation:HumansCells
    17. Xu J, Watkins T, Reddy A, Reddy ES, Rao VN. A novel mechanism whereby BRCA1/1a/1b fine tunes the dynamic complex interplay between SUMO-dependent/independent activities of Ubc9 on E2-induced ERalpha activation/repression and degradation in breast cancer cells. Int J Oncol. 2009 Apr; 34(4):939-49. PMID: 19287951.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    18. Du J, Cai X, Yao J, Ding X, Wu Q, Pei S, Jiang K, Zhang Y, Wang W, Shi Y, Lai Y, Shen J, Teng M, Huang H, Fei Q, Reddy ES, Zhu J, Jin C, Yao X. The mitotic checkpoint kinase NEK2A regulates kinetochore microtubule attachment stability. Oncogene. 2008 Jul 03; 27(29):4107-14. PMID: 18297113.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    19. Reddy ES, Patil NP, Guttal SS, Jagadish HG. Effect of different finishing and polishing agents on the surface roughness of cast pure titanium. J Prosthodont. 2007 Jul-Aug; 16(4):263-8. PMID: 17451480.
      Citations:    Fields:    Translation:Humans
    20. Yuli C, Shao N, Rao R, Aysola P, Reddy V, Oprea-llies G, Lee L, Okoli J, Partridge E, Reddy ES, Rao VN. BRCA1a has antitumor activity in TN breast, ovarian and prostate cancers. Oncogene. 2007 Sep 06; 26(41):6031-7. PMID: 17384678.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    21. Dhulipala PD, Datta PK, Reddy ES, Lianos EA. Differential regulation of the rat heme oxygenase-1 expression by Ets oncoproteins in glomerular mesangial cells. J Lab Clin Med. 2005 Dec; 146(6):326-32. PMID: 16310515.
      Citations: 1     Fields:    Translation:AnimalsCells
    22. Ramakrishnan R, Fujimura Y, Zou JP, Liu F, Lee L, Rao VN, Reddy ES. Role of protein-protein interactions in the antiapoptotic function of EWS-Fli-1. Oncogene. 2004 Sep 16; 23(42):7087-94. PMID: 15273724.
      Citations: 16     Fields:    Translation:HumansCells
    23. Fujimura Y, Siddique H, Lee L, Rao VN, Reddy ES. EWS-ATF-1 chimeric protein in soft tissue clear cell sarcoma associates with CREB-binding protein and interferes with p53-mediated trans-activation function. Oncogene. 2001 Oct 11; 20(46):6653-9. PMID: 11709699.
      Citations: 11     Fields:    Translation:HumansCells
    24. Chai Y, Chipitsyna G, Cui J, Liao B, Liu S, Aysola K, Yezdani M, Reddy ES, Rao VN. c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth suppression in breast cancer cells. Oncogene. 2001 Mar 15; 20(11):1357-67. PMID: 11313879.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    25. Zou JP, Hirose Y, Siddique H, Rao VN, Reddy ES. Structure and expression of variant BRCA2a lacking the transactivation domain. Oncol Rep. 1999 Mar-Apr; 6(2):437-40. PMID: 10023017.
      Citations: 2     Fields:    Translation:HumansCells
    26. Dhulipala PD, Lee L, Rao VN, Reddy ES. Fli-1b is generated by usage of differential splicing and alternative promoter. Oncogene. 1998 Sep 03; 17(9):1149-57. PMID: 9764825.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    27. Shao N, Chai Y, Cui JQ, Wang N, Aysola K, Reddy ES, Rao VN. Induction of apoptosis by Elk-1 and deltaElk-1 proteins. Oncogene. 1998 Jul 30; 17(4):527-32. PMID: 9696047.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    28. Pereira DS, Dorrell C, Ito CY, Gan OI, Murdoch B, Rao VN, Zou JP, Reddy ES, Dick JE. Retroviral transduction of TLS-ERG initiates a leukemogenic program in normal human hematopoietic cells. Proc Natl Acad Sci U S A. 1998 Jul 07; 95(14):8239-44. PMID: 9653171.
      Citations: 25     Fields:    Translation:HumansCells
    29. Cui JQ, Wang H, Reddy ES, Rao VN. Differential transcriptional activation by the N-terminal region of BRCA1 splice variants BRCA1a and BRCA1b. Oncol Rep. 1998 May-Jun; 5(3):585-9. PMID: 9538156.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    30. Cui JQ, Shao N, Chai Y, Wang H, Reddy ES, Rao VN. BRCA1 splice variants BRCA1a and BRCA1b associate with CBP co-activator. Oncol Rep. 1998 May-Jun; 5(3):591-5. PMID: 9538157.
      Citations: 3     Fields:    Translation:HumansCells
    31. Siddique H, Zou JP, Rao VN, Reddy ES. The BRCA2 is a histone acetyltransferase. Oncogene. 1998 Apr 30; 16(17):2283-5. PMID: 9619837.
      Citations: 15     Fields:    Translation:HumansCells
    32. Wang H, Shao N, Ding QM, Cui J, Reddy ES, Rao VN. BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases. Oncogene. 1997 Jul 10; 15(2):143-57. PMID: 9244350.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    33. Yi H, Fujimura Y, Ouchida M, Prasad DD, Rao VN, Reddy ES. Inhibition of apoptosis by normal and aberrant Fli-1 and erg proteins involved in human solid tumors and leukemias. Oncogene. 1997 Mar 20; 14(11):1259-68. PMID: 9178886.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    34. Rao VN, Shao N, Ahmad M, Reddy ES. Antisense RNA to the putative tumor suppressor gene BRCA1 transforms mouse fibroblasts. Oncogene. 1996 Feb 01; 12(3):523-8. PMID: 8637708.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    35. Fujimura Y, Ohno T, Siddique H, Lee L, Rao VN, Reddy ES. The EWS-ATF-1 gene involved in malignant melanoma of soft parts with t(12;22) chromosome translocation, encodes a constitutive transcriptional activator. Oncogene. 1996 Jan 04; 12(1):159-67. PMID: 8552387.
      Citations: 16     Fields:    Translation:HumansCells
    36. Ouchida M, Ohno T, Fujimura Y, Rao VN, Reddy ES. Loss of tumorigenicity of Ewing's sarcoma cells expressing antisense RNA to EWS-fusion transcripts. Oncogene. 1995 Sep 21; 11(6):1049-54. PMID: 7566963.
      Citations: 40     Fields:    Translation:Animals
    37. Prasad DD, Ouchida M, Lee L, Rao VN, Reddy ES. TLS/FUS fusion domain of TLS/FUS-erg chimeric protein resulting from the t(16;21) chromosomal translocation in human myeloid leukemia functions as a transcriptional activation domain. Oncogene. 1994 Dec; 9(12):3717-29. PMID: 7970732.
      Citations: 51     Fields:    Translation:HumansCells
    38. Ohno T, Ouchida M, Lee L, Gatalica Z, Rao VN, Reddy ES. The EWS gene, involved in Ewing family of tumors, malignant melanoma of soft parts and desmoplastic small round cell tumors, codes for an RNA binding protein with novel regulatory domains. Oncogene. 1994 Oct; 9(10):3087-97. PMID: 8084618.
      Citations: 56     Fields:    Translation:HumansCells
    39. Rao VN, Reddy ES. elk-1 proteins interact with MAP kinases. Oncogene. 1994 Jul; 9(7):1855-60. PMID: 8208531.
      Citations: 25     Fields:    Translation:AnimalsCells
    40. Prasad DD, Rao VN, Lee L, Reddy ES. Differentially spliced erg-3 product functions as a transcriptional activator. Oncogene. 1994 Feb; 9(2):669-73. PMID: 8290279.
      Citations: 7     Fields:    Translation:HumansCells
    41. Ohno T, Rao VN, Reddy ES. EWS/Fli-1 chimeric protein is a transcriptional activator. Cancer Res. 1993 Dec 15; 53(24):5859-63. PMID: 7503813.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    42. Bhattacharya G, Lee L, Reddy ES, Rao VN. Transcriptional activation domains of elk-1, delta elk-1 and SAP-1 proteins. Oncogene. 1993 Dec; 8(12):3459-64. PMID: 8247551.
      Citations:    Fields:    Translation:AnimalsCells
    43. Rao VN, Ohno T, Prasad DD, Bhattacharya G, Reddy ES. Analysis of the DNA-binding and transcriptional activation functions of human Fli-1 protein. Oncogene. 1993 Aug; 8(8):2167-73. PMID: 8336942.
      Citations: 28     Fields:    Translation:HumansCells
    44. Rao VN, Reddy ES. Elk-1 proteins are phosphoproteins and activators of mitogen-activated protein kinase. Cancer Res. 1993 Aug 01; 53(15):3449-54. PMID: 8339245.
      Citations: 3     Fields:    Translation:AnimalsCells
    45. Siddique HR, Rao VN, Lee L, Reddy ES. Characterization of the DNA binding and transcriptional activation domains of the erg protein. Oncogene. 1993 Jul; 8(7):1751-5. PMID: 8510921.
      Citations: 17     Fields:    Translation:AnimalsCells
    46. Rao VN, Reddy ES. Delta elk-1, a variant of elk-1, fails to interact with the serum response factor and binds to DNA with modulated specificity. Cancer Res. 1993 Jan 15; 53(2):215-20. PMID: 8417810.
      Citations: 3     Fields:    Translation:AnimalsCells
    47. Rao VN, Reddy ES. elk-1 domains responsible for autonomous DNA binding, SRE:SRF interaction and negative regulation of DNA binding. Oncogene. 1992 Nov; 7(11):2335-40. PMID: 1437156.
      Citations: 11     Fields:    
    48. Prasad DD, Rao VN, Reddy ES. Structure and expression of human Fli-1 gene. Cancer Res. 1992 Oct 15; 52(20):5833-7. PMID: 1394211.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    49. Dudek H, Tantravahi RV, Rao VN, Reddy ES, Reddy EP. Myb and Ets proteins cooperate in transcriptional activation of the mim-1 promoter. Proc Natl Acad Sci U S A. 1992 Feb 15; 89(4):1291-5. PMID: 1741383.
      Citations: 42     Fields:    Translation:Cells
    50. Rao VN, Reddy ES. A divergent ets-related protein, elk-1, recognizes similar c-ets-1 proto-oncogene target sequences and acts as a transcriptional activator. Oncogene. 1992 Jan; 7(1):65-70. PMID: 1741166.
      Citations: 20     Fields:    Translation:Cells
    51. Hipskind RA, Rao VN, Mueller CG, Reddy ES, Nordheim A. Ets-related protein Elk-1 is homologous to the c-fos regulatory factor p62TCF. Nature. 1991 Dec 19-26; 354(6354):531-4. PMID: 1722028.
      Citations: 158     Fields:    Translation:AnimalsCells
    52. Reddy ES, Rao VN. erg, an ets-related gene, codes for sequence-specific transcriptional activators. Oncogene. 1991 Dec; 6(12):2285-9. PMID: 1766675.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    53. Reddy ES, Rao VN. Localization and modulation of the DNA-binding activity of the human c-ets-1 protooncogene. Cancer Res. 1990 Aug 15; 50(16):5013-6. PMID: 2165853.
      Citations: 2     Fields:    Translation:AnimalsCells
    54. Rao VN, Huebner K, Isobe M, ar-Rushdi A, Croce CM, Reddy ES. elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpoints. Science. 1989 Apr 07; 244(4900):66-70. PMID: 2539641.
      Citations: 77     Fields:    Translation:HumansAnimalsCells
    55. Rao VN, Modi WS, Drabkin HD, Patterson D, O'Brien SJ, Papas TS, Reddy ES. The human erg gene maps to chromosome 21, band q22: relationship to the 8; 21 translocation of acute myelogenous leukemia. Oncogene. 1988 Nov; 3(5):497-500. PMID: 3274086.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    56. Reddy ES, Rao VN. Structure, expression and alternative splicing of the human c-ets-1 proto-oncogene. Oncogene Res. 1988; 3(3):239-46. PMID: 3060801.
      Citations: 11     Fields:    Translation:HumansCells
    57. Reddy ES, Rao VN, Papas TS. The erg gene: a human gene related to the ets oncogene. Proc Natl Acad Sci U S A. 1987 Sep; 84(17):6131-5. PMID: 3476934.
      Citations: 55     Fields:    Translation:HumansCells
    58. Rao VN, Papas TS, Reddy ES. erg, a human ets-related gene on chromosome 21: alternative splicing, polyadenylation, and translation. Science. 1987 Aug 07; 237(4815):635-9. PMID: 3299708.
      Citations: 64     Fields:    Translation:HumansCells
    59. Rao VN, Zweig M, Papas TS, Reddy ES. Expression in E. coli of erg: a novel gene in humans related to the ets oncogene. Oncogene Res. 1987; 2(1):95-101. PMID: 2851121.
      Citations:    Fields:    Translation:HumansCells
    60. Reddy ES, Pan JY. Molecular cloning and sequencing of H-2Kk cDNA: comparison with other H-2 genes and evidence for alternative splicing. Gene. 1985; 38(1-3):239-44. PMID: 3840763.
      Citations: 3     Fields:    Translation:AnimalsCells
    61. Yoshie O, Schmidt H, Lengyel P, Reddy ES, Morgan WR, Weissman SM. Transcripts of human HLA gene fragments lacking the 5'-terminal region in transfected mouse cells. Proc Natl Acad Sci U S A. 1984 Feb; 81(3):649-53. PMID: 6322158.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    62. Rao VN, Reddy ES, Torriani A, Bhargava PM. Seminalplasmin inhibits transcription and translation of phi80 DNA in vitro. FEBS Lett. 1983 Feb 07; 152(1):6-10. PMID: 6840278.
      Citations: 2     Fields:    Translation:Cells
    63. Reddy ES, Das MR, Reddy EP, Bhargava PM. Inhibition of reverse transcriptases by seminalplasmin. Biochem J. 1983 Jan 01; 209(1):183-8. PMID: 6189479.
      Citations: 1     Fields:    Translation:Cells
    64. Reddy ES, Vijayarangam D, Bhargava PM. Effect of spermine, ethylenediamine tetraacetate, urea, and high salt on the activity of ribonuclease SPL on Mg2+- containing undenatured total E. coli and rat liver RNAs. J Biochem. 1983 Jan; 93(1):307-10. PMID: 6188753.
      Citations:    Fields:    Translation:AnimalsCells
    65. Yoshie O, Schmidt H, Reddy ES, Weissman S, Lengyel P. Mouse interferons enhance the accumulation of a human HLA RNA and protein in transfected mouse and hamster cells. J Biol Chem. 1982 Nov 25; 257(22):13169-72. PMID: 6183260.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    66. Reddy ES, Scheit KH, Bhargava PM. Atypical behaviour of ribonuclease SPL: different concentrations of the enzyme give different limit digests. FEBS Lett. 1981 Aug 31; 131(2):377-80. PMID: 6170526.
      Citations:    Fields:    Translation:AnimalsCells
    67. Bhargava PM, Reddy ES, Sitaram N, Scheit KH. Amino acid composition of RNAase from seminal plasma: a correction. J Mol Biol. 1981 Feb 25; 146(2):265-7. PMID: 7265230.
      Citations:    Fields:    Translation:Animals
    68. Reddy ES, Sitaram N, Bhargava PM, Scheit KH. A new pyrimidine-specific ribonuclease from bovine seminal plasma that is active on both single and double-stranded polyribonucleotides and that can distinguish between Mg2+-containing and Mg2+-depleted naturally occurring RNAs. J Mol Biol. 1979 Dec 15; 135(3):525-44. PMID: 537087.
      Citations: 2     Fields:    Translation:AnimalsCells
    69. Scheit KH, Reddy ES, Bhargava PM. Seminaplasmin is a potent inhibitor of E. coli RNA polymerase in vivo. Nature. 1979 Jun 21; 279(5715):728-31. PMID: 377101.
      Citations: 7     Fields:    Translation:Cells
    70. Reddy ES, Bhargava PM. Seminalplasmin--an antimicrobial protein from bovine seminal plasma which acts in E. coli by specific inhibition of rRNA synthesis. Nature. 1979 Jun 21; 279(5715):725-8. PMID: 377100.
      Citations: 17     Fields:    Translation:AnimalsCells
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