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Gregory J. Quirk

Faculty RankFull Professor
InstitutionUniversity of Puerto Rico
DepartmentSchool of Medicine
AddressUPR-Medical Sciences Campus
Department of Psychiatry
San Juan PR 936
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    Other Positions
    TitleAdjunct Professor
    InstitutionUniv PR School of Medicine
    DepartmentDept. of Anatomy & Neurobiology

    Collapse Affiliation 

    Collapse Biography 
    Collapse awards and honors
    1992 - 1993Fulbright Award, CIES
    1999 - 1999Presidental Early Career Award (PECASE), Clinton White Hourse
    2012 - 2012AAAS Fellow, AAAS
    2014 - 2014Highly Cited Researcher (top 1%), Thompson-Reuters
    2014 - 2016MERIT Award, NIMH

    Collapse Overview 
    Collapse overview
    My research focuses on the neural circuits of fear regulation, using rodent and human models of fear conditioning, extinction, and active avoidance. My lab uses a variety of experimental techniques including multichannel unit recording, optogenetics, immunocytochemistry, electrical stimulation, and computational modeling. We focus on how the prefrontal cortex influences fear-related activity in the amygdala, thalamus and striatum. This work is applicable to PTSD and OCD, and is funded by the National Institute of Mental Health. My lab has been in Puerto Rico for 18 years and consists of approximately 14 students, post-docs, and technicians, from the U.S., Puerto Rico, and other parts of Latin America. My long-term goal is to promote neuroscience research and training in Latin America.
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Bravo-Rivera H, Rubio Arzola P, Caban-Murillo A, Vélez-Avilés AN, Ayala-Rosario SN, Quirk GJ. Characterizing Different Strategies for Resolving Approach-Avoidance Conflict. Front Neurosci. 2021; 15:608922. PMID: 33716644.
    2. Yanagihara R, Berry MJ, Carson MJ, Chang SP, Corliss H, Cox MB, Haddad G, Hohmann C, Kelley ST, Lee ESY, Link BG, Noel RJ, Pickrel J, Porter JT, Quirk GJ, Samuel T, Stiles JK, Sy AU, Taira DA, Trepka MJ, Villalta F, Wiese TE. Building a Diverse Workforce and Thinkforce to Reduce Health Disparities. Int J Environ Res Public Health. 2021 02 07; 18(4). PMID: 33562262.
      Citations:    Fields:    Translation:Humans
    3. Diehl MM, Iravedra-Garcia JM, Morán-Sierra J, Rojas-Bowe G, Gonzalez-Diaz FN, Valentín-Valentín VP, Quirk GJ. Divergent projections of the prelimbic cortex bidirectionally regulate active avoidance. Elife. 2020 10 15; 9. PMID: 33054975.
      Citations: 1     Fields:    Translation:Animals
    4. Chase HW, Graur S, Versace A, Greenberg T, Bonar L, Hudak R, Quirk GJ, Greenberg BD, Rasmussen SA, Haber SN, Phillips ML. Neural mechanisms of persistent avoidance in OCD: A novel avoidance devaluation study. Neuroimage Clin. 2020; 28:102404. PMID: 32916468.
      Citations:    Fields:    
    5. Martínez-Rivera FJ, Sánchez-Navarro MJ, Huertas-Pérez CI, Greenberg BD, Rasmussen SA, Quirk GJ. Prolonged avoidance training exacerbates OCD-like behaviors in a rodent model. Transl Psychiatry. 2020 07 03; 10(1):212. PMID: 32620740.
      Citations:    Fields:    
    6. Sha Z, Versace A, Edmiston EK, Fournier J, Graur S, Greenberg T, Santos JPL, Chase HW, Stiffler RS, Bonar L, Hudak R, Yendiki A, Greenberg BD, Rasmussen S, Liu H, Quirk G, Haber S, Phillips ML. Functional disruption in prefrontal-striatal network in obsessive-compulsive disorder. Psychiatry Res Neuroimaging. 2020 06 30; 300:111081. PMID: 32344156.
      Citations: 1     Fields:    Translation:Humans
    7. Sha Z, Edmiston EK, Versace A, Fournier JC, Graur S, Greenberg T, Lima Santos JP, Chase HW, Stiffler RS, Bonar L, Hudak R, Yendiki A, Greenberg BD, Rasmussen S, Liu H, Quirk G, Haber S, Phillips ML. Functional Disruption of Cerebello-thalamo-cortical Networks in Obsessive-Compulsive Disorder. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 04; 5(4):438-447. PMID: 32033923.
      Citations: 3     Fields:    Translation:Humans
    8. Martinez-Conde S, Alexander RG, Blum D, Britton N, Lipska BK, Quirk GJ, Swiss JI, Willems RM, Macknik SL. The Storytelling Brain: How Neuroscience Stories Help Bridge the Gap between Research and Society. J Neurosci. 2019 10 16; 39(42):8285-8290. PMID: 31619498.
      Citations:    Fields:    Translation:Humans
    9. Diehl MM, Bravo-Rivera C, Quirk GJ. The study of active avoidance: A platform for discussion. Neurosci Biobehav Rev. 2019 12; 107:229-237. PMID: 31509767.
      Citations: 9     Fields:    Translation:Animals
    10. Chen YC, Ma NX, Pei ZF, Wu Z, Do-Monte FH, Keefe S, Yellin E, Chen MS, Yin JC, Lee G, Minier-Toribio A, Hu Y, Bai YT, Lee K, Quirk GJ, Chen G. A NeuroD1 AAV-Based Gene Therapy for Functional Brain Repair after Ischemic Injury through In Vivo Astrocyte-to-Neuron Conversion. Mol Ther. 2020 01 08; 28(1):217-234. PMID: 31551137.
      Citations: 17     Fields:    Translation:AnimalsCells
    11. Dopfel D, Perez PD, Verbitsky A, Bravo-Rivera H, Ma Y, Quirk GJ, Zhang N. Individual variability in behavior and functional networks predicts vulnerability using an animal model of PTSD. Nat Commun. 2019 05 30; 10(1):2372. PMID: 31147546.
      Citations: 9     Fields:    Translation:Animals
    12. Quirk GJ. Neuroscience Research and Mentoring in Puerto Rico: What Succeeds in This Environment? J Neurosci. 2019 01 30; 39(5):776-782. PMID: 30700524.
      Citations: 1     Fields:    Translation:HumansAnimals
    13. Martínez-Rivera FJ, Bravo-Rivera C, Velázquez-Díaz CD, Montesinos-Cartagena M, Quirk GJ. Prefrontal circuits signaling active avoidance retrieval and extinction. Psychopharmacology (Berl). 2019 Jan; 236(1):399-406. PMID: 30259076.
      Citations: 9     Fields:    Translation:AnimalsCells
    14. Rosas-Vidal LE, Lozada-Miranda V, Cantres-Rosario Y, Vega-Medina A, Melendez L, Quirk GJ. Alteration of BDNF in the medial prefrontal cortex and the ventral hippocampus impairs extinction of avoidance. Neuropsychopharmacology. 2018 12; 43(13):2636-2644. PMID: 30127343.
      Citations: 8     Fields:    Translation:AnimalsCells
    15. Diehl MM, Bravo-Rivera C, Rodriguez-Romaguera J, Pagan-Rivera PA, Burgos-Robles A, Roman-Ortiz C, Quirk GJ. Active avoidance requires inhibitory signaling in the rodent prelimbic prefrontal cortex. Elife. 2018 05 31; 7. PMID: 29851381.
      Citations: 19     Fields:    Translation:Animals
    16. Sah P, Fanselow M, Quirk GJ, Hattie J, Mattingley J, Tokuhama-Espinosa T. The nature and nurture of education. NPJ Sci Learn. 2018; 3:6. PMID: 30631467.
    17. Do-Monte FH, Minier-Toribio A, Quiñones-Laracuente K, Medina-Colón EM, Quirk GJ. Thalamic Regulation of Sucrose Seeking during Unexpected Reward Omission. Neuron. 2017 Apr 19; 94(2):388-400.e4. PMID: 28426970.
      Citations: 30     Fields:    Translation:AnimalsCells
    18. Quirk GJ. Less fear, more diversity. PLoS Biol. 2017 04; 15(4):e2002079. PMID: 28414713.
      Citations:    Fields:    Translation:HumansAnimals
    20. Delgado MR, Beer JS, Fellows LK, Huettel SA, Platt ML, Quirk GJ, Schiller D. Viewpoints: Dialogues on the functional role of the ventromedial prefrontal cortex. Nat Neurosci. 2016 11 29; 19(12):1545-1552. PMID: 27898086.
      Citations: 37     Fields:    Translation:HumansAnimals
    21. Martínez-Rivera FJ, Rodriguez-Romaguera J, Lloret-Torres ME, Do Monte FH, Quirk GJ, Barreto-Estrada JL. Bidirectional Modulation of Extinction of Drug Seeking by Deep Brain Stimulation of the Ventral Striatum. Biol Psychiatry. 2016 11 01; 80(9):682-690. PMID: 27449798.
      Citations: 13     Fields:    Translation:Animals
    22. Heilbronner SR, Rodriguez-Romaguera J, Quirk GJ, Groenewegen HJ, Haber SN. Circuit-Based Corticostriatal Homologies Between Rat and Primate. Biol Psychiatry. 2016 10 01; 80(7):509-21. PMID: 27450032.
      Citations: 82     Fields:    Translation:Animals
    23. Sah P, Fanselow M, Hattie J, Magsamen S, Mattingley J, Quirk G, Williams S. Integrating neuroscience and learning: now's the time... NPJ Sci Learn. 2016; 1:16007. PMID: 30792893.
    24. Rodriguez-Romaguera J, Greenberg BD, Rasmussen SA, Quirk GJ. An Avoidance-Based Rodent Model of Exposure With Response Prevention Therapy for Obsessive-Compulsive Disorder. Biol Psychiatry. 2016 10 01; 80(7):534-40. PMID: 27086546.
      Citations: 8     Fields:    Translation:Animals
    25. Rodriguez-Romaguera J, Greenberg BD, Haber SN, Quirk GJ. A Cross Species Approach to Understanding DBS Modulation of Fear. Brain Stimul. 2015 Sep-Oct; 8(5):986-8. PMID: 26358491.
      Citations: 1     Fields:    
    26. Quiñones-Laracuente K, Hernández-Rodríguez MY, Bravo-Rivera C, Melendez RI, Quirk GJ. The effect of repeated exposure to ethanol on pre-existing fear memories in rats. Psychopharmacology (Berl). 2015 Oct; 232(19):3615-22. PMID: 26194914.
      Citations: 8     Fields:    Translation:Animals
    27. Bravo-Rivera C, Roman-Ortiz C, Montesinos-Cartagena M, Quirk GJ. Persistent active avoidance correlates with activity in prelimbic cortex and ventral striatum. Front Behav Neurosci. 2015; 9:184. PMID: 26236209.
    28. Do-Monte FH, Manzano-Nieves G, Quiñones-Laracuente K, Ramos-Medina L, Quirk GJ. Revisiting the role of infralimbic cortex in fear extinction with optogenetics. J Neurosci. 2015 Feb 25; 35(8):3607-15. PMID: 25716859.
      Citations: 104     Fields:    Translation:AnimalsCells
    29. Rodriguez-Romaguera J, Do-Monte FH, Tanimura Y, Quirk GJ, Haber SN. Enhancement of fear extinction with deep brain stimulation: evidence for medial orbitofrontal involvement. Neuropsychopharmacology. 2015 Jun; 40(7):1726-33. PMID: 25601229.
      Citations: 15     Fields:    Translation:Animals
    30. Do-Monte FH, Quiñones-Laracuente K, Quirk GJ. A temporal shift in the circuits mediating retrieval of fear memory. Nature. 2015 Mar 26; 519(7544):460-3. PMID: 25600268.
      Citations: 136     Fields:    Translation:AnimalsCells
    31. Aguilar-Rivera MI, Casanova JP, Gatica RI, Quirk GJ, Fuentealba JA. Amphetamine sensitization is accompanied by an increase in prelimbic cortex activity. Neuroscience. 2015 Mar 12; 288:1-9. PMID: 25542419.
      Citations: 2     Fields:    Translation:AnimalsCells
    32. Martínez KG, Franco-Chaves JA, Milad MR, Quirk GJ. Ethnic differences in physiological responses to fear conditioned stimuli. PLoS One. 2014; 9(12):e114977. PMID: 25501365.
      Citations: 2     Fields:    Translation:Humans
    33. Bravo-Rivera C, Roman-Ortiz C, Brignoni-Perez E, Sotres-Bayon F, Quirk GJ. Neural structures mediating expression and extinction of platform-mediated avoidance. J Neurosci. 2014 Jul 16; 34(29):9736-42. PMID: 25031411.
      Citations: 62     Fields:    Translation:Animals
    34. Rosas-Vidal LE, Do-Monte FH, Sotres-Bayon F, Quirk GJ. Hippocampal--prefrontal BDNF and memory for fear extinction. Neuropsychopharmacology. 2014 Aug; 39(9):2161-9. PMID: 24625752.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    35. Do-Monte FH, Rodriguez-Romaguera J, Rosas-Vidal LE, Quirk GJ. Deep brain stimulation of the ventral striatum increases BDNF in the fear extinction circuit. Front Behav Neurosci. 2013; 7:102. PMID: 23964215.
    36. Pendyam S, Bravo-Rivera C, Burgos-Robles A, Sotres-Bayon F, Quirk GJ, Nair SS. Fear signaling in the prelimbic-amygdala circuit: a computational modeling and recording study. J Neurophysiol. 2013 Aug; 110(4):844-61. PMID: 23699055.
      Citations: 14     Fields:    Translation:AnimalsCells
    37. Burgos-Robles A, Bravo-Rivera H, Quirk GJ. Prelimbic and infralimbic neurons signal distinct aspects of appetitive instrumental behavior. PLoS One. 2013; 8(2):e57575. PMID: 23460877.
      Citations: 40     Fields:    Translation:AnimalsCells
    38. Felmingham KL, Dobson-Stone C, Schofield PR, Quirk GJ, Bryant RA. The brain-derived neurotrophic factor Val66Met polymorphism predicts response to exposure therapy in posttraumatic stress disorder. Biol Psychiatry. 2013 Jun 01; 73(11):1059-63. PMID: 23312562.
      Citations: 50     Fields:    Translation:Humans
    39. Sotres-Bayon F, Sierra-Mercado D, Pardilla-Delgado E, Quirk GJ. Gating of fear in prelimbic cortex by hippocampal and amygdala inputs. Neuron. 2012 Nov 21; 76(4):804-12. PMID: 23177964.
      Citations: 169     Fields:    Translation:AnimalsCells
    40. Martínez KG, Castro-Couch M, Franco-Chaves JA, Ojeda-Arce B, Segura G, Milad MR, Quirk GJ. Correlations between psychological tests and physiological responses during fear conditioning and renewal. Biol Mood Anxiety Disord. 2012 Sep 17; 2:16. PMID: 22985550.
    41. Rodriguez-Romaguera J, Do Monte FH, Quirk GJ. Deep brain stimulation of the ventral striatum enhances extinction of conditioned fear. Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8764-9. PMID: 22586125.
      Citations: 54     Fields:    Translation:Animals
    42. Linnman C, Zeidan MA, Furtak SC, Pitman RK, Quirk GJ, Milad MR. Resting amygdala and medial prefrontal metabolism predicts functional activation of the fear extinction circuit. Am J Psychiatry. 2012 Apr; 169(4):415-23. PMID: 22318762.
      Citations: 46     Fields:    Translation:Humans
    43. Milad MR, Quirk GJ. Fear extinction as a model for translational neuroscience: ten years of progress. Annu Rev Psychol. 2012; 63:129-51. PMID: 22129456.
      Citations: 422     Fields:    Translation:Humans
    44. Padilla-Coreano N, Do-Monte FH, Quirk GJ. A time-dependent role of midline thalamic nuclei in the retrieval of fear memory. Neuropharmacology. 2012 Jan; 62(1):457-63. PMID: 21903111.
      Citations: 32     Fields:    Translation:Animals
    45. Mueller D, Bravo-Rivera C, Quirk GJ. Infralimbic D2 receptors are necessary for fear extinction and extinction-related tone responses. Biol Psychiatry. 2010 Dec 01; 68(11):1055-60. PMID: 20926066.
      Citations: 53     Fields:    Translation:AnimalsCells
    46. Quirk GJ, Paré D, Richardson R, Herry C, Monfils MH, Schiller D, Vicentic A. Erasing fear memories with extinction training. J Neurosci. 2010 Nov 10; 30(45):14993-7. PMID: 21068303.
      Citations: 74     Fields:    Translation:Animals
    47. Sierra-Mercado D, Padilla-Coreano N, Quirk GJ. Dissociable roles of prelimbic and infralimbic cortices, ventral hippocampus, and basolateral amygdala in the expression and extinction of conditioned fear. Neuropsychopharmacology. 2011 Jan; 36(2):529-38. PMID: 20962768.
      Citations: 413     Fields:    Translation:Animals
    48. Fontanez-Nuin DE, Santini E, Quirk GJ, Porter JT. Memory for fear extinction requires mGluR5-mediated activation of infralimbic neurons. Cereb Cortex. 2011 Mar; 21(3):727-35. PMID: 20705895.
      Citations: 51     Fields:    Translation:AnimalsCells
    49. Peters J, Dieppa-Perea LM, Melendez LM, Quirk GJ. Induction of fear extinction with hippocampal-infralimbic BDNF. Science. 2010 Jun 04; 328(5983):1288-90. PMID: 20522777.
      Citations: 168     Fields:    Translation:HumansAnimals
    50. Sotres-Bayon F, Quirk GJ. Prefrontal control of fear: more than just extinction. Curr Opin Neurobiol. 2010 Apr; 20(2):231-5. PMID: 20303254.
      Citations: 238     Fields:    Translation:HumansAnimals
    51. Quirk GJ, Milad MR. Neuroscience: Editing out fear. Nature. 2010 Jan 07; 463(7277):36-7. PMID: 20054384.
      Citations: 11     Fields:    Translation:HumansAnimals
    52. Holmes A, Quirk GJ. Pharmacological facilitation of fear extinction and the search for adjunct treatments for anxiety disorders--the case of yohimbine. Trends Pharmacol Sci. 2010 Jan; 31(1):2-7. PMID: 20036429.
      Citations: 39     Fields:    Translation:HumansAnimals
    53. Burgos-Robles A, Vidal-Gonzalez I, Quirk GJ. Sustained conditioned responses in prelimbic prefrontal neurons are correlated with fear expression and extinction failure. J Neurosci. 2009 Jul 01; 29(26):8474-82. PMID: 19571138.
      Citations: 203     Fields:    Translation:AnimalsCells
    54. Peters J, Kalivas PW, Quirk GJ. Extinction circuits for fear and addiction overlap in prefrontal cortex. Learn Mem. 2009 May; 16(5):279-88. PMID: 19380710.
      Citations: 313     Fields:    Translation:HumansAnimals
    55. Martínez KG, Quirk GJ. Extending fear extinction beyond anxiety disorders. Biol Psychiatry. 2009 Mar 15; 65(6):453-4. PMID: 19236997.
      Citations: 2     Fields:    Translation:Humans
    56. Quirk GJ, Sotres-Bayon F. Signaling aversive events in the midbrain: worse than expected. Neuron. 2009 Mar 12; 61(5):655-6. PMID: 19285461.
      Citations: 2     Fields:    Translation:AnimalsCells
    57. Mueller D, Olivera-Figueroa LA, Pine DS, Quirk GJ. The effects of yohimbine and amphetamine on fear expression and extinction in rats. Psychopharmacology (Berl). 2009 Jul; 204(4):599-606. PMID: 19242678.
      Citations: 20     Fields:    Translation:Animals
    58. Rodriguez-Romaguera J, Sotres-Bayon F, Mueller D, Quirk GJ. Systemic propranolol acts centrally to reduce conditioned fear in rats without impairing extinction. Biol Psychiatry. 2009 May 15; 65(10):887-92. PMID: 19246030.
      Citations: 46     Fields:    Translation:AnimalsCells
    59. Li G, Nair SS, Quirk GJ. A biologically realistic network model of acquisition and extinction of conditioned fear associations in lateral amygdala neurons. J Neurophysiol. 2009 Mar; 101(3):1629-46. PMID: 19036872.
      Citations: 34     Fields:    Translation:AnimalsCells
    60. Santini E, Quirk GJ, Porter JT. Fear conditioning and extinction differentially modify the intrinsic excitability of infralimbic neurons. J Neurosci. 2008 Apr 09; 28(15):4028-36. PMID: 18400902.
      Citations: 122     Fields:    Translation:AnimalsCells
    61. Mueller D, Porter JT, Quirk GJ. Noradrenergic signaling in infralimbic cortex increases cell excitability and strengthens memory for fear extinction. J Neurosci. 2008 Jan 09; 28(2):369-75. PMID: 18184779.
      Citations: 116     Fields:    Translation:AnimalsCells
    62. Quirk GJ, Martinez KG, Nazario Rodríguez LL. Translating findings from basic fear research to clinical psychiatry in Puerto Rico. P R Health Sci J. 2007 Dec; 26(4):321-8. PMID: 18246959.
      Citations: 5     Fields:    Translation:HumansAnimals
    63. Quirk GJ, Mueller D. Neural mechanisms of extinction learning and retrieval. Neuropsychopharmacology. 2008 Jan; 33(1):56-72. PMID: 17882236.
      Citations: 579     Fields:    Translation:HumansAnimalsCells
    64. Milad MR, Quirk GJ, Pitman RK, Orr SP, Fischl B, Rauch SL. A role for the human dorsal anterior cingulate cortex in fear expression. Biol Psychiatry. 2007 Nov 15; 62(10):1191-4. PMID: 17707349.
      Citations: 192     Fields:    Translation:Humans
    65. Burgos-Robles A, Vidal-Gonzalez I, Santini E, Quirk GJ. Consolidation of fear extinction requires NMDA receptor-dependent bursting in the ventromedial prefrontal cortex. Neuron. 2007 Mar 15; 53(6):871-80. PMID: 17359921.
      Citations: 212     Fields:    Translation:AnimalsCells
    66. Corcoran KA, Quirk GJ. Recalling safety: cooperative functions of the ventromedial prefrontal cortex and the hippocampus in extinction. CNS Spectr. 2007 Mar; 12(3):200-6. PMID: 17329980.
      Citations: 39     Fields:    Translation:Animals
    67. Corcoran KA, Quirk GJ. Activity in prelimbic cortex is necessary for the expression of learned, but not innate, fears. J Neurosci. 2007 Jan 24; 27(4):840-4. PMID: 17251424.
      Citations: 189     Fields:    Translation:Animals
    68. Milad MR, Wright CI, Orr SP, Pitman RK, Quirk GJ, Rauch SL. Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concert. Biol Psychiatry. 2007 Sep 01; 62(5):446-54. PMID: 17217927.
      Citations: 418     Fields:    Translation:Humans
    69. Quirk GJ, Beer JS. Prefrontal involvement in the regulation of emotion: convergence of rat and human studies. Curr Opin Neurobiol. 2006 Dec; 16(6):723-7. PMID: 17084617.
      Citations: 255     Fields:    Translation:HumansAnimals
    70. Vidal-Gonzalez I, Vidal-Gonzalez B, Rauch SL, Quirk GJ. Microstimulation reveals opposing influences of prelimbic and infralimbic cortex on the expression of conditioned fear. Learn Mem. 2006 Nov-Dec; 13(6):728-33. PMID: 17142302.
      Citations: 261     Fields:    Translation:Animals
    71. Quirk GJ, Vidal-Gonzalez I. Keeping the memories flowing. Nat Neurosci. 2006 Oct; 9(10):1199-200. PMID: 17001332.
      Citations:    Fields:    Translation:Animals
    72. Sierra-Mercado D, Corcoran KA, Lebrón-Milad K, Quirk GJ. Inactivation of the ventromedial prefrontal cortex reduces expression of conditioned fear and impairs subsequent recall of extinction. Eur J Neurosci. 2006 Sep; 24(6):1751-8. PMID: 17004939.
      Citations: 91     Fields:    Translation:Animals
    73. Quirk GJ. Extinction: new excitement for an old phenomenon. Biol Psychiatry. 2006 Aug 15; 60(4):317-8. PMID: 16919520.
      Citations: 13     Fields:    Translation:HumansAnimals
    74. Quirk GJ, Garcia R, González-Lima F. Prefrontal mechanisms in extinction of conditioned fear. Biol Psychiatry. 2006 Aug 15; 60(4):337-43. PMID: 16712801.
      Citations: 224     Fields:    Translation:Animals
    75. Milad MR, Rauch SL, Pitman RK, Quirk GJ. Fear extinction in rats: implications for human brain imaging and anxiety disorders. Biol Psychol. 2006 Jul; 73(1):61-71. PMID: 16476517.
      Citations: 217     Fields:    Translation:HumansAnimals
    76. Anglada-Figueroa D, Quirk GJ. Lesions of the basal amygdala block expression of conditioned fear but not extinction. J Neurosci. 2005 Oct 19; 25(42):9680-5. PMID: 16237172.
      Citations: 92     Fields:    Translation:Animals
    77. Quirk GJ, Peña de Ortiz S. Stuck in time without a nucleus: theoretical comment on Sangha et Al. (2005). Behav Neurosci. 2005 Aug; 119(4):1155-7. PMID: 16187846.
      Citations:    Fields:    Translation:AnimalsCells
    78. Maren S, Quirk GJ. Neuronal signalling of fear memory. Nat Rev Neurosci. 2004 Nov; 5(11):844-52. PMID: 15496862.
      Citations: 464     Fields:    Translation:HumansAnimalsCells
    79. Lebrón K, Milad MR, Quirk GJ. Delayed recall of fear extinction in rats with lesions of ventral medial prefrontal cortex. Learn Mem. 2004 Sep-Oct; 11(5):544-8. PMID: 15466306.
      Citations: 75     Fields:    Translation:Animals
    80. Paré D, Quirk GJ, Ledoux JE. New vistas on amygdala networks in conditioned fear. J Neurophysiol. 2004 Jul; 92(1):1-9. PMID: 15212433.
      Citations: 279     Fields:    Translation:HumansAnimals
    81. Santini E, Ge H, Ren K, Peña de Ortiz S, Quirk GJ. Consolidation of fear extinction requires protein synthesis in the medial prefrontal cortex. J Neurosci. 2004 Jun 23; 24(25):5704-10. PMID: 15215292.
      Citations: 171     Fields:    Translation:Animals
    82. Milad MR, Vidal-Gonzalez I, Quirk GJ. Electrical stimulation of medial prefrontal cortex reduces conditioned fear in a temporally specific manner. Behav Neurosci. 2004 Apr; 118(2):389-94. PMID: 15113265.
      Citations: 111     Fields:    Translation:Animals
    83. Quirk GJ. Learning not to fear, faster. Learn Mem. 2004 Mar-Apr; 11(2):125-6. PMID: 15054126.
      Citations: 4     Fields:    Translation:HumansAnimals
    84. Quirk GJ, Likhtik E, Pelletier JG, Paré D. Stimulation of medial prefrontal cortex decreases the responsiveness of central amygdala output neurons. J Neurosci. 2003 Sep 24; 23(25):8800-7. PMID: 14507980.
      Citations: 326     Fields:    Translation:AnimalsCells
    85. Quirk GJ, Gehlert DR. Inhibition of the amygdala: key to pathological states? Ann N Y Acad Sci. 2003 Apr; 985:263-72. PMID: 12724164.
      Citations: 99     Fields:    Translation:HumansAnimals
    86. Milad MR, Quirk GJ. Neurons in medial prefrontal cortex signal memory for fear extinction. Nature. 2002 Nov 07; 420(6911):70-4. PMID: 12422216.
      Citations: 617     Fields:    Translation:AnimalsCells
    87. Quirk GJ. Memory for extinction of conditioned fear is long-lasting and persists following spontaneous recovery. Learn Mem. 2002 Nov-Dec; 9(6):402-7. PMID: 12464700.
      Citations: 104     Fields:    Translation:Animals
    88. Santini E, Muller RU, Quirk GJ. Consolidation of extinction learning involves transfer from NMDA-independent to NMDA-dependent memory. J Neurosci. 2001 Nov 15; 21(22):9009-17. PMID: 11698611.
      Citations: 104     Fields:    Translation:Animals
    89. Quirk GJ, Russo GK, Barron JL, Lebron K. The role of ventromedial prefrontal cortex in the recovery of extinguished fear. J Neurosci. 2000 Aug 15; 20(16):6225-31. PMID: 10934272.
      Citations: 322     Fields:    Translation:Animals
    90. Quirk GJ. Neuroscience in developing countries: getting around the problems. Int J Neurosci. 1999 Aug; 99(1-4):89-90. PMID: 10495199.
      Citations: 3     Fields:    Translation:Humans
    91. Armony JL, Quirk GJ, LeDoux JE. Differential effects of amygdala lesions on early and late plastic components of auditory cortex spike trains during fear conditioning. J Neurosci. 1998 Apr 01; 18(7):2592-601. PMID: 9502818.
      Citations: 34     Fields:    Translation:Animals
    92. Quirk GJ. Fear research: implications for anxiety disorders. Bol Asoc Med P R. 1998 Jan-Mar; 90(1-3):27-9. PMID: 9734154.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    93. Hesse H, Rivera MF, de Díaz I, Quirk GJ. Central somatosensory conduction time in severely growth-stunted children. Am J Clin Nutr. 1998 Jan; 67(1):93-6. PMID: 9440381.
      Citations:    Fields:    Translation:Humans
    94. Quirk GJ, Armony JL, LeDoux JE. Fear conditioning enhances different temporal components of tone-evoked spike trains in auditory cortex and lateral amygdala. Neuron. 1997 Sep; 19(3):613-24. PMID: 9331352.
      Citations: 149     Fields:    Translation:AnimalsCells
    95. Quirk GJ, Weisskopf MG. Science in developing countries: whose agenda? Am J Physiol. 1997 Jun; 272(6 Pt 3):S50-1. PMID: 9227651.
      Citations:    Fields:    Translation:Humans
    96. Quirk GJ, Armony JL, Repa JC, Li XF, LeDoux JE. Emotional memory: a search for sites of plasticity. Cold Spring Harb Symp Quant Biol. 1996; 61:247-57. PMID: 9246453.
      Citations: 3     Fields:    Translation:HumansAnimals
    97. Quirk GJ. Starting a neuroscience research laboratory in a developing country: a Fulbright experience in Honduras. Am J Physiol. 1995 Dec; 269(6 Pt 3):S61-7. PMID: 8554098.
      Citations:    Fields:    Translation:Humans
    98. Quirk GJ, Repa C, LeDoux JE. Fear conditioning enhances short-latency auditory responses of lateral amygdala neurons: parallel recordings in the freely behaving rat. Neuron. 1995 Nov; 15(5):1029-39. PMID: 7576647.
      Citations: 215     Fields:    Translation:AnimalsCells
    99. Quirk GJ, Mejia WR, Hesse H, Su H. Early malnutrition followed by nutritional restoration lowers the conduction velocity and excitability of the corticospinal tract. Brain Res. 1995 Jan 30; 670(2):277-82. PMID: 7743191.
      Citations: 1     Fields:    Translation:AnimalsCells
    100. Quirk GJ, Casco L. Stress disorders of families of the disappeared: a controlled study in Honduras. Soc Sci Med. 1994 Dec; 39(12):1675-9. PMID: 7846565.
      Citations: 4     Fields:    Translation:Humans
    101. Quirk GJ, Muller RU, Kubie JL, Ranck JB. The positional firing properties of medial entorhinal neurons: description and comparison with hippocampal place cells. J Neurosci. 1992 May; 12(5):1945-63. PMID: 1578279.
      Citations: 70     Fields:    Translation:AnimalsCells
    102. Stewart M, Quirk GJ, Barry M, Fox SE. Firing relations of medial entorhinal neurons to the hippocampal theta rhythm in urethane anesthetized and walking rats. Exp Brain Res. 1992; 90(1):21-8. PMID: 1521610.
      Citations: 20     Fields:    Translation:AnimalsCells
    103. Amassian VE, Quirk GJ, Stewart M. A comparison of corticospinal activation by magnetic coil and electrical stimulation of monkey motor cortex. Electroencephalogr Clin Neurophysiol. 1990 Sep-Oct; 77(5):390-401. PMID: 1697531.
      Citations: 42     Fields:    Translation:Animals
    104. Quirk GJ, Muller RU, Kubie JL. The firing of hippocampal place cells in the dark depends on the rat's recent experience. J Neurosci. 1990 Jun; 10(6):2008-17. PMID: 2355262.
      Citations: 80     Fields:    Translation:AnimalsCells
    105. Stewart M, Quirk GJ, Amassian VE. Corticospinal responses to electrical stimulation of motor cortex in the rat. Brain Res. 1990 Feb 05; 508(2):341-4. PMID: 2306626.
      Citations: 2     Fields:    Translation:Animals
    106. Collier TJ, Quirk GJ, Routtenberg A. Separable roles of hippocampal granule cells in forgetting and pyramidal cells in remembering spatial information. Brain Res. 1987 Apr 21; 409(2):316-28. PMID: 3580879.
      Citations: 9     Fields:    Translation:Animals
    107. Amassian VE, Stewart M, Quirk GJ, Rosenthal JL. Physiological basis of motor effects of a transient stimulus to cerebral cortex. Neurosurgery. 1987 Jan; 20(1):74-93. PMID: 3543727.
      Citations: 86     Fields:    Translation:HumansAnimalsCells
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