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Peter R. Hoffmann, PhD

Faculty RankProfessor
InstitutionUniversity of Hawaii
DepartmentCell and Molecular Biology
AddressJohn A. Burns School of Medicine
University of Hawaii at Manoa
651 Ilalo Street
Honolulu HI 96813
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ma C, Hoffmann FW, Marciel MP, Page KE, Williams-Aduja MA, Akana ENL, Gojanovich GS, Gerschenson M, Urschitz J, Moisyadi S, Khadka VS, Rozovsky S, Deng Y, Horgen FD, Hoffmann PR. Upregulated ethanolamine phospholipid synthesis via selenoprotein I is required for effective metabolic reprogramming during T cell activation. Mol Metab. 2021 Jan 20; 47:101170. PMID: 33484950.
      Citations:    Fields:    
    2. Acland M, Arentz G, Mussared M, Whitehead F, Hoffmann P, Klingler-Hoffmann M, Oehler MK. Proteomic Analysis of Pre-Invasive Serous Lesions of the Endometrium and Fallopian Tube Reveals Their Metastatic Potential. Front Oncol. 2020; 10:523989. PMID: 33384952.
    3. Ma C, Hoffmann PR. Selenoproteins as regulators of T cell proliferation, differentiation, and metabolism. Semin Cell Dev Biol. 2020 Nov 17. PMID: 33214077.
      Citations:    Fields:    
    4. Weiland F, Lokman NA, Klingler-Hoffmann M, Jobling T, Stephens AN, Sundfeldt K, Hoffmann P, Oehler MK. Ovarian Blood Sampling Identifies Junction Plakoglobin as a Novel Biomarker of Early Ovarian Cancer. Front Oncol. 2020; 10:1767. PMID: 33102207.
    5. Lorthiois E, Roache J, Barnes-Seeman D, Altmann E, Hassiepen U, Turner G, Duvadie R, Hornak V, Karki RG, Schiering N, Weihofen WA, Perruccio F, Calhoun A, Fazal T, Dedic D, Durand C, Dussauge S, Fettis K, Tritsch F, Dentel C, Druet A, Liu D, Kirman L, Lachal J, Namoto K, Bevan D, Mo R, Monnet G, Muller L, Zessis R, Huang X, Lindsley L, Currie T, Chiu YH, Fridrich C, Delgado P, Wang S, Hollis-Symynkywicz M, Berghausen J, Williams E, Liu H, Liang G, Kim H, Hoffmann P, Hein A, Ramage P, D'Arcy A, Harlfinger S, Renatus M, Ruedisser S, Feldman D, Elliott J, Sedrani R, Maibaum J, Adams CM. Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Approach. J Med Chem. 2020 08 13; 63(15):8088-8113. PMID: 32551603.
      Citations:    Fields:    Translation:HumansAnimalsCells
    6. Zhang ZH, Chen C, Jia SZ, Cao XC, Liu M, Tian J, Hoffmann PR, Xu HX, Ni JZ, Song GL. Selenium Restores Synaptic Deficits by Modulating NMDA Receptors and Selenoprotein K in an Alzheimer's Disease Model. Antioxid Redox Signal. 2020 Jul 07. PMID: 32475153.
      Citations:    Fields:    
    7. Avery JC, Yamazaki Y, Hoffmann FW, Folgelgren B, Hoffmann PR. Selenoprotein I is essential for murine embryogenesis. Arch Biochem Biophys. 2020 08 15; 689:108444. PMID: 32502470.
      Citations:    Fields:    Translation:Animals
    8. Cai Z, Dong L, Song C, Zhang Y, Zhu C, Zhang Y, Ling Q, Hoffmann PR, Li J, Huang Z, Li W. Author Correction: Methylseleninic Acid Provided at Nutritional Selenium Levels Inhibits Angiogenesis by Down-regulating Integrin ß3 Signaling. Sci Rep. 2020 Mar 24; 10(1):5673. PMID: 32214221.
      Citations:    Fields:    
    9. Schoenefuss F, Hoffmann P. Serum ?-globulin and albumin concentrations predict secondary loss of response to anti-TNFa in inflammatory bowel disease patients. Eur J Gastroenterol Hepatol. 2019 Dec; 31(12):1563-1568. PMID: 31567711.
      Citations: 1     Fields:    Translation:Humans
    10. Klingler-Hoffmann M, Mittal P, Hoffmann P. The Emerging Role of Cytoskeletal Proteins as Reliable Biomarkers. Proteomics. 2019 11; 19(21-22):e1800483. PMID: 31525818.
      Citations:    Fields:    Translation:HumansCells
    11. Hoffmann P, Krisam J, Wehling C, Kloeters-Plachky P, Leopold Y, Belling N, Gauss A. Ustekinumab: "Real-world" outcomes and potential predictors of nonresponse in treatment-refractory Crohn's disease. World J Gastroenterol. 2019 Aug 21; 25(31):4481-4492. PMID: 31496626.
      Citations: 1     Fields:    Translation:Humans
    12. Hoffmann PR, Hoffmann FW, Premeaux TA, Fujita T, Soprana E, Panigada M, Chew GM, Richard G, Hindocha P, Menor M, Khadka VS, Deng Y, Moise L, Ndhlovu LC, Siccardi A, Weinberg AD, De Groot AS, Bertino P. Multi-antigen Vaccination With Simultaneous Engagement of the OX40 Receptor Delays Malignant Mesothelioma Growth and Increases Survival in Animal Models. Front Oncol. 2019; 9:720. PMID: 31428586.
    13. Cai Z, Zhang Y, Zhang Y, Miao X, Li S, Yang H, Ling Q, Hoffmann PR, Huang Z. Use of a Mouse Model and Human Umbilical Vein Endothelial Cells to Investigate the Effect of Arsenic Exposure on Vascular Endothelial Function and the Associated Role of Calpains. Environ Health Perspect. 2019 07; 127(7):77003. PMID: 31274337.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    14. Marciel MP, Hoffmann PR. Molecular Mechanisms by Which Selenoprotein K Regulates Immunity and Cancer. Biol Trace Elem Res. 2019 Nov; 192(1):60-68. PMID: 31187393.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    15. Bertino P, Premeaux TA, Fujita T, Haun BK, Marciel MP, Hoffmann FW, Garcia A, Yiang H, Pastorino S, Carbone M, Niki T, Berestecky J, Hoffmann PR, Ndhlovu LC. Targeting the C-terminus of galectin-9 induces mesothelioma apoptosis and M2 macrophage depletion. Oncoimmunology. 2019; 8(8):1601482. PMID: 31413910.
    16. Li YQ, Ngo A, Hoffmann P, Ferrante A, Hii CS. Regulation of endothelial cell survival and death by the MAP kinase/ERK kinase kinase 3 - glyceraldehyde-3-phosphate dehydrogenase signaling axis. Cell Signal. 2019 06; 58:20-33. PMID: 30831195.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    17. Zolekar A, Lin VJT, Mishra NM, Ho YY, Hayatshahi HS, Parab A, Sampat R, Liao X, Hoffmann P, Liu J, Emmitte KA, Wang YC. Stress and interferon signalling-mediated apoptosis contributes to pleiotropic anticancer responses induced by targeting NGLY1. Br J Cancer. 2018 12; 119(12):1538-1551. PMID: 30385822.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    18. Avery JC, Hoffmann PR. Selenium, Selenoproteins, and Immunity. Nutrients. 2018 Sep 01; 10(9). PMID: 30200430.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    19. Marciel MP, Khadka VS, Deng Y, Kilicaslan P, Pham A, Bertino P, Lee K, Chen S, Glibetic N, Hoffmann FW, Matter ML, Hoffmann PR. Correction: Selenoprotein K deficiency inhibits melanoma by reducing calcium flux required for tumor growth and metastasis. Oncotarget. 2018 07 20; 9(56):30937. PMID: 30112120.
      Citations:    Fields:    
    20. Marciel MP, Khadka VS, Deng Y, Kilicaslan P, Pham A, Bertino P, Lee K, Chen S, Glibetic N, Hoffmann FW, Matter ML, Hoffmann PR. Selenoprotein K deficiency inhibits melanoma by reducing calcium flux required for tumor growth and metastasis. Oncotarget. 2018 03 02; 9(17):13407-13422. PMID: 29568366.
      Citations: 3     Fields:    
    21. Fredericks GJ, Hoffmann FW, Hondal RJ, Rozovsky S, Urschitz J, Hoffmann PR. Selenoprotein K Increases Efficiency of DHHC6 Catalyzed Protein Palmitoylation by Stabilizing the Acyl-DHHC6 Intermediate. Antioxidants (Basel). 2017 Dec 29; 7(1). PMID: 29286308.
    22. Marciel MP, Rose AH, Martinez V, Horio DT, Hashimoto AS, Hoffmann FW, Bertino P, Hoffmann PR. Calpain-2 inhibitor treatment preferentially reduces tumor progression for human colon cancer cells expressing highest levels of this enzyme. Cancer Med. 2018 01; 7(1):175-183. PMID: 29210197.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    23. Marciel MP, Hoffmann PR. Selenoproteins and Metastasis. Adv Cancer Res. 2017; 136:85-108. PMID: 29054423.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    24. Cai Z, Dong L, Song C, Zhang Y, Zhu C, Zhang Y, Ling Q, Hoffmann PR, Li J, Huang Z, Li W. Methylseleninic Acid Provided at Nutritional Selenium Levels Inhibits Angiogenesis by Down-regulating Integrin ß3 Signaling. Sci Rep. 2017 08 25; 7(1):9445. PMID: 28842587.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    25. Pitts MW, Hoffmann PR. Endoplasmic reticulum-resident selenoproteins as regulators of calcium signaling and homeostasis. Cell Calcium. 2018 03; 70:76-86. PMID: 28506443.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    26. Ricciardelli C, Lokman NA, Pyragius CE, Ween MP, Macpherson AM, Ruszkiewicz A, Hoffmann P, Oehler MK. Keratin 5 overexpression is associated with serous ovarian cancer recurrence and chemotherapy resistance. Oncotarget. 2017 Mar 14; 8(11):17819-17832. PMID: 28147318.
      Citations: 7     Fields:    Translation:HumansCells
    27. Youngren-Ortiz SR, Hill DB, Hoffmann PR, Morris KR, Barrett EG, Forest MG, Chougule MB. Development of Optimized, Inhalable, Gemcitabine-Loaded Gelatin Nanocarriers for Lung Cancer. J Aerosol Med Pulm Drug Deliv. 2017 Oct; 30(5):299-321. PMID: 28277892.
      Citations: 3     Fields:    Translation:HumansCells
    28. Zhu C, Zhang S, Song C, Zhang Y, Ling Q, Hoffmann PR, Li J, Chen T, Zheng W, Huang Z. Selenium nanoparticles decorated with Ulva lactuca polysaccharide potentially attenuate colitis by inhibiting NF-?B mediated hyper inflammation. J Nanobiotechnology. 2017 Mar 07; 15(1):20. PMID: 28270147.
      Citations: 13     Fields:    Translation:Animals
    29. Zhang ZH, Wu QY, Zheng R, Chen C, Chen Y, Liu Q, Hoffmann PR, Ni JZ, Song GL. Selenomethionine Mitigates Cognitive Decline by Targeting Both Tau Hyperphosphorylation and Autophagic Clearance in an Alzheimer's Disease Mouse Model. J Neurosci. 2017 03 01; 37(9):2449-2462. PMID: 28137967.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    30. Mittal P, Klingler-Hoffmann M, Arentz G, Winderbaum L, Kaur G, Anderson L, Scurry J, Leung Y, Stewart CJ, Carter J, Hoffmann P, Oehler MK. Annexin A2 and alpha actinin 4 expression correlates with metastatic potential of primary endometrial cancer. Biochim Biophys Acta Proteins Proteom. 2017 Jul; 1865(7):846-857. PMID: 27784647.
      Citations: 5     Fields:    Translation:HumansCells
    31. Gladyshev VN, Arnér ES, Berry MJ, Brigelius-Flohé R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Flohé L, Green FR, Guigó R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, Köhrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonovic M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y. Selenoprotein Gene Nomenclature. J Biol Chem. 2016 Nov 11; 291(46):24036-24040. PMID: 27645994.
      Citations: 43     Fields:    Translation:Humans
    32. Norton RL, Fredericks GJ, Huang Z, Fay JD, Hoffmann FW, Hoffmann PR. Selenoprotein K regulation of palmitoylation and calpain cleavage of ASAP2 is required for efficient Fc?R-mediated phagocytosis. J Leukoc Biol. 2017 02; 101(2):439-448. PMID: 27601625.
      Citations: 9     Fields:    Translation:AnimalsCells
    33. Yamada K, Park HM, Rigel DF, DiPetrillo K, Whalen EJ, Anisowicz A, Beil M, Berstler J, Brocklehurst CE, Burdick DA, Caplan SL, Capparelli MP, Chen G, Chen W, Dale B, Deng L, Fu F, Hamamatsu N, Harasaki K, Herr T, Hoffmann P, Hu QY, Huang WJ, Idamakanti N, Imase H, Iwaki Y, Jain M, Jeyaseelan J, Kato M, Kaushik VK, Kohls D, Kunjathoor V, LaSala D, Lee J, Liu J, Luo Y, Ma F, Mo R, Mowbray S, Mogi M, Ossola F, Pandey P, Patel SJ, Raghavan S, Salem B, Shanado YH, Trakshel GM, Turner G, Wakai H, Wang C, Weldon S, Wielicki JB, Xie X, Xu L, Yagi YI, Yasoshima K, Yin J, Yowe D, Zhang JH, Zheng G, Monovich L. Small-molecule WNK inhibition regulates cardiovascular and renal function. Nat Chem Biol. 2016 Nov; 12(11):896-898. PMID: 27595330.
      Citations: 20     Fields:    Translation:HumansAnimals
    34. Zhong W, Yi Q, Xu B, Li S, Wang T, Liu F, Zhu B, Hoffmann PR, Ji G, Lei P, Li G, Li J, Li J, Olkkonen VM, Yan D. ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival. Nat Commun. 2016 09 01; 7:12702. PMID: 27581363.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    35. Zhang ZH, Chen C, Wu QY, Zheng R, Liu Q, Ni JZ, Hoffmann PR, Song GL. Selenomethionine reduces the deposition of beta-amyloid plaques by modulating ß-secretase and enhancing selenoenzymatic activity in a mouse model of Alzheimer's disease. Metallomics. 2016 08 01; 8(8):782-9. PMID: 27465436.
      Citations: 3     Fields:    Translation:AnimalsCells
    36. Zhu C, Ling Q, Cai Z, Wang Y, Zhang Y, Hoffmann PR, Zheng W, Zhou T, Huang Z. Selenium-Containing Phycocyanin from Se-Enriched Spirulina platensis Reduces Inflammation in Dextran Sulfate Sodium-Induced Colitis by Inhibiting NF-?B Activation. J Agric Food Chem. 2016 Jun 22; 64(24):5060-70. PMID: 27223481.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    37. Eyre NS, Hampton-Smith RJ, Aloia AL, Eddes JS, Simpson KJ, Hoffmann P, Beard MR. Phosphorylation of NS5A Serine-235 is essential to hepatitis C virus RNA replication and normal replication compartment formation. Virology. 2016 Apr; 491:27-44. PMID: 26874015.
      Citations: 13     Fields:    Translation:HumansCells
    38. Rose AH, Huang Z, Mafnas C, Hara JH, Hoffmann FW, Hashimoto AS, Bertino P, Hoffmann PR. Calpain-2 Inhibitor Therapy Reduces Murine Colitis and Colitis-associated Cancer. Inflamm Bowel Dis. 2015 Sep; 21(9):2005-15. PMID: 26076056.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    39. Rose AH, Hoffmann FW, Hara JH, Urschitz J, Moisyadi S, Hoffmann PR, Bertino P. Adjuvants may reduce in vivo transfection levels for DNA vaccination in mice leading to reduced antigen-specific CD8+ T cell responses. Hum Vaccin Immunother. 2015; 11(9):2305-11. PMID: 26091088.
      Citations: 2     Fields:    Translation:AnimalsCells
    40. Fredericks GJ, Hoffmann PR. Selenoprotein K and protein palmitoylation. Antioxid Redox Signal. 2015 Oct 01; 23(10):854-62. PMID: 26058750.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    41. Ricciardelli C, Lokman NA, Cheruvu S, Tan IA, Ween MP, Pyragius CE, Ruszkiewicz A, Hoffmann P, Oehler MK. Transketolase is upregulated in metastatic peritoneal implants and promotes ovarian cancer cell proliferation. Clin Exp Metastasis. 2015 Jun; 32(5):441-55. PMID: 25895698.
      Citations: 14     Fields:    Translation:HumansCells
    42. Berry MJ, Astern J, Bellinger F, Brampton C, Cann R, Gerschenson M, Haymer D, James NG, Jameson DM, LeSaux O, Hoffmann PR, Nichols R, Pitts M, Seale L, Seifried S, Stokes AJ, Todorovic C. Medical school hotline: the research mission of the cell and molecular biology department and program at the john a. Burns school of medicine. Hawaii J Med Public Health. 2015 Apr; 74(4):150-3. PMID: 25954603.
      Citations:    Fields:    Translation:Humans
    43. Turvey ME, Klingler-Hoffmann M, Hoffmann P, McColl SR. p84 forms a negative regulatory complex with p110? to control PI3K? signalling during cell migration. Immunol Cell Biol. 2015 Sep; 93(8):735-43. PMID: 25753393.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    44. Hoffmann PR, Panigada M, Soprana E, Terry F, Bandar IS, Napolitano A, Rose AH, Hoffmann FW, Ndhlovu LC, Belcaid M, Moise L, De Groot AS, Carbone M, Gaudino G, Matsui T, Siccardi A, Bertino P. Preclinical development of HIvax: Human survivin highly immunogenic vaccines. Hum Vaccin Immunother. 2015; 11(7):1585-95. PMID: 26042612.
      Citations: 9     Fields:    Translation:HumansCellsPHPublic Health
    45. Bui LM, Hoffmann P, Turnidge JD, Zilm PS, Kidd SP. Prolonged growth of a clinical Staphylococcus aureus strain selects for a stable small-colony-variant cell type. Infect Immun. 2015 Feb; 83(2):470-81. PMID: 25385795.
      Citations: 9     Fields:    Translation:HumansCells
    46. Fredericks GJ, Hoffmann FW, Rose AH, Osterheld HJ, Hess FM, Mercier F, Hoffmann PR. Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex. Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):16478-83. PMID: 25368151.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    47. Berry MJ, Cann R, Haymer D, Hoffmann P, Jameson D, LeSaux O, Nichols R, Seifried S, Stokes A, Todorovic C. Medical school hotline: The educational mission of the cell and molecular biology department and program at the John A. Burns School of Medicine. Hawaii J Med Public Health. 2014 Nov; 73(11):362-4. PMID: 25414807.
      Citations:    Fields:    Translation:Humans
    48. Rose AH, Hoffmann PR. Selenoproteins and cardiovascular stress. Thromb Haemost. 2015 Mar; 113(3):494-504. PMID: 25354851.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    49. Hughes PA, Moretta M, Lim A, Grasby DJ, Bird D, Brierley SM, Liebregts T, Adam B, Blackshaw LA, Holtmann G, Bampton P, Hoffmann P, Andrews JM, Zola H, Krumbiegel D. Immune derived opioidergic inhibition of viscerosensory afferents is decreased in Irritable Bowel Syndrome patients. Brain Behav Immun. 2014 Nov; 42:191-203. PMID: 25063707.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    50. Turvey ME, Koudelka T, Comerford I, Greer JM, Carroll W, Bernard CC, Hoffmann P, McColl SR. Quantitative proteome profiling of CNS-infiltrating autoreactive CD4+ cells reveals selective changes during experimental autoimmune encephalomyelitis. J Proteome Res. 2014 Aug 01; 13(8):3655-70. PMID: 24933266.
      Citations: 5     Fields:    Translation:AnimalsCells
    51. Humphries JM, Penno MA, Weiland F, Klingler-Hoffmann M, Zuber A, Boussioutas A, Ernst M, Hoffmann P. Identification and validation of novel candidate protein biomarkers for the detection of human gastric cancer. Biochim Biophys Acta. 2014 May; 1844(5):1051-8. PMID: 24512919.
      Citations: 17     Fields:    Translation:HumansAnimals
    52. Bertino P, Urschitz J, Hoffmann FW, You BR, Rose AH, Park WH, Moisyadi S, Hoffmann PR. Vaccination with a piggyBac plasmid with transgene integration potential leads to sustained antigen expression and CD8(+) T cell responses. Vaccine. 2014 Mar 26; 32(15):1670-7. PMID: 24513010.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    53. Rose AH, Bertino P, Hoffmann FW, Gaudino G, Carbone M, Hoffmann PR. Increasing dietary selenium elevates reducing capacity and ERK activation associated with accelerated progression of select mesothelioma tumors. Am J Pathol. 2014 Apr; 184(4):1041-1049. PMID: 24492200.
      Citations: 6     Fields:    Translation:AnimalsCells
    54. Hoffmann P, Beckman D, McLean LA, Yan JH. Aliskiren toxicity in juvenile rats is determined by ontogenic regulation of intestinal P-glycoprotein expression. Toxicol Appl Pharmacol. 2014 Feb 15; 275(1):36-43. PMID: 24388840.
      Citations: 1     Fields:    Translation:AnimalsCells
    55. Youngren SR, Tekade RK, Gustilo B, Hoffmann PR, Chougule MB. STAT6 siRNA matrix-loaded gelatin nanocarriers: formulation, characterization, and ex vivo proof of concept using adenocarcinoma cells. Biomed Res Int. 2013; 2013:858946. PMID: 24191252.
      Citations: 7     Fields:    Translation:HumansCells
    56. Youngren SR, Mulik R, Jun B, Hoffmann PR, Morris KR, Chougule MB. Freeze-dried targeted mannosylated selenium-loaded nanoliposomes: development and evaluation. AAPS PharmSciTech. 2013 Sep; 14(3):1012-24. PMID: 23797303.
      Citations: 5     Fields:    Translation:AnimalsCells
    57. Huang Z, Rose AH, Hoffmann FW, Hashimoto AS, Bertino P, Denk T, Takano J, Iwata N, Saido TC, Hoffmann PR. Calpastatin prevents NF-?B-mediated hyperactivation of macrophages and attenuates colitis. J Immunol. 2013 Oct 01; 191(7):3778-88. PMID: 23986533.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    58. Lee BC, Péterfi Z, Hoffmann FW, Moore RE, Kaya A, Avanesov A, Tarrago L, Zhou Y, Weerapana E, Fomenko DE, Hoffmann PR, Gladyshev VN. MsrB1 and MICALs regulate actin assembly and macrophage function via reversible stereoselective methionine oxidation. Mol Cell. 2013 Aug 08; 51(3):397-404. PMID: 23911929.
      Citations: 72     Fields:    Translation:AnimalsCells
    59. Lokman NA, Elder AS, Ween MP, Pyragius CE, Hoffmann P, Oehler MK, Ricciardelli C. Annexin A2 is regulated by ovarian cancer-peritoneal cell interactions and promotes metastasis. Oncotarget. 2013 Aug; 4(8):1199-211. PMID: 23945256.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    60. Meiler S, Baumer Y, Huang Z, Hoffmann FW, Fredericks GJ, Rose AH, Norton RL, Hoffmann PR, Boisvert WA. Selenoprotein K is required for palmitoylation of CD36 in macrophages: implications in foam cell formation and atherogenesis. J Leukoc Biol. 2013 May; 93(5):771-80. PMID: 23444136.
      Citations: 20     Fields:    Translation:AnimalsCells
    61. Bertino P, Panigada M, Soprana E, Bianchi V, Bertilaccio S, Sanvito F, Rose AH, Yang H, Gaudino G, Hoffmann PR, Siccardi A, Carbone M. Fowlpox-based survivin vaccination for malignant mesothelioma therapy. Int J Cancer. 2013 Aug 01; 133(3):612-23. PMID: 23335100.
      Citations: 13     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    62. Niu M, Klingler-Hoffmann M, Brazzatti JA, Forbes B, Akekawatchai C, Hoffmann P, McColl SR. Comparative proteomic analysis implicates eEF2 as a novel target of PI3K? in the MDA-MB-231 metastatic breast cancer cell line. Proteome Sci. 2013 Jan 15; 11(1):4. PMID: 23320409.
    63. Sheppard AL, Wolffsohn JS, Bhatt U, Hoffmann PC, Scheider A, Hütz WW, Shah S. Clinical outcomes after implantation of a new hydrophobic acrylic toric IOL during routine cataract surgery. J Cataract Refract Surg. 2013 Jan; 39(1):41-47. PMID: 23158681.
      Citations: 6     Fields:    Translation:Humans
    64. Penno MA, Klingler-Hoffmann M, Brazzatti JA, Boussioutas A, Putoczki T, Ernst M, Hoffmann P. 2D-DIGE analysis of sera from transgenic mouse models reveals novel candidate protein biomarkers for human gastric cancer. J Proteomics. 2012 Dec 21; 77:40-58. PMID: 22789672.
      Citations: 9     Fields:    Translation:HumansAnimalsCTClinical Trials
    65. Arentz G, Chataway T, Condina MR, Price TJ, Hoffmann P, Hardingham JE. Increased Phospho-Keratin 8 Isoforms in Colorectal Tumors Associated with EGFR Pathway Activation and Reduced Apoptosis. ISRN Mol Biol. 2012; 2012:706545. PMID: 27398237.
    66. Huang Z, Rose AH, Hoffmann PR. The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal. 2012 Apr 01; 16(7):705-43. PMID: 21955027.
      Citations: 107     Fields:    Translation:HumansAnimalsCells
    67. Huang Z, Hoffmann FW, Fay JD, Hashimoto AC, Chapagain ML, Kaufusi PH, Hoffmann PR. Stimulation of unprimed macrophages with immune complexes triggers a low output of nitric oxide by calcium-dependent neuronal nitric-oxide synthase. J Biol Chem. 2012 Feb 10; 287(7):4492-502. PMID: 22205701.
      Citations: 23     Fields:    Translation:AnimalsCells
    68. Norton RL, Hoffmann PR. Selenium and asthma. Mol Aspects Med. 2012 Feb; 33(1):98-106. PMID: 22024250.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    69. Huang Z, Hoffmann FW, Norton RL, Hashimoto AC, Hoffmann PR. Selenoprotein K is a novel target of m-calpain, and cleavage is regulated by Toll-like receptor-induced calpastatin in macrophages. J Biol Chem. 2011 Oct 07; 286(40):34830-8. PMID: 21849499.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    70. Hoffmann FW, Hashimoto AS, Lee BC, Rose AH, Shohet RV, Hoffmann PR. Specific antioxidant selenoproteins are induced in the heart during hypertrophy. Arch Biochem Biophys. 2011 Aug 01; 512(1):38-44. PMID: 21621505.
      Citations: 12     Fields:    Translation:AnimalsCells
    71. Hoffmann P, Sturm A, Stein J, Dignass AU. Interferon-? modulates intestinal epithelial cell function in-vitro through a TGFß-dependent mechanism. Regul Pept. 2011 Jun 07; 168(1-3):27-31. PMID: 21385594.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    72. Fung KY, Brierley GV, Henderson S, Hoffmann P, McColl SR, Lockett T, Head R, Cosgrove L. Butyrate-induced apoptosis in HCT116 colorectal cancer cells includes induction of a cell stress response. J Proteome Res. 2011 Apr 01; 10(4):1860-9. PMID: 21235278.
      Citations: 15     Fields:    Translation:HumansCells
    73. Fung KY, Cursaro C, Lewanowitsch T, Brierley GV, McColl SR, Lockett T, Head R, Hoffmann P, Cosgrove L. A combined free-flow electrophoresis and DIGE approach to identify proteins regulated by butyrate in HT29 cells. Proteomics. 2011 Mar; 11(5):964-71. PMID: 21280223.
      Citations: 1     Fields:    Translation:HumansCells
    74. Verma S, Hoffmann FW, Kumar M, Huang Z, Roe K, Nguyen-Wu E, Hashimoto AS, Hoffmann PR. Selenoprotein K knockout mice exhibit deficient calcium flux in immune cells and impaired immune responses. J Immunol. 2011 Feb 15; 186(4):2127-37. PMID: 21220695.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    75. Hülper P, Schulz-Schaeffer W, Dullin C, Hoffmann P, Harper J, Kurtzberg L, Lonning S, Kugler W, Lakomek M, Erdlenbruch B. Tumor localization of an anti-TGF-ß antibody and its effects on gliomas. Int J Oncol. 2011 Jan; 38(1):51-9. PMID: 21109925.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    76. Scholz RP, Gustafsson JO, Hoffmann P, Jaiswal M, Ahmadian MR, Eisler SA, Erlmann P, Schmid S, Hausser A, Olayioye MA. The tumor suppressor protein DLC1 is regulated by PKD-mediated GAP domain phosphorylation. Exp Cell Res. 2011 Feb 15; 317(4):496-503. PMID: 21087603.
      Citations: 8     Fields:    Translation:HumansCells
    77. Mrozik KM, Zilm PS, Bagley CJ, Hack S, Hoffmann P, Gronthos S, Bartold PM. Proteomic characterization of mesenchymal stem cell-like populations derived from ovine periodontal ligament, dental pulp, and bone marrow: analysis of differentially expressed proteins. Stem Cells Dev. 2010 Oct; 19(10):1485-99. PMID: 20050811.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    78. Ogunniyi AD, Mahdi LK, Jennings MP, McEwan AG, McDevitt CA, Van der Hoek MB, Bagley CJ, Hoffmann P, Gould KA, Paton JC. Central role of manganese in regulation of stress responses, physiology, and metabolism in Streptococcus pneumoniae. J Bacteriol. 2010 Sep; 192(17):4489-97. PMID: 20601473.
      Citations: 47     Fields:    Translation:Cells
    79. Ween MP, Lokman NA, Hoffmann P, Rodgers RJ, Ricciardelli C, Oehler MK. Transforming growth factor-beta-induced protein secreted by peritoneal cells increases the metastatic potential of ovarian cancer cells. Int J Cancer. 2011 Apr 01; 128(7):1570-84. PMID: 20521251.
      Citations: 34     Fields:    Translation:HumansCells
    80. Hoffmann FW, Hashimoto AC, Shafer LA, Dow S, Berry MJ, Hoffmann PR. Dietary selenium modulates activation and differentiation of CD4+ T cells in mice through a mechanism involving cellular free thiols. J Nutr. 2010 Jun; 140(6):1155-61. PMID: 20375261.
      Citations: 46     Fields:    Translation:AnimalsCells
    81. Hoffmann P, Hoeck K, Deters S, Werner-Martini I, Schmidt WE. Substance P and calcitonin gene related peptide induce TGF-alpha expression in epithelial cells via mast cells and fibroblasts. Regul Pept. 2010 Apr 09; 161(1-3):33-7. PMID: 20079377.
      Citations: 3     Fields:    Translation:AnimalsCells
    82. Bulut K, Felderbauer P, Hoeck K, Schmidt WE, Hoffmann P. Carbachol induces TGF-alpha expression and colonic epithelial cell proliferation in sensory-desensitised rats. Int J Colorectal Dis. 2010 Mar; 25(3):335-41. PMID: 20012300.
      Citations: 1     Fields:    Translation:AnimalsCells
    83. Penno MA, Bacic A, Colegate SM, Hoffmann P, Michalski WP. Identifying candidate serum biomarkers of exposure to tunicamycins in rats using two-dimensional electrophoresis. J Proteome Res. 2009 Jun; 8(6):2812-26. PMID: 19317491.
      Citations: 1     Fields:    Translation:AnimalsCells
    84. Fung KY, Lewanowitsch T, Henderson ST, Priebe I, Hoffmann P, McColl SR, Lockett T, Head R, Cosgrove LJ. Proteomic analysis of butyrate effects and loss of butyrate sensitivity in HT29 colorectal cancer cells. J Proteome Res. 2009 Mar; 8(3):1220-7. PMID: 19195990.
      Citations: 9     Fields:    Translation:HumansCells
    85. Barry EF, Felquer FA, Powell JA, Biggs L, Stomski FC, Urbani A, Ramshaw H, Hoffmann P, Wilce MC, Grimbaldeston MA, Lopez AF, Guthridge MA. 14-3-3:Shc scaffolds integrate phosphoserine and phosphotyrosine signaling to regulate phosphatidylinositol 3-kinase activation and cell survival. J Biol Chem. 2009 May 01; 284(18):12080-90. PMID: 19218246.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    86. Hoffmann PR, Berry MJ. The influence of selenium on immune responses. Mol Nutr Food Res. 2008 Nov; 52(11):1273-80. PMID: 18384097.
      Citations: 68     Fields:    Translation:Humans
    87. Bulut K, Felderbauer P, Hoeck K, Schmidt WE, Hoffmann P. Increased duodenal expression of transforming growth factor-alpha and epidermal growth factor during experimental colitis in rats. Eur J Gastroenterol Hepatol. 2008 Oct; 20(10):989-94. PMID: 18787466.
      Citations: 1     Fields:    Translation:Animals
    88. Bulut K, Felderbauer P, Deters S, Hoeck K, Schmidt-Choudhury A, Schmidt WE, Hoffmann P. Sensory neuropeptides and epithelial cell restitution: the relevance of SP- and CGRP-stimulated mast cells. Int J Colorectal Dis. 2008 May; 23(5):535-41. PMID: 18274763.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    89. Ecroyd H, Koudelka T, Thorn DC, Williams DM, Devlin G, Hoffmann P, Carver JA. Dissociation from the oligomeric state is the rate-limiting step in fibril formation by kappa-casein. J Biol Chem. 2008 Apr 04; 283(14):9012-22. PMID: 18245081.
      Citations: 7     Fields:    Translation:Animals
    90. Le Saux CJ, Teeters K, Miyasato SK, Hoffmann PR, Bollt O, Douet V, Shohet RV, Broide DH, Tam EK. Down-regulation of caveolin-1, an inhibitor of transforming growth factor-beta signaling, in acute allergen-induced airway remodeling. J Biol Chem. 2008 Feb 29; 283(9):5760-8. PMID: 18056268.
      Citations: 26     Fields:    Translation:AnimalsCells
    91. Bulut K, Pennartz C, Felderbauer P, Meier JJ, Banasch M, Bulut D, Schmitz F, Schmidt WE, Hoffmann P. Glucagon like peptide-2 induces intestinal restitution through VEGF release from subepithelial myofibroblasts. Eur J Pharmacol. 2008 Jan 14; 578(2-3):279-85. PMID: 17920582.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    92. Hoffmann PR, Jourdan-Le Saux C, Hoffmann FW, Chang PS, Bollt O, He Q, Tam EK, Berry MJ. A role for dietary selenium and selenoproteins in allergic airway inflammation. J Immunol. 2007 Sep 01; 179(5):3258-67. PMID: 17709542.
      Citations: 26     Fields:    Translation:AnimalsCells
    93. Hoffmann PR. Mechanisms by which selenium influences immune responses. Arch Immunol Ther Exp (Warsz). 2007 Sep-Oct; 55(5):289-97. PMID: 18219759.
      Citations: 19     Fields:    Translation:HumansAnimals
    94. Hoffmann PR, Gurary A, Hoffmann FW, Jourdan-Le Saux C, Teeters K, Hashimoto AC, Tam EK, Berry MJ. A new approach for analyzing cellular infiltration during allergic airway inflammation. J Immunol Methods. 2007 Dec 01; 328(1-2):21-33. PMID: 17825315.
      Citations: 7     Fields:    Translation:AnimalsCells
    95. Olayioye MA, Buchholz M, Schmid S, Schöffler P, Hoffmann P, Pomorski T. Phosphorylation of StarD10 on serine 284 by casein kinase II modulates its lipid transfer activity. J Biol Chem. 2007 Aug 03; 282(31):22492-8. PMID: 17561512.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    96. Hoffmann PR, Höge SC, Li PA, Hoffmann FW, Hashimoto AC, Berry MJ. The selenoproteome exhibits widely varying, tissue-specific dependence on selenoprotein P for selenium supply. Nucleic Acids Res. 2007; 35(12):3963-73. PMID: 17553827.
      Citations: 40     Fields:    Translation:Animals
    97. Felderbauer P, Bulut K, Hoeck K, Deters S, Schmidt WE, Hoffmann P. Substance P induces intestinal wound healing via fibroblasts--evidence for a TGF-beta-dependent effect. Int J Colorectal Dis. 2007 Dec; 22(12):1475-80. PMID: 17520266.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    98. de Jesus LA, Hoffmann PR, Michaud T, Forry EP, Small-Howard A, Stillwell RJ, Morozova N, Harney JW, Berry MJ. Nuclear assembly of UGA decoding complexes on selenoprotein mRNAs: a mechanism for eluding nonsense-mediated decay? Mol Cell Biol. 2006 Mar; 26(5):1795-805. PMID: 16478999.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    99. Hoffmann PR, Berry MJ. Selenoprotein synthesis: a unique translational mechanism used by a diverse family of proteins. Thyroid. 2005 Aug; 15(8):769-75. PMID: 16131320.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    100. Hoffmann P, Olayioye MA, Moritz RL, Lindeman GJ, Visvader JE, Simpson RJ, Kemp BE. Breast cancer protein StarD10 identified by three-dimensional separation using free-flow electrophoresis, reversed-phase high-performance liquid chromatography, and sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Electrophoresis. 2005 Mar; 26(6):1029-37. PMID: 15704244.
      Citations:    Fields:    Translation:AnimalsCells
    101. Hoffmann PR, Kench JA, Vondracek A, Kruk E, Daleke DL, Jordan M, Marrack P, Henson PM, Fadok VA. Interaction between phosphatidylserine and the phosphatidylserine receptor inhibits immune responses in vivo. J Immunol. 2005 Feb 01; 174(3):1393-404. PMID: 15661897.
      Citations: 71     Fields:    Translation:AnimalsCells
    102. Hoffmann PR, Woodrow RJ, Calimlim PS, Sciulli R, Effler PV, Miyamoto V, Imrie A, Yanagihara R, Nerurkar VR. West Nile virus surveillance: A simple method for verifying the integrity of RNA in mosquito (Diptera: Culicidae) pools. J Med Entomol. 2004 Jul; 41(4):731-5. PMID: 15311468.
      Citations: 3     Fields:    Translation:AnimalsCells
    103. Olayioye MA, Hoffmann P, Pomorski T, Armes J, Simpson RJ, Kemp BE, Lindeman GJ, Visvader JE. The phosphoprotein StarD10 is overexpressed in breast cancer and cooperates with ErbB receptors in cellular transformation. Cancer Res. 2004 May 15; 64(10):3538-44. PMID: 15150109.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    104. Felderbauer P, Hoffmann P, Einwächter H, Bulut K, Ansorge N, Schmitz F, Schmidt WE. A novel mutation of the calcium sensing receptor gene is associated with chronic pancreatitis in a family with heterozygous SPINK1 mutations. BMC Gastroenterol. 2003 Nov 29; 3:34. PMID: 14641934.
      Citations: 20     Fields:    Translation:Humans
    105. Vandivier RW, Ogden CA, Fadok VA, Hoffmann PR, Brown KK, Botto M, Walport MJ, Fisher JH, Henson PM, Greene KE. Role of surfactant proteins A, D, and C1q in the clearance of apoptotic cells in vivo and in vitro: calreticulin and CD91 as a common collectin receptor complex. J Immunol. 2002 Oct 01; 169(7):3978-86. PMID: 12244199.
      Citations: 136     Fields:    Translation:HumansAnimalsCells
    106. Vandivier RW, Fadok VA, Hoffmann PR, Bratton DL, Penvari C, Brown KK, Brain JD, Accurso FJ, Henson PM. Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis. J Clin Invest. 2002 Mar; 109(5):661-70. PMID: 11877474.
      Citations: 111     Fields:    Translation:HumansCells
    107. Vandivier RW, Fadok VA, Ogden CA, Hoffmann PR, Brain JD, Accurso FJ, Fisher JH, Greene KE, Henson PM. Impaired clearance of apoptotic cells from cystic fibrosis airways. Chest. 2002 Mar; 121(3 Suppl):89S. PMID: 11893715.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
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