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Mahesh Narayan

Faculty RankAssociate Professor
InstitutionUniversity of Texas at El Paso
Address500 West University
El Paso TX 79968
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Narayan M. The Formation of Native Disulfide Bonds: Treading a Fine Line in Protein Folding. Protein J. 2021 Apr; 40(2):134-139. PMID: 33765253.
      Citations:    Fields:    
    2. Narayan M, Berliner LJ. Supplement to the Special Issue on Protein Folding and Harold A. Scheraga. Protein J. 2021 Apr; 40(2):133. PMID: 33723695.
      Citations:    Fields:    
    3. Ahlawat J, Masoudi Asil S, Guillama Barroso G, Nurunnabi M, Narayan M. Application of carbon nano onions in the biomedical field: recent advances and challenges. Biomater Sci. 2021 Feb 09; 9(3):626-644. PMID: 33241797.
      Citations: 2     Fields:    
    4. Narayan GM, Valles A, Venegas F, Yi J, Narayan M. Learnings from the Relation between the Number of Forward and Reverse Reactions (Transfer Cycles) Required to Converge to Equilibrium and the Ratio of the Forward to the Reverse Rate Constants in Simple Chemical Reactions. ACS Omega. 2021 Jan 12; 6(1):38-45. PMID: 33458457.
    5. Narayan M. Revisiting the Formation of a Native Disulfide Bond: Consequences for Protein Regeneration and Beyond. Molecules. 2020 Nov 16; 25(22). PMID: 33207635.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    6. Jung LS, Gund TM, Narayan M. Comparison of Binding Site of Remdesivir and Its Metabolites with NSP12-NSP7-NSP8, and NSP3 of SARS CoV-2 Virus and Alternative Potential Drugs for COVID-19 Treatment. Protein J. 2020 12; 39(6):619-630. PMID: 33185784.
      Citations:    Fields:    Translation:HumansCells
    7. Narayan M, Berliner LJ. Introduction to the Special Issue on Protein Folding and Harold A. Scherega. Protein J. 2020 10; 39(5):394-396. PMID: 33141423.
      Citations:    Fields:    Translation:HumansCells
    8. Narayan M. Harold A. Scheraga [1921-2020]: Eminent Researcher, Mentor, Teacher, Friend. Protein J. 2020 10; 39(5):397-399. PMID: 33037535.
      Citations:    Fields:    
    9. Henríquez G, Gomez A, Guerrero E, Narayan M. Potential Role of Natural Polyphenols against Protein Aggregation Toxicity: In Vitro, In Vivo, and Clinical Studies. ACS Chem Neurosci. 2020 10 07; 11(19):2915-2934. PMID: 32822152.
      Citations: 3     Fields:    
    10. Masoudi Asil S, Ahlawat J, Guillama Barroso G, Narayan M. Nanomaterial based drug delivery systems for the treatment of neurodegenerative diseases. Biomater Sci. 2020 Aug 07; 8(15):4109-4128. PMID: 32638706.
      Citations: 2     Fields:    
    11. Gomez A, Narayan M, Zhao L, Jia X, Bernal RA, Lopez-Moreno ML, Peralta-Videa JR. Effects of nano-enabled agricultural strategies on food quality: Current knowledge and future research needs. J Hazard Mater. 2021 01 05; 401:123385. PMID: 32763688.
      Citations:    Fields:    
    12. Henríquez G, Mendez L, Schmid AN, Guerrero ED, Collins SA, Castañeda E, Narayan M. Testing Amyloid Cross-Toxicity in the Vertebrate Brain. ACS Omega. 2020 Jun 30; 5(25):15586-15591. PMID: 32637834.
    13. Henríquez G, Mendez L, Varela-Ramirez A, Guerrero E, Narayan M. Neuroprotective Effect of Brazilin on Amyloid ß (25-35)-Induced Pathology in a Human Neuroblastoma Model. ACS Omega. 2020 Jun 16; 5(23):13785-13792. PMID: 32566844.
    14. Ahlawat J, Guillama Barroso G, Masoudi Asil S, Alvarado M, Armendariz I, Bernal J, Carabaza X, Chavez S, Cruz P, Escalante V, Estorga S, Fernandez D, Lozano C, Marrufo M, Ahmad N, Negrete S, Olvera K, Parada X, Portillo B, Ramirez A, Ramos R, Rodriguez V, Rojas P, Romero J, Suarez D, Urueta G, Viel S, Narayan M. Nanocarriers as Potential Drug Delivery Candidates for Overcoming the Blood-Brain Barrier: Challenges and Possibilities. ACS Omega. 2020 Jun 09; 5(22):12583-12595. PMID: 32548442.
    15. Ahlawat J, Neupane R, Deemer E, Sreenivasan ST, Narayan M. Chitosan-Ellagic Acid Nanohybrid for Mitigating Rotenone-induced Oxidative Stress. ACS Appl Mater Interfaces. 2020 Apr 22; 12(16):18964-18977. PMID: 32216327.
      Citations: 2     Fields:    Translation:HumansCells
    16. Henriquez G, Mendez L, Narayan M. A Hybrid Model to Study Amyloid Cross-Toxicity. ACS Chem Neurosci. 2020 02 05; 11(3):228-230. PMID: 31920071.
      Citations:    Fields:    Translation:HumansCells
    17. Sreenivasan S, Narayan M. Learnings from Protein Folding Projected onto Amyloid Misfolding. ACS Chem Neurosci. 2019 09 18; 10(9):3911-3913. PMID: 31456389.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    18. Narayan M. The Era of Neurodegenerative Metastasis. ACS Chem Neurosci. 2019 08 21; 10(8):3346-3348. PMID: 31305063.
      Citations: 3     Fields:    Translation:HumansAnimals
    19. Sreeprasad S, Narayan M. Nanoscopic Portrait of an Amyloidogenic Pathway Visualized through Tip-Enhanced Raman Spectroscopy. ACS Chem Neurosci. 2019 08 21; 10(8):3343-3345. PMID: 31290321.
      Citations: 1     Fields:    Translation:HumansAnimals
    20. Ahlawat J, Deemer EM, Narayan M. Chitosan Nanoparticles Rescue Rotenone-Mediated Cell Death. Materials (Basel). 2019 Apr 11; 12(7). PMID: 30978909.
    21. Ullah K, Zubia E, Narayan M, Yang J, Xu G. Diverse roles of the E2/E3 hybrid enzyme UBE2O in the regulation of protein ubiquitination, cellular functions, and disease onset. FEBS J. 2019 06; 286(11):2018-2034. PMID: 30468556.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    22. Dana D, Gadhiya SV, St Surin LG, Li D, Naaz F, Ali Q, Paka L, Yamin MA, Narayan M, Goldberg ID, Narayan P. Deep Learning in Drug Discovery and Medicine; Scratching the Surface. Molecules. 2018 Sep 18; 23(9). PMID: 30231499.
      Citations: 9     Fields:    
    23. Ahlawat J, Henriquez G, Narayan M. Enhancing the Delivery of Chemotherapeutics: Role of Biodegradable Polymeric Nanoparticles. Molecules. 2018 Aug 27; 23(9). PMID: 30150595.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    24. Xiong L, Yan W, Zubia E, Zhou Y, Zhang Y, Duan Q, Narayan M, Xu G. Quantitative proteomics and biochemical analyses reveal the role of endoplasmin in the regulation of the expression and secretion of A Disintegrin And Metalloproteinase 12. J Proteomics. 2018 06 30; 182:34-44. PMID: 29729432.
      Citations: 2     Fields:    Translation:HumansCells
    25. Mendez L, Henriquez G, Sirimulla S, Narayan M. Looking Back, Looking Forward at Halogen Bonding in Drug Discovery. Molecules. 2017 Aug 24; 22(9). PMID: 28837116.
      Citations: 11     Fields:    Translation:HumansAnimals
    26. Serrano M, Gonzalez V, Ray S, Chavez MD, Narayan M. Identification of Structure-Stabilizing Interactions in Enzymes: A Novel Mechanism to Impact Enzyme Activity. Cell Biochem Biophys. 2018 Jun; 76(1-2):59-71. PMID: 28756483.
      Citations:    Fields:    Translation:HumansAnimalsCells
    27. Narayan M. The Structure-Forming Juncture in Oxidative Protein Folding: What Happens in the ER? Adv Exp Med Biol. 2017; 966:163-179. PMID: 28815511.
      Citations: 2     Fields:    Translation:AnimalsCells
    28. Koebel MR, Cooper A, Schmadeke G, Jeon S, Narayan M, Sirimulla S. S···O and S···N Sulfur Bonding Interactions in Protein-Ligand Complexes: Empirical Considerations and Scoring Function. J Chem Inf Model. 2016 12 27; 56(12):2298-2309. PMID: 27936771.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    29. Kabiraj P, Marin JE, Varela-Ramirez A, Narayan M. An 11-mer Amyloid Beta Peptide Fragment Provokes Chemical Mutations and Parkinsonian Biomarker Aggregation in Dopaminergic Cells: A Novel Road Map for "Transfected" Parkinson's. ACS Chem Neurosci. 2016 11 16; 7(11):1519-1530. PMID: 27635664.
      Citations: 5     Fields:    Translation:AnimalsCells
    30. Khalil MF, Valenzuela C, Sisniega D, Skouta R, Narayan M. ER Protein Processing Under Oxidative Stress: Implications and Prevention. Cell Biochem Biophys. 2016 Jun; 74(2):213-20. PMID: 26983927.
      Citations: 4     Fields:    Translation:AnimalsCells
    31. Subramani R, Gonzalez E, Arumugam A, Nandy S, Gonzalez V, Medel J, Camacho F, Ortega A, Bonkoungou S, Narayan M, Dwivedi Ak, Lakshmanaswamy R. Nimbolide inhibits pancreatic cancer growth and metastasis through ROS-mediated apoptosis and inhibition of epithelial-to-mesenchymal transition. Sci Rep. 2016 Jan 25; 6:19819. PMID: 26804739.
      Citations: 43     Fields:    Translation:HumansCells
    32. Kabiraj P, Valenzuela CA, Marin JE, Ramirez DA, Mendez L, Hwang MS, Varela-Ramirez A, Fenelon K, Narayan M, Skouta R. The neuroprotective role of ferrostatin-1 under rotenone-induced oxidative stress in dopaminergic neuroblastoma cells. Protein J. 2015 Oct; 34(5):349-58. PMID: 26385697.
      Citations: 13     Fields:    Translation:HumansCells
    33. Kabiraj P, Marin JE, Varela-Ramirez A, Zubia E, Narayan M. Ellagic acid mitigates SNO-PDI induced aggregation of Parkinsonian biomarkers. ACS Chem Neurosci. 2014 Dec 17; 5(12):1209-20. PMID: 25247703.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    34. Shah BR, Narayan M, Seth A, Schulman KA. Health City Cayman Islands and the globalization of health services delivery. Am Heart J. 2014 May; 167(5):770-4. PMID: 24766989.
      Citations: 2     Fields:    Translation:Humans
    35. Sirimulla S, Bailey JB, Vegesna R, Narayan M. Halogen interactions in protein-ligand complexes: implications of halogen bonding for rational drug design. J Chem Inf Model. 2013 Nov 25; 53(11):2781-91. PMID: 24134121.
      Citations: 58     Fields:    
    36. Arumugam A, Agullo P, Boopalan T, Nandy S, Lopez R, Gutierrez C, Narayan M, Rajkumar L. Neem leaf extract inhibits mammary carcinogenesis by altering cell proliferation, apoptosis, and angiogenesis. . 2014 Jan; 15(1):26-34. PMID: 24146019.
    37. Kabiraj P, Pal R, Varela-Ramirez A, Miranda M, Narayan M. Nitrosative stress mediated misfolded protein aggregation mitigated by Na-D-ß-hydroxybutyrate intervention. Biochem Biophys Res Commun. 2012 Sep 28; 426(3):438-44. PMID: 22974977.
      Citations:    Fields:    Translation:HumansCells
    38. Narayan M. Disulfide bonds: protein folding and subcellular protein trafficking. FEBS J. 2012 Jul; 279(13):2272-82. PMID: 22594874.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    39. Sirimulla S, Pal R, Raparla M, Bailey JB, Duran R, Altamirano AM, Herndon WC, Narayan M. Identification of Novel Nitrosative Stress Inhibitors through Virtual Screening and Experimental Evaluation. Mol Inform. 2012 Feb; 31(2):167-72. PMID: 27476961.
      Citations:    Fields:    
    40. Pal R, Miranda M, Narayan M. Nitrosative stress-induced Parkinsonian Lewy-like aggregates prevented through polyphenolic phytochemical analog intervention. Biochem Biophys Res Commun. 2011 Jan 07; 404(1):324-9. PMID: 21130735.
      Citations: 15     Fields:    Translation:HumansCells
    41. Gonzalez V, Pal R, Narayan M. The oxidoreductase behavior of protein disulfide isomerase impedes fold maturation of endoplasmic reticulum-processed proteins in the pivotal structure-coupled step of oxidative folding: implications for subcellular protein trafficking. Biochemistry. 2010 Jul 27; 49(29):6282-9. PMID: 20568731.
      Citations: 6     Fields:    Translation:Cells
    42. Pal R, Cristan EA, Schnittker K, Narayan M. Rescue of ER oxidoreductase function through polyphenolic phytochemical intervention: implications for subcellular traffic and neurodegenerative disorders. Biochem Biophys Res Commun. 2010 Feb 19; 392(4):567-71. PMID: 20097158.
      Citations: 11     Fields:    Translation:HumansCells
    43. Peralta-Videa JR, Lopez ML, Narayan M, Saupe G, Gardea-Torresdey J. The biochemistry of environmental heavy metal uptake by plants: implications for the food chain. Int J Biochem Cell Biol. 2009 Aug-Sep; 41(8-9):1665-77. PMID: 19433308.
      Citations: 77     Fields:    Translation:AnimalsCells
    44. Wang YH, Narayan M. pH dependence of the isomerase activity of protein disulfide isomerase: insights into its functional relevance. Protein J. 2008 Apr; 27(3):181-5. PMID: 18074210.
      Citations: 2     Fields:    Translation:AnimalsCells
    45. Narayan M, Welker E, Zhai H, Han X, Xu G, McLafferty FW, Scheraga HA. Detecting native folds in mixtures of proteins that contain disulfide bonds. Nat Biotechnol. 2008 Apr; 26(4):427-9. PMID: 18278035.
      Citations: 2     Fields:    Translation:Cells
    46. Gahl RF, Narayan M, Xu G, Scheraga HA. Dissimilarity in the oxidative folding of onconase and ribonuclease A, two structural homologues. Protein Eng Des Sel. 2008 Apr; 21(4):223-31. PMID: 18245105.
      Citations: 5     Fields:    Translation:AnimalsCells
    47. Barrett JS, Mondick JT, Narayan M, Vijayakumar K, Vijayakumar S. Integration of modeling and simulation into hospital-based decision support systems guiding pediatric pharmacotherapy. BMC Med Inform Decis Mak. 2008 Jan 28; 8:6. PMID: 18226244.
      Citations: 22     Fields:    Translation:Humans
    48. Fink M, Nieves P, Chang S, Narayan M. Non-redox-active small-molecules can accelerate oxidative protein folding by novel mechanisms. Biophys Chem. 2008 Feb; 132(2-3):104-9. PMID: 18045767.
      Citations: 1     Fields:    Translation:AnimalsCells
    49. Gomez G, Mansouraty G, Gardea J, Narayan M. Acceleration of oxidative protein folding by curcumin through novel non-redox chemistry. Biochem Biophys Res Commun. 2007 Dec 21; 364(3):561-6. PMID: 17959149.
      Citations: 3     Fields:    Translation:Cells
    50. Zuppa A, Vijayakumar S, Jayaraman B, Patel D, Narayan M, Vijayakumar K, Mondick JT, Barrett JS. An informatics approach to assess pediatric pharmacotherapy: design and implementation of a hospital drug utilization system. J Clin Pharmacol. 2007 Sep; 47(9):1172-80. PMID: 17656617.
      Citations: 4     Fields:    Translation:Humans
    51. Welker E, Hathaway L, Xu G, Narayan M, Pradeep L, Shin HC, Scheraga HA. Oxidative folding and N-terminal cyclization of onconase. Biochemistry. 2007 May 08; 46(18):5485-93. PMID: 17439243.
      Citations: 8     Fields:    Translation:AnimalsCells
    52. Xu G, Narayan M, Kurinov I, Ripoll DR, Welker E, Khalili M, Ealick SE, Scheraga HA. A localized specific interaction alters the unfolding pathways of structural homologues. J Am Chem Soc. 2006 Feb 01; 128(4):1204-13. PMID: 16433537.
      Citations: 6     Fields:    Translation:AnimalsCells
    53. Xu G, Narayan M, Scheraga HA. The oxidative folding rate of bovine pancreatic ribonuclease is enhanced by a covalently attached oligosaccharide. Biochemistry. 2005 Jul 19; 44(28):9817-23. PMID: 16008366.
      Citations: 2     Fields:    Translation:AnimalsCells
    54. Gahl RF, Narayan M, Xu G, Scheraga HA. Trimethylamine-N-oxide modulates the reductive unfolding of onconase. Biochem Biophys Res Commun. 2004 Dec 17; 325(3):707-10. PMID: 15541346.
      Citations: 5     Fields:    Translation:Cells
    55. Narayan M, Xu G, Ripoll DR, Zhai H, Breuker K, Wanjalla C, Leung HJ, Navon A, Welker E, McLafferty FW, Scheraga HA. Dissimilarity in the reductive unfolding pathways of two ribonuclease homologues. J Mol Biol. 2004 May 07; 338(4):795-809. PMID: 15099746.
      Citations: 12     Fields:    Translation:AnimalsCells
    56. Xu G, Zhai H, Narayan M, McLafferty FW, Scheraga HA. Simultaneous characterization of the reductive unfolding pathways of RNase B isoforms by top-down mass spectrometry. Chem Biol. 2004 Apr; 11(4):517-24. PMID: 15123246.
      Citations: 6     Fields:    Translation:AnimalsCells
    57. Xu G, Narayan M, Welker E, Scheraga HA. Characterization of the fast-forming intermediate, des [30-75], in the reductive unfolding of onconase. Biochemistry. 2004 Mar 23; 43(11):3246-54. PMID: 15023075.
      Citations: 7     Fields:    Translation:AnimalsCells
    58. Chaudhuri D, Narayan M, Berliner LJ. Conformation-dependent interaction of alpha-lactalbumin with model and biological membranes: a spin-label ESR study. Protein J. 2004 Jan; 23(1):95-101. PMID: 15115187.
      Citations: 2     Fields:    Translation:Animals
    59. Narayan M, Xu G, Schultz SK, Scheraga HA. Assessing the magnitude of folding forces along the oxidative folding pathway of multi-disulfide-containing proteins. J Am Chem Soc. 2003 Dec 31; 125(52):16184-5. PMID: 14692748.
      Citations: 1     Fields:    Translation:AnimalsCells
    60. Xu G, Narayan M, Welker E, Scheraga HA. A novel method to determine thermal transition curves of disulfide-containing proteins and their structured folding intermediates. Biochem Biophys Res Commun. 2003 Nov 14; 311(2):514-7. PMID: 14592446.
      Citations: 4     Fields:    Translation:Cells
    61. Shin HC, Narayan M, Song MC, Scheraga HA. Role of the [65-72] disulfide bond in oxidative folding of bovine pancreatic ribonuclease A. Biochemistry. 2003 Oct 07; 42(39):11514-9. PMID: 14516203.
      Citations: 2     Fields:    Translation:AnimalsCells
    62. Narayan M, Welker E, Wanjalla C, Xu G, Scheraga HA. Shifting the competition between the intramolecular Reshuffling reaction and the direct oxidation reaction during the oxidative folding of kinetically trapped disulfide-insecure intermediates. Biochemistry. 2003 Sep 16; 42(36):10783-9. PMID: 12962503.
      Citations: 2     Fields:    Translation:AnimalsCells
    63. Narayan M, Welker E, Scheraga HA. Characterizing the unstructured intermediates in oxidative folding. Biochemistry. 2003 Jun 17; 42(23):6947-55. PMID: 12795589.
      Citations:    Fields:    Translation:Cells
    64. Narayan M, Welker E, Scheraga HA. Native conformational tendencies in unfolded polypeptides: development of a novel method to assess native conformational tendencies in the reduced forms of multiple disulfide-bonded proteins. J Am Chem Soc. 2003 Feb 26; 125(8):2036-7. PMID: 12590517.
      Citations: 2     Fields:    Translation:AnimalsCells
    65. English BP, Welker E, Narayan M, Scheraga HA. Development of a novel method to populate native disulfide-bonded intermediates for structural characterization of proteins: implications for the mechanism of oxidative folding of RNase A. J Am Chem Soc. 2002 May 08; 124(18):4995-9. PMID: 11982363.
      Citations: 1     Fields:    Translation:AnimalsCells
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