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Ramon Jorquera

Faculty RankAssistant Professor
InstitutionUniversidad Central Del Caribe
Address2U6 Ave. Laurel, Lomas verdes
Bayamon PR 00956
Phone7877983001x 2166
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    Neurotransmitter release is a specialized form of vesicle fusion that shares a common SNARE-mediated fusion mechanism with other vesicle trafficking pathways within cells. With the appearance of multicellular organisms and just before of the formation of the primitive nervous system, two principal families of SNARE complex-binding proteins emerged, synaptotagmins and complexins. Current data suggest that SNARE binding by the two proteins allows Synaptotagmin 1 to promote fusion in a calcium dependent manner, while complexin prevents premature fusion in the absence of calcium influx. However, their precise roles in regulated secretion and effects on short-term synaptic plasticity are poorly understood. My research is focused on a thorough analysis of synaptic transmission at NMJs of mutant and overexpression animals using high fidelity current recordings of postsynaptic evoked and spontaneous currents using voltage-clamp at the Drosophila NMJ. We are combining quantal analysis with immunocytochemical determination of the number of release sites, allowing a robust description of release properties regulated by complexin and synaptotagmin.

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hartwig C, Méndez GM, Bhattacharjee S, Vrailas-Mortimer AD, Zlatic SA, Freeman AAH, Gokhale A, Concilli M, Werner E, Sapp Savas C, Rudin-Rush S, Palmer L, Shearing N, Margewich L, McArthy J, Taylor S, Roberts B, Lupashin V, Polishchuk RS, Cox DN, Jorquera RA, Faundez V. Golgi-Dependent Copper Homeostasis Sustains Synaptic Development and Mitochondrial Content. J Neurosci. 2021 Jan 13; 41(2):215-233. PMID: 33208468.
      Citations:    Fields:    
    2. Guan Z, Bykhovskaia M, Jorquera RA, Sutton RB, Akbergenova Y, Littleton JT. A synaptotagmin suppressor screen indicates SNARE binding controls the timing and Ca2+ cooperativity of vesicle fusion. Elife. 2017 09 12; 6. PMID: 28895532.
      Citations: 10     Fields:    Translation:AnimalsCells
    3. Astorga C, Jorquera RA, Ramírez M, Kohler A, López E, Delgado R, Córdova A, Olguín P, Sierralta J. Presynaptic DLG regulates synaptic function through the localization of voltage-activated Ca(2+) Channels. Sci Rep. 2016 08 30; 6:32132. PMID: 27573697.
      Citations: 4     Fields:    Translation:AnimalsCells
    4. Stevens RJ, Akbergenova Y, Jorquera RA, Littleton JT. Abnormal synaptic vesicle biogenesis in Drosophila synaptogyrin mutants. J Neurosci. 2012 Dec 12; 32(50):18054-67, 18067a. PMID: 23238721.
      Citations: 19     Fields:    Translation:AnimalsCells
    5. Jorquera RA, Huntwork-Rodriguez S, Akbergenova Y, Cho RW, Littleton JT. Complexin controls spontaneous and evoked neurotransmitter release by regulating the timing and properties of synaptotagmin activity. J Neurosci. 2012 Dec 12; 32(50):18234-45. PMID: 23238737.
      Citations: 54     Fields:    Translation:AnimalsCells
    6. Buhl LK, Jorquera RA, Akbergenova Y, Huntwork-Rodriguez S, Volfson D, Littleton JT. Differential regulation of evoked and spontaneous neurotransmitter release by C-terminal modifications of complexin. Mol Cell Neurosci. 2013 Jan; 52:161-72. PMID: 23159779.
      Citations: 23     Fields:    Translation:AnimalsCells
    7. Rodal AA, Blunk AD, Akbergenova Y, Jorquera RA, Buhl LK, Littleton JT. A presynaptic endosomal trafficking pathway controls synaptic growth signaling. J Cell Biol. 2011 Apr 04; 193(1):201-17. PMID: 21464232.
      Citations: 42     Fields:    Translation:AnimalsCells
    8. Schulte J, Sepp KJ, Jorquera RA, Wu C, Song Y, Hong P, Littleton JT. DMob4/Phocein regulates synapse formation, axonal transport, and microtubule organization. J Neurosci. 2010 Apr 14; 30(15):5189-203. PMID: 20392941.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    9. Barber CF, Jorquera RA, Melom JE, Littleton JT. Postsynaptic regulation of synaptic plasticity by synaptotagmin 4 requires both C2 domains. J Cell Biol. 2009 Oct 19; 187(2):295-310. PMID: 19822673.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    10. Rodríguez-Valentín R, López-González I, Jorquera R, Labarca P, Zurita M, Reynaud E. Oviduct contraction in Drosophila is modulated by a neural network that is both, octopaminergic and glutamatergic. J Cell Physiol. 2006 Oct; 209(1):183-98. PMID: 16826564.
      Citations: 38     Fields:    Translation:AnimalsCells
    11. Acharya U, Edwards MB, Jorquera RA, Silva H, Nagashima K, Labarca P, Acharya JK. Drosophila melanogaster Scramblases modulate synaptic transmission. J Cell Biol. 2006 Apr 10; 173(1):69-82. PMID: 16606691.
      Citations: 14     Fields:    Translation:AnimalsCells
    12. Jorquera RA, Berrios J, Sans J, Vergara C, Benos DJ, Reyes JG. Permeability changes induced by polylysines in rat spermatids. Biol Cell. 2002 Sep; 94(4-5):233-41. PMID: 12489692.
      Citations: 1     Fields:    Translation:AnimalsCells
    13. Reyes JG, Herrera E, Lobos L, Salas K, Lagos N, Jorquera RA, Labarca P, Benos DJ. Dynamics of intracellular calcium induced by lactate and glucose in rat pachytene spermatocytes and round spermatids. Reproduction. 2002 May; 123(5):701-10. PMID: 12006098.
      Citations: 4     Fields:    Translation:AnimalsCells
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