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Luisa Alvarado

TitlePrincipal Investigator & Project Director
Faculty RankProfessor
InstitutionPonce Health Sciences University
AddressP.O. Box 7043
Ponce PR 00755
Phone7878442080 Ext. 1435
ORCID ORCID Icon0000-0002-1905-1524 Additional info
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    Collapse Biography 
    Collapse awards and honors
    2007Founding Member Award, Puerto Rico Taskforce on Prematurity, March of Dimes, Puerto Rico
    2007Special Achievement Award, American Academy of Pediatrics
    2010Certificate of Appreciation Puerto Rico Physician Master Trainer for Dengue Management, CDC - Dengue Branch
    2010Distinguished Service Rendered as a Member of the Committee on Pediatric Workforce, 2007-2010, American Academy of Pediatrics
    2011Exemplary Service as a Physician Master Trainer for the Dengue Clinical Case Management Course, CDC - Dengue Branch
    2018Nakano Citation Award for the “Persistence of ZIKV in Body Fluids – NEJM 2017 , Centers for Disease Control and Prevention

    Collapse Overview 
    Collapse overview
    After completing my Pediatric Residency training in Boston, Massachusetts, I returned to Puerto Rico in 1982 to establish a community-based practice in Coamo, a rural town in the southern part of the island. At the same time, I started my academic career at the Ponce School of Medicine through the teaching and clinical supervision of students and residents in my clinical practice and the medical school campus. I am now Professor of Pediatrics of the Ponce Health Sciences University (PHSU) having enjoyed a distinguished career of more than 30 years as a clinician, educator, academic administrator and researcher at the School of Medicine and its principal clinical affiliate, Saint Luke’s Episcopal Hospital (SLEH) in Ponce. At the PHSU, my work as a teacher and my dedication to medical education were recognized through key leadership positions in the university: Director of Medical Education (1995), Chair of the Department of Pediatrics (1997) and Associate Dean for Academic Affairs (2000). I joined SLEH medical staff in 2003, where I led resident training efforts as Director of the Pediatric Residency Program (2003) and Director of Graduate Medical Education (2011). As an academic general pediatrician, I have cared for 2 generations of pediatric patients in Coamo and in the pediatric wards of the SLEH in Ponce. My clinical practice from 1982 through 2011 followed principles of the medical home with emphasis on prevention and the provision of comprehensive and coordinated care to children with special needs. My commitment to pediatrics and public health is evidenced through active participation in many child health initiatives at the state and national levels, such as the advancement of the pediatric medical home, developmental screening in pediatric practices and the prevention of prematurity. This interest in population health became my main motivation when the opportunity to expand my academic career to research presented in 2012. Through a CDC cooperative agreement grant and the dedication and hard work of a talented group of public health staff members, university, and hospital collaborators; we have implemented the first Sentinel Enhanced Dengue Surveillance System (SEDSS) in Puerto Rico. SEDSS is now a 6-year-old research platform dedicated to the study of clinical manifestations, prevention, and outcomes of dengue and other acute febrile illnesses (AFI) endemic to our island and of global importance. We have developed more than 10 nested studies and collaborations, and published important scholarly products. As Principal Investigator I have strengthened the collaboration between the PHSU School of Medicine and Public Health Program and the SLEH in the implementation of research, and have sparked the interest and developed the skills in research of public health and medical students, and residents and faculty of residency programs, which is research capacity building for the future of the island. My partnership with Dr. Vanessa Rivera Amill from the PHSU Biomedical Sciences Program since 2015 has added extraordinary value and depth to the research program. Under my leadership, SEDSS captured the 2016-17 Zika epidemic that has made possible the study of the spectrum of consequences of Zika in the pediatric population. This is for me a return to my pediatric career’s advocacy beginnings on behalf of the health and well-being of children. The experiences and accomplishments described have prepared me to assume an important role in arboviral diseases research in Puerto Rico.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Sánchez-González L, Quandelacy TM, Johansson M, Torres-Velásquez B, Lorenzi O, Tavarez M, Torres S, Alvarado LI, Paz-Bailey G. Viral etiology and seasonal trends of pediatric acute febrile illness in southern Puerto Rico; a seven-year review. PLoS One. 2021; 16(2):e0247481. PMID: 33606839.
      Citations:    Fields:    
    2. Sharp TM, Quandelacy TM, Adams LE, Aponte JT, Lozier MJ, Ryff K, Flores M, Rivera A, Santiago GA, Muñoz-Jordán JL, Alvarado LI, Rivera-Amill V, Garcia-Negrón M, Waterman SH, Paz-Bailey G, Johansson MA, Rivera-Garcia B. Epidemiologic and spatiotemporal trends of Zika Virus disease during the 2016 epidemic in Puerto Rico. PLoS Negl Trop Dis. 2020 09; 14(9):e0008532. PMID: 32956416.
      Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
    3. Paz-Bailey G, Quandelacy TM, Adams LE, Olsen SJ, Blanton L, Munoz-Jordan JL, Lozier M, Alvarado LI, Johansson MA. Recent influenza activity in tropical Puerto Rico has become synchronized with mainland US. Influenza Other Respir Viruses. 2020 09; 14(5):515-523. PMID: 32614504.
      Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
    4. Frasqueri-Quintana VM, Oliveras García CA, Adams LE, Torres-Figueroa X, Iriarte RI, Ryff K, Sánchez-González L, Pérez Gómez V, Pérez-Rodríguez NM, Alvarado LI, Paz-Bailey G. Injury-Related Emergency Department Visits After Hurricane Maria in a Southern Puerto Rico Hospital. Disaster Med Public Health Prep. 2020 02; 14(1):63-70. PMID: 31455463.
      Citations: 3     Fields:    Translation:HumansPHPublic Health
    5. Caraballo E, Poole-Smith BK, Tomashek KM, Torres-Velasquez B, Alvarado LI, Lorenzi OD, Ramos C, Carrión J, Hunsperger E. The detection of anti-dengue virus IgM in urine in participants enrolled in an acute febrile illness study in Puerto Rico. PLoS Negl Trop Dis. 2020 01; 14(1):e0007971. PMID: 31995560.
      Citations:    Fields:    Translation:HumansCells
    6. Adams LE, Vargas L, Frasqueri-Quintana VM, Torres-Figueroa X, Ryff K, Sanchez-Gonzalez L, Little E, Ciampaglio K, Reyes Claudio JM, Ponton-Cruz E, Santiago W, Paz-Bailey G, Alvarado LI. Evaluation of Emergency Department-Based Surveillance Systems at 2 Healthcare Facilities After Hurricane Maria: Puerto Rico, 2017-2018. Disaster Med Public Health Prep. 2019 Sep 02; 1-9. PMID: 31475668.
      Citations:    Fields:    
    7. Alvarado LI, Lorenzi OD, Torres-Velásquez BC, Sharp TM, Vargas L, Muñoz-Jordán JL, Hunsperger EA, Pérez-Padilla J, Rivera A, González-Zeno GE, Galloway RL, Glass Elrod M, Mathis DL, Oberste MS, Nix WA, Henderson E, McQuiston J, Singleton J, Kato C, García-Gubern C, Santiago-Rivera W, Muns-Sosa R, Ortiz-Rivera JD, Jiménez G, Rivera-Amill V, Andújar-Pérez DA, Horiuchi K, Tomashek KM. Distinguishing patients with laboratory-confirmed chikungunya from dengue and other acute febrile illnesses, Puerto Rico, 2012-2015. PLoS Negl Trop Dis. 2019 07; 13(7):e0007562. PMID: 31329598.
      Citations: 2     Fields:    Translation:Humans
    8. Santiago GA, Sharp TM, Rosenberg E, Sosa Cardona II, Alvarado L, Paz-Bailey G, Muñoz-Jordán JL. Prior Dengue Virus Infection Is Associated With Increased Viral Load in Patients Infected With Dengue but Not Zika Virus. Open Forum Infect Dis. 2019 Jul 01; 6(7). PMID: 31363765.
    9. Pérez-Padilla J, Paz-Bailey G, Meaney-Delman D, Doyle K, Gary J, Rodriguez DM, Bhatnagar J, Pérez-Rodriguez NM, Montalvo S, Alvarado L, Sharp TM. Persistent Zika Virus Infection Associated with Early Fetal Demise: A Case Report. Open J Obstet Gynecol. 2019 May; 9(5):698-706. PMID: 31799062.
    10. Hsu CH, Cruz-Lopez F, Vargas Torres D, Perez-Padilla J, Lorenzi OD, Rivera A, Staples JE, Lugo E, Munoz-Jordan J, Fischer M, Garcia Gubern C, Rivera Garcia B, Alvarado L, Sharp TM. Risk factors for hospitalization of patients with chikungunya virus infection at sentinel hospitals in Puerto Rico. PLoS Negl Trop Dis. 2019 01; 13(1):e0007084. PMID: 30640900.
      Citations: 5     Fields:    Translation:HumansCells
    11. Medina FA, Torres G, Acevedo J, Fonseca S, Casiano L, De León-Rodríguez CM, Santiago GA, Doyle K, Sharp TM, Alvarado LI, Paz-Bailey G, Muñoz-Jordán JL. Duration of the Presence of Infectious Zika Virus in Semen and Serum. J Infect Dis. 2019 01 01; 219(1):31-40. PMID: 30059980.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    12. Lozier MJ, Rosenberg ES, Doyle K, Adams L, Klein L, Muñoz-Jordan J, Alvarado LI, Sharp TM, Paz-Bailey G. Prolonged Detection of Zika Virus Nucleic Acid Among Symptomatic Pregnant Women: A Cohort Study. Clin Infect Dis. 2018 08 01; 67(4):624-627. PMID: 29534160.
      Citations: 8     Fields:    Translation:HumansCells
    13. Read JS, Torres-Velasquez B, Lorenzi O, Rivera Sanchez A, Torres-Torres S, Rivera LV, Capre-Franceschi SM, Garcia-Gubern C, Munoz-Jordan J, Santiago GA, Alvarado LI. Symptomatic Zika Virus Infection in Infants, Children, and Adolescents Living in Puerto Rico. JAMA Pediatr. 2018 07 01; 172(7):686-693. PMID: 29813148.
      Citations: 7     Fields:    Translation:HumansCellsPHPublic Health
    14. Tomashek KM, Lorenzi OD, Andújar-Pérez DA, Torres-Velásquez BC, Hunsperger EA, Munoz-Jordan JL, Perez-Padilla J, Rivera A, Gonzalez-Zeno GE, Sharp TM, Galloway RL, Glass Elrod M, Mathis DL, Oberste MS, Nix WA, Henderson E, McQuiston J, Singleton J, Kato C, García Gubern C, Santiago-Rivera W, Cruz-Correa J, Muns-Sosa R, Ortiz-Rivera JD, Jiménez G, Galarza IE, Horiuchi K, Margolis HS, Alvarado LI. Clinical and epidemiologic characteristics of dengue and other etiologic agents among patients with acute febrile illness, Puerto Rico, 2012-2015. PLoS Negl Trop Dis. 2017 Sep; 11(9):e0005859. PMID: 28902845.
      Citations: 12     Fields:    Translation:Humans
    15. Paz-Bailey G, Rosenberg ES, Doyle K, Munoz-Jordan J, Santiago GA, Klein L, Perez-Padilla J, Medina FA, Waterman SH, Gubern CG, Alvarado LI, Sharp TM. Persistence of Zika Virus in Body Fluids - Final Report. N Engl J Med. 2018 Sep 27; 379(13):1234-1243. PMID: 28195756.
      Citations: 148     Fields:    
    16. Sharp TM, Ryff KR, Alvarado L, Shieh WJ, Zaki SR, Margolis HS, Rivera-Garcia B. Surveillance for Chikungunya and Dengue During the First Year of Chikungunya Virus Circulation in Puerto Rico. J Infect Dis. 2016 Dec 15; 214(suppl 5):S475-S481. PMID: 27920177.
      Citations: 10     Fields:    Translation:HumansCells
    17. Erratum: Vol. 65, No. 44. MMWR Morb Mortal Wkly Rep. 2016 Dec 09; 65(48):1382. PMID: 27932779.
      Citations:    Fields:    
    18. Lozier M, Adams L, Febo MF, Torres-Aponte J, Bello-Pagan M, Ryff KR, Munoz-Jordan J, Garcia M, Rivera A, Read JS, Waterman SH, Sharp TM, Rivera-Garcia B. Incidence of Zika Virus Disease by Age and Sex - Puerto Rico, November 1, 2015-October 20, 2016. MMWR Morb Mortal Wkly Rep. 2016 Nov 11; 65(44):1219-1223. PMID: 27832051.
      Citations: 26     Fields:    Translation:Humans
    19. Adams L, Bello-Pagan M, Lozier M, Ryff KR, Espinet C, Torres J, Perez-Padilla J, Febo MF, Dirlikov E, Martinez A, Munoz-Jordan J, Garcia M, Segarra MO, Malave G, Rivera A, Shapiro-Mendoza C, Rosinger A, Kuehnert MJ, Chung KW, Pate LL, Harris A, Hemme RR, Lenhart A, Aquino G, Zaki S, Read JS, Waterman SH, Alvarado LI, Alvarado-Ramy F, Valencia-Prado M, Thomas D, Sharp TM, Rivera-Garcia B. Update: Ongoing Zika Virus Transmission - Puerto Rico, November 1, 2015-July 7, 2016. MMWR Morb Mortal Wkly Rep. 2016 Aug 05; 65(30):774-9. PMID: 27490087.
      Citations: 24     Fields:    Translation:HumansCellsPHPublic Health
    20. Dirlikov E, Ryff KR, Torres-Aponte J, Thomas DL, Perez-Padilla J, Munoz-Jordan J, Caraballo EV, Garcia M, Segarra MO, Malave G, Simeone RM, Shapiro-Mendoza CK, Reyes LR, Alvarado-Ramy F, Harris AF, Rivera A, Major CG, Mayshack M, Alvarado LI, Lenhart A, Valencia-Prado M, Waterman S, Sharp TM, Rivera-Garcia B. Update: Ongoing Zika Virus Transmission - Puerto Rico, November 1, 2015-April 14, 2016. MMWR Morb Mortal Wkly Rep. 2016 May 06; 65(17):451-5. PMID: 27149205.
      Citations: 17     Fields:    Translation:HumansCellsPHPublic Health
    21. Gregory CJ, Lorenzi OD, Colón L, García AS, Santiago LM, Rivera RC, Bermúdez LJ, Báez FO, Aponte DV, Tomashek KM, Gutierrez J, Alvarado L. Utility of the tourniquet test and the white blood cell count to differentiate dengue among acute febrile illnesses in the emergency room. PLoS Negl Trop Dis. 2011 Dec; 5(12):e1400. PMID: 22163057.
      Citations: 17     Fields:    Translation:HumansCellsPHPublic Health
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