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Devin Mueller

TitleAssociate Professor
Faculty RankAssociate Professor
InstitutionPonce School of Medicine
DepartmentBasic Sciences
AddressPO Box 7004
Ponce PR 00732-7004
Phone(787) 840-2575 Ext. 5688
Fax(787) 844-1980
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    Collapse Biography 
    Collapse awards and honors
    1995 - 1996Wilfrid Laurier University Incentive Scholarship
    1996 - 1997Craig R. Williams Scholarship
    1996NSERC (Canada) Undergraduate Student Research Award
    1996 - 1997Wilfrid Laurier University Incentive Scholarship
    1998 - 2002Concordia External Award Holder Scholarship
    1998 - 2000NSERC (Canada) Post Graduate Scholarship A
    2000 - 2002NSERC (Canada) Post Graduate Scholarship B
    2005 - 2007FQRNT (Quebec, Canada) Postdoctoral Fellowship
    2007Society for Neuroscience Postdoctoral Travel Award
    2009UW-Milwaukee Graduate School Research Fellow
    2012Ann Kelley Memorial Travel Fellow (Winter Conference on Brain Research)

    Collapse Overview 
    Collapse overview
    I research the neural mechanisms of learning and memory underlying drug abuse and emotional regulation, with emphasis on neurophysiology. Compulsive drug seeking and drug taking are the hallmarks of addiction, and overcoming these behaviors has proven difficult. Regulating these behaviors can be achieved by enhancing extinction learning and inhibiting retrieval of drug-associated memories. Recent work in my lab has uncovered the neural mechanisms underlying extinction learning and memory retrieval, and we have used these findings to target specific receptors and molecules to reduce or eliminate drug seeking using a variety of manipulations. We use animal models of drug administration combined with electrophysiological (in vivo and in vitro), pharmacological, molecular, and epigenetic techniques to examine extinction and retrieval mechanisms and sex differences. Understanding the neural bases of extinction and drug-associated memory retrieval could lead to the development of pharmacotherapies that improve the therapeutic outcome of rehabilitation programs.

    Collapse Research 
    Collapse research activities and funding
    R03DA027870     (MUELLER, DEVIN)Apr 1, 2010 - Mar 31, 2012
    Glutamate and prefrontal regulation of cocaine seeking after extinction
    Role: Principal Investigator

    R01DA038042     (MUELLER, DEVIN)Jun 1, 2014 - May 31, 2021
    Neural mechanisms underlying estradiol-enhanced extinction of cocaine seeking
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Liu J, Lu L, Mueller D. Editorial: Overcome Fear and Addiction by Manipulating Reconsolidation and Extinction of Emotional Memories. Front Behav Neurosci. 2020; 14:613612. PMID: 33250725.
    2. Yousuf H, Smies CW, Hafenbreidel M, Tuscher JJ, Fortress AM, Frick KM, Mueller D. Infralimbic Estradiol Enhances Neuronal Excitability and Facilitates Extinction of Cocaine Seeking in Female Rats via a BDNF/TrkB Mechanism. Front Behav Neurosci. 2019; 13:168. PMID: 31417375.
    3. Doncheck EM, Hafenbreidel M, Ruder SA, Fitzgerald MK, Torres L, Mueller D. bFGF expression is differentially regulated by cocaine seeking versus extinction in learning-related brain regions. Learn Mem. 2018 08; 25(8):361-368. PMID: 30012881.
      Citations: 1     Fields:    Translation:Animals
    4. Otis JM, Fitzgerald MK, Yousuf H, Burkard JL, Drake M, Mueller D. Prefrontal Neuronal Excitability Maintains Cocaine-Associated Memory During Retrieval. Front Behav Neurosci. 2018; 12:119. PMID: 29962941.
    5. Otis JM, Mueller D. Reversal of Cocaine-Associated Synaptic Plasticity in Medial Prefrontal Cortex Parallels Elimination of Memory Retrieval. Neuropsychopharmacology. 2017 Sep; 42(10):2000-2010. PMID: 28466871.
      Citations: 13     Fields:    Translation:AnimalsCells
    6. Hafenbreidel M, Rafa Todd C, Mueller D. Infralimbic GluN2A-Containing NMDA Receptors Modulate Reconsolidation of Cocaine Self-Administration Memory. Neuropsychopharmacology. 2017 Apr; 42(5):1113-1125. PMID: 28042872.
      Citations: 6     Fields:    Translation:Animals
    7. Fitzgerald MK, Otis JM, Mueller D. Dissociation of ß1- and ß2-adrenergic receptor subtypes in the retrieval of cocaine-associated memory. Behav Brain Res. 2016 Jan 01; 296:94-99. PMID: 26318933.
      Citations: 7     Fields:    Translation:Animals
    8. Hafenbreidel M, Twining RC, Rafa Todd C, Mueller D. Blocking Infralimbic Basic Fibroblast Growth Factor (bFGF or FGF2) Facilitates Extinction of Drug Seeking After Cocaine Self-Administration. Neuropsychopharmacology. 2015 Dec; 40(13):2907-15. PMID: 25994078.
      Citations: 9     Fields:    Translation:Animals
    9. Otis JM, Werner CT, Mueller D. Noradrenergic regulation of fear and drug-associated memory reconsolidation. Neuropsychopharmacology. 2015 Mar; 40(4):793-803. PMID: 25315025.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    10. Hafenbreidel M, Rafa Todd C, Twining RC, Tuscher JJ, Mueller D. Bidirectional effects of inhibiting or potentiating NMDA receptors on extinction after cocaine self-administration in rats. Psychopharmacology (Berl). 2014 Dec; 231(24):4585-94. PMID: 24847958.
      Citations: 8     Fields:    Translation:Animals
    11. Otis JM, Fitzgerald MK, Mueller D. Infralimbic BDNF/TrkB enhancement of GluN2B currents facilitates extinction of a cocaine-conditioned place preference. J Neurosci. 2014 Apr 23; 34(17):6057-64. PMID: 24760865.
      Citations: 30     Fields:    Translation:AnimalsCells
    12. Otis JM, Fitzgerald MK, Mueller D. Inhibition of hippocampal ß-adrenergic receptors impairs retrieval but not reconsolidation of cocaine-associated memory and prevents subsequent reinstatement. Neuropsychopharmacology. 2014 Jan; 39(2):303-10. PMID: 23907403.
      Citations: 21     Fields:    Translation:Animals
    13. Twining RC, Tuscher JJ, Doncheck EM, Frick KM, Mueller D. 17ß-estradiol is necessary for extinction of cocaine seeking in female rats. Learn Mem. 2013 May 15; 20(6):300-6. PMID: 23676202.
      Citations: 14     Fields:    Translation:Animals
    14. Otis JM, Dashew KB, Mueller D. Neurobiological dissociation of retrieval and reconsolidation of cocaine-associated memory. J Neurosci. 2013 Jan 16; 33(3):1271-81a. PMID: 23325262.
      Citations: 45     Fields:    Translation:Animals
    15. Otis JM, Mueller D. Inhibition of ß-adrenergic receptors induces a persistent deficit in retrieval of a cocaine-associated memory providing protection against reinstatement. Neuropsychopharmacology. 2011 Aug; 36(9):1912-20. PMID: 21544069.
      Citations: 36     Fields:    Translation:AnimalsPHPublic Health
    16. Mueller D, Bravo-Rivera C, Quirk GJ. Infralimbic D2 receptors are necessary for fear extinction and extinction-related tone responses. Biol Psychiatry. 2010 Dec 01; 68(11):1055-60. PMID: 20926066.
      Citations: 53     Fields:    Translation:AnimalsCells
    17. Mueller, D., and De Wit, H. . Neuromethods book series (NM, volume 50). Animal Models of Behavioral Analysis. 2010; 133-152. View Publication.
    18. Mueller D, Cahill SP. Noradrenergic modulation of extinction learning and exposure therapy. Behav Brain Res. 2010 Mar 17; 208(1):1-11. PMID: 19931568.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    19. Mueller, D., and Quirk, G.J. . Learning and extinction. Encyclopedia of Neuroscience. 2009; 2126-2129. View Publication.
    20. Afonso VM, Mueller D, Stewart J, Pfaus JG. Amphetamine pretreatment facilitates appetitive sexual behaviors in the female rat. Psychopharmacology (Berl). 2009 Jul; 205(1):35-43. PMID: 19283363.
      Citations: 9     Fields:    Translation:Animals
    21. Mueller D, Olivera-Figueroa LA, Pine DS, Quirk GJ. The effects of yohimbine and amphetamine on fear expression and extinction in rats. Psychopharmacology (Berl). 2009 Jul; 204(4):599-606. PMID: 19242678.
      Citations: 20     Fields:    Translation:Animals
    22. Rodriguez-Romaguera J, Sotres-Bayon F, Mueller D, Quirk GJ. Systemic propranolol acts centrally to reduce conditioned fear in rats without impairing extinction. Biol Psychiatry. 2009 May 15; 65(10):887-92. PMID: 19246030.
      Citations: 46     Fields:    Translation:AnimalsCells
    23. Mueller D, Porter JT, Quirk GJ. Noradrenergic signaling in infralimbic cortex increases cell excitability and strengthens memory for fear extinction. J Neurosci. 2008 Jan 09; 28(2):369-75. PMID: 18184779.
      Citations: 116     Fields:    Translation:AnimalsCells
    24. Quirk GJ, Mueller D. Neural mechanisms of extinction learning and retrieval. Neuropsychopharmacology. 2008 Jan; 33(1):56-72. PMID: 17882236.
      Citations: 579     Fields:    Translation:HumansAnimalsCells
    25. Mueller D, Chapman CA, Stewart J. Amphetamine induces dendritic growth in ventral tegmental area dopaminergic neurons in vivo via basic fibroblast growth factor. Neuroscience. 2006 Feb; 137(3):727-35. PMID: 16338078.
      Citations: 25     Fields:    Translation:AnimalsCells
    26. Mueller D, Perdikaris D, Stewart J. Persistence and drug-induced reinstatement of a morphine-induced conditioned place preference. Behav Brain Res. 2002 Nov 15; 136(2):389-97. PMID: 12429400.
      Citations: 50     Fields:    Translation:Animals
    27. Mueller D, Stewart J. Cocaine-induced conditioned place preference: reinstatement by priming injections of cocaine after extinction. Behav Brain Res. 2000 Oct; 115(1):39-47. PMID: 10996406.
      Citations: 102     Fields:    Translation:Animals
    28. Erb S, Hitchcott PK, Rajabi H, Mueller D, Shaham Y, Stewart J. Alpha-2 adrenergic receptor agonists block stress-induced reinstatement of cocaine seeking. Neuropsychopharmacology. 2000 Aug; 23(2):138-50. PMID: 10882840.
      Citations: 122     Fields:    Translation:Animals
    29. Mueller DT, Herman G, Eikelboom R. Effects of short- and long-term wheel deprivation on running. Physiol Behav. 1999 Mar; 66(1):101-7. PMID: 10222480.
      Citations: 1     Fields:    Translation:Animals
    30. Mueller DT, Loft A, Eikelboom R. Alternate-day wheel access: effects on feeding, body weight, and running. Physiol Behav. 1997 Oct; 62(4):905-8. PMID: 9284515.
      Citations: 5     Fields:    Translation:Animals
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