I research the neural mechanisms of learning and memory underlying drug abuse and emotional regulation, with emphasis on neurophysiology. Compulsive drug seeking and drug taking are the hallmarks of addiction, and overcoming these behaviors has proven difficult. Regulating these behaviors can be achieved by enhancing extinction learning and inhibiting retrieval of drug-associated memories. Recent work in my lab has uncovered the neural mechanisms underlying extinction learning and memory retrieval, and we have used these findings to target specific receptors and molecules to reduce or eliminate drug seeking using a variety of manipulations. We use animal models of drug administration combined with electrophysiological (in vivo and in vitro), pharmacological, molecular, and epigenetic techniques to examine extinction and retrieval mechanisms and sex differences. Understanding the neural bases of extinction and drug-associated memory retrieval could lead to the development of pharmacotherapies that improve the therapeutic outcome of rehabilitation programs.