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Diana M. Morales

TitlePhD in Neuroscience
Faculty RankAssistant Professor
InstitutionPonce School of Medicine
AddressEl Monte Calle El Monte 2836
Ponce PR 00716
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    2014 - 2016Loan Repayment Program, Ponce School of Medicine

    Collapse Overview 
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    My academic training and professional experience cover areas in neurosciences, public health, statistics, epidemiology, and clinical research.
    My doctoral thesis dissertation was on the topic of neurodegeneration caused by HIV infection in Puerto Rican women. The study was based on the specific role of certain folding proteins that regulate neurocognitive function. Through the progress of these research activities, I have gained expertise with multiple models of signaling pathways which may contribute to the progression of neural damage in HIV patients. I am furthering these studies in close collaboration with Dr. Summer Acevedo, a leading neuroscientist associated to the University of Southern Texas. I am well acquainted with a wide range of immuno/genetics techniques including but not limited to; western blots, PCR-Taq Man and ELISA’s, as well as solid background on statistical analyses. Further, I have considerable experience in the clinical research arena gained through my previous involvement as Study Coordinator in the Pediatrics HIV Clinic at the Universidad Central del Caribe and at the Ramon Ruiz Arnau Hospital. While working at this clinic, I was able to complete a Master’s degree in Public Health with a concentration in Epidemiology at the University of Puerto Rico- Medical Science Campus. My Master’s thesis project was developed on the incidence and prevalence of HIV/AIDS in children in the northern region of Puerto Rico. I strongly believe my experience in different areas of the basic sciences, public health, and epidemiology, and statistics, brings a unique opportunity to develop multiple collaborative research projects with a clinically and translationally relevant perspective. I am part of the Puerto Rico Clinical and Translational Research Consortium (PRCTRC) with particular emphasis in the duties and responsibilities of the DBE Core.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Sakhtah H, Koyama L, Zhang Y, Morales DK, Fields BL, Price-Whelan A, Hogan DA, Shepard K, Dietrich LE. The Pseudomonas aeruginosa efflux pump MexGHI-OpmD transports a natural phenazine that controls gene expression and biofilm development. Proc Natl Acad Sci U S A. 2016 06 21; 113(25):E3538-47. PMID: 27274079.
      Citations: 38     Fields:    Translation:Cells
    2. Lindsay AK, Morales DK, Liu Z, Grahl N, Zhang A, Willger SD, Myers LC, Hogan DA. Analysis of Candida albicans mutants defective in the Cdk8 module of mediator reveal links between metabolism and biofilm formation. PLoS Genet. 2014 Oct; 10(10):e1004567. PMID: 25275466.
      Citations: 23     Fields:    Translation:AnimalsCells
    3. Morales D, Hechavarria R, Wojna V, Acevedo SF. YWHAE/14-3-3e: a potential novel genetic risk factor and CSF biomarker for HIV neurocognitive impairment. J Neurovirol. 2013 Oct; 19(5):471-8. PMID: 23982958.
      Citations: 5     Fields:    Translation:HumansCells
    4. Morales DK, Grahl N, Okegbe C, Dietrich LE, Jacobs NJ, Hogan DA. Control of Candida albicans metabolism and biofilm formation by Pseudomonas aeruginosa phenazines. mBio. 2013 Jan 29; 4(1):e00526-12. PMID: 23362320.
      Citations: 84     Fields:    Translation:AnimalsCells
    5. Morales D, Acevedo SF, Skolasky RL, Hechavarria R, Santiago S, De La Torre T, Maldonado E, Wojna V. Translational spatial task and its relationship to HIV-associated neurocognitive disorders and apolipoprotein E in HIV-seropositive women. J Neurovirol. 2012 Dec; 18(6):488-502. PMID: 22972599.
      Citations: 5     Fields:    Translation:Humans
    6. Morales D, Skoulakis EC, Acevedo SF. 14-3-3s are potential biomarkers for HIV-related neurodegeneration. J Neurovirol. 2012 Oct; 18(5):341-53. PMID: 22811265.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    7. Merritt JH, Ha DG, Cowles KN, Lu W, Morales DK, Rabinowitz J, Gitai Z, O'Toole GA. Specific control of Pseudomonas aeruginosa surface-associated behaviors by two c-di-GMP diguanylate cyclases. mBio. 2010 Oct 19; 1(4). PMID: 20978535.
      Citations: 78     Fields:    Translation:Cells
    8. Morales DK, Jacobs NJ, Rajamani S, Krishnamurthy M, Cubillos-Ruiz JR, Hogan DA. Antifungal mechanisms by which a novel Pseudomonas aeruginosa phenazine toxin kills Candida albicans in biofilms. Mol Microbiol. 2010 Dec; 78(6):1379-92. PMID: 21143312.
      Citations: 45     Fields:    Translation:AnimalsCells
    9. Cugini C, Morales DK, Hogan DA. Candida albicans-produced farnesol stimulates Pseudomonas quinolone signal production in LasR-defective Pseudomonas aeruginosa strains. Microbiology (Reading). 2010 Oct; 156(Pt 10):3096-3107. PMID: 20656785.
    10. Morales DK, Hogan DA. Candida albicans interactions with bacteria in the context of human health and disease. PLoS Pathog. 2010 Apr 29; 6(4):e1000886. PMID: 20442787.
      Citations: 93     Fields:    Translation:HumansAnimals
    11. Cugini C, Calfee MW, Farrow JM, Morales DK, Pesci EC, Hogan DA. Farnesol, a common sesquiterpene, inhibits PQS production in Pseudomonas aeruginosa. Mol Microbiol. 2007 Aug; 65(4):896-906. PMID: 17640272.
      Citations: 98     Fields:    Translation:AnimalsCells
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