Dr. Yakubu’s research interest focuses on the regulation of signaling molecules by pathological and toxicological insults. The overall objective of his research interest is to identify signaling molecules involved in cerebrovascular dysfunction following exposure to environmental toxicants, subarachnoid hemorrhage and traumatic brain injury as well as pathology-induced brain dysfunction. Such molecules will serve as molecular neuroprotection and therapeutic targets to stem the consequences of cerebral vasospasm, stroke and neurological dysfunctions. Dr. Yakubu’s laboratory employs techniques involving animal models of cardiovascular disease, Laser Doppler flowmetry and imaging; vascular biology, cellular, molecular as well as protein profiling strategies to meet his research objectives. Dr. Yakubu’s research is synergized by an integrated environmental analysis involving the use instrumental HPLC-Uv-Vs, MALDIT-TOP, GS/MS, FT-IR to analyze environmental toxicants in biological and environmental samples to understand the consequences of exposure-induced pathologies. The use of these instruments has enabled identifications of modified proteins and genes following exposure. Currently, instrumental analysis of biological samples from persistent environmental toxicants such as PCB, BPA, Dioxin, nano-particles exposure animals are ongoing. Dr. Yakubu’s research had attracted various honors, awards, and funding from the American Heart Association, the National Heart, Lung and Blood Institute of the NIH amongst others.
Dr. Yakubu is a member of many professional bodies, including the American Heart Association, American Physiological Society, American Society for Experimental Pharmacology and Therapeutics and the Association of African Biomedical Scientists (AABS Inc). Dr. Yakubu is currently the Editor of the BioMed Scientist – an official Newsletter of AABS Inc.
1. Environmental impact Assessment
2. Analysis of Houston Ship Channels for the presence of emerging contaminant
3. Small signaling proteins PKC and PTK in early brain injury-induced cerebrovascular constriction.
4. PPAR and Heme-oxygenase: Molecular targets for cellular stress abatment.
5. Integrated analysis of exposure to pesticides and persistent chlorinated organic compounds (complex chemical mixtures)
6. Synthesis and evaluation of metal complexes with aromatic N-ligands as anticancer agents
7. Profiling and analysis of emerging contaminants in Houston area drinking water sources/ WTP.
8. Analysis of herbal/ medicinal plants and their potential in alternative medicine and therapeutic
9. Environmental forensic: An integrated environmental Research
10. Profiling of gut and saliva of trypanosomes’ infected tsetse fly for regulated biomolecules
11 The role of gasotransmitters – NO, CO, and H2S in physiology, pathology, and pharmacology
12, Environmental Analysis
13. Environmental Toxicology